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DRYAD; NARCIS
Dataset . 2019
License: CC 0
Data sources: Datacite; NARCIS
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ZENODO
Dataset . 2019
License: CC 0
Data sources: ZENODO
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DANS-EASY
Dataset . 2019
Data sources: B2FIND
versions View all 4 versions

Data from: Microglial activation in early Alzheimer trajectory is associated with higher grey matter volume

Authors: Femminella, Grazia Daniela; Dani, Melanie; Wood, Melanie; Fan, Zhen; Calsolaro, Valeria; Atkinson, Rebecca; Edginton, Trudi; +3 Authors

Data from: Microglial activation in early Alzheimer trajectory is associated with higher grey matter volume

Abstract

Objective: To investigate the influence of microglial activation in the early stages of Alzheimer’s disease trajectory, we assessed the relationship between microglial activation and grey matter volume and hippocampal volume in MCI patients. Methods: In this study, fifty-five participants (37 early stages MCI and 18 controls) underwent [11C]PBR28 PET, a marker of microglial activation; volumetric MRI to evaluate grey matter and hippocampal volumes as well as clinical and neuropsychometric evaluation. [11C]PBR28 VT (volume of distribution) was calculated using arterial input function and Logan Graphical analysis. Grey matter volume and hippocampal volumes were calculated from MRI for each subject. Statistical parametric mapping software was used to perform voxel-wise correlations and biological parametric mapping analysis. Amyloid status was assessed using [18F]Flutemetamol PET. Results: Higher [11C]PBR28 VT in different cortical areas correlated with higher grey matter volume in both amyloid positive and negative MCI. Additionally, higher hippocampal volume correlated with higher cortical [11C]PBR28 Logan VT. Conclusions: In this in vivo study, we have demonstrated that microglial activation quantified using [11C]PBR28 PET was associated with higher grey matter volume and higher hippocampal volume in MCI patients. This may suggest that microglial activation may not always be associated with neuronal damage, and indeed it may have beneficial effect in early stages of Alzheimer’s trajectory. While further longitudinal studies are necessary, these findings have significant implications on therapeutic strategies targeting microglial activation.

Supplemental Table 1Supplemental Table 2Supplemental Table 3Supplemental Table 4Supplemental Figure 1 600 dpi

Keywords

medicine and health care, Medicine, [ 120 ] MRI, [ 122 ] PET, Life sciences

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download
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
downloads
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0
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9
9
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
,
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
result:project:semrel
Related to Research communities
European Marine Science
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