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description Publicationkeyboard_double_arrow_right Article 2018Publisher:Ovid Technologies (Wolters Kluwer Health) Dániel, Veréb; Nikoletta, Szabó; Bernadett, Tuka; János, Tajti; András, Király; Péter, Faragó; Krisztián, Kocsis; Eszter, Tóth; Bálint, Kincses; Teréz, Bagoly; Zsuzsanna, Helyes; László, Vécsei; Zsigmond Tamás, Kincses;pmid: 30135251
Objective To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. Methods Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB9s Software Library. Results Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity ( p p p p Conclusion We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 6 citations 6 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014Publisher:Oxford University Press (OUP) Funded by:AKA | Parallel or convergent ev..., AKA | Parallel, convergent and ..., AKA | Adaptive divergence in bo... +1 projectsAKA| Parallel or convergent evolution? Evolutionary genetics of gigantism in the wild ,AKA| Parallel, convergent and cryptic evolution - uncovering the hidden adaptive differentiation in the wild ,AKA| Adaptive divergence in body size, brain size and behaviour: a quantitative genetic and functional genomic approach ,AKA| Parallel, convergent and cryptic evolution - uncovering the hidden adaptive differentiation in the wildAuthors: Gábor Herczeg; Kaisa Välimäki; Abigél Gonda; Juha Merilä;Gábor Herczeg; Kaisa Välimäki; Abigél Gonda; Juha Merilä;doi: 10.1111/jeb.12409
pmid: 24898271
AbstractTheory predicts that the sex making greater investments into reproductive behaviours demands higher cognitive ability, and as a consequence, larger brains or brain parts. Further, the resulting sexual dimorphism can differ between populations adapted to different environments, or among individuals developing under different environmental conditions. In the nine‐spine stickleback (Pungitius pungitius), males perform nest building, courtship, territory defence and parental care, whereas females perform mate choice and produce eggs. Also, predation‐adapted marine and competition‐adapted pond populations have diverged in a series of ecologically relevant traits, including the level of phenotypic plasticity. Here, we studied sexual dimorphism in brain size and architecture in nine‐spined stickleback from marine and pond populations reared in a factorial experiment with predation and food treatments in a common garden experiment. Males had relatively larger brains, larger telencephala, cerebella and hypothalami (6–16% divergence) than females, irrespective of habitat. Females tended to have larger bulbi olfactorii than males (13%) in the high food treatment, whereas no such difference was found in the low food treatment. The strong sexual dimorphism in brain architecture implies that the different reproductive allocation strategies (behaviour vs. egg production) select for different investments into the costly brains between males and females. The lack of habitat dependence in brain sexual dimorphism suggests that the sex‐specific selection forces on brains differ only negligibly between habitats. Although significance of the observed sex‐specific brain plasticity in the size of bulbus olfactorius remains unclear, it demonstrates the potential for sex‐specific neural plasticity.
Journal of Evolution... arrow_drop_down Journal of Evolutionary BiologyArticle . 2014 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 21 citations 21 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Evolution... arrow_drop_down Journal of Evolutionary BiologyArticle . 2014 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 HungaryPublisher:The Royal Society Orsolya Vincze; Csongor I. Vágási; Péter L. Pap; Gergely Osváth; Anders Pape Møller;Long-distance migratory birds have relatively smaller brains than short-distance migrants or residents. Here, we test whether reduction in brain size with migration distance can be generalized across the different brain regions suggested to play key roles in orientation during migration. Based on 152 bird species, belonging to 61 avian families from six continents, we show that the sizes of both the telencephalon and the whole brain decrease, and the relative size of the optic lobe increases, while cerebellum size does not change with increasing migration distance. Body mass, whole brain size, optic lobe size and wing aspect ratio together account for a remarkable 46% of interspecific variation in average migration distance across bird species. These results indicate that visual acuity might be a primary neural adaptation to the ecological challenge of migration.
