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description Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Italy, United Kingdom, Ireland, Netherlands, Turkey, Italy, Italy, France, Denmark, Turkey, United States, Denmark, United Kingdom, ItalyPublisher:Elsevier BV Publicly fundedFunded by:NHMRC | Modifiable risk factors f..., SNSF | Morbidity and cost of hel..., UKRI | MICA: Centre for the Impr... +2 projectsNHMRC| Modifiable risk factors for Serious Mental Illness - an integrated program of epidemiology, genetics and clinical trials ,SNSF| Morbidity and cost of helminth infections: fitting existing and investigating missing pieces of evidence ,UKRI| MICA: Centre for the Improvement of Population Health through E-health Research (CIPHER) ,SNSF| Morbidity and cost of helminth infections: learning from the past to prepare for the future ,NIH| Pediatric Injury Research Training ProgramAdrian Davis; Ayse Abbasoglu Ozgoren; Foad Abd-Allah; Victor Aboyans; Jerry Puthenpurakal Abraham; Katrina Abuabara; Ibrahim Abubakar; Tom Achoki; Zanfina Ademi; Johan Ärnlöv; Miguel Angel Alegretti; Alicia Aleman; Rafael Alfonso-Cristancho; Samia Alhabib; Raghib Ali; François Alla; Peter Allebeck; Rustam Al-Shahi Salman; Ubai Alsharif; Adansi A. Amankwaa; Azmeraw T. Amare; Omid Ameli; Hassan Amini; Walid Ammar; Benjamin O. Anderson; Carl Abelardo T. Antonio; Henry Apfel; Solveig A. Cunningham; Valentina Arsić Arsenijević; Al Artaman; Lydia S. Atkins; Charles Atkinson; Kalpana Balakrishnan; Shivanthi Balalla; Amitava Banerjee; Lope H Barrero; Tonatiuh Barrientos-Gutiérrez; Sanjay Basu; Mohammed Basulaiman; Justin Beardsley; Neeraj Bedi; Ettore Beghi; Michelle L. Bell; Corina Benjet; Derrick A Bennett; Habib Benzian; Tariku Jibat Beyene; Neeraj Bhala; Boris Bikbov; Fiona M. Blyth; Megan Bohensky; Guilherme Borges; Soufiane Boufous; Michael Brainin; Carol Brayne; Alexandra Brazinova; Hermann Brenner; Adam D M Briggs; Traolach S. Brugha; Geoffrey Buckle; Gene Bukhman; Ismael Ricardo Campos Nonato; Rosario Cárdenas; Carlos A Castañeda-Orjuela; Ruben Castro; Ferrán Catalá-López; Fiorella Cavalleri; Jung-Chen Chang; Fiona C. Charlson; Xuan Che; Honglei Chen; Odgerel Chimed-Ochir; Rajiv Chowdhury; Hanne Christensen; Massimo Cirillo; Matthew M Coates; Luc E. Coffeng; Aaron Cohen; Valentina Colistro; Samantha M. Colquhoun; Leslie T. Cooper; Luis M. Coppola; Karen J. Courville; Benjamin C Cowie; Michael H. Criqui; Rakhi Dandona; Paul I. Dargan; Vanessa De la Cruz-Góngora; Diego De Leo; Louisa Degenhardt; Borja del Pozo-Cruz; Kebede Deribe; Muluken Dessalegn; Gabrielle de Veber; Mukesh Dherani; José Luis Díaz-Ortega; Cesar Diaz-Torne; Daniel Dicker; Eric L. Ding; Klara Dokova; E. Ray Dorsey; Herbert C. Duber; Richard G. Ellenbogen; Yousef M. Elshrek; Sergey Petrovich Ermakov; Alireza Esteghamati; Thomas Fürst; Saman Fahimi; Emerito Jose A. Faraon; Farshad Farzadfar; Valery L. Feigin; Alize J. Ferrari; Thomas D. Fleming; Nataliya Foigt; Mohammad H. Forouzanfar; Urbano Fra Paleo; Fortuné Gbètoho Gankpé; Johanna M. Geleijnse; Katherine B Gibney; Ibrahim Abdelmageem Mohamed Ginawi; Elizabeth Glaser; Shifalika Goenka; Philimon Gona; Caterina Guinovart; Rashmi Gupta; Atsushi Goto; Hebe N. Gouda; David Gunnell; Holly Hagan; Maria Hagströmer; Randah R. Hamadeh; Mouhanad Hammami; Graeme J. Hankey; Josep Maria Haro; Rasmus Havmoeller; Simon I. Hay; Mohammad Taghi Hedayati; Pouria Heydarpour; Hideki Higashi; Hans W. Hoek; H. Dean Hosgood; Mazeda Hossain; Peter J. Hotez; Damian G Hoy; Guoqing Hu; Mark D. Huffman; Abdullatif Husseini; Marissa Iannarone; Bulat Idrisov; Nayu Ikeda; Kaire Innos; Farhad Islami; Kathryn H. Jacobsen; Sudha Jayaraman; Vivekanand Jha; Ying Jiang; Jost B. Jonas; Knud Juel; Edmond K. Kabagambe; André Karch; Ganesan Karthikeyan; Nicholas J Kassebaum; Andre Pascal Kengne; Yousef Khader; Shams Eldin Ali Hassan Khalifa; Ejaz Ahmad Khan; Gulfaraz Khan; Young-Ho Khang; Christian Kieling; Yohannes Kinfu; Daniel Kim; Miia Kivipelto; Luke D. Knibbs; Ann Kristin Knudsen; Sowarta Kosen; Meera Kotagal; Michael Kravchenko; Barthelemy Kuate Defo; Ernst J. Kuipers; Burcu Kucuk Bicer; Kaushalendra Kumar; Ravi Kumar; Hmwe H Kyu; Ratilal Lalloo; Tea Lallukka; Hilton Lam; Qing Lan; Van C. Lansingh; Heidi J. Larson; Pablo M. Lavados; Alicia Elena Beatriz Lawrynowicz; Janet L Leasher; James Leigh; Mall Leinsalu; Ricky Leung; Carly E Levitz; Bin Li; Shiwei Liu; Yang Liu; Belinda K Lloyd; Giancarlo Logroscino; Stephanie J. London; Joannie Lortet-Tieulent; Paulo A. Lotufo; Robyn M. Lucas; Raimundas Lunevicius; Ronan A Lyons; Michael F. MacIntyre; Mark T Mackay; Jennifer H MacLachlan; Carlos Magis-Rodriguez; Abbas Ali Mahdi; Marek Majdan; Reza Malekzadeh; Christopher C. Mapoma; Wagner Marcenes; Christopher Margono; Guy B. Marks; Melvin Barrientos Marzan; Mohammad T Mashal; Felix Masiye; Amanda J. Mason-Jones; Richard Matzopolous; Bongani M. Mayosi; John J. McGrath; Abigail C. McKay; Martin McKee; Man Mohan Mehndiratta; Yohannes Adama Melaku; Atte Meretoja; Francis Apolinary Mhimbira; Ted R. Miller; Edward J Mills; Terrie E. Moffitt; Lorenzo Monasta; Jonathan de la Cruz Monis; Marcella Montico; Thomas J. Montine; Ami R. Moore; Maziar Moradi-Lakeh; Andrew E. Moran; Rintaro Mori; Wilkister N. Moturi; Mitsuru Mukaigawara; Joseph Murray; Adetoun Mustapha; Paria Naghavi; Aliya Naheed; Luigi Naldi; Devina Nand; K.M. Venkat Narayan; Denis Nash; Jamal Nasher; Chakib Nejjari; Sudan Prasad Neupane; Grant Nguyen; Muhammad Imran Nisar; Sandra Nolte; Ole Frithjof Norheim; Rosana E. Norman; Bo Norrving; Luke Nyakarahuka; Shaun Odell; Martin O'Donnell; Takayoshi Ohkubo; Bolajoko O. Olusanya; Orish Ebere Orisakwe; Alberto Ortiz; Jeyaraj D Pandian; Jeemon Panniyammakal; Scott B. Patten; George C Patton; Vinod K. Paul; Boris I. Pavlin; Neil Pearce; Fernando Perez-Ruiz; Norberto Perico; Konrad Pesudovs; Carrie Beth Peterson; David Phillips; Frédéric B. Piel; Richie Poulton; Farshad Pourmalek; Dorairaj Prabhakaran; Dima M. Qato; Felicia A. Rabito; Anwar Rafay; Kazem Rahimi; Vafa Rahimi-Movaghar; Ivo Rakovac; Saleem M Rana; Amany H Refaat; Giuseppe Remuzzi; Antonio Luiz Pinho Ribeiro; Patricia M. Riccio; Jan Hendrik Richardus; Bayard Roberts; D. Allen Roberts; Margaret Robinson; Anna Roca; Alina Rodriguez; Dietrich Rothenbacher; Nobhojit Roy; George Mugambage Ruhago; Lesley Rushton; Sankar Sambandam; Kjetil Søreide; Mohammad Yahya Saeedi; Sukanta Saha; Ramesh Sahathevan; Berhe W. Sahle; Joshua A. Salomon; Deborah Salvo; Itamar S. Santos; Maheswar Satpathy; Mete Saylan; Ben Schöttker; Jürgen C Schmidt; Austin E Schumacher; David C. Schwebel; James Scott; Sadaf G. Sepanlou; Edson Serván-Mori; Jun She; Donald S. Shepard; Kenji Shibuya; Kawkab Shishani; Ivy Shiue; Rupak Shivakoti; Shireen Sindi; Jasvinder A. Singh; Edgar Sioson; Karen Sliwa; Michael Soljak; Sergey Soshnikov; Luciano A. Sposato; Chandrashekhar T Sreeramareddy; Jeffrey D. Stanaway; Kyle Steenland; Antony Stevens; Heidi Stöckl; Konstantinos Stroumpoulis; Bruno F. Sunguya; Soumya Swaminathan; Mamta Swaroop; Ken Takahashi; Feng Tan; David Tanne; Mohammad Tavakkoli; Braden Te Ao; Eric Y. Tenkorang; Abdullah Sulieman Terkawi; Amanda G. Thrift; Taavi Tillmann; Imad M. Tleyjeh; Marcello Tonelli; Fotis Topouzis; Hideaki Toyoshima; Jefferson Traebert; Bach Xuan Tran; Matias Trillini; Miltiadis K. Tsilimbaris; E. Murat Tuzcu; Kingsley N. Ukwaja; Eduardo A. Undurraga; Andrew Vallely; Coen H. Van Gool; Tommi Vasankari; Ana Maria Nogales Vasconcelos; Lakshmi Vijayakumar; Salvador Villalpando; Vasiliy Victorovich Vlassov; Gregory R. Wagner; Xiao Rong Wang; Tati S. Warouw; Elisabete Weiderpass; K. Ryan Wessells; Ronny Westerman; Harvey Whiteford; James D. Wilkinson; Solomon Meseret Woldeyohannes; Timothy M. Wolock; Anthony D. Woolf; Sarah Wulf; Gelin Xu; Hiroshi Yatsuya; Seok Jun Yoon; Mustafa Z. Younis; Maysaa El Sayed Zaki; Hajo Zeeb; Yong Zhao; Yingfeng Zheng; Jun Zhu; Shankuan Zhu; Joseph R. Zunt; Gabriel Alcalá-Cerra; Howard Hu;handle: 2445/127624 , 11386/4651448 , 11588/733398 , 2434/336619 , 11370/99c4adbd-894f-4ac6-922b-8c039e490bac
pmc: PMC4379111 , PMC4340604
handle: 2445/127624 , 11386/4651448 , 11588/733398 , 2434/336619 , 11370/99c4adbd-894f-4ac6-922b-8c039e490bac
pmc: PMC4379111 , PMC4340604
Background Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specific causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65·3 years (UI 65·0–65·6) in 1990, to 71·5 years (UI 71·0–71·9) in 2013, while the number of deaths increased from 47·5 million (UI 46·8–48·2) to 54·9 million (UI 53·6–56·3) over the same interval. Global progress masked variation by age and sex: for children, average absolute differences between countries decreased but relative differences increased. For women aged 25–39 years and older than 75 years and for men aged 20–49 years and 65 years and older, both absolute and relative differences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10·7%, from 4·3 million deaths in 1990 to 4·8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specific mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade. Funding Bill & Melinda Gates Foundation. Background Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specific causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65·3 years (UI 65·0–65·6) in 1990, to 71·5 years (UI 71·0–71·9) in 2013, while the number of deaths increased from 47·5 million (UI 46·8–48·2) to 54·9 million (UI 53·6–56·3) over the same interval. Global progress masked variation by age and sex: for children, average absolute differences between countries decreased but relative differences increased. For women aged 25–39 years and older than 75 years and for men aged 20–49 years and 65 years and older, both absolute and relative differences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10·7%, from 4·3 million deaths in 1990 to 4·8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specific mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade. Funding Bill & Melinda Gates Foundation.
