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9 research outcomes, page 1 of 1
  • other research product . 2019
    Open Access Japanese
    Authors:
    Ooi, Akishi;
    Persistent Identifiers
    Publisher: 金沢大学医薬保健研究域医学系

    In solid cancers amplified genes are potential targets of molecular therapies. In this study the 16 genes and 22 genes reportedly amplified in gastric and mammary cancers were examined by multiplex ligation-dependent probe amplification and fluorescence in situ hybridiz...

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  • other research product . 2019
    Open Access Japanese
    Authors:
    Oyama, Takeru;
    Persistent Identifiers
    Publisher: 金沢大学医薬保健研究域医学系

    Genome-wide copy number analysis in human gastric carcinoma identifed an amplified gene locus including vascular endothelial growth factor A (VEGFA). VEGFA gene amplification was validated by fluorescence in situ hybridization assay. The levels of VEGFA gene amplificati...

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  • other research product . 2018
    Open Access Japanese
    Authors:
    Horike, Shinichi;
    Persistent Identifiers

    15q11-q13領域はゲノム刷り込み遺伝子クラスターであり,PWS-ICを中心とした染色体ドメインレベルの転写制御の存在が明らかになっている。このPWS-IC近傍からは父方アレル特異的な長鎖ncRNA(UBE3A-ATS)が転写され,染色体ドメインレベルの転写制御の一役を担っていると考えられている。そこで,本研究ではヒト染色体工学技術を用いてPWS-ICのノックアウトを行い,UBE3A-ATSによる遺伝子発現制御機構を解析した。前年度,PWS-IC欠失染色体でUBE3A-ATSの発現を解析したところ,SNRPN,HBII-85を含め...

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  • other research product . 2018
    Open Access Japanese
    Publisher: 高知県立大学
  • other research product . 2016
    Open Access Japanese
    Persistent Identifiers
    Publisher: 鹿児島大学
    Country: Japan

    Studies of chromosome were conducted to progress breeding of pear through genome studies. The results are as follows; (1) Preparation of good chromosome sample using enzymatic maceration and air drying method was established, (2) The chromosome configuration was elucida...

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  • other research product . 2016
    Open Access Japanese
    Authors:
    Oi, Akishi;
    Persistent Identifiers

    Gene amplification is a major type of genetic aberration found in human cancers of solid types. The amplified genes so far have been useful targets or will be potential targets for molecular therapies. In this study, cancers of the stomach, breast and colon, which are f...

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  • other research product . 2013
    Open Access Japanese
    Authors:
    Ooi, Akishi;
    Persistent Identifiers
    Publisher: 金沢大学医学系

    By combined analysis of immunohistochemistry and fluorescence in situ hybridization (FISH) on 475 formalin-fixed paraffin-embedded tissue, 51 gastric adenocarcinoma with HER2-amplified cancer cells. The heterogeneity of HER2 amplification, if defined as the existence of...

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  • other research product . 2009
    Open Access Japanese
    Authors:
    Oi, Akishi;
    Persistent Identifiers
    Publisher: 金沢大学医学系

    胆嚢癌および乳癌について、DNA転写物質をコードするMYC, 容体型チロシンキナーゼをコードするERBB2, EGFR の遺伝子の増幅をfluorescence in situ hybridizationを用いて検索した。胆嚢癌では97 例中3例にMYCの増幅があり、1例でERBB2とEGFR、1例でERBB2の同時増幅を認めた。乳癌では91例中31例にMYCの増幅がみられ、このうち10例にERBB2の同時増幅をみとめた。

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  • other research product . 2005
    Open Access Japanese
    Authors:
    Hirai, Hirohisa;
    Persistent Identifiers
    Publisher: 京都大学

    平成13-16年度科学研究費補助金(基盤研究((B)(2))研究成果報告書 課題番号:13557021 研究代表者:平井啓久(京都大学霊長類研究所)

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9 research outcomes, page 1 of 1