Biology Letters arrow_drop_down Biology LettersArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Biology Letters arrow_drop_down Biology LettersArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rsbl.2015.0678&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016Publisher:The Royal Society Funded by:FWF | Evolution of vertebrate b...FWF| Evolution of vertebrate brain size: an experimental approachAuthors: Alexander Kotrschal; Niclas Kolm; Dustin J. Penn;Alexander Kotrschal; Niclas Kolm; Dustin J. Penn;Both the brain and the immune system are energetically demanding organs, and when natural selection favours increased investment into one, then the size or performance of the other should be reduced. While comparative analyses have attempted to test this potential evolutionary trade-off, the results remain inconclusive. To test this hypothesis, we compared the tissue graft rejection (an assay for measuring innate and acquired immune responses) in guppies ( Poecilia reticulata ) artificially selected for large and small relative brain size. Individual scales were transplanted between pairs of fish, creating reciprocal allografts, and the rejection reaction was scored over 8 days (before acquired immunity develops). Acquired immune responses were tested two weeks later, when the same pairs of fish received a second set of allografts and were scored again. Compared with large-brained animals, small-brained animals of both sexes mounted a significantly stronger rejection response to the first allograft. The rejection response to the second set of allografts did not differ between large- and small-brained fish. Our results show that selection for large brain size reduced innate immune responses to an allograft, which supports the hypothesis that there is a selective trade-off between investing into brain size and innate immunity.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4810857Data sources: PubMed CentralProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallProceedings of the Royal Society B Biological SciencesArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rspb.2015.2857&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 45 citations 45 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4810857Data sources: PubMed CentralProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallProceedings of the Royal Society B Biological SciencesArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rspb.2015.2857&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 HungaryPublisher:Public Library of Science (PLoS) Emil Rudobeck; John A. Bellone; Attila Szücs; Kristine Bonnick; Shalini Mehrotra-Carter; Jérôme Badaut; Gregory A. Nelson; Richard E. Hartman; Roman Vlkolinský;Space radiation represents a significant health risk for astronauts. Ground-based animal studies indicate that space radiation affects neuronal functions such as excitability, synaptic transmission, and plasticity, and it may accelerate the onset of Alzheimer's disease (AD). Although protons represent the main constituent in the space radiation spectrum, their effects on AD-related pathology have not been tested. We irradiated 3 month-old APP/PSEN1 transgenic (TG) and wild type (WT) mice with protons (150 MeV; 0.1-1.0 Gy; whole body) and evaluated functional and biochemical hallmarks of AD. We performed behavioral tests in the water maze (WM) before irradiation and in the WM and Barnes maze at 3 and 6 months post-irradiation to evaluate spatial learning and memory. We also performed electrophysiological recordings in vitro in hippocampal slices prepared 6 and 9 months post irradiation to evaluate excitatory synaptic transmission and plasticity. Next, we evaluated amyloid 3 (A(3) deposition in the contralateral hippocampus and adjacent cortex using immunohistochemistry. In cortical homogenates, we analyzed the levels of the presynaptic marker synaptophysin by Western blotting and measured pro-inflammatory cytokine levels (INF alpha, IL-beta, IL-6, CXCL10 and CCL2) by bead-based multiplex assay. TG mice performed significantly worse than WT mice in the WM. Irradiation of TG mice did not affect their behavioral performance, but reduced the amplitudes of population spikes and inhibited paired-pulse facilitation in CA1 neurons. These electrophysiological alterations in the TG mice were qualitatively different from those observed in WT mice, in which irradiation increased excitability and synaptic efficacy. Irradiation increased A beta deposition in the cortex of TG mice without affecting cytokine levels and increased synaptophysin expression in WT mice (but not in the TG mice). Although irradiation with protons increased A beta deposition, the complex functional and biochemical results indicate that irradiation effects are not synergistic to AD pathology.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5706673Data sources: PubMed CentralELTE Digital Institutional Repository (EDIT)Article . 2017Data sources: ELTE Digital Institutional Repository (EDIT)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0186168&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 32 citations 32 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5706673Data sources: PubMed CentralELTE Digital Institutional Repository (EDIT)Article . 2017Data sources: ELTE Digital Institutional Repository (EDIT)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0186168&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United Kingdom, ItalyPublisher:The Royal Society Funded by:UKRI | The International Centre ..., FCT | LA 1, EC | REPCOLLABUKRI| The International Centre for Language and Communicative Development ,FCT| LA 1 ,EC| REPCOLLABAuthors: Dora Kampis; Eugenio Parise; Gergely Csibra; Ágnes Melinda Kovács;Dora Kampis; Eugenio Parise; Gergely Csibra; Ágnes Melinda Kovács;pmc: PMC4685805 , PMC4971203 , PMC4971214
handle: 11572/311604 , 11572/311549
A major feat of\ud social beings is to encode what their conspecifics see, know or believe. \ud While various nonhuman animals show precursors of these abilities, humans perform \ud uniquely sophisticated inferences about other people’s mental states. However, it is still \ud unclear how these possibly human-specific capacities develop and whether preverbal \ud infants, similarly to adults form representations of other agents’ mental states, specifically \ud metarepresentations. We explored the neuro-cognitive bases of 8-month-olds’ ability to \ud encode the world from another person’s perspective, using gamma-band EEG activity over \ud the temporal lobes, an established neural signature for sustained object representation \ud after occlusion. We observed such gamma-band activity when an object was occluded \ud from the infants’ perspective, as well as when it was occluded only from the other person \ud (Experiment 1), and also when subsequently the object disappeared but the person falsely \ud believed the object to be present (Experiment 2). These findings suggest that the cognitive \ud systems involved in representing the world from infants’ own perspective are also recruited \ud for encoding others’ beliefs. Such results point to an early developing, powerful apparatus \ud suitable to deal with multiple concurrent representations; and suggest that infants can \ud have a metarepresentational understanding of other minds even before the onset of \ud language.
