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- Data Repository United Kingdom Compatibility:Not yet registeredPartners:University of Oxford Biotherapeutics, Structural Biology, immunoglobulin complex, circulatingUniversity of Oxford
The Therapeutic Structural Antibody Database tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab are downloadable as a single file with accompanying metadata.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25504/fairsharing.uip2kl&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eumore_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25504/fairsharing.uip2kl&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Institutional Repository United States Compatibility:Not yet registeredPartners:Temple UniversityTemple UniversityAll Research products
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The Chromium Epigenomics Toxicology (EpiCrDB) database contains a variety of epigenomics experimental assays relating to research on how Cr(VI) perturbs chromatin organization and dynamics. This data is used in reseach into how its toxicity may be attributed to epigenetic carcinogenicity. Manually-annotated sample and experiment metadata is included to facilitate FAIR data access. Hexavalent chromium [Cr(VI)] compounds are well-established respiratory carcinogens utilized in industrial processes. While inhalation exposure constitutes an occupational risk affecting mostly chromium workers, environmental exposure from drinking water contamination is a widespread gastrointestinal carcinogen, affecting millions of people throughout the world. The mechanism of action of Cr(VI) at the molecular level is poorly understood.
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Relative evolutionary importance of amino acids within a protein sequence.
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re3data: r3d100011669
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re3data: r3d100010252
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VertNet uses the Integrated Publishing Toolkit (IPT) to host published biodiversity data on the VertNet IPT for its participating institutions. The IPT is a free, open source web application designed to publish primary occurrence data, species checklists and taxonomies, and associated dataset metadata available for use on the Internet. Data are published as web-based Darwin Core Archives (simple ZIP files that contain tab-delimited or comma-separated text files organized using the Darwin Core Standard).
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- Data Repository United Kingdom Compatibility:Not yet registeredPartners:University of Oxford Biotherapeutics, Structural Biology, immunoglobulin complex, circulatingUniversity of Oxford
The Therapeutic Structural Antibody Database tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab are downloadable as a single file with accompanying metadata.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25504/fairsharing.uip2kl&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eumore_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25504/fairsharing.uip2kl&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Institutional Repository United States Compatibility:Not yet registeredPartners:Temple UniversityTemple UniversityAll Research products
arrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=opendoar____::6d9c547cf146054a5a720606a7694467&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eumore_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=opendoar____::6d9c547cf146054a5a720606a7694467&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Data Repository United States Compatibility:Not yet registeredPartners:Department of Environmental and Public Health Sciences, University of Cincinnati Life Science, Epigenomics, ToxicologyDepartment of Environmental and Public Health Sciences, University of Cincinnati
The Chromium Epigenomics Toxicology (EpiCrDB) database contains a variety of epigenomics experimental assays relating to research on how Cr(VI) perturbs chromatin organization and dynamics. This data is used in reseach into how its toxicity may be attributed to epigenetic carcinogenicity. Manually-annotated sample and experiment metadata is included to facilitate FAIR data access. Hexavalent chromium [Cr(VI)] compounds are well-established respiratory carcinogens utilized in industrial processes. While inhalation exposure constitutes an occupational risk affecting mostly chromium workers, environmental exposure from drinking water contamination is a widespread gastrointestinal carcinogen, affecting millions of people throughout the world. The mechanism of action of Cr(VI) at the molecular level is poorly understood.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=fairsharing_::e37b08dd3015330dcbb5d6663667b8b8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eumore_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=fairsharing_::e37b08dd3015330dcbb5d6663667b8b8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Institutional Repository United Kingdom Compatibility:Not yet registeredPartners:FSAFSAAll Research products
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Relative evolutionary importance of amino acids within a protein sequence.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25504/fairsharing.4eanvm&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eumore_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25504/fairsharing.4eanvm&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Data Repository United States Compatibility:Not yet registeredPartners:University of Illinois at Urbanan-Champaign, Prairie Research Institute Life Sciences, Agriculture, Forestry, Horticulture and Veterinary Medicine, Natural SciencesUniversity of Illinois at Urbanan-Champaign, Prairie Research Institute
re3data: r3d100011669
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=r3d100011669&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eumore_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=r3d100011669&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Data Repository United States Compatibility:Not yet registeredPartners:IHME, BMGF Humanities and Social Sciences, Social Sciences, Social and Behavioural SciencesIHME,BMGF
re3data: r3d100010252
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=r3d100010252&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eumore_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=r3d100010252&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Institutional Repository United States Compatibility:Not yet registeredPartners:Liberty UniversityLiberty UniversityAll Research products
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VertNet uses the Integrated Publishing Toolkit (IPT) to host published biodiversity data on the VertNet IPT for its participating institutions. The IPT is a free, open source web application designed to publish primary occurrence data, species checklists and taxonomies, and associated dataset metadata available for use on the Internet. Data are published as web-based Darwin Core Archives (simple ZIP files that contain tab-delimited or comma-separated text files organized using the Darwin Core Standard).
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