Archivio istituziona... arrow_drop_down Hacettepe Üniversitesi Açık Erişim SistemiArticle . 2015Data sources: Hacettepe Üniversitesi Açık Erişim SistemiVBN; Aalborg University Research PortalArticle . 2015Spiral - Imperial College Digital RepositoryArticle . 2014License: rioxx All Rights ReservedData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2015Data sources: Recolector de Ciencia Abierta, RECOLECTAeScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of CaliforniaNARCIS; The LancetArticle . 2015PURE Aarhus UniversityArticle . 2015 . Peer-reviewedNature Reviews NephrologyArticle . 2015 . Peer-reviewedLicense: Springer TDMData sources: CrossrefArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoHyper Article en Ligne; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 6K citations 6,083 popularity Top 0.01% influence Top 0.01% impulse Top 0.01% Powered by BIP!visibility 52visibility views 52 download downloads 164 Powered bymore_vert Archivio istituziona... arrow_drop_down Hacettepe Üniversitesi Açık Erişim SistemiArticle . 2015Data sources: Hacettepe Üniversitesi Açık Erişim SistemiVBN; Aalborg University Research PortalArticle . 2015Spiral - Imperial College Digital RepositoryArticle . 2014License: rioxx All Rights ReservedData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2015Data sources: Recolector de Ciencia Abierta, RECOLECTAeScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of CaliforniaNARCIS; The LancetArticle . 2015PURE Aarhus UniversityArticle . 2015 . Peer-reviewedNature Reviews NephrologyArticle . 2015 . Peer-reviewedLicense: Springer TDMData sources: CrossrefArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoHyper Article en Ligne; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 Switzerland, Italy, Portugal, Cyprus, SwitzerlandPublisher:Ovid Technologies (Wolters Kluwer Health) Funded by:FCT | SFRH/BPD/115112/2016, NIH | HERCULES: Health and Expo..., EC | EXHAUSTION +3 projectsFCT| SFRH/BPD/115112/2016 ,NIH| HERCULES: Health and Exposome Research Center at Emory ,EC| EXHAUSTION ,NIH| AIR POLLUTION AND IMPLANTABLE CARDIOVERTER DEFIBRILLATORS ,NHMRC| Climate Change and Human Health in Asia: Current Impacts, Future Risks, and Health Benefits of Mitigation Policies ,NHMRC| Environmental exposure, human behaviour and respiratory health for children with asthmaAlahmad, Barrak; Khraishah, Haitham; Royé, Dominic; Vicedo-Cabrera, Ana Maria; Guo, Yuming; Papatheodorou, Stefania I; Achilleos, Souzana; Acquaotta, Fiorella; Armstrong, Ben; Bell, Michelle L; Pan, Shih-Chun; Coelho, Micheline de Sousa Zanotti Stagliorio; Colistro, Valentina; Dang, Tran Ngoc; Dung, Do-Van; De' Donato, Francesca K; Entezari, Alireza; Guo, Yue-Liang Leon; Hashizume, Masahiro; Honda, Yasushi; Indermitte, Ene; Íñiguez, Carmen; Jaakkola, Jouni J K; Kim, Ho; Lavigne, Eric; Lee, Whanhee; Li, Shanshan; Madureira, Joana; Mayvaneh, Fatemeh; Orru, Hans; Overcenco, Ala Vladimir; Ragettli, Martina S; Ryti, Niilo R I; Saldiva, Paulo Hilario Nascimento; Scovronick, Noah; Seposo, Xerxes; Sera, Francesco; Silva, Susana Pereira; Stafoggia, Massimo; Tobias, Aurelio; Garshick, Eric; Bernstein, Aaron S; Zanobetti, Antonella; Schwartz, Joel D; Gasparrini, Antonio; Koutrakis, Petros;Background: Cardiovascular disease is the leading cause of death worldwide. Existing studies on the association between temperatures and cardiovascular deaths have been limited in geographic zones and have generally considered associations with total cardiovascular deaths rather than cause-specific cardiovascular deaths. Methods: We used unified data collection protocols within the Multi-Country Multi-City Collaborative Network to assemble a database of daily counts of specific cardiovascular causes of death from 567 cities in 27 countries across 5 continents in overlapping periods ranging from 1979 to 2019. City-specific daily ambient temperatures were obtained from weather stations and climate reanalysis models. To investigate cardiovascular mortality associations with extreme hot and cold temperatures, we fit case-crossover models in each city and then used a mixed-effects meta-analytic framework to pool individual city estimates. Extreme temperature percentiles were compared with the minimum mortality temperature in each location. Excess deaths were calculated for a range of extreme temperature days. Results: The analyses included deaths from any cardiovascular cause (32 154 935), ischemic heart disease (11 745 880), stroke (9 351 312), heart failure (3 673 723), and arrhythmia (670 859). At extreme temperature percentiles, heat (99th percentile) and cold (1st percentile) were associated with higher risk of dying from any cardiovascular cause, ischemic heart disease, stroke, and heart failure as compared to the minimum mortality temperature, which is the temperature associated with least mortality. Across a range of extreme temperatures, hot days (above 97.5th percentile) and cold days (below 2.5th percentile) accounted for 2.2 (95% empirical CI [eCI], 2.1–2.3) and 9.1 (95% eCI, 8.9–9.2) excess deaths for every 1000 cardiovascular deaths, respectively. Heart failure was associated with the highest excess deaths proportion from extreme hot and cold days with 2.6 (95% eCI, 2.4–2.8) and 12.8 (95% eCI, 12.2–13.1) for every 1000 heart failure deaths, respectively. Conclusions: Across a large, multinational sample, exposure to extreme hot and cold temperatures was associated with a greater risk of mortality from multiple common cardiovascular conditions. The intersections between extreme temperatures and cardiovascular health need to be thoroughly characterized in the present day—and especially under a changing climate. Clinical Perspective_ What Is New?: This study provided evidence from what we believe is the largest multinational dataset ever assembled on cardiovascular outcomes and environmental exposures; Extreme hot and cold temperatures were associated with increased risk of death from any cardiovascular cause, ischemic heart disease, stroke, and heart failure; For every 1000 cardiovascular deaths, 2 and 9 excess deaths were attributed to extreme hot and cold days, respectively. _ What Are the Clinical Implications?: Extreme temperatures from a warming planet may become emerging priorities for public health and preventative cardiology; The findings of this study should prompt professional cardiology societies to commission scientific statements on the intersections of extreme temperature exposure and cardiovascular health. This study was supported by the Kuwait Foundation for the Advancement of Science (CB21-63BO-01); the US Environmental Protection Agency (RD-835872); Harvard Chan National Institute of Environmental Health Sciences Center for Environmental Health (P01ES009825); the UK Medical Research Council (MR/R013349/1); the UK Natural Environment Research Council (NE/R009384/1); the European Union’s Horizon 2020 Project Exhaustion (820655); the Australian National Health and Medical Research Council (APP 2000581, APP 1109193, APP 1163693); the National Institute of Environmental Health Sciences–funded HERCULES Center (P30ES019776); the MCIN/AEI/10.13039/501100011033 (grant CEX2018-000794-S); the Taiwanese Ministry of Science and Technology (MOST 109–2621-M-002–021); the Environmental Restoration and Conservation Agency, Environment Research and Technology Development Fund (JPMEERF15S11412); the São Paulo Research Foundation; and Fundação para a Ciência e a Tecnlogia (SFRH/BPD/115112/2016) info:eu-repo/semantics/publishedVersion
Flore (Florence Rese... arrow_drop_down Flore (Florence Research Repository)Article . 2023Data sources: Flore (Florence Research Repository)Repositório Aberto da Universidade do PortoArticle . 2022Data sources: Repositório Aberto da Universidade do PortoRepositório Científico do Instituto Nacional de SaúdeArticle . 2022License: CC BY NDData sources: Repositório Científico do Instituto Nacional de SaúdeBern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!visibility 104visibility views 104 download downloads 241 Powered bymore_vert Flore (Florence Rese... arrow_drop_down Flore (Florence Research Repository)Article . 2023Data sources: Flore (Florence Research Repository)Repositório Aberto da Universidade do PortoArticle . 2022Data sources: Repositório Aberto da Universidade do PortoRepositório Científico do Instituto Nacional de SaúdeArticle . 2022License: CC BY NDData sources: Repositório Científico do Instituto Nacional de SaúdeBern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Italy, France, Germany, Turkey, Netherlands, Australia, Italy, Italy, Italy, Italy, Denmark, United Kingdom, Italy, Denmark, United KingdomPublisher:Elsevier BV Funded by:UKRI | The impact and social eco..., WT | Epidemiological mapping o..., Jazz Pharmaceuticals +6 projectsUKRI| The impact and social ecology of bacterial zoonoses in northern Tanzania ,WT| Epidemiological mapping of podoconiosis in Ethiopia . ,Jazz Pharmaceuticals ,NHMRC| Assessing the population health impact of illicit drug use: prevalence, trajectories, and contributions to disease burden ,WT ,Allergan ,WT| Defining the population at risk and burden of disease of Plasmodium vivax malaria. ,WT| The health consequences of inherited red blood cell disorders in Kenya. ,SNSF| Morbidity and cost of helminth infections: fitting existing and investigating missing pieces of evidenceRyan M Barber; Brad Bell; Ian Bolliger; Fiona J Charlson; Adrian Davis; Louisa Degenhardt; Holly E. Erskine; Valery L. Feigin; Alize J. Ferrari; Christina Fitzmaurice; Caterina Guinovart; Juanita A. Haagsma; Hideki Higashi; Hmwe H Kyu; Evan Laurie; Maziar Moradi-Lakeh; Mohsen Naghavi; David Allen Roberts; Jeffrey D. Stanaway; Harvey Whiteford; Pengpeng Ye; Gunn Marit Aasvang; Cristiana Abbafati; Ayse Abbasoglu Ozgoren; Foad Abd-Allah; Semaw Ferede Abera; Victor Aboyans; Jerry Puthenpurakal Abraham; Ibrahim Abubakar; Tania C Aburto; Tom Achoki; Ilana N. Ackerman; Zanfina Ademi; Arsène Kouablan Adou; Johan Ärnlöv; Sayed Saidul Alam; Zewdie Aderaw Alemu; Rafael Alfonso-Cristancho; François Alla; Peter J. Allen; Ubai Alsharif; Nelson Alvis-Guzman; Omid Ameli; Heresh Amini; Benjamin O. Anderson; Palwasha Anwari; Henry Apfel; Al Artaman; Rana J. Asghar; Reza Assadi; Charles Atkinson; Maria Cecilia Bahit; Kalpana Balakrishnan; Shivanthi Balalla; Amitava Banerjee; Suzanne Barker-Collo; Simón Barquera; Lope H Barrero; Arindam Basu; Justin Beardsley; Neeraj Bedi; Ettore Beghi; Tolesa Bekele; Corina Benjet; Derrick A Bennett; Isabela M. Benseñor; Habib Benzian; Eduardo Bernabé; Tariku Jibat Beyene; Neeraj Bhala; Zulfiqar A Bhutta; Boris Bikbov; Jed D. Blore; Fiona M. Blyth; Berrak Bora Basara; Guilherme Borges; Natan M. Bornstein; Soufiane Boufous; Michael Brainin; Michael Brauer; Carol Brayne; Hermann Brenner; Adam D M Briggs; Peter Brooks; J Brown; Traolach S. Brugha; Geoffrey Buckle; Ismael R. Campos-Nonato; Jonathan R. Carapetis; David Carpenter; Valeria Caso; Carlos A Castañeda-Orjuela; Ferrán Catalá-López; Jung-Chen Chang; Wanqing Chen; Odgerel Chimed-Ochir; Rajiv Chowdhury; Hanne Christensen; Sumeet S. Chugh; Massimo Cirillo; Aaron Cohen; Valentina Colistro; Samantha M. Colquhoun; Alejandra G. Contreras; Leslie T. Cooper; Kimberly Cooperrider; Lucía Cuevas-Nasu; Rakhi Dandona; Paul I. Dargan; Gail Davey; Dragos Virgil Davitoiu; Vanessa De la Cruz-Góngora; Diego De Leo; Borja del Pozo-Cruz; Robert P. Dellavalle; Kebede Deribe; Sarah Derrett; Don C. Des Jarlais; Eric L. Ding; Klara Dokova; E. R. Dorsey; Herbert C. Duber; Matthias Endres; Sergey Petrovich Ermakov; Alireza Esteghamati; Kara Estep; Saman Fahimi; Farshad Farzadfar; Derek F J Fay; Abraham D. Flaxman; Nataliya Foigt; Fortuné Gbètoho Gankpé; Johanna M. Geleijnse; Bradford D. Gessner; Katherine B Gibney; Richard F. Gillum; Giorgia Giussani; Shifalika Goenka; Richard A. Gosselin; Atsushi Goto; Hebe N. Gouda; David Gunnell; Rashmi Gupta; Reyna A Gutiérrez; Nima Hafezi-Nejad; Mouhanad Hammami; Graeme J. Hankey; Hilda L Harb; Roderick J. Hay; Simon I. Hay; Mohammad Taghi Hedayati; Pouria Heydarpour; Hans W. Hoek; Mazeda Hossain; Peter J. Hotez; Damian G Hoy; Howard Hu; Cheng Huang; Laetitia Huiart; Abdullatif Husseini; Kaire Innos; Kathryn H. Jacobsen; Panniyammakal Jeemon; Vivekanand Jha; Ying Jiang; Knud Juel; André Karch; Ganesan Karthikeyan; Ronit Katz; Norito Kawakami; Andrew H. Kemp; Andre Pascal Kengne; Yousef Khader; Shams Eldin Ali Hassan Khalifa; Ejaz Ahmad Khan; Gulfaraz Khan; Young-Ho Khang; Christian Kieling; Daniel Kim; Ruth W Kimokoti; Yohannes Kinfu; Brett M. Kissela; Luke D. Knibbs; Ann Kristin Knudsen; Soewarta Kosen; Alexander Krämer; Michael Kravchenko; Rita Krishnamurthi; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Ernst J. Kuipers; Kaushalendra Kumar; G Anil Kumar; Ratilal Lalloo; Van C. Lansingh; Heidi J. Larson; Alicia Elena Beatriz Lawrynowicz; Janet L Leasher; James Leigh; Ricky Leung; Miriam Levi; Bin Li; Juan Liang; Hsien-Ho Lin; Margaret Lind; Shiwei Liu; Belinda Lloyd; Summer Lockett Ohno; Giancarlo Logroscino; Joannie Lortet-Tieulent; Paulo A. Lotufo; Robyn M. Lucas; Raimundas Lunevicius; Ronan A Lyons; Stefan Ma; Mark T Mackay; Marek Majdan; Lyn March; Guy B. Marks; Melvin Barrientos Marzan; Amanda J. Mason-Jones; Richard Matzopoulos; Neil McGill; Martin McKee; Abby McLain; Fabiola Mejía-Rodríguez; Wubegzier Mekonnen; Yohannes Adama Melaku; Atte Meretoja; Francis Apolinary Mhimbira; Ted R. Miller; Philip B. Mitchell; Terrie E. Moffitt; Norlinah Mohamed Ibrahim; Karzan Abdulmuhsin Mohammad; Lorenzo Monasta; Marcella Montico; Ami R. Moore; Andrew E. Moran; Lidia Morawska; Rintaro Mori; Wilkister N. Moturi; Dariush Mozaffarian; Mitsuru Mukaigawara; Michele E. Murdoch; Joseph Murray; Kinnari S. Murthy; Paria Naghavi; Ziad Nahas; Aliya Naheed; Kovin Naidoo; Luigi Naldi; Devina Nand; K.M. Venkat Narayan; Denis Nash; Chakib Nejjari; Sudan Prasad Neupane; Muhammad Imran Nisar; Sandra Nolte; Ole Frithjof Norheim; Luke Nyakarahuka; Takayoshi Ohkubo; John Nelson Opio; Alberto Ortiz; Jeyaraj D Pandian; Christina Papachristou; Charles D. H. Parry; Scott B. Patten; Vinod K. Paul; Boris I. Pavlin; Lilia S Pedraza; Carlos A. Pellegrini; Fernando Perez-Ruiz; Norberto Perico; Konrad Pesudovs; Michael R. Phillips; Frédéric B. Piel; Dietrich Plass; Dan Poenaru; Guilherme V. Polanczyk; Farshad Pourmalek; Dorairaj Prabhakaran; Dima M. Qato; Kazem Rahimi; Sajjad Ur Rahman; Ivo Rakovac; Saleem M Rana; Homie Razavi; Amany H Refaat; Giuseppe Remuzzi; Serge Resnikoff; Antonio Luiz Pinho Ribeiro; Patricia M. Riccio; Jan Hendrik Richardus; Anna Roca; Alina Rodriguez; Nobhojit Roy; George Mugambage Ruhago; Ralph L. Sacco; Sukanta Saha; Ramesh Sahathevan; Lidia Sanchez-Riera; Itamar S. Santos; Maheswar Satpathy; Mete Saylan; Peter Scarborough; Soraya Seedat; Edson Serván-Mori; Amira Shaheen; Saeid Shahraz; Kenji Shibuya; Yukito Shinohara; Ivy Shiue; Shireen Sindi; Jasvinder A. Singh; Vegard Skirbekk; Karen Sliwa; Sergey Soshnikov; Luciano A. Sposato; Chandrashekhar T Sreeramareddy; Heidi Stoeckl; Murray B. Stein; A W Stewart; Konstantinos Stroumpoulis; Bruno F. Sunguya; Mamta Swaroop; Karen M. Tabb; Ken Takahashi; Mohammad Tavakkoli; Hugh R. Taylor; Braden Te Ao; Eric Y. Tenkorang; Abdullah Sulieman Terkawi; Alice Theadom; Amanda G. Thrift; Imad M. Tleyjeh; Marcello Tonelli; Fotis Topouzis; Hideaki Toyoshima; Jefferson Traebert; Bach Xuan Tran; Leonardo Trasande; Matias Trillini; Miltiadis K. Tsilimbaris; Emin Murat Tuzcu; Kingsley N. Ukwaja; Coen H. Van Gool; Lennert J. Veerman; Narayanaswamy Venketasubramanian; Salvador Villalpando; Vasiliy Victorovich Vlassov; Stephen G. Waller; Tati S. Warouw; Scott Weichenthal; Elisabete Weiderpass; James D. Wilkinson; Hywel C Williams; Thomas N. Williams; Solomon Meseret Woldeyohannes; Haidong Wong; Anthony D. Woolf; Jonathan L. Wright; Gelin Xu; Gonghuan Yang; Seok Jun Yoon; Mustafa Z. Younis; Chuanhua Yu; Zheng Zhao; David Zonies; Joshua A. Salomon; Christopher J L Murray;pmc: PMC4561509
Summary Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. Funding Bill & Melinda Gates Foundation. Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. Funding Bill & Melinda Gates Foundation.