Proceedings of the R... arrow_drop_down Proceedings of the Royal Society B Biological SciencesArticle . 2015Full-Text: http://europepmc.org/articles/PMC4685805Data sources: PubMed CentralLancaster EPrints; Proceedings of the Royal Society B Biological Sciences; IRIS - Institutional Research Information System of the University of TrentoArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4971214Data sources: PubMed CentralEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4971203Data sources: PubMed CentralProceedings of the Royal Society B Biological Sciences; IRIS - Institutional Research Information System of the University of TrentoArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityLancaster EPrintsArticle . 2015 . Peer-reviewedFull-Text: https://eprints.lancs.ac.uk/id/eprint/76468/7/Manuscript_proc_b_kampis_parise_csibra_kovacs.pdfData sources: Lancaster EPrintsProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rspb.2015.1683&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 10visibility views 10 download downloads 123 Powered bymore_vert Proceedings of the R... arrow_drop_down Proceedings of the Royal Society B Biological SciencesArticle . 2015Full-Text: http://europepmc.org/articles/PMC4685805Data sources: PubMed CentralLancaster EPrints; Proceedings of the Royal Society B Biological Sciences; IRIS - Institutional Research Information System of the University of TrentoArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4971214Data sources: PubMed CentralEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4971203Data sources: PubMed CentralProceedings of the Royal Society B Biological Sciences; IRIS - Institutional Research Information System of the University of TrentoArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityLancaster EPrintsArticle . 2015 . Peer-reviewedFull-Text: https://eprints.lancs.ac.uk/id/eprint/76468/7/Manuscript_proc_b_kampis_parise_csibra_kovacs.pdfData sources: Lancaster EPrintsProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rspb.2015.1683&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 United Kingdom, ItalyPublisher:The Company of Biologists Filippo Casoni; Samuel A. Malone; Morgane Belle; Federico Luzzati; Francis Collier; Cecile Allet; Erik Hrabovszky; Sowmyalakshmi Rasika; Vincent Prevot; Alain Chédotal; Paolo Giacobini;Fertility in mammals is controlled by hypothalamic neurons that secrete gonadotropin-releasing hormone (GnRH). These neurons differentiate in the olfactory placodes during embryogenesis and migrate from the nose to the hypothalamus before birth. Information regarding this process in humans is sparse. Here, we adapted new tissue-clearing and whole-mount immunohistochemical techniques to entire human embryos/fetuses to meticulously study this system during the first trimester of gestation in the largest series of human fetuses examined to date. Combining these cutting-edge techniques with conventional immunohistochemistry, we provide the first chronological and quantitative analysis of GnRH neuron origins, differentiation and migration, as well as a 3D atlas of their distribution in the fetal brain. We reveal not only that the number of GnRH-immunoreactive neurons in humans is significantly higher than previously thought, but that GnRH cells migrate into several extrahypothalamic brain regions in addition to the hypothalamus. Their presence in these areas raises the possibility that GnRH has non-reproductive roles, creating new avenues for research on GnRH functions in cognitive, behavioral and physiological processes.
Archivio Istituziona... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 141 citations 141 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 1visibility views 1 download downloads 33 Powered bymore_vert Archivio Istituziona... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1242/dev.139444&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United StatesPublisher:Public Library of Science (PLoS) Funded by:NIH | Pittsburgh Biomedical Inf..., NIH | Extending the Phenotype o..., NIH | Molecular characterizatio...NIH| Pittsburgh Biomedical Informatics Training Program ,NIH| Extending the Phenotype of Nonsyndromic Orofacial Clefting ,NIH| Molecular characterization of novel loci for orofacial clefting using canine modeWolf, Zena T.; Brand, Harrison A.; Shaffer, John R.; Leslie, Elizabeth J.; Arzi, Boaz; Willet, Cali E.; Cox, Timothy C.; McHenry, Toby; Narayan, Nicole; Feingold, Eleanor; Wang, Xioajing; Sliskovic, Saundra; Karmi, Nili; Safra, Noa; Sanchez, Carla; Deleyiannis, Frederic W. B.; Murray, Jeffrey C.; Wade, Claire M.; Marazita, Mary L.; Bannasch, Danika L.;Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth defect. We provide insight into the genetic etiology of this birth defect by performing genome-wide association studies in two species: dogs and humans. In the dog, a genome-wide association study of 7 CL/P cases and 112 controls from the Nova Scotia Duck Tolling Retriever (NSDTR) breed identified a significantly associated region on canine chromosome 27 (unadjusted p=1.1 x 10-13; adjusted p= 2.2 x 10-3). Further analysis in NSDTR families and additional full sibling cases identified a 1.44 Mb homozygous haplotype (chromosome 27: 9.29 – 10.73 Mb) segregating with a more complex phenotype of cleft lip, cleft palate, and syndactyly (CLPS) in 13 cases. Whole-genome sequencing of 3 CLPS cases and 4 controls at 15X coverage led to the discovery of a frameshift mutation within ADAMTS20 (c.1360_1361delAA (p.Lys453Ilefs*3)), which segregated concordant with the phenotype. In a parallel study in humans, a family-based association analysis (DFAM) of 125 CL/P cases, 420 unaffected relatives, and 392 controls from a Guatemalan cohort, identified a suggestive association (rs10785430; p =2.67 x 10-6) with the same gene, ADAMTS20. Sequencing of cases from the Guatemalan cohort was unable to identify a causative mutation within the coding region of ADAMTS20, but four coding variants were found in additional cases of CL/P. In summary, this study provides genetic evidence for a role of ADAMTS20 in CL/P development in dogs and as a candidate gene for CL/P development in humans. Author Summary Cleft lip with or without cleft palate (CL/P) is a commonly occurring birth defect that can lead to a lifetime of complications in affected children. To better understand the genetic cause of these disorders, we investigated CL/P in both dogs and humans. Genome-wide association studies in both species independently identify ADAMTS20 as a candidate gene for CL/P development. In dogs, a deletion within a functional domain of ADAMTS20 is responsible for CL/P in the Nova Scotia Duck Tolling Retriever dog breed. In humans, an associated region containing the same gene, ADAMTS20, was identified in a study population of native Guatemalans. Subsequent sequencing in humans was unable to identify a causative mutation within the coding region of ADAMTS20 in the Guatemalan cohort; however, sequencing of ADAMTS20 in additional cases with CL/P identified four novel coding variants. This work provides genetic evidence for a role for ADAMTS20 in CL/P development in both dogs and humans.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4370697Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pgen.1005059&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 95 citations 95 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4370697Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015Publisher:The Royal Society Kristina Noreikiene; Gábor Herczeg; Abigél Gonda; Gergely Balázs; Arild Husby; Juha Merilä;The mosaic model of brain evolution postulates that different brain regions are relatively free to evolve independently from each other. Such independent evolution is possible only if genetic correlations among the different brain regions are less than unity. We estimated heritabilities, evolvabilities and genetic correlations of relative size of the brain, and its different regions in the three-spined stickleback ( Gasterosteus aculeatus ). We found that heritabilities were low (average h 2 = 0.24), suggesting a large plastic component to brain architecture. However, evolvabilities of different brain parts were moderate, suggesting the presence of additive genetic variance to sustain a response to selection in the long term. Genetic correlations among different brain regions were low (average r G = 0.40) and significantly less than unity. These results, along with those from analyses of phenotypic and genetic integration, indicate a high degree of independence between different brain regions, suggesting that responses to selection are unlikely to be severely constrained by genetic and phenotypic correlations. Hence, the results give strong support for the mosaic model of brain evolution. However, the genetic correlation between brain and body size was high ( r G = 0.89), suggesting a constraint for independent evolution of brain and body size in sticklebacks.
Europe PubMed Centra... arrow_drop_down Proceedings of the Royal Society B Biological SciencesArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 46 citations 46 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Proceedings of the Royal Society B Biological SciencesArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Publisher:Oxford University Press (OUP) Gábor Herczeg; Tamás János Urszán; Stephanie Orf; Gergely Nagy; Alexander Kotrschal; Niclas Kolm;doi: 10.1111/jeb.13405
pmid: 31604005
AbstractUnderstanding how animal personality (consistent between‐individual behavioural differences) arises has become a central topic in behavioural sciences. This endeavour is complicated by the fact that not only the mean behaviour of individuals (behavioural type) but also the strength of their reaction to environmental change (behavioural plasticity) varies consistently. Personality and cognitive abilities are linked, and we suggest that behavioural plasticity could also be explained by differences in brain size (a proxy for cognitive abilities), since accurate decisions are likely essential to make behavioural plasticity beneficial. We test this idea in guppies (Poecilia reticulata), artificially selected for large and small brain size, which show clear cognitive differences between selection lines. To test whether those lines differed in behavioural plasticity, we reared them in groups in structurally enriched environments and then placed adults individually into empty tanks, where we presented them daily with visual predator cues and monitored their behaviour for 20 days with video‐aided motion tracking. We found that individuals differed consistently in activity and risk‐taking, as well as in behavioural plasticity. In activity, only the large‐brained lines demonstrated habituation (increased activity) to the new environment, whereas in risk‐taking, we found sensitization (decreased risk‐taking) in both brain size lines. We conclude that brain size, potentially via increasing cognitive abilities, may increase behavioural plasticity, which in turn can improve habituation to novel environments. However, the effects seem to be behaviour‐specific. Our results suggest that brain size likely explains some of the variation in behavioural plasticity found at the intraspecific level.
Journal of Evolution... arrow_drop_down Journal of Evolutionary BiologyArticle . 2018 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Evolution... arrow_drop_down Journal of Evolutionary BiologyArticle . 2018 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2018Publisher:Ovid Technologies (Wolters Kluwer Health) Dániel, Veréb; Nikoletta, Szabó; Bernadett, Tuka; János, Tajti; András, Király; Péter, Faragó; Krisztián, Kocsis; Eszter, Tóth; Bálint, Kincses; Teréz, Bagoly; Zsuzsanna, Helyes; László, Vécsei; Zsigmond Tamás, Kincses;pmid: 30135251
Objective To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. Methods Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB9s Software Library. Results Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity ( p p p p Conclusion We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 6 citations 6 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014Publisher:Oxford University Press (OUP) Funded by:AKA | Parallel or convergent ev..., AKA | Parallel, convergent and ..., AKA | Adaptive divergence in bo... +1 projectsAKA| Parallel or convergent evolution? Evolutionary genetics of gigantism in the wild ,AKA| Parallel, convergent and cryptic evolution - uncovering the hidden adaptive differentiation in the wild ,AKA| Adaptive divergence in body size, brain size and behaviour: a quantitative genetic and functional genomic approach ,AKA| Parallel, convergent and cryptic evolution - uncovering the hidden adaptive differentiation in the wildAuthors: Gábor Herczeg; Kaisa Välimäki; Abigél Gonda; Juha Merilä;Gábor Herczeg; Kaisa Välimäki; Abigél Gonda; Juha Merilä;doi: 10.1111/jeb.12409
pmid: 24898271
AbstractTheory predicts that the sex making greater investments into reproductive behaviours demands higher cognitive ability, and as a consequence, larger brains or brain parts. Further, the resulting sexual dimorphism can differ between populations adapted to different environments, or among individuals developing under different environmental conditions. In the nine‐spine stickleback (Pungitius pungitius), males perform nest building, courtship, territory defence and parental care, whereas females perform mate choice and produce eggs. Also, predation‐adapted marine and competition‐adapted pond populations have diverged in a series of ecologically relevant traits, including the level of phenotypic plasticity. Here, we studied sexual dimorphism in brain size and architecture in nine‐spined stickleback from marine and pond populations reared in a factorial experiment with predation and food treatments in a common garden experiment. Males had relatively larger brains, larger telencephala, cerebella and hypothalami (6–16% divergence) than females, irrespective of habitat. Females tended to have larger bulbi olfactorii than males (13%) in the high food treatment, whereas no such difference was found in the low food treatment. The strong sexual dimorphism in brain architecture implies that the different reproductive allocation strategies (behaviour vs. egg production) select for different investments into the costly brains between males and females. The lack of habitat dependence in brain sexual dimorphism suggests that the sex‐specific selection forces on brains differ only negligibly between habitats. Although significance of the observed sex‐specific brain plasticity in the size of bulbus olfactorius remains unclear, it demonstrates the potential for sex‐specific neural plasticity.
Journal of Evolution... arrow_drop_down Journal of Evolutionary BiologyArticle . 2014 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 21 citations 21 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Evolution... arrow_drop_down Journal of Evolutionary BiologyArticle . 2014 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 HungaryPublisher:The Royal Society Orsolya Vincze; Csongor I. Vágási; Péter L. Pap; Gergely Osváth; Anders Pape Møller;Long-distance migratory birds have relatively smaller brains than short-distance migrants or residents. Here, we test whether reduction in brain size with migration distance can be generalized across the different brain regions suggested to play key roles in orientation during migration. Based on 152 bird species, belonging to 61 avian families from six continents, we show that the sizes of both the telencephalon and the whole brain decrease, and the relative size of the optic lobe increases, while cerebellum size does not change with increasing migration distance. Body mass, whole brain size, optic lobe size and wing aspect ratio together account for a remarkable 46% of interspecific variation in average migration distance across bird species. These results indicate that visual acuity might be a primary neural adaptation to the ecological challenge of migration.