Flore (Florence Rese... arrow_drop_down Flore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Publications at Bielefeld University; Research@WUR; The LancetOther literature type . Article . 2015 . Peer-reviewedLicense: Elsevier TDMFlore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Spiral - Imperial College Digital RepositoryArticle . 2015Data sources: Spiral - Imperial College Digital RepositoryArchivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; Archivio della Ricerca - Università di Salerno; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; The Lancet; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2015 . Peer-reviewedData sources: University of Groningen Research Portal; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; Archivio della Ricerca - Università di Salerno; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; SNSF P3 Database; Archivio della ricerca - Università degli studi di Napoli Federico IIArchivio della ricerca- Università di Roma La SapienzaArticle . 2015Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoVBN; Aalborg University Research PortalArticle . 2015Hyper Article en Ligne; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 5K citations 4,805 popularity Top 0.01% influence Top 0.01% impulse Top 0.01% Powered by BIP!visibility 55visibility views 55 download downloads 1,498 Powered bymore_vert Flore (Florence Rese... arrow_drop_down Flore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Publications at Bielefeld University; Research@WUR; The LancetOther literature type . Article . 2015 . Peer-reviewedLicense: Elsevier TDMFlore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Spiral - Imperial College Digital RepositoryArticle . 2015Data sources: Spiral - Imperial College Digital RepositoryArchivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; Archivio della Ricerca - Università di Salerno; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; The Lancet; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2015 . Peer-reviewedData sources: University of Groningen Research Portal; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; Archivio della Ricerca - Università di Salerno; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; SNSF P3 Database; Archivio della ricerca - Università degli studi di Napoli Federico IIArchivio della ricerca- Università di Roma La SapienzaArticle . 2015Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoVBN; Aalborg University Research PortalArticle . 2015Hyper Article en Ligne; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 IrelandPublisher:Elsevier BV Publicly fundedFunded by:SFI | Bioeconomy Research Centr...SFI| Bioeconomy Research Centre (BiOrbic)Alaydi, Hadil; Zhu, Xianglu; Mondala, Julie Rose Mae; Tiwari, Brijesh K.; Kumari, Bibha; Curtin, James F.; Downey, Peter; McKeon-Bennett, Michelle; Beletskaya, Tanya;Sitka spruce (Picea sitchensis) needles contain a variety of bioactive compounds including phenolic compounds and flavonoids, many of which have been used in the cosmetic, pharmaceutical, and food industries. This study aimed to investigate the effects of novel extraction techniques, including ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE) and simultaneous ultrasound–microwave-assisted extraction (UMAE) on the recovery of phenolic, flavonoids and associated antioxidant and anti-cancer properties from Sitka spruce (Picea sitchensis) needles. The ferric reducing antioxidant power (FRAP) assay was used to evaluate the antioxidant capacity, and the Alamar Blue assay using the human brain glioblastoma cancer cell line (U-251 MG) was used to evaluate the cytotoxicity activity. Results showed that US-probe accomplished the highest recovery of phenolic and flavonoids at 38 W cm−2 for 10 min (106.3 ± 2.5 mg GAE g−1 DW and 63.2 ± 3.8 mg QE g−1 DW, respectively). Hence, the highest cytotoxicity activity of IC50 (0.0114% w/v) was achieved by US-probe at 19 W cm−2 for 10 min. However, the antioxidant capacity of (2591.3 ± 92.5 mM TE g−1 DW) was achieved under UMAE at ultrasound intensity of 38 W cm−2, microwave power of 302.4 W for 10 min. This study emphasised the potential application of UAE and MAE in the extraction of bioactive as an environmentally friendly method to be used in the valorisation of by-products in food and agro-industries. This supports the use of renewable natural resources in an efficient way to produce high-value compounds therefore it is in line with the new era of bioeconomy and its new biorefinery concepts yes
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013 CyprusPublisher:ASME International Publicly fundedDavid A. Steinman; Yiemeng Hoi; Paul Fahy; Liam Morris; Michael Walsh; Nicolas Aristokleous; Andreas S. Anayiotos; Yannis Papaharilaou; Amirhossein Arzani; Shawn C. Shadden; Philipp Berg; Gábor Janiga; Joris Bols; Patrick Segers; Neil W. Bressloff; Merih Cibis; Frank H. Gijsen; Salvatore Cito; Jordi Pallares; Leonard D. Browne; J. A. Costelloe; Adrian G. Lynch; Joris Degroote; Jan Vierendeels; Wenyu Fu; Aike Qiao; Simona Hodis; David F. Kallmes; Hardeep S. Kalsi; Quan Long; Vitaly O. Kheyfets; Ender A. Finol; Kenichi Kono; Adel M. Malek; Alexandra Lauric; Prahlad G. Menon; Kerem Pekkan; Mahdi Esmaily Moghadam; Alison L. Marsden; Marie Oshima; Kengo Katagiri; Véronique Peiffer; Yumnah Mohamied; Spencer J. Sherwin; Jens Schaller; Leonid Goubergrits; Gabriel Usera; Mariana Mendina; Kristian Valen-Sendstad; Damiaan F. Habets; Jianping Xiang; Hui Meng; Yue Yu; George Em Karniadakis; Nicholas Shaffer; Francis Loth;doi: 10.1115/1.4023382
pmid: 23445061
Stimulated by a recent controversy regarding pressure drops predicted in a giant aneurysm with a proximal stenosis, the present study sought to assess variability in the prediction of pressures and flow by a wide variety of research groups. In phase I, lumen geometry, flow rates, and fluid properties were specified, leaving each research group to choose their solver, discretization, and solution strategies. Variability was assessed by having each group interpolate their results onto a standardized mesh and centerline. For phase II, a physical model of the geometry was constructed, from which pressure and flow rates were measured. Groups repeated their simulations using a geometry reconstructed from a micro-computed tomography (CT) scan of the physical model with the measured flow rates and fluid properties. Phase I results from 25 groups demonstrated remarkable consistency in the pressure patterns, with the majority predicting peak systolic pressure drops within 8% of each other. Aneurysm sac flow patterns were more variable with only a few groups reporting peak systolic flow instabilities owing to their use of high temporal resolutions. Variability for phase II was comparable, and the median predicted pressure drops were within a few millimeters of mercury of the measured values but only after accounting for submillimeter errors in the reconstruction of the life-sized flow model from micro-CT. In summary, pressure can be predicted with consistency by CFD across a wide range of solvers and solution strategies, but this may not hold true for specific flow patterns or derived quantities. Future challenges are needed and should focus on hemodynamic quantities thought to be of clinical interest.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 119 citations 119 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019Publisher:Elsevier BV Authors: Alberto, Cárceles-Álvarez; Juan A, Ortega-García; Fernando A, López-Hernández; José L, Fuster-Soler; +6 AuthorsAlberto, Cárceles-Álvarez; Juan A, Ortega-García; Fernando A, López-Hernández; José L, Fuster-Soler; Rebeca, Ramis; Nicole, Kloosterman; Luis, Castillo; Manuel, Sánchez-Solís; Luz, Claudio; Josep, Ferris-Tortajada;pmid: 31479979
The 5-year overall survival (OS) in childhood acute lymphoblastic leukemia (ALL) has reached 90% in high-income countries, levels that can no be longer overcome with strategies based on intensification of treatment. Other approaches in the search for new and modifiable prognostic factors are necessary to continue to improve these rates. The importance of environmental factors in the etiopathogenesis of childhood ALL has been regaining interest but its role in the prognosis and survival of this disease is not well explored. We aim to investigate the association between secondhand smoke (SHS) and survival in children diagnosed with ALL.We analyzed survival rates in 146 patients under the age of 15 years diagnosed with ALL between January 1998 and May 2016 in the Region of Murcia, Spain. Evaluation of parental SHS and other known prognostic factors (sex, age, white blood cell count at diagnosis, cytogenetics, NCI/Rome Criteria, early response to therapy, and relapse) were assessed for impact on OS, event-free survival (EFS), cumulative incidence of relapse (CIR), and treatment-related mortality (CITRM) using Kaplan-Meier analysis, Cox regression, and Fine-Gray model.The mean follow-up time was 105.3 months (±66.5). Prenatal exposure to SHS due to parental smoking was highly prevalent. Of the mothers, 44.4% and 55.5% of the fathers smoked at some point during pregnancy. After the child's diagnosis of ALL 39.7% of mothers and 45.9% of fathers reported smoking. The Cox proportional hazards model showed that maternal smoking during pregnancy and after diagnosis (HR = 4.396, 95% CI: 1.173-16.474, p = 0.028); and relapse (HR = 7.919; 95% CI: 2.683-21.868; p 0.001) are independent prognostic factors in determining survival. The Fine-Gray model showed that maternal smoking during pregnancy and after diagnosis (HR = 14.525, 95% CI: 4.228-49.90, p 0.001) is an independent prognostic factor in CITRM.Persistent SHS worsens OS and TRM in children with ALL. This negative impact contributes to a different prognosis and may possibly provide an exceptional insight into new therapeutic approaches, including environmental aspects such as prevention and smoking cessation to improve survival outcomes.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envres.2019.108689&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 7 citations 7 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envres.2019.108689&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 SpainPublisher:Elsevier BV Funded by:FCT | MS3FCT| MS3Authors: Paulsen Gómez, Erika; Moreno Fernández, Diego Ángel; Periago Bayonas, Paula María; Lema Larrieu, Patricia;Paulsen Gómez, Erika; Moreno Fernández, Diego Ángel; Periago Bayonas, Paula María; Lema Larrieu, Patricia;Cooking vegetables in microwave bags is becoming a popular domestic cooking method, being relevant to know how this cooking method affects health-promoting phytochemicals of staples such as broccoli. The aim of this work was to study the effect of microwave bag cooking versus conventional microwaving on bioactive compound content (glucosinolates and hydroxycinnamic acid derivatives) and other quality parameters (such as antioxidant capacity, mineral content and microbial load) of broccoli florets. The influence of cooking time on bioactive compounds content was also evaluated. The study was carried out in two independent experiments; using intact broccoli and broccoli preprocessed in industry. Microwave bag cooked broccoli for 5 min (following label recommendation) showed higher glucosinolate content retention compared to conventional microwaving. Results suggest that volatilization could be an important phenomenon in reduction of glucosinolates during microwave cooking of broccoli florets. Glucosinolate profile did not change after cooking, regardless of cooking method applied. Furthermore, microwave bag cooked broccoli presented higher antioxidant capacity (by DPPH assay) than conventional microwaved broccoli. Hydroxycinnamic acid derivatives content was reduced in microwave cooking, regardless of method applied. Altogether, the use of microwave bags for microwaving is a novel method that retains main bioactive components of broccoli. This option is a fast, easy and considerably clean cooking option to fulfill modern consumer needs. This work was supported by Comision ´ Sectorial de Investigacion ´ Científica, Universidad de la República. Authors are indebted to Agencia Nacional de Innovacion ´ e Investigacion ´ for granting Erika Paulsen a PhD scholarship and an internship at Phytochemistry and Healthy Foods Laboratory of the Department of Food Science and Technology at CEBAS-CSIC (scholarship reference: POS_EMHE_2018_1_1007740)