Biology Letters arrow_drop_down Biology LettersArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rsbl.2015.0678&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Biology Letters arrow_drop_down Biology LettersArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rsbl.2015.0678&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016Publisher:The Royal Society Funded by:FWF | Evolution of vertebrate b...FWF| Evolution of vertebrate brain size: an experimental approachAuthors: Alexander Kotrschal; Niclas Kolm; Dustin J. Penn;Alexander Kotrschal; Niclas Kolm; Dustin J. Penn;Both the brain and the immune system are energetically demanding organs, and when natural selection favours increased investment into one, then the size or performance of the other should be reduced. While comparative analyses have attempted to test this potential evolutionary trade-off, the results remain inconclusive. To test this hypothesis, we compared the tissue graft rejection (an assay for measuring innate and acquired immune responses) in guppies ( Poecilia reticulata ) artificially selected for large and small relative brain size. Individual scales were transplanted between pairs of fish, creating reciprocal allografts, and the rejection reaction was scored over 8 days (before acquired immunity develops). Acquired immune responses were tested two weeks later, when the same pairs of fish received a second set of allografts and were scored again. Compared with large-brained animals, small-brained animals of both sexes mounted a significantly stronger rejection response to the first allograft. The rejection response to the second set of allografts did not differ between large- and small-brained fish. Our results show that selection for large brain size reduced innate immune responses to an allograft, which supports the hypothesis that there is a selective trade-off between investing into brain size and innate immunity.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4810857Data sources: PubMed CentralProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallProceedings of the Royal Society B Biological SciencesArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 45 citations 45 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4810857Data sources: PubMed CentralProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallProceedings of the Royal Society B Biological SciencesArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rspb.2015.2857&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 HungaryPublisher:Public Library of Science (PLoS) Emil Rudobeck; John A. Bellone; Attila Szücs; Kristine Bonnick; Shalini Mehrotra-Carter; Jérôme Badaut; Gregory A. Nelson; Richard E. Hartman; Roman Vlkolinský;Space radiation represents a significant health risk for astronauts. Ground-based animal studies indicate that space radiation affects neuronal functions such as excitability, synaptic transmission, and plasticity, and it may accelerate the onset of Alzheimer's disease (AD). Although protons represent the main constituent in the space radiation spectrum, their effects on AD-related pathology have not been tested. We irradiated 3 month-old APP/PSEN1 transgenic (TG) and wild type (WT) mice with protons (150 MeV; 0.1-1.0 Gy; whole body) and evaluated functional and biochemical hallmarks of AD. We performed behavioral tests in the water maze (WM) before irradiation and in the WM and Barnes maze at 3 and 6 months post-irradiation to evaluate spatial learning and memory. We also performed electrophysiological recordings in vitro in hippocampal slices prepared 6 and 9 months post irradiation to evaluate excitatory synaptic transmission and plasticity. Next, we evaluated amyloid 3 (A(3) deposition in the contralateral hippocampus and adjacent cortex using immunohistochemistry. In cortical homogenates, we analyzed the levels of the presynaptic marker synaptophysin by Western blotting and measured pro-inflammatory cytokine levels (INF alpha, IL-beta, IL-6, CXCL10 and CCL2) by bead-based multiplex assay. TG mice performed significantly worse than WT mice in the WM. Irradiation of TG mice did not affect their behavioral performance, but reduced the amplitudes of population spikes and inhibited paired-pulse facilitation in CA1 neurons. These electrophysiological alterations in the TG mice were qualitatively different from those observed in WT mice, in which irradiation increased excitability and synaptic efficacy. Irradiation increased A beta deposition in the cortex of TG mice without affecting cytokine levels and increased synaptophysin expression in WT mice (but not in the TG mice). Although irradiation with protons increased A beta deposition, the complex functional and biochemical results indicate that irradiation effects are not synergistic to AD pathology.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5706673Data sources: PubMed CentralELTE Digital Institutional Repository (EDIT)Article . 2017Data sources: ELTE Digital Institutional Repository (EDIT)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 32 citations 32 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5706673Data sources: PubMed CentralELTE Digital Institutional Repository (EDIT)Article . 2017Data sources: ELTE Digital Institutional Repository (EDIT)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United Kingdom, ItalyPublisher:The Royal Society Funded by:UKRI | The International Centre ..., FCT | LA 1, EC | REPCOLLABUKRI| The International Centre for Language and Communicative Development ,FCT| LA 1 ,EC| REPCOLLABAuthors: Dora Kampis; Eugenio Parise; Gergely Csibra; Ágnes Melinda Kovács;Dora Kampis; Eugenio Parise; Gergely Csibra; Ágnes Melinda Kovács;pmc: PMC4685805 , PMC4971203 , PMC4971214
handle: 11572/311604 , 11572/311549
A major feat of\ud social beings is to encode what their conspecifics see, know or believe. \ud While various nonhuman animals show precursors of these abilities, humans perform \ud uniquely sophisticated inferences about other people’s mental states. However, it is still \ud unclear how these possibly human-specific capacities develop and whether preverbal \ud infants, similarly to adults form representations of other agents’ mental states, specifically \ud metarepresentations. We explored the neuro-cognitive bases of 8-month-olds’ ability to \ud encode the world from another person’s perspective, using gamma-band EEG activity over \ud the temporal lobes, an established neural signature for sustained object representation \ud after occlusion. We observed such gamma-band activity when an object was occluded \ud from the infants’ perspective, as well as when it was occluded only from the other person \ud (Experiment 1), and also when subsequently the object disappeared but the person falsely \ud believed the object to be present (Experiment 2). These findings suggest that the cognitive \ud systems involved in representing the world from infants’ own perspective are also recruited \ud for encoding others’ beliefs. Such results point to an early developing, powerful apparatus \ud suitable to deal with multiple concurrent representations; and suggest that infants can \ud have a metarepresentational understanding of other minds even before the onset of \ud language.