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021Food Research InternationalArticle . 2021 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.foodres.2020.110077&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 23visibility views 23 download downloads 183 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021Food Research InternationalArticle . 2021 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.foodres.2020.110077&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Poland, Netherlands, Spain, Switzerland, Croatia, Norway, Poland, United Kingdom, Australia, Italy, Portugal, Italy, Portugal, Portugal, Italy, ItalyPublisher:SAGE Publications Publicly fundedFunded by:NIH | Enhancing Cross Disciplin..., EC | CIC, UKRI | The Paradox of Gender-Con...NIH| Enhancing Cross Disciplinary Infrastructure and Training at Oregon (EXITO) Research Enrich ,EC| CIC ,UKRI| The Paradox of Gender-Conscious Diversity Initiatives: How Accentuating Gender Differences May Perpetuate Workplace Gender InequalityAuthors: Kosakowska-Berezecka, Natasza; Bosson, Jennifer K.; Jurek, Paweł; Besta, Tomasz; +159 AuthorsKosakowska-Berezecka, Natasza; Bosson, Jennifer K.; Jurek, Paweł; Besta, Tomasz; Olech, Michał; Vandello, Joseph A.; Bender, Michael; Dandy, Justine; Hoorens, Vera; Jasinskaja-Lahti, Inga; Mankowski, Eric; Venäläinen, Satu; Abuhamdeh, Sami; Agyemang, Collins Badu; Akbaş, Gülçin; Albayrak-Aydemir, Nihan; Ammirati, Soline; Anderson, Joel; Anjum, Gulnaz; Ariyanto, Amarina; Aruta, John Jamir Benzon R.; Ashraf, Mujeeba; Bakaitytė, Aistė; Becker, Maja; Bertolli, Chiara; Bërxulli, Dashamir; Best, Deborah L.; Bi, Chongzeng; Block, Katharina; Boehnke, Mandy; Bongiorno, Renata; Bosak, Janine; Casini, Annalisa; Chen, Qingwei; Chi, Peilian; Cubela Adoric, Vera; Daalmans, Serena; de Lemus, Soledad; Dhakal, Sandesh; Dvorianchikov, Nikolay; Egami, Sonoko; Etchezahar, Edgardo; Esteves, Carla Sofia; Froehlich, Laura; Garcia-Sanchez, Efrain; Gavreliuc, Alin; Gavreliuc, Dana; Gomez, Ángel; Guizzo, Francesca; Graf, Sylvie; Greijdanus, Hedy; Grigoryan, Ani; Grzymała-Moszczyńska, Joanna; Guerch, Keltouma; Gustafsson Sendén, Marie; Hale, Miriam-Linnea; Hämer, Hannah; Hirai, Mika; Hoang Duc, Lam; Hřebíčková, Martina; Hutchings, Paul B.; Jensen, Dorthe Høj; Karabati, Serdar; Kelmendi, Kaltrina; Kengyel, Gabriella; Khachatryan, Narine; Ghazzawi, Rawan; Kinahan, Mary; Kirby, Teri A.; Kovacs, Monika; Kozlowski, Desiree; Krivoshchekov, Vladislav; Kryś, Kuba; Kulich, Clara; Kurosawa, Tai; Lac An, Nhan Thi; Labarthe-Carrara, Javier; Lauri, Mary Anne; Latu, Ioana; Lawal, Abiodun Musbau; Li, Junyi; Lindner, Jana; Lindqvist, Anna; Maitner, Angela T.; Makarova, Elena; Makashvili, Ana; Malayeri, Shera; Malik, Sadia; Mancini, Tiziana; Manzi, Claudia; Mari, Silvia; Martiny, Sarah E.; Mayer, Claude-Hélène; Mihić, Vladimir; MiloševićĐorđević, Jasna; Moreno-Bella, Eva; Moscatelli, Silvia; Moynihan, Andrew Bryan; Muller, Dominique; Narhetali, Erita; Neto, Félix; Noels, Kimberly A.; Nyúl, Boglárka; O’Connor, Emma C.; Ochoa, Danielle P.; Ohno, Sachiko; Olanrewaju Adebayo, Sulaiman; Osborne, Randall; Pacilli, Maria Giuseppina; Palacio, Jorge; Patnaik, Snigdha; Pavlopoulos, Vassilis; de León, Pablo Pérez; Piterová, Ivana; Porto, Juliana Barreiros; Puzio, Angelica; Pyrkosz-Pacyna, Joanna; Rentería Pérez, Erico; Renström, Emma; Rousseaux, Tiphaine; Ryan, Michelle K.; Safdar, Saba; Sainz, Mario; Salvati, Marco; Samekin, Adil; Schindler, Simon; Sevincer, A. Timur; Seydi, Masoumeh; Shepherd, Debra; Sherbaji, Sara; Schmader, Toni; Simão, Cláudia; Sobhie, Rosita; Sobiecki, Jurand; De Souza, Lucille; Sarter, Emma; Sulejmanović, Dijana; Sullivan, Katie E.; Tatsumi, Mariko; Tavitian-Elmadjian, Lucy; Thakur, Suparna Jain; Thi Mong Chi, Quang; Torre, Beatriz; Torres, Ana; Torres, Claudio V.; Türkoğlu, Beril; Ungaretti, Joaquín; Valshtein, Timothy; Van Laar, Colette; van der Noll, Jolanda; Vasiutynskyi, Vadym; Vauclair, Christin-Melanie; Vohra, Neharika; Walentynowicz, Marta; Ward, Colleen; Włodarczyk, Anna; Yang, Yaping; Yzerbyt, Vincent; Zanello, Valeska; Zapata-Calvente, Antonella Ludmila; Zawisza, Magdalena; Žukauskienė, Rita; Żadkowska, Magdalena;Social role theory posits that binary gender gaps in agency and communion should be larger in less egalitarian countries, reflecting these countries’ more pronounced sex-based power divisions. Conversely, evolutionary and self-construal theorists suggest that gender gaps in agency and communion should be larger in more egalitarian countries, reflecting the greater autonomy support and flexible self-construction processes present in these countries. Using data from 62 countries (N = 28,640), we examine binary gender gaps in agentic and communal self-views as a function of country-level objective gender equality (the Global Gender Gap Index) and subjective distributions of social power (the Power Distance Index). Findings show that in more egalitarian countries, gender gaps in agency are smaller and gender gaps in communality are larger. These patterns are driven primarily by cross-country differences in men’s self-views and by the Power Distance Index (PDI) more robustly than the Global Gender Gap Index (GGGI). We consider possible causes and implications of these findings. Swedish Research Council Swedish Research Council for Health Working Life & Welfare (Forte) 2017-00414 Economic & Social Research Council (ESRC) ES/S00274X/1 MCIN/AEI PID2019-111549GB-I00 Universidad Nacional de Educacion a Distancia, Spain RTI2018-093550-B-I00 European Research Council (ERC) European Commission ERC-2016-COG 725128 NIH National Institute of General Medical Sciences (NIGMS) RL5GM118963 Institute of Psychology, Czech Academy of Sciences RVO: 68081740 National Science Centre, Poland 2017/26/M/HS6/00360 United States Department of Health & Human Services Grant Agency of the Czech Republic 20-01214S National Institutes of Health (NIH) - USA UK Research & Innovation (UKRI) University of Brasilia 04/2019
BOA - Bicocca Open A... arrow_drop_down BOA - Bicocca Open Archive; IRIS - Università degli Studi di Verona; Social Psychological and Personality Science; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2022 . 2023 . Peer-reviewedLicense: SAGE TDMRepositorio Institucional Universidad de GranadaArticle . 2022Data sources: Repositorio Institucional Universidad de GranadaIRIS - Università degli Studi di VeronaArticle . 2022Data sources: IRIS - Università degli Studi di VeronaRepositório Institucional da Universidade Católica PortuguesaOther literature type . 2023License: CC BY NC NDMunin - Open Research Archive; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BYMémoires en Sciences de l'Information et de la CommunicationArticle . 2022Full-Text: https://hal.science/hal-03846884/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 74visibility views 74 download downloads 289 Powered bymore_vert BOA - Bicocca Open A... arrow_drop_down BOA - Bicocca Open Archive; IRIS - Università degli Studi di Verona; Social Psychological and Personality Science; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2022 . 2023 . Peer-reviewedLicense: SAGE TDMRepositorio Institucional Universidad de GranadaArticle . 2022Data sources: Repositorio Institucional Universidad de GranadaIRIS - Università degli Studi di VeronaArticle . 2022Data sources: IRIS - Università degli Studi di VeronaRepositório Institucional da Universidade Católica PortuguesaOther literature type . 2023License: CC BY NC NDMunin - Open Research Archive; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BYMémoires en Sciences de l'Information et de la CommunicationArticle . 2022Full-Text: https://hal.science/hal-03846884/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2015 Netherlands, Spain, Netherlands, Turkey, Netherlands, United Kingdom, Italy, France, Italy, United Kingdom, Netherlands, Denmark, Italy, Netherlands, Italy, Italy, Turkey, United Kingdom, Germany, Netherlands, Netherlands, DenmarkPublisher:Elsevier BV Publicly fundedAuthors: Forouzanfar, Mohammad H; Alexander, Lily; Anderson, H. Ross; Bachman, Victoria F.; +393 AuthorsForouzanfar, Mohammad H; Alexander, Lily; Anderson, H. Ross; Bachman, Victoria F.; Biryukov, Stan; Brauer, Michael; Burnett, Richard; Casey, Daniel; Coates, Matthew M.; Cohen, Aaron; Delwiche, Kristen; Estep, Kara; Frostad, Joseph J.; Astha, K. C.; Kyu, Hmwe H.; Moradi Lakeh, Maziar; Ng, Marie; Slepak, Erica Leigh; Thomas, Bernadette A.; Wagner, Joseph; Aasvang, Gunn Marit; Abbafati, Cristiana; Abbasoglu Ozgoren, Ayse; Abd Allah, Foad; Abera, Semaw F.; Aboyans, Victor; Abraham, Biju; Puthenpurakal Abraham, Jerry; Abubakar, Ibrahim; Abu Rmeileh, Niveen M. E.; Aburto, Tania C.; Achoki, Tom; Adelekan, Ademola; Adofo, Koranteng; Adou, Arsène K.; Adsuar, José C.; Afshin, Ashkan; Agardh, Emilie E.; Al Khabouri, Mazin J.; Al Lami, Faris H.; Alam, Sayed Saidul; Alasfoor, Deena; Albittar, Mohammed I.; Alegretti, Miguel A.; Aleman, Alicia V.; Alemu, Zewdie A.; Alfonso Cristancho, Rafael; Alhabib, Samia; Ali, Raghib; Ali, Mohammed K.; Alla, François; Allebeck, Peter; Allen, Peter J.; Alsharif, Ubai; Alvarez, Elena; Alvis Guzman, Nelson; Amankwaa, Adansi A.; Amare, Azmeraw T.; Ameh, Emmanuel A.; Ameli, Omid; Amini, Heresh; Ammar, Walid; Anderson, Benjamin O.; Antonio, Carl Abelardo T.; Anwari, Palwasha; Argeseanu Cunningham, Solveig; Arnlöv, Johan; Arsic Arsenijevic, Valentina S.; Artaman, Al; Asghar, Rana J.; Assadi, Reza; Atkins, Lydia S.; Atkinson, Charles; Avila, Marco A.; Awuah, Baffour; Badawi, Alaa; Bahit, Maria C.; Bakfalouni, Talal; Balakrishnan, Kalpana; Balalla, Shivanthi; Balu, Ravi Kumar; Banerjee, Amitava; Barber, Ryan M.; Barker Collo, Suzanne L.; Barquera, Simon; Barregard, Lars; Barrero, Lope H.; Barrientos Gutierrez, Tonatiuh; Basto Abreu, Ana C.; Basu, Arindam; Basu, Sanjay; Basulaiman, Mohammed O.; Batis Ruvalcaba, Carolina; Beardsley, Justin; Bedi, Neeraj; Bekele, Tolesa; Bell, Michelle L.; Benjet, Corina; Bennett, Derrick A.; Benzian, Habib; Bernabé, Eduardo; Beyene, Tariku J.; Bhala, Neeraj; Bhalla, Ashish; Bhutta, Zulfiqar A.; Bikbov, Boris; Bin Abdulhak, Aref A.; Blore, Jed D.; Blyth, Fiona M.; Bohensky, Megan A.; Bora Başara, Berrak; Borges, Guilherme; Bornstein, Natan M.; Bose, Dipan; Boufous, Soufiane; Bourne, Rupert R.; Brainin, Michael; Brazinova, Alexandra; Breitborde, Nicholas J.; Brenner, Hermann; Briggs, Adam D. M.; Broday, David M.; Brooks, Peter M.; Bruce, Nigel G.; Brugha, Traolach S.; Brunekreef, Bert; Buchbinder, Rachelle; Bui, Linh N.; Bukhman, Gene; Bulloch, Andrew G.; Burch, Michael; Burney, Peter G. J.; Campos Nonato, Ismael R.; Campuzano, Julio C.; Cantoral, Alejandra J.; Caravanos, Jack; Cárdenas, Rosario; Cardis, Elisabeth; Carpenter, David O.; Caso, Valeria; Castañeda Orjuela, Carlos A.; Castro, Ruben E.; Catalá López, Ferrán; Cavalleri, Fiorella; Çavlin, Alanur; Chadha, Vineet K.; Chang, Jung Chen; Charlson, Fiona J.; Chen, Honglei; Chen, Wanqing; Chen, Zhengming; Chiang, Peggy P.; Chimed Ochir, Odgerel; Chowdhury, Rajiv; Christophi, Costas A.; Chuang, Ting Wu; Chugh, Sumeet S.; Cirillo, Massimo; Claßen, Thomas K. D.; Colistro, Valentina; Colomar, Mercedes; Colquhoun, Samantha M.; Contreras, Alejandra G.; Cooper, Cyrus; Cooperrider, Kimberly; Cooper, Leslie T.; Coresh, Josef; Courville, Karen J.; Criqui, Michael H.; Cuevas Nasu, Lucia; Damsere Derry, James; Danawi, Hadi; Dandona, Lalit; Dandona, Rakhi; Dargan, Paul I.; Davis, Adrian; Davitoiu, Dragos V.; Dayama, Anand; De Castro, E. Filipa; De La Cruz Góngora, Vanessa; De Leo, Diego; De Lima, Graça; Degenhardt, Louisa; Del Pozo Cruz, Borja; Dellavalle, Robert P.; Deribe, Kebede; Derrett, Sarah; Des Jarlais, Don C.; Dessalegn, Muluken; Deveber, Gabrielle A.; Devries, Karen M.; Dharmaratne, Samath D.; Dherani, Mukesh K.; Dicker, Daniel; Ding, Eric L.; Dokova, Klara; Dorsey, E. Ray; Driscoll, Tim R.; Duan, Leilei; Durrani, Adnan M.; Endres, Matthias; Erskine, Holly E.; Esteghamati, Alireza; Faraon, Emerito Jose A.; Farzadfar, Farshad; Feigin, Valery L.; Ferrari, Alize J.; Foigt, Nataliya; Fra Paleo, Urbano; Franklin, Richard C.; Gabbe, Belinda; Geleijnse, Johanna M.; Ginawi, Ibrahim A. M.; Giussani, Giorgia; Goenka, Shifalika; Goto, Atsushi; Gouda, Hebe N.; Hankey, Graeme J.; Haro, Josep Maria; Hay, Simon I.; Hedayati, Mohammad T.; Heydarpour, Pouria; Hoek, Hans W.; Hu, Howard; Hubbell, Bryan J.; Husseini, Abdullatif; Idrisov, Bulat T.; Innos, Kaire; Islami, Farhad; Jacobsen, Kathryn H.; Jansen, Henrica A.; Jarvis, Deborah L.; Jayaraman, Sudha; Jeemon, Panniyammakal; Jha, Vivekanand; Juel, Knud; Karch, André; Karthikeyan, Ganesan; Kemp, Andrew H.; Kengne, Andre P.; Khader, Yousef S.; Khan, Ejaz A.; Kieling, Christian; Kim, Daniel; Kimokoti, Ruth W.; Kinfu, Yohannes; Kissela, Brett M.; Knibbs, Luke D.; Knudsen, Ann Kristin; Kosen, Soewarta; Kravchenko, Michael; Kromhout, Hans; Kuate Defo, Barthelemy; Kucuk Bicer, Burcu; Kuipers, Ernst J.; Kumar, G. Anil; Kwan, Gene F.; Lalloo, Ratilal; Lallukka, Tea; Lansingh, Van C.; Larson, Heidi J.; Laryea, Dennis O.; Leasher, Janet L.; Leung, Ricky; Li, Yichong; Liu, Yang; Logroscino, Giancarlo; London, Stephanie J.; Lotufo, Paulo A.; Lozano, Rafael; Lunevicius, Raimundas; Mahdi, Abbas A.; Majdan, Marek; Marks, Guy B.; Martin, Randall V.; Marzan, Melvin B.; Matzopoulos, Richard; Mckee, Martin; Meaney, Peter A.; Melaku, Yohannes A.; Meretoja, Atte; Apolinary Mhimbira, Francis; Miller, Ted R.; Mohammad, Karzan A.; Mokdad, Ali H.; Monasta, Lorenzo; Montico, Marcella; Morawska, Lidia; Mori, Rintaro; Moturi, Wilkister N.; Mukaigawara, Mitsuru; Nahas, Ziad; Naheed, Aliya; Naldi, Luigi; Nash, Denis; Neal, Bruce; Nejjari, Chakib; Neupane, Sudan P.; Newton, Charles R.; Nguyen, Nhung T.; Nisar, Muhammad I.; Nogueira, José R.; Nolte, Sandra; Norheim, Ole F.; Nyakarahuka, Luke; Ohkubo, Takayoshi; Olusanya, Bolajoko O.; Pandian, Jeyaraj D.; Parry, Charles D.; Patten, Scott B.; Pearce, Neil; Pedraza, Lilia S.; Pereira, David M.; Perico, Norberto; Pesudovs, Konrad; Phillips, Michael R.; Polanczyk, Guilherme V.; Pope, Daniel; Prabhakaran, Dorairaj; Qato, Dima M.; Rahimi, Kazem; Rakovac, Ivo; Rana, Saleem M.; Razavi, Homie; Reddy, K. Srinath; Refaat, Amany H.; Remuzzi, Giuseppe; Riccio, Patricia M.; Rodriguez, Alina; Roy, Nobhojit; Ruhago, George M.; Sahathevan, Ramesh; Sahraian, Mohammad Ali; Salomon, Joshua A.; Salvo, Deborah; Sánchez Pimienta, Tania G.; Sanchez Riera, Lidia; Santos, Itamar S.; Sapkota, Amir; Satpathy, Maheswar; Saylan, Mete I.; Schneider, Ione J. C.; Schöttker, Ben; Scott, James G.; Seedat, Soraya; Shibuya, Kenji; Shin, Hwashin H.; Shiri, Rahman; Shishani, Kawkab; Shiue, Ivy; Sindi, Shireen; Singh, Jasvinder A.; Soljak, Michael; Søreide, Kjetil; Soshnikov, Sergey; Sreeramareddy, Chandrashekhar T.; Stein, Dan J.; Stöckl, Heidi; Stroumpoulis, Konstantinos; Sunguya, Bruno F.; Swaroop, Mamta; Tabb, Karen M.; Takahashi, Ken; Te Ao, Braden J.; Téllez Rojo, Martha M.; Terkawi, Abdullah S.; Texcalac Sangrador, José Luis; Thomson, Blake; Thrift, Amanda G.; Tillmann, Taavi; Tonelli, Marcello; Topouzis, Fotis; Traebert, Jefferson; Tran, Bach X.; Trasande, Leonardo; Trillini, Matias; Tsilimbaris, Miltiadis; Ukwaja, Kingsley N.; Van Dingenen, Rita; Van Gool, Coen H.; Van Os, Jim; Vasconcelos, Ana Maria N.; Veerman, Lennert J.; Villalpando, Salvador; Victorovich Vlassov, Vasiliy; Warouw, Tati S.; Weiderpass, Elisabete; Whiteford, Harvey A.; Wilkinson, James D.; Williams, Hywel C.; Woldeyohannes, Solomon M.; Woolf, Anthony D.; Xu, Gelin; Ye, Pengpeng; Younis, Mustafa Z.; Zaki, Maysaa E.; Zhao, Yong;pmc: PMC4685753
Summary Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian metaregression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5−89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks. Funding Bill & Melinda Gates Foundation. Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the fi rst of a series of annual updates of the GBD. Risk factor quantifi cation, particularly of modifi able risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the fi rst level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular fi ltration rate. For most risks, data for exposure were synthesised with a Bayesian metaregression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5−89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks. Funding Bill & Melinda Gates Foundation.
Flore (Florence Rese... arrow_drop_down Hacettepe Üniversitesi Açık Erişim SistemiArticle . 2015Data sources: Hacettepe Üniversitesi Açık Erişim SistemiDigitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2015 . Peer-reviewedFlore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Recolector de Ciencia Abierta, RECOLECTAArticle . 2015Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2015License: CC BYOxford University Research ArchiveOther literature type . 2018Data sources: Oxford University Research ArchiveArchivio della Ricerca - Università di Salerno; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; The Lancet; PURE Aarhus University; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2015Data sources: Erasmus University Rotterdam - Research Information Portal; OD-Maastricht University | MUMC+ Research Information; Archivio della Ricerca - Università di Salerno; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; PURE Aarhus University; Archivio della ricerca - Università degli studi di Napoli Federico IIResearch@WUR; Publications at Bielefeld University; The LancetOther literature type . Article . 2015 . Peer-reviewedLicense: Elsevier TDMArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoArchivio della ricerca- Università di Roma La SapienzaArticle . 2015Data sources: Archivio della ricerca- Università di Roma La SapienzaVBN; Aalborg University Research PortalArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 2K citations 2,177 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!visibility 224visibility views 224 download downloads 286 Powered bymore_vert Flore (Florence Rese... arrow_drop_down Hacettepe Üniversitesi Açık Erişim SistemiArticle . 2015Data sources: Hacettepe Üniversitesi Açık Erişim SistemiDigitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2015 . Peer-reviewedFlore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Recolector de Ciencia Abierta, RECOLECTAArticle . 2015Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2015License: CC BYOxford University Research ArchiveOther literature type . 2018Data sources: Oxford University Research ArchiveArchivio della Ricerca - Università di Salerno; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; The Lancet; PURE Aarhus University; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2015Data sources: Erasmus University Rotterdam - Research Information Portal; OD-Maastricht University | MUMC+ Research Information; Archivio della Ricerca - Università di Salerno; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; PURE Aarhus University; Archivio della ricerca - Università degli studi di Napoli Federico IIResearch@WUR; Publications at Bielefeld University; The LancetOther literature type . Article . 2015 . Peer-reviewedLicense: Elsevier TDMArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoArchivio della ricerca- Università di Roma La SapienzaArticle . 2015Data sources: Archivio della ricerca- Università di Roma La SapienzaVBN; Aalborg University Research PortalArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2013 France, Switzerland, Italy, CyprusPublisher:Cold Spring Harbor Laboratory Fariello, María Inés; Servin, Bertrand; Tosser-Klopp, Gwenola; Rupp, Rachel; Moreno, Carole Rénée; Cristobal, Magali San; Boitard, Simon B.; Arranz, Juan Jose; Banos, Georgios; Barendse, William J.; El Beltagy, Ahmedn; Benenwitz, Jorn; Bishop, Steve C.; Bunger, Lutz; Calvo, Jorge H.; Carta, Antonello; Cemal, İbrahim; Ciani, Elena; Cockett, Noelle E.; Coltman, David W.; Dalrymple, Brian P.; D'Andrea, Mariasilvia Silvia; Distl, Ottmar; Drogemuller, Cord; Erhardt, Georg J.; Eythorsdottir, Emma; Gietzen, Kimberly J.; Gill, Clare; Gootwine, Clare; Gupta, Vidya Shrikant; Hanotte, Olivier H.; Hayes, Ben J.; Heaton, Michael P.; Hiendleder, Stefan G.; Jialin, Han; Kantanen, Juha; Kent, Matthew; Kijas, James W.; Larkin, Denis M.; Lenstra, Johannes A.; Li, Kui; Longhurst, Terry; Ma, Runlin; McCulloch, Russell J.; MacHugh, David E.; McWilliam, Sean M.; McEwan, John C.; Maddox, Jillian F.; Malek, Massoud; Mdomar, Faruque; Miltiadou, Despoina; Monteagudo Ibez, Luis V.; Nicholas, Frank W.; Nowak, Kristen J.; Oddy, Victor Hutton; Paiva, Samuel Rezende; Pardeshi, Varsha Chhotusing; Pemberton, Josephine M. M.; Pilla, Fabio; Porto Neto, Laércio R.; Raadsma, Herman W.; Roberts, Cyril; San Cristobal, Magali; Sechi, Tiziana; Scheet, Paul A.; Shariflou, Mohammad Reza; Silva, Pradeepa; Simianer, Henner; Slate, Jon; Tapio, Miika; Vattathil, Selina; Whan V., Vicki A.;International audience; The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset to identify selection signatures in worldwide sheep populations. Compared to previous analyses, we made use of statistical methods that (i) take account of the hierarchical structure of sheep populations, (ii) make use of linkage disequilibrium information and (iii) focus specifically on either recent or older selection signatures. We show that this allows pinpointing several new selection signatures in the sheep genome and distinguishing those related to modern breeding objectives and to earlier post-domestication constraints. The newly identified regions, together with the ones previously identified, reveal the extensive genome response to selection on morphology, color and adaptation to new environments.
bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4134316Data sources: PubMed CentralBern Open Repository and Information System (BORIS)Article . 2014 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 129 citations 129 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 4visibility views 4 download downloads 15 Powered bymore_vert bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4134316Data sources: PubMed CentralBern Open Repository and Information System (BORIS)Article . 2014 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Italy, United Kingdom, Ireland, Netherlands, Turkey, Italy, Italy, France, Denmark, Turkey, United States, Denmark, United Kingdom, ItalyPublisher:Elsevier BV Publicly fundedFunded by:NHMRC | Modifiable risk factors f..., SNSF | Morbidity and cost of hel..., UKRI | MICA: Centre for the Impr... +2 projectsNHMRC| Modifiable risk factors for Serious Mental Illness - an integrated program of epidemiology, genetics and clinical trials ,SNSF| Morbidity and cost of helminth infections: fitting existing and investigating missing pieces of evidence ,UKRI| MICA: Centre for the Improvement of Population Health through E-health Research (CIPHER) ,SNSF| Morbidity and cost of helminth infections: learning from the past to prepare for the future ,NIH| Pediatric Injury Research Training ProgramAdrian Davis; Ayse Abbasoglu Ozgoren; Foad Abd-Allah; Victor Aboyans; Jerry Puthenpurakal Abraham; Katrina Abuabara; Ibrahim Abubakar; Tom Achoki; Zanfina Ademi; Johan Ärnlöv; Miguel Angel Alegretti; Alicia Aleman; Rafael Alfonso-Cristancho; Samia Alhabib; Raghib Ali; François Alla; Peter Allebeck; Rustam Al-Shahi Salman; Ubai Alsharif; Adansi A. Amankwaa; Azmeraw T. Amare; Omid Ameli; Hassan Amini; Walid Ammar; Benjamin O. Anderson; Carl Abelardo T. Antonio; Henry Apfel; Solveig A. Cunningham; Valentina Arsić Arsenijević; Al Artaman; Lydia S. Atkins; Charles Atkinson; Kalpana Balakrishnan; Shivanthi Balalla; Amitava Banerjee; Lope H Barrero; Tonatiuh Barrientos-Gutiérrez; Sanjay Basu; Mohammed Basulaiman; Justin Beardsley; Neeraj Bedi; Ettore Beghi; Michelle L. Bell; Corina Benjet; Derrick A Bennett; Habib Benzian; Tariku Jibat Beyene; Neeraj Bhala; Boris Bikbov; Fiona M. Blyth; Megan Bohensky; Guilherme Borges; Soufiane Boufous; Michael Brainin; Carol Brayne; Alexandra Brazinova; Hermann Brenner; Adam D M Briggs; Traolach S. Brugha; Geoffrey Buckle; Gene Bukhman; Ismael Ricardo Campos Nonato; Rosario Cárdenas; Carlos A Castañeda-Orjuela; Ruben Castro; Ferrán Catalá-López; Fiorella Cavalleri; Jung-Chen Chang; Fiona C. Charlson; Xuan Che; Honglei Chen; Odgerel Chimed-Ochir; Rajiv Chowdhury; Hanne Christensen; Massimo Cirillo; Matthew M Coates; Luc E. Coffeng; Aaron Cohen; Valentina Colistro; Samantha M. Colquhoun; Leslie T. Cooper; Luis M. Coppola; Karen J. Courville; Benjamin C Cowie; Michael H. Criqui; Rakhi Dandona; Paul I. Dargan; Vanessa De la Cruz-Góngora; Diego De Leo; Louisa Degenhardt; Borja del Pozo-Cruz; Kebede Deribe; Muluken Dessalegn; Gabrielle de Veber; Mukesh Dherani; José Luis Díaz-Ortega; Cesar Diaz-Torne; Daniel Dicker; Eric L. Ding; Klara Dokova; E. Ray Dorsey; Herbert C. Duber; Richard G. Ellenbogen; Yousef M. Elshrek; Sergey Petrovich Ermakov; Alireza Esteghamati; Thomas Fürst; Saman Fahimi; Emerito Jose A. Faraon; Farshad Farzadfar; Valery L. Feigin; Alize J. Ferrari; Thomas D. Fleming; Nataliya Foigt; Mohammad H. Forouzanfar; Urbano Fra Paleo; Fortuné Gbètoho Gankpé; Johanna M. Geleijnse; Katherine B Gibney; Ibrahim Abdelmageem Mohamed Ginawi; Elizabeth Glaser; Shifalika Goenka; Philimon Gona; Caterina Guinovart; Rashmi Gupta; Atsushi Goto; Hebe N. Gouda; David Gunnell; Holly Hagan; Maria Hagströmer; Randah R. Hamadeh; Mouhanad Hammami; Graeme J. Hankey; Josep Maria Haro; Rasmus Havmoeller; Simon I. Hay; Mohammad Taghi Hedayati; Pouria Heydarpour; Hideki Higashi; Hans W. Hoek; H. Dean Hosgood; Mazeda Hossain; Peter J. Hotez; Damian G Hoy; Guoqing Hu; Mark D. Huffman; Abdullatif Husseini; Marissa Iannarone; Bulat Idrisov; Nayu Ikeda; Kaire Innos; Farhad Islami; Kathryn H. Jacobsen; Sudha Jayaraman; Vivekanand Jha; Ying Jiang; Jost B. Jonas; Knud Juel; Edmond K. Kabagambe; André Karch; Ganesan Karthikeyan; Nicholas J Kassebaum; Andre Pascal Kengne; Yousef Khader; Shams Eldin Ali Hassan Khalifa; Ejaz Ahmad Khan; Gulfaraz Khan; Young-Ho Khang; Christian Kieling; Yohannes Kinfu; Daniel Kim; Miia Kivipelto; Luke D. Knibbs; Ann Kristin Knudsen; Sowarta Kosen; Meera Kotagal; Michael Kravchenko; Barthelemy Kuate Defo; Ernst J. Kuipers; Burcu Kucuk Bicer; Kaushalendra Kumar; Ravi Kumar; Hmwe H Kyu; Ratilal Lalloo; Tea Lallukka; Hilton Lam; Qing Lan; Van C. Lansingh; Heidi J. Larson; Pablo M. Lavados; Alicia Elena Beatriz Lawrynowicz; Janet L Leasher; James Leigh; Mall Leinsalu; Ricky Leung; Carly E Levitz; Bin Li; Shiwei Liu; Yang Liu; Belinda K Lloyd; Giancarlo Logroscino; Stephanie J. London; Joannie Lortet-Tieulent; Paulo A. Lotufo; Robyn M. Lucas; Raimundas Lunevicius; Ronan A Lyons; Michael F. MacIntyre; Mark T Mackay; Jennifer H MacLachlan; Carlos Magis-Rodriguez; Abbas Ali Mahdi; Marek Majdan; Reza Malekzadeh; Christopher C. Mapoma; Wagner Marcenes; Christopher Margono; Guy B. Marks; Melvin Barrientos Marzan; Mohammad T Mashal; Felix Masiye; Amanda J. Mason-Jones; Richard Matzopolous; Bongani M. Mayosi; John