Proceedings of the R... arrow_drop_down Proceedings of the Royal Society B Biological SciencesArticle . 2015Full-Text: http://europepmc.org/articles/PMC4685805Data sources: PubMed CentralLancaster EPrints; Proceedings of the Royal Society B Biological Sciences; IRIS - Institutional Research Information System of the University of TrentoArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4971214Data sources: PubMed CentralEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4971203Data sources: PubMed CentralProceedings of the Royal Society B Biological Sciences; IRIS - Institutional Research Information System of the University of TrentoArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityLancaster EPrintsArticle . 2015 . Peer-reviewedFull-Text: https://eprints.lancs.ac.uk/id/eprint/76468/7/Manuscript_proc_b_kampis_parise_csibra_kovacs.pdfData sources: Lancaster EPrintsProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 10visibility views 10 download downloads 123 Powered bymore_vert Proceedings of the R... arrow_drop_down Proceedings of the Royal Society B Biological SciencesArticle . 2015Full-Text: http://europepmc.org/articles/PMC4685805Data sources: PubMed CentralLancaster EPrints; Proceedings of the Royal Society B Biological Sciences; IRIS - Institutional Research Information System of the University of TrentoArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4971214Data sources: PubMed CentralEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4971203Data sources: PubMed CentralProceedings of the Royal Society B Biological Sciences; IRIS - Institutional Research Information System of the University of TrentoArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityLancaster EPrintsArticle . 2015 . Peer-reviewedFull-Text: https://eprints.lancs.ac.uk/id/eprint/76468/7/Manuscript_proc_b_kampis_parise_csibra_kovacs.pdfData sources: Lancaster EPrintsProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rspb.2015.1683&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 United Kingdom, ItalyPublisher:The Company of Biologists Filippo Casoni; Samuel A. Malone; Morgane Belle; Federico Luzzati; Francis Collier; Cecile Allet; Erik Hrabovszky; Sowmyalakshmi Rasika; Vincent Prevot; Alain Chédotal; Paolo Giacobini;Fertility in mammals is controlled by hypothalamic neurons that secrete gonadotropin-releasing hormone (GnRH). These neurons differentiate in the olfactory placodes during embryogenesis and migrate from the nose to the hypothalamus before birth. Information regarding this process in humans is sparse. Here, we adapted new tissue-clearing and whole-mount immunohistochemical techniques to entire human embryos/fetuses to meticulously study this system during the first trimester of gestation in the largest series of human fetuses examined to date. Combining these cutting-edge techniques with conventional immunohistochemistry, we provide the first chronological and quantitative analysis of GnRH neuron origins, differentiation and migration, as well as a 3D atlas of their distribution in the fetal brain. We reveal not only that the number of GnRH-immunoreactive neurons in humans is significantly higher than previously thought, but that GnRH cells migrate into several extrahypothalamic brain regions in addition to the hypothalamus. Their presence in these areas raises the possibility that GnRH has non-reproductive roles, creating new avenues for research on GnRH functions in cognitive, behavioral and physiological processes.
Archivio Istituziona... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1242/dev.139444&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 141 citations 141 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 1visibility views 1 download downloads 33 Powered bymore_vert Archivio Istituziona... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1242/dev.139444&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United StatesPublisher:Public Library of Science (PLoS) Funded by:NIH | Pittsburgh Biomedical Inf..., NIH | Extending the Phenotype o..., NIH | Molecular characterizatio...NIH| Pittsburgh Biomedical Informatics Training Program ,NIH| Extending the Phenotype of Nonsyndromic Orofacial Clefting ,NIH| Molecular characterization of novel loci for orofacial clefting using canine modeWolf, Zena T.; Brand, Harrison A.; Shaffer, John R.; Leslie, Elizabeth J.; Arzi, Boaz; Willet, Cali E.; Cox, Timothy C.; McHenry, Toby; Narayan, Nicole; Feingold, Eleanor; Wang, Xioajing; Sliskovic, Saundra; Karmi, Nili; Safra, Noa; Sanchez, Carla; Deleyiannis, Frederic W. B.; Murray, Jeffrey C.; Wade, Claire M.; Marazita, Mary L.; Bannasch, Danika L.;Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth defect. We provide insight into the genetic etiology of this birth defect by performing genome-wide association studies in two species: dogs and humans. In the dog, a genome-wide association study of 7 CL/P cases and 112 controls from the Nova Scotia Duck Tolling Retriever (NSDTR) breed identified a significantly associated region on canine chromosome 27 (unadjusted p=1.1 x 10-13; adjusted p= 2.2 x 10-3). Further analysis in NSDTR families and additional full sibling cases identified a 1.44 Mb homozygous haplotype (chromosome 27: 9.29 – 10.73 Mb) segregating with a more complex phenotype of cleft lip, cleft palate, and syndactyly (CLPS) in 13 cases. Whole-genome sequencing of 3 CLPS cases and 4 controls at 15X coverage led to the discovery of a frameshift mutation within ADAMTS20 (c.1360_1361delAA (p.Lys453Ilefs*3)), which segregated concordant with the phenotype. In a parallel study in humans, a family-based association analysis (DFAM) of 125 CL/P cases, 420 unaffected relatives, and 392 controls from a Guatemalan cohort, identified a suggestive association (rs10785430; p =2.67 x 10-6) with the same gene, ADAMTS20. Sequencing of cases from the Guatemalan cohort was unable to identify a causative mutation within the coding region of