J. McGrath; Abigail C. McKay; Martin McKee; Man Mohan Mehndiratta; Yohannes Adama Melaku; Atte Meretoja; Francis Apolinary Mhimbira; Ted R. Miller; Edward J Mills; Terrie E. Moffitt; Lorenzo Monasta; Jonathan de la Cruz Monis; Marcella Montico; Thomas J. Montine; Ami R. Moore; Maziar Moradi-Lakeh; Andrew E. Moran; Rintaro Mori; Wilkister N. Moturi; Mitsuru Mukaigawara; Joseph Murray; Adetoun Mustapha; Paria Naghavi; Aliya Naheed; Luigi Naldi; Devina Nand; K.M. Venkat Narayan; Denis Nash; Jamal Nasher; Chakib Nejjari; Sudan Prasad Neupane; Grant Nguyen; Muhammad Imran Nisar; Sandra Nolte; Ole Frithjof Norheim; Rosana E. Norman; Bo Norrving; Luke Nyakarahuka; Shaun Odell; Martin O'Donnell; Takayoshi Ohkubo; Bolajoko O. Olusanya; Orish Ebere Orisakwe; Alberto Ortiz; Jeyaraj D Pandian; Jeemon Panniyammakal; Scott B. Patten; George C Patton; Vinod K. Paul; Boris I. Pavlin; Neil Pearce; Fernando Perez-Ruiz; Norberto Perico; Konrad Pesudovs; Carrie Beth Peterson; David Phillips; Frédéric B. Piel; Richie Poulton; Farshad Pourmalek; Dorairaj Prabhakaran; Dima M. Qato; Felicia A. Rabito; Anwar Rafay; Kazem Rahimi; Vafa Rahimi-Movaghar; Ivo Rakovac; Saleem M Rana; Amany H Refaat; Giuseppe Remuzzi; Antonio Luiz Pinho Ribeiro; Patricia M. Riccio; Jan Hendrik Richardus; Bayard Roberts; D. Allen Roberts; Margaret Robinson; Anna Roca; Alina Rodriguez; Dietrich Rothenbacher; Nobhojit Roy; George Mugambage Ruhago; Lesley Rushton; Sankar Sambandam; Kjetil Søreide; Mohammad Yahya Saeedi; Sukanta Saha; Ramesh Sahathevan; Berhe W. Sahle; Joshua A. Salomon; Deborah Salvo; Itamar S. Santos; Maheswar Satpathy; Mete Saylan; Ben Schöttker; Jürgen C Schmidt; Austin E Schumacher; David C. Schwebel; James Scott; Sadaf G. Sepanlou; Edson Serván-Mori; Jun She; Donald S. Shepard; Kenji Shibuya; Kawkab Shishani; Ivy Shiue; Rupak Shivakoti; Shireen Sindi; Jasvinder A. Singh; Edgar Sioson; Karen Sliwa; Michael Soljak; Sergey Soshnikov; Luciano A. Sposato; Chandrashekhar T Sreeramareddy; Jeffrey D. Stanaway; Kyle Steenland; Antony Stevens; Heidi Stöckl; Konstantinos Stroumpoulis; Bruno F. Sunguya; Soumya Swaminathan; Mamta Swaroop; Ken Takahashi; Feng Tan; David Tanne; Mohammad Tavakkoli; Braden Te Ao; Eric Y. Tenkorang; Abdullah Sulieman Terkawi; Amanda G. Thrift; Taavi Tillmann; Imad M. Tleyjeh; Marcello Tonelli; Fotis Topouzis; Hideaki Toyoshima; Jefferson Traebert; Bach Xuan Tran; Matias Trillini; Miltiadis K. Tsilimbaris; E. Murat Tuzcu; Kingsley N. Ukwaja; Eduardo A. Undurraga; Andrew Vallely; Coen H. Van Gool; Tommi Vasankari; Ana Maria Nogales Vasconcelos; Lakshmi Vijayakumar; Salvador Villalpando; Vasiliy Victorovich Vlassov; Gregory R. Wagner; Xiao Rong Wang; Tati S. Warouw; Elisabete Weiderpass; K. Ryan Wessells; Ronny Westerman; Harvey Whiteford; James D. Wilkinson; Solomon Meseret Woldeyohannes; Timothy M. Wolock; Anthony D. Woolf; Sarah Wulf; Gelin Xu; Hiroshi Yatsuya; Seok Jun Yoon; Mustafa Z. Younis; Maysaa El Sayed Zaki; Hajo Zeeb; Yong Zhao; Yingfeng Zheng; Jun Zhu; Shankuan Zhu; Joseph R. Zunt; Gabriel Alcalá-Cerra; Howard Hu;handle: 2445/127624 , 11386/4651448 , 11588/733398 , 2434/336619 , 11370/99c4adbd-894f-4ac6-922b-8c039e490bac
pmc: PMC4379111 , PMC4340604
handle: 2445/127624 , 11386/4651448 , 11588/733398 , 2434/336619 , 11370/99c4adbd-894f-4ac6-922b-8c039e490bac
pmc: PMC4379111 , PMC4340604
Background Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specific causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65·3 years (UI 65·0–65·6) in 1990, to 71·5 years (UI 71·0–71·9) in 2013, while the number of deaths increased from 47·5 million (UI 46·8–48·2) to 54·9 million (UI 53·6–56·3) over the same interval. Global progress masked variation by age and sex: for children, average absolute differences between countries decreased but relative differences increased. For women aged 25–39 years and older than 75 years and for men aged 20–49 years and 65 years and older, both absolute and relative differences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10·7%, from 4·3 million deaths in 1990 to 4·8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specific mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade. Funding Bill & Melinda Gates Foundation. Background Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specific causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65·3 years (UI 65·0–65·6) in 1990, to 71·5 years (UI 71·0–71·9) in 2013, while the number of deaths increased from 47·5 million (UI 46·8–48·2) to 54·9 million (UI 53·6–56·3) over the same interval. Global progress masked variation by age and sex: for children, average absolute differences between countries decreased but relative differences increased. For women aged 25–39 years and older than 75 years and for men aged 20–49 years and 65 years and older, both absolute and relative differences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10·7%, from 4·3 million deaths in 1990 to 4·8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specific mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade. Funding Bill & Melinda Gates Foundation.
Archivio istituziona... arrow_drop_down Hacettepe Üniversitesi Açık Erişim SistemiArticle . 2015Data sources: Hacettepe Üniversitesi Açık Erişim SistemiVBN; Aalborg University Research PortalArticle . 2015Spiral - Imperial College Digital RepositoryArticle . 2014License: rioxx All Rights ReservedData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2015Data sources: Recolector de Ciencia Abierta, RECOLECTAeScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of CaliforniaNARCIS; The LancetArticle . 2015PURE Aarhus UniversityArticle . 2015 . Peer-reviewedNature Reviews NephrologyArticle . 2015 . Peer-reviewedLicense: Springer TDMData sources: CrossrefArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoHyper Article en Ligne; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 6K citations 6,083 popularity Top 0.01% influence Top 0.01% impulse Top 0.01% Powered by BIP!visibility 52visibility views 52 download downloads 164 Powered bymore_vert Archivio istituziona... arrow_drop_down Hacettepe Üniversitesi Açık Erişim SistemiArticle . 2015Data sources: Hacettepe Üniversitesi Açık Erişim SistemiVBN; Aalborg University Research PortalArticle . 2015Spiral - Imperial College Digital RepositoryArticle . 2014License: rioxx All Rights ReservedData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2015Data sources: Recolector de Ciencia Abierta, RECOLECTAeScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of CaliforniaNARCIS; The LancetArticle . 2015PURE Aarhus UniversityArticle . 2015 . Peer-reviewedNature Reviews NephrologyArticle . 2015 . Peer-reviewedLicense: Springer TDMData sources: CrossrefArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoHyper Article en Ligne; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 Switzerland, Italy, Portugal, Cyprus, SwitzerlandPublisher:Ovid Technologies (Wolters Kluwer Health) Funded by:FCT | SFRH/BPD/115112/2016, NIH | HERCULES: Health and Expo..., EC | EXHAUSTION +3 projectsFCT| SFRH/BPD/115112/2016 ,NIH| HERCULES: Health and Exposome Research Center at Emory ,EC| EXHAUSTION ,NIH| AIR POLLUTION AND IMPLANTABLE CARDIOVERTER DEFIBRILLATORS ,NHMRC| Climate Change and Human Health in Asia: Current Impacts, Future Risks, and Health Benefits of Mitigation Policies ,NHMRC| Environmental exposure, human behaviour and respiratory health for children with asthmaAlahmad, Barrak; Khraishah, Haitham; Royé, Dominic; Vicedo-Cabrera, Ana Maria; Guo, Yuming; Papatheodorou, Stefania I; Achilleos, Souzana; Acquaotta, Fiorella; Armstrong, Ben; Bell, Michelle L; Pan, Shih-Chun; Coelho, Micheline de Sousa Zanotti Stagliorio; Colistro, Valentina; Dang, Tran Ngoc; Dung, Do-Van; De' Donato, Francesca K; Entezari, Alireza; Guo, Yue-Liang Leon; Hashizume, Masahiro; Honda, Yasushi; Indermitte, Ene; Íñiguez, Carmen; Jaakkola, Jouni J K; Kim, Ho; Lavigne, Eric; Lee, Whanhee; Li, Shanshan; Madureira, Joana; Mayvaneh, Fatemeh; Orru, Hans; Overcenco, Ala Vladimir; Ragettli, Martina S; Ryti, Niilo R I; Saldiva, Paulo Hilario Nascimento; Scovronick, Noah; Seposo, Xerxes; Sera, Francesco; Silva, Susana Pereira; Stafoggia, Massimo; Tobias, Aurelio; Garshick, Eric; Bernstein, Aaron S; Zanobetti, Antonella; Schwartz, Joel D; Gasparrini, Antonio; Koutrakis, Petros;Background: Cardiovascular disease is the leading cause of death worldwide. Existing studies on the association between temperatures and cardiovascular deaths have been limited in geographic zones and have generally considered associations with total cardiovascular deaths rather than cause-specific cardiovascular deaths. Methods: We used unified data collection protocols within the Multi-Country Multi-City Collaborative Network to assemble a database of daily counts of specific cardiovascular causes of death from 567 cities in 27 countries across 5 continents in overlapping periods ranging from 1979 to 2019. City-specific daily ambient temperatures were obtained from weather stations and climate reanalysis models. To investigate cardiovascular mortality associations with extreme hot and cold temperatures, we fit case-crossover models in each city and then used a mixed-effects meta-analytic framework to pool individual city estimates. Extreme temperature percentiles were compared with the minimum mortality temperature in each location. Excess deaths were calculated for a range of extreme temperature days. Results: The analyses included deaths from any cardiovascular cause (32 154 935), ischemic heart disease (11 745 880), stroke (9 351 312), heart failure (3 673 723), and arrhythmia (670 859). At extreme temperature percentiles, heat (99th percentile) and cold (1st percentile) were associated with higher risk of dying from any cardiovascular cause, ischemic heart disease, stroke, and heart failure as compared to the minimum mortality temperature, which is the temperature associated with least mortality. Across a range of extreme temperatures, hot days (above 97.5th percentile) and cold days (below 2.5th percentile) accounted for 2.2 (95% empirical CI [eCI], 2.1–2.3) and 9.1 (95% eCI, 8.9–9.2) excess deaths for every 1000 cardiovascular deaths, respectively. Heart failure was associated with the highest excess deaths proportion from extreme hot and cold days with 2.6 (95% eCI, 2.4–2.8) and 12.8 (95% eCI, 12.2–13.1) for every 1000 heart failure deaths, respectively. Conclusions: Across a large, multinational sample, exposure to extreme hot and cold temperatures was associated with a greater risk of mortality from multiple common cardiovascular conditions. The intersections between extreme temperatures and cardiovascular health need to be thoroughly characterized in the present day—and especially under a changing climate. Clinical Perspective_ What Is New?: This study provided evidence from what we believe is the largest multinational dataset ever assembled on cardiovascular outcomes and environmental exposures; Extreme hot and cold temperatures were associated with increased risk of death from any cardiovascular cause, ischemic heart disease, stroke, and heart failure; For every 1000 cardiovascular deaths, 2 and 9 excess deaths were attributed to extreme hot and cold days, respectively. _ What Are the Clinical Implications?: Extreme temperatures from a warming planet may become emerging priorities for public health and preventative cardiology; The findings of this study should prompt professional cardiology societies to commission scientific statements on the intersections of extreme temperature exposure and cardiovascular health. This study was supported by the Kuwait Foundation for the Advancement of Science (CB21-63BO-01); the US Environmental Protection Agency (RD-835872); Harvard Chan National Institute of Environmental Health Sciences Center for Environmental Health (P01ES009825); the UK Medical Research Council (MR/R013349/1); the UK Natural Environment Research Council (NE/R009384/1); the European Union’s Horizon 2020 Project Exhaustion (820655); the Australian National Health and Medical Research Council (APP 2000581, APP 1109193, APP 1163693); the National Institute of Environmental Health Sciences–funded HERCULES Center (P30ES019776); the MCIN/AEI/10.13039/501100011033 (grant CEX2018-000794-S); the Taiwanese Ministry of Science and Technology (MOST 109–2621-M-002–021); the Environmental Restoration and Conservation Agency, Environment Research and Technology Development Fund (JPMEERF15S11412); the São Paulo Research Foundation; and Fundação para a Ciência e a Tecnlogia (SFRH/BPD/115112/2016) info:eu-repo/semantics/publishedVersion
Flore (Florence Rese... arrow_drop_down Flore (Florence Research Repository)Article . 2023Data sources: Flore (Florence Research Repository)Repositório Aberto da Universidade do PortoArticle . 2022Data sources: Repositório Aberto da Universidade do PortoRepositório Científico do Instituto Nacional de SaúdeArticle . 2022License: CC BY NDData sources: Repositório Científico do Instituto Nacional de SaúdeBern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!visibility 104visibility views 104 download downloads 241 Powered bymore_vert Flore (Florence Rese... arrow_drop_down Flore (Florence Research Repository)Article . 2023Data sources: Flore (Florence Research Repository)Repositório Aberto da Universidade do PortoArticle . 2022Data sources: Repositório Aberto da Universidade do PortoRepositório Científico do Instituto Nacional de SaúdeArticle . 2022License: CC BY NDData sources: Repositório Científico do Instituto Nacional de SaúdeBern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Italy, France, Germany, Turkey, Netherlands, Australia, Italy, Italy, Italy, Italy, Denmark, United Kingdom, Italy, Denmark, United KingdomPublisher:Elsevier BV Funded by:UKRI | The impact and social eco..., WT | Epidemiological mapping o..., Jazz Pharmaceuticals +6 projectsUKRI| The impact and social ecology of bacterial zoonoses in northern Tanzania ,WT| Epidemiological mapping of podoconiosis in Ethiopia . ,Jazz Pharmaceuticals ,NHMRC| Assessing the population health impact of illicit drug use: prevalence, trajectories, and contributions to disease burden ,WT ,Allergan ,WT| Defining the population at risk and burden of disease of Plasmodium vivax malaria. ,WT| The health consequences of inherited red blood cell disorders in Kenya. ,SNSF| Morbidity and cost of helminth infections: fitting existing and investigating missing pieces of evidenceRyan M Barber; Brad Bell; Ian Bolliger; Fiona J Charlson; Adrian Davis; Louisa Degenhardt; Holly E. Erskine; Valery L. Feigin; Alize J. Ferrari; Christina Fitzmaurice; Caterina Guinovart; Juanita A. Haagsma; Hideki Higashi; Hmwe H Kyu; Evan Laurie; Maziar Moradi-Lakeh; Mohsen Naghavi; David Allen Roberts; Jeffrey D. Stanaway; Harvey Whiteford; Pengpeng Ye; Gunn Marit Aasvang; Cristiana Abbafati; Ayse Abbasoglu Ozgoren; Foad Abd-Allah; Semaw Ferede Abera; Victor Aboyans; Jerry Puthenpurakal Abraham; Ibrahim Abubakar; Tania C Aburto; Tom Achoki; Ilana N. Ackerman; Zanfina Ademi; Arsène Kouablan Adou; Johan Ärnlöv; Sayed Saidul Alam; Zewdie Aderaw Alemu; Rafael Alfonso-Cristancho; François Alla; Peter J. Allen; Ubai Alsharif; Nelson Alvis-Guzman; Omid Ameli; Heresh Amini; Benjamin O. Anderson; Palwasha Anwari; Henry Apfel; Al Artaman; Rana J. Asghar; Reza Assadi; Charles Atkinson; Maria Cecilia Bahit; Kalpana Balakrishnan; Shivanthi Balalla; Amitava Banerjee; Suzanne Barker-Collo; Simón Barquera; Lope H Barrero; Arindam Basu; Justin Beardsley; Neeraj Bedi; Ettore Beghi; Tolesa Bekele; Corina Benjet; Derrick A Bennett; Isabela M. Benseñor; Habib Benzian; Eduardo Bernabé; Tariku Jibat Beyene; Neeraj Bhala; Zulfiqar A Bhutta; Boris Bikbov; Jed D. Blore; Fiona M. Blyth; Berrak Bora Basara; Guilherme Borges; Natan M. Bornstein; Soufiane Boufous; Michael Brainin; Michael Brauer; Carol Brayne; Hermann Brenner; Adam D M Briggs; Peter Brooks; J Brown; Traolach S. Brugha; Geoffrey Buckle; Ismael R. Campos-Nonato; Jonathan R. Carapetis; David Carpenter; Valeria Caso; Carlos A Castañeda-Orjuela; Ferrán Catalá-López; Jung-Chen Chang; Wanqing Chen; Odgerel Chimed-Ochir; Rajiv Chowdhury; Hanne Christensen; Sumeet S. Chugh; Massimo Cirillo; Aaron Cohen; Valentina Colistro; Samantha M. Colquhoun; Alejandra G. Contreras; Leslie T. Cooper; Kimberly Cooperrider; Lucía Cuevas-Nasu; Rakhi Dandona; Paul I. Dargan; Gail Davey; Dragos Virgil Davitoiu; Vanessa De la Cruz-Góngora; Diego De Leo; Borja del Pozo-Cruz; Robert P. Dellavalle; Kebede Deribe; Sarah Derrett; Don C. Des Jarlais; Eric L. Ding; Klara Dokova; E. R. Dorsey; Herbert C. Duber; Matthias Endres; Sergey Petrovich Ermakov; Alireza Esteghamati; Kara Estep; Saman Fahimi; Farshad Farzadfar; Derek F J Fay; Abraham D. Flaxman; Nataliya Foigt; Fortuné Gbètoho Gankpé; Johanna M. Geleijnse; Bradford D. Gessner; Katherine B Gibney; Richard F. Gillum; Giorgia Giussani; Shifalika Goenka; Richard A. Gosselin; Atsushi Goto; Hebe N. Gouda; David Gunnell; Rashmi Gupta; Reyna A Gutiérrez; Nima Hafezi-Nejad; Mouhanad Hammami; Graeme J. Hankey; Hilda L Harb; Roderick J. Hay; Simon I. Hay; Mohammad Taghi Hedayati; Pouria Heydarpour; Hans W. Hoek; Mazeda Hossain; Peter J. Hotez; Damian G Hoy; Howard Hu; Cheng Huang; Laetitia Huiart; Abdullatif Husseini; Kaire Innos; Kathryn H. Jacobsen; Panniyammakal Jeemon; Vivekanand Jha; Ying Jiang; Knud Juel; André Karch; Ganesan Karthikeyan; Ronit Katz; Norito Kawakami; Andrew H. Kemp; Andre Pascal Kengne; Yousef Khader; Shams Eldin Ali Hassan Khalifa; Ejaz Ahmad Khan; Gulfaraz Khan; Young-Ho Khang; Christian Kieling; Daniel Kim; Ruth W Kimokoti; Yohannes Kinfu; Brett M. Kissela; Luke D. Knibbs; Ann Kristin Knudsen; Soewarta Kosen; Alexander Krämer; Michael Kravchenko; Rita Krishnamurthi; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Ernst J. Kuipers; Kaushalendra Kumar; G Anil Kumar; Ratilal Lalloo; Van C. Lansingh; Heidi J. Larson; Alicia Elena Beatriz Lawrynowicz; Janet L Leasher; James Leigh; Ricky Leung; Miriam Levi; Bin Li; Juan Liang; Hsien-Ho Lin; Margaret Lind; Shiwei Liu; Belinda Lloyd; Summer Lockett Ohno; Giancarlo Logroscino; Joannie Lortet-Tieulent; Paulo A. Lotufo; Robyn M. Lucas; Raimundas Lunevicius; Ronan A Lyons; Stefan Ma; Mark T Mackay; Marek Majdan; Lyn March; Guy B. Marks; Melvin Barrientos Marzan; Amanda J. Mason-Jones; Richard Matzopoulos; Neil McGill; Martin McKee; Abby McLain; Fabiola Mejía-Rodríguez; Wubegzier Mekonnen; Yohannes Adama Melaku; Atte Meretoja; Francis Apolinary Mhimbira; Ted R. Miller; Philip B. Mitchell; Terrie E. Moffitt; Norlinah Mohamed Ibrahim; Karzan Abdulmuhsin Mohammad; Lorenzo Monasta; Marcella Montico; Ami R. Moore; Andrew E. Moran; Lidia Morawska; Rintaro Mori; Wilkister N. Moturi; Dariush Mozaffarian; Mitsuru Mukaigawara; Michele E. Murdoch; Joseph Murray; Kinnari S. Murthy; Paria Naghavi; Ziad Nahas; Aliya Naheed; Kovin Naidoo; Luigi Naldi; Devina Nand; K.M. Venkat Narayan; Denis Nash; Chakib Nejjari; Sudan Prasad Neupane; Muhammad Imran Nisar; Sandra Nolte; Ole Frithjof Norheim; Luke Nyakarahuka; Takayoshi Ohkubo; John Nelson Opio; Alberto Ortiz; Jeyaraj D Pandian; Christina Papachristou; Charles D. H. Parry; Scott B. Patten; Vinod K. Paul; Boris I. Pavlin; Lilia S Pedraza; Carlos A. Pellegrini; Fernando Perez-Ruiz; Norberto Perico; Konrad Pesudovs; Michael R. Phillips; Frédéric B. Piel; Dietrich Plass; Dan Poenaru; Guilherme V. Polanczyk; Farshad Pourmalek; Dorairaj Prabhakaran; Dima M. Qato; Kazem Rahimi; Sajjad Ur Rahman; Ivo Rakovac; Saleem M Rana; Homie Razavi; Amany H Refaat; Giuseppe Remuzzi; Serge Resnikoff; Antonio Luiz Pinho Ribeiro; Patricia M. Riccio; Jan Hendrik Richardus; Anna Roca; Alina Rodriguez; Nobhojit Roy; George Mugambage Ruhago; Ralph L. Sacco; Sukanta Saha; Ramesh Sahathevan; Lidia Sanchez-Riera; Itamar S. Santos; Maheswar Satpathy; Mete Saylan; Peter Scarborough; Soraya Seedat; Edson Serván-Mori; Amira Shaheen; Saeid Shahraz; Kenji Shibuya; Yukito Shinohara; Ivy Shiue; Shireen Sindi; Jasvinder A. Singh; Vegard Skirbekk; Karen Sliwa; Sergey Soshnikov; Luciano A. Sposato; Chandrashekhar T Sreeramareddy; Heidi Stoeckl; Murray B. Stein; A W Stewart; Konstantinos Stroumpoulis; Bruno F. Sunguya; Mamta Swaroop; Karen M. Tabb; Ken Takahashi; Mohammad Tavakkoli; Hugh R. Taylor; Braden Te Ao; Eric Y. Tenkorang; Abdullah Sulieman Terkawi; Alice Theadom; Amanda G. Thrift; Imad M. Tleyjeh; Marcello Tonelli; Fotis Topouzis; Hideaki Toyoshima; Jefferson Traebert; Bach Xuan Tran; Leonardo Trasande; Matias Trillini; Miltiadis K. Tsilimbaris; Emin Murat Tuzcu; Kingsley N. Ukwaja; Coen H. Van Gool; Lennert J. Veerman; Narayanaswamy Venketasubramanian; Salvador Villalpando; Vasiliy Victorovich Vlassov; Stephen G. Waller; Tati S. Warouw; Scott Weichenthal; Elisabete Weiderpass; James D. Wilkinson; Hywel C Williams; Thomas N. Williams; Solomon Meseret Woldeyohannes; Haidong Wong; Anthony D. Woolf; Jonathan L. Wright; Gelin Xu; Gonghuan Yang; Seok Jun Yoon; Mustafa Z. Younis; Chuanhua Yu; Zheng Zhao; David Zonies; Joshua A. Salomon; Christopher J L Murray;pmc: PMC4561509
Summary Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. Funding Bill & Melinda Gates Foundation. Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. Funding Bill & Melinda Gates Foundation.
Flore (Florence Rese... arrow_drop_down Flore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Publications at Bielefeld University; Research@WUR; The LancetOther literature type . Article . 2015 . Peer-reviewedLicense: Elsevier TDMFlore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Spiral - Imperial College Digital RepositoryArticle . 2015Data sources: Spiral - Imperial College Digital RepositoryArchivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; Archivio della Ricerca - Università di Salerno; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; The Lancet; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2015 . Peer-reviewedData sources: University of Groningen Research Portal; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; Archivio della Ricerca - Università di Salerno; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; SNSF P3 Database; Archivio della ricerca - Università degli studi di Napoli Federico IIArchivio della ricerca- Università di Roma La SapienzaArticle . 2015Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoVBN; Aalborg University Research PortalArticle . 2015Hyper Article en Ligne; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 5K citations 4,805 popularity Top 0.01% influence Top 0.01% impulse Top 0.01% Powered by BIP!visibility 55visibility views 55 download downloads 1,498 Powered bymore_vert Flore (Florence Rese... arrow_drop_down Flore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Publications at Bielefeld University; Research@WUR; The LancetOther literature type . Article . 2015 . Peer-reviewedLicense: Elsevier TDMFlore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Spiral - Imperial College Digital RepositoryArticle . 2015Data sources: Spiral - Imperial College Digital RepositoryArchivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; Archivio della Ricerca - Università di Salerno; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; The Lancet; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2015 . Peer-reviewedData sources: University of Groningen Research Portal; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; Archivio della Ricerca - Università di Salerno; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; SNSF P3 Database; Archivio della ricerca - Università degli studi di Napoli Federico IIArchivio della ricerca- Università di Roma La SapienzaArticle . 2015Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoVBN; Aalborg University Research PortalArticle . 2015Hyper Article en Ligne; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 IrelandPublisher:Elsevier BV Publicly fundedFunded by:SFI | Bioeconomy Research Centr...SFI| Bioeconomy Research Centre (BiOrbic)Alaydi, Hadil; Zhu, Xianglu; Mondala, Julie Rose Mae; Tiwari, Brijesh K.; Kumari, Bibha; Curtin, James F.; Downey, Peter; McKeon-Bennett, Michelle; Beletskaya, Tanya;Sitka spruce (Picea sitchensis) needles contain a variety of bioactive compounds including phenolic compounds and flavonoids, many of which have been used in the cosmetic, pharmaceutical, and food industries. This study aimed to investigate the effects of novel extraction techniques, including ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE) and simultaneous ultrasound–microwave-assisted extraction (UMAE) on the recovery of phenolic, flavonoids and associated antioxidant and anti-cancer properties from Sitka spruce (Picea sitchensis) needles. The ferric reducing antioxidant power (FRAP) assay was used to evaluate the antioxidant capacity, and the Alamar Blue assay using the human brain glioblastoma cancer cell line (U-251 MG) was used to evaluate the cytotoxicity activity. Results showed that US-probe accomplished the highest recovery of phenolic and flavonoids at 38 W cm−2 for 10 min (106.3 ± 2.5 mg GAE g−1 DW and 63.2 ± 3.8 mg QE g−1 DW, respectively). Hence, the highest cytotoxicity activity of IC50 (0.0114% w/v) was achieved by US-probe at 19 W cm−2 for 10 min. However, the antioxidant capacity of (2591.3 ± 92.5 mM TE g−1 DW) was achieved under UMAE at ultrasound intensity of 38 W cm−2, microwave power of 302.4 W for 10 min. This study emphasised the potential application of UAE and MAE in the extraction of bioactive as an environmentally friendly method to be used in the valorisation of by-products in food and agro-industries. This supports the use of renewable natural resources in an efficient way to produce high-value compounds therefore it is in line with the new era of bioeconomy and its new biorefinery concepts yes
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013 CyprusPublisher:ASME International Publicly fundedDavid A. Steinman; Yiemeng Hoi; Paul Fahy; Liam Morris; Michael Walsh; Nicolas Aristokleous; Andreas S. Anayiotos; Yannis Papaharilaou; Amirhossein Arzani; Shawn C. Shadden; Philipp Berg; Gábor Janiga; Joris Bols; Patrick Segers; Neil W. Bressloff; Merih Cibis; Frank H. Gijsen; Salvatore Cito; Jordi Pallares; Leonard D. Browne; J. A. Costelloe; Adrian G. Lynch; Joris Degroote; Jan Vierendeels; Wenyu Fu; Aike Qiao; Simona Hodis; David F. Kallmes; Hardeep S. Kalsi; Quan Long; Vitaly O. Kheyfets; Ender A. Finol; Kenichi Kono; Adel M. Malek; Alexandra Lauric; Prahlad G. Menon; Kerem Pekkan; Mahdi Esmaily Moghadam; Alison L. Marsden; Marie Oshima; Kengo Katagiri; Véronique Peiffer; Yumnah Mohamied; Spencer J. Sherwin; Jens Schaller; Leonid Goubergrits; Gabriel Usera; Mariana Mendina; Kristian Valen-Sendstad; Damiaan F. Habets; Jianping Xiang; Hui Meng; Yue Yu; George Em Karniadakis; Nicholas Shaffer; Francis Loth;doi: 10.1115/1.4023382
pmid: 23445061
Stimulated by a recent controversy regarding pressure drops predicted in a giant aneurysm with a proximal stenosis, the present study sought to assess variability in the prediction of pressures and flow by a wide variety of research groups. In phase I, lumen geometry, flow rates, and fluid properties were specified, leaving each research group to choose their solver, discretization, and solution strategies. Variability was assessed by having each group interpolate their results onto a standardized mesh and centerline. For phase II, a physical model of the geometry was constructed, from which pressure and flow rates were measured. Groups repeated their simulations using a geometry reconstructed from a micro-computed tomography (CT) scan of the physical model with the measured flow rates and fluid properties. Phase I results from 25 groups demonstrated remarkable consistency in the pressure patterns, with the majority predicting peak systolic pressure drops within 8% of each other. Aneurysm sac flow patterns were more variable with only a few groups reporting peak systolic flow instabilities owing to their use of high temporal resolutions. Variability for phase II was comparable, and the median predicted pressure drops were within a few millimeters of mercury of the measured values but only after accounting for submillimeter errors in the reconstruction of the life-sized flow model from micro-CT. In summary, pressure can be predicted with consistency by CFD across a wide range of solvers and solution strategies, but this may not hold true for specific flow patterns or derived quantities. Future challenges are needed and should focus on hemodynamic quantities thought to be of clinical interest.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 119 citations 119 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019Publisher:Elsevier BV Authors: Alberto, Cárceles-Álvarez; Juan A, Ortega-García; Fernando A, López-Hernández; José L, Fuster-Soler; +6 AuthorsAlberto, Cárceles-Álvarez; Juan A, Ortega-García; Fernando A, López-Hernández; José L, Fuster-Soler; Rebeca, Ramis; Nicole, Kloosterman; Luis, Castillo; Manuel, Sánchez-Solís; Luz, Claudio; Josep, Ferris-Tortajada;pmid: 31479979
The 5-year overall survival (OS) in childhood acute lymphoblastic leukemia (ALL) has reached 90% in high-income countries, levels that can no be longer overcome with strategies based on intensification of treatment. Other approaches in the search for new and modifiable prognostic factors are necessary to continue to improve these rates. The importance of environmental factors in the etiopathogenesis of childhood ALL has been regaining interest but its role in the prognosis and survival of this disease is not well explored. We aim to investigate the association between secondhand smoke (SHS) and survival in children diagnosed with ALL.We analyzed survival rates in 146 patients under the age of 15 years diagnosed with ALL between January 1998 and May 2016 in the Region of Murcia, Spain. Evaluation of parental SHS and other known prognostic factors (sex, age, white blood cell count at diagnosis, cytogenetics, NCI/Rome Criteria, early response to therapy, and relapse) were assessed for impact on OS, event-free survival (EFS), cumulative incidence of relapse (CIR), and treatment-related mortality (CITRM) using Kaplan-Meier analysis, Cox regression, and Fine-Gray model.The mean follow-up time was 105.3 months (±66.5). Prenatal exposure to SHS due to parental smoking was highly prevalent. Of the mothers, 44.4% and 55.5% of the fathers smoked at some point during pregnancy. After the child's diagnosis of ALL 39.7% of mothers and 45.9% of fathers reported smoking. The Cox proportional hazards model showed that maternal smoking during pregnancy and after diagnosis (HR = 4.396, 95% CI: 1.173-16.474, p = 0.028); and relapse (HR = 7.919; 95% CI: 2.683-21.868; p 0.001) are independent prognostic factors in determining survival. The Fine-Gray model showed that maternal smoking during pregnancy and after diagnosis (HR = 14.525, 95% CI: 4.228-49.90, p 0.001) is an independent prognostic factor in CITRM.Persistent SHS worsens OS and TRM in children with ALL. This negative impact contributes to a different prognosis and may possibly provide an exceptional insight into new therapeutic approaches, including environmental aspects such as prevention and smoking cessation to improve survival outcomes.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 7 citations 7 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 SpainPublisher:Elsevier BV Funded by:FCT | MS3FCT| MS3Authors: Paulsen Gómez, Erika; Moreno Fernández, Diego Ángel; Periago Bayonas, Paula María; Lema Larrieu, Patricia;Paulsen Gómez, Erika; Moreno Fernández, Diego Ángel; Periago Bayonas, Paula María; Lema Larrieu, Patricia;Cooking vegetables in microwave bags is becoming a popular domestic cooking method, being relevant to know how this cooking method affects health-promoting phytochemicals of staples such as broccoli. The aim of this work was to study the effect of microwave bag cooking versus conventional microwaving on bioactive compound content (glucosinolates and hydroxycinnamic acid derivatives) and other quality parameters (such as antioxidant capacity, mineral content and microbial load) of broccoli florets. The influence of cooking time on bioactive compounds content was also evaluated. The study was carried out in two independent experiments; using intact broccoli and broccoli preprocessed in industry. Microwave bag cooked broccoli for 5 min (following label recommendation) showed higher glucosinolate content retention compared to conventional microwaving. Results suggest that volatilization could be an important phenomenon in reduction of glucosinolates during microwave cooking of broccoli florets. Glucosinolate profile did not change after cooking, regardless of cooking method applied. Furthermore, microwave bag cooked broccoli presented higher antioxidant capacity (by DPPH assay) than conventional microwaved broccoli. Hydroxycinnamic acid derivatives content was reduced in microwave cooking, regardless of method applied. Altogether, the use of microwave bags for microwaving is a novel method that retains main bioactive components of broccoli. This option is a fast, easy and considerably clean cooking option to fulfill modern consumer needs. This work was supported by Comision ´ Sectorial de Investigacion ´ Científica, Universidad de la República. Authors are indebted to Agencia Nacional de Innovacion ´ e Investigacion ´ for granting Erika Paulsen a PhD scholarship and an internship at Phytochemistry and Healthy Foods Laboratory of the Department of Food Science and Technology at CEBAS-CSIC (scholarship reference: POS_EMHE_2018_1_1007740)
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021Food Research InternationalArticle . 2021 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 23visibility views 23 download downloads 183 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021Food Research InternationalArticle . 2021 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Poland, Netherlands, Spain, Switzerland, Croatia, Norway, Poland, United Kingdom, Australia, Italy, Portugal, Italy, Portugal, Portugal, Italy, ItalyPublisher:SAGE Publications Publicly fundedFunded by:NIH | Enhancing Cross Disciplin..., EC | CIC, UKRI | The Paradox of Gender-Con...NIH| Enhancing Cross Disciplinary Infrastructure and Training at Oregon (EXITO) Research Enrich ,EC| CIC ,UKRI| The Paradox of Gender-Conscious Diversity Initiatives: How Accentuating Gender Differences May Perpetuate Workplace Gender InequalityAuthors: Kosakowska-Berezecka, Natasza; Bosson, Jennifer K.; Jurek, Paweł; Besta, Tomasz; +159 AuthorsKosakowska-Berezecka, Natasza; Bosson, Jennifer K.; Jurek, Paweł; Besta, Tomasz; Olech, Michał; Vandello, Joseph A.; Bender, Michael; Dandy, Justine; Hoorens, Vera; Jasinskaja-Lahti, Inga; Mankowski, Eric; Venäläinen, Satu; Abuhamdeh, Sami; Agyemang, Collins Badu; Akbaş, Gülçin; Albayrak-Aydemir, Nihan; Ammirati, Soline; Anderson, Joel; Anjum, Gulnaz; Ariyanto, Amarina; Aruta, John Jamir Benzon R.; Ashraf, Mujeeba; Bakaitytė, Aistė; Becker, Maja; Bertolli, Chiara; Bërxulli, Dashamir; Best, Deborah L.; Bi, Chongzeng; Block, Katharina; Boehnke, Mandy; Bongiorno, Renata; Bosak, Janine; Casini, Annalisa; Chen, Qingwei; Chi, Peilian; Cubela Adoric, Vera; Daalmans, Serena; de Lemus, Soledad; Dhakal, Sandesh; Dvorianchikov, Nikolay; Egami, Sonoko; Etchezahar, Edgardo; Esteves, Carla Sofia; Froehlich, Laura; Garcia-Sanchez, Efrain; Gavreliuc, Alin; Gavreliuc, Dana; Gomez, Ángel; Guizzo, Francesca; Graf, Sylvie; Greijdanus, Hedy; Grigoryan, Ani; Grzymała-Moszczyńska, Joanna; Guerch, Keltouma; Gustafsson Sendén, Marie; Hale, Miriam-Linnea; Hämer, Hannah; Hirai, Mika; Hoang Duc, Lam; Hřebíčková, Martina; Hutchings, Paul B.; Jensen, Dorthe Høj; Karabati, Serdar; Kelmendi, Kaltrina; Kengyel, Gabriella; Khachatryan, Narine; Ghazzawi, Rawan; Kinahan, Mary; Kirby, Teri A.; Kovacs, Monika; Kozlowski, Desiree; Krivoshchekov, Vladislav; Kryś, Kuba; Kulich, Clara; Kurosawa, Tai; Lac An, Nhan Thi; Labarthe-Carrara, Javier; Lauri, Mary Anne; Latu, Ioana; Lawal, Abiodun Musbau; Li, Junyi; Lindner, Jana; Lindqvist, Anna; Maitner, Angela T.; Makarova, Elena; Makashvili, Ana; Malayeri, Shera; Malik, Sadia; Mancini, Tiziana; Manzi, Claudia; Mari, Silvia; Martiny, Sarah E.; Mayer, Claude-Hélène; Mihić, Vladimir; MiloševićĐorđević, Jasna; Moreno-Bella, Eva; Moscatelli, Silvia; Moynihan, Andrew Bryan; Muller, Dominique; Narhetali, Erita; Neto, Félix; Noels, Kimberly A.; Nyúl, Boglárka; O’Connor, Emma C.; Ochoa, Danielle P.; Ohno, Sachiko; Olanrewaju Adebayo, Sulaiman; Osborne, Randall; Pacilli, Maria Giuseppina; Palacio, Jorge; Patnaik, Snigdha; Pavlopoulos, Vassilis; de León, Pablo Pérez; Piterová, Ivana; Porto, Juliana Barreiros; Puzio, Angelica; Pyrkosz-Pacyna, Joanna; Rentería Pérez, Erico; Renström, Emma; Rousseaux, Tiphaine; Ryan, Michelle K.; Safdar, Saba; Sainz, Mario; Salvati, Marco; Samekin, Adil; Schindler, Simon; Sevincer, A. Timur; Seydi, Masoumeh; Shepherd, Debra; Sherbaji, Sara; Schmader, Toni; Simão, Cláudia; Sobhie, Rosita; Sobiecki, Jurand; De Souza, Lucille; Sarter, Emma; Sulejmanović, Dijana; Sullivan, Katie E.; Tatsumi, Mariko; Tavitian-Elmadjian, Lucy; Thakur, Suparna Jain; Thi Mong Chi, Quang; Torre, Beatriz; Torres, Ana; Torres, Claudio V.; Türkoğlu, Beril; Ungaretti, Joaquín; Valshtein, Timothy; Van Laar, Colette; van der Noll, Jolanda; Vasiutynskyi, Vadym; Vauclair, Christin-Melanie; Vohra, Neharika; Walentynowicz, Marta; Ward, Colleen; Włodarczyk, Anna; Yang, Yaping; Yzerbyt, Vincent; Zanello, Valeska; Zapata-Calvente, Antonella Ludmila; Zawisza, Magdalena; Žukauskienė, Rita; Żadkowska, Magdalena;Social role theory posits that binary gender gaps in agency and communion should be larger in less egalitarian countries, reflecting these countries’ more pronounced sex-based power divisions. Conversely, evolutionary and self-construal theorists suggest that gender gaps in agency and communion should be larger in more egalitarian countries, reflecting the greater autonomy support and flexible self-construction processes present in these countries. Using data from 62 countries (N = 28,640), we examine binary gender gaps in agentic and communal self-views as a function of country-level objective gender equality (the Global Gender Gap Index) and subjective distributions of social power (the Power Distance Index). Findings show that in more egalitarian countries, gender gaps in agency are smaller and gender gaps in communality are larger. These patterns are driven primarily by cross-country differences in men’s self-views and by the Power Distance Index (PDI) more robustly than the Global Gender Gap Index (GGGI). We consider possible causes and implications of these findings. Swedish Research Council Swedish Research Council for Health Working Life & Welfare (Forte) 2017-00414 Economic & Social Research Council (ESRC) ES/S00274X/1 MCIN/AEI PID2019-111549GB-I00 Universidad Nacional de Educacion a Distancia, Spain RTI2018-093550-B-I00 European Research Council (ERC) European Commission ERC-2016-COG 725128 NIH National Institute of General Medical Sciences (NIGMS) RL5GM118963 Institute of Psychology, Czech Academy of Sciences RVO: 68081740 National Science Centre, Poland 2017/26/M/HS6/00360 United States Department of Health & Human Services Grant Agency of the Czech Republic