ADAMTS20, but four coding variants were found in additional cases of CL/P. In summary, this study provides genetic evidence for a role of ADAMTS20 in CL/P development in dogs and as a candidate gene for CL/P development in humans. Author Summary Cleft lip with or without cleft palate (CL/P) is a commonly occurring birth defect that can lead to a lifetime of complications in affected children. To better understand the genetic cause of these disorders, we investigated CL/P in both dogs and humans. Genome-wide association studies in both species independently identify ADAMTS20 as a candidate gene for CL/P development. In dogs, a deletion within a functional domain of ADAMTS20 is responsible for CL/P in the Nova Scotia Duck Tolling Retriever dog breed. In humans, an associated region containing the same gene, ADAMTS20, was identified in a study population of native Guatemalans. Subsequent sequencing in humans was unable to identify a causative mutation within the coding region of ADAMTS20 in the Guatemalan cohort; however, sequencing of ADAMTS20 in additional cases with CL/P identified four novel coding variants. This work provides genetic evidence for a role for ADAMTS20 in CL/P development in both dogs and humans.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4370697Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pgen.1005059&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 95 citations 95 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4370697Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pgen.1005059&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015Publisher:The Royal Society Kristina Noreikiene; Gábor Herczeg; Abigél Gonda; Gergely Balázs; Arild Husby; Juha Merilä;The mosaic model of brain evolution postulates that different brain regions are relatively free to evolve independently from each other. Such independent evolution is possible only if genetic correlations among the different brain regions are less than unity. We estimated heritabilities, evolvabilities and genetic correlations of relative size of the brain, and its different regions in the three-spined stickleback ( Gasterosteus aculeatus ). We found that heritabilities were low (average h 2 = 0.24), suggesting a large plastic component to brain architecture. However, evolvabilities of different brain parts were moderate, suggesting the presence of additive genetic variance to sustain a response to selection in the long term. Genetic correlations among different brain regions were low (average r G = 0.40) and significantly less than unity. These results, along with those from analyses of phenotypic and genetic integration, indicate a high degree of independence between different brain regions, suggesting that responses to selection are unlikely to be severely constrained by genetic and phenotypic correlations. Hence, the results give strong support for the mosaic model of brain evolution. However, the genetic correlation between brain and body size was high ( r G = 0.89), suggesting a constraint for independent evolution of brain and body size in sticklebacks.
Europe PubMed Centra... arrow_drop_down Proceedings of the Royal Society B Biological SciencesArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rspb.2015.1008&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 46 citations 46 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Proceedings of the Royal Society B Biological SciencesArticle . 2015 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rspb.2015.1008&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Publisher:Oxford University Press (OUP) Gábor Herczeg; Tamás János Urszán; Stephanie Orf; Gergely Nagy; Alexander Kotrschal; Niclas Kolm;doi: 10.1111/jeb.13405
pmid: 31604005
AbstractUnderstanding how animal personality (consistent between‐individual behavioural differences) arises has become a central topic in behavioural sciences. This endeavour is complicated by the fact that not only the mean behaviour of individuals (behavioural type) but also the strength of their reaction to environmental change (behavioural plasticity) varies consistently. Personality and cognitive abilities are linked, and we suggest that behavioural plasticity could also be explained by differences in brain size (a proxy for cognitive abilities), since accurate decisions are likely essential to make behavioural plasticity beneficial. We test this idea in guppies (Poecilia reticulata), artificially selected for large and small brain size, which show clear cognitive differences between selection lines. To test whether those lines differed in behavioural plasticity, we reared them in groups in structurally enriched environments and then placed adults individually into empty tanks, where we presented them daily with visual predator cues and monitored their behaviour for 20 days with video‐aided motion tracking. We found that individuals differed consistently in activity and risk‐taking, as well as in behavioural plasticity. In activity, only the large‐brained lines demonstrated habituation (increased activity) to the new environment, whereas in risk‐taking, we found sensitization (decreased risk‐taking) in both brain size lines. We conclude that brain size, potentially via increasing cognitive abilities, may increase behavioural plasticity, which in turn can improve habituation to novel environments. However, the effects seem to be behaviour‐specific. Our results suggest that brain size likely explains some of the variation in behavioural plasticity found at the intraspecific level.
Journal of Evolution... arrow_drop_down Journal of Evolutionary BiologyArticle . 2018 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/jeb.13405&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Evolution... arrow_drop_down Journal of Evolutionary BiologyArticle . 2018 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/jeb.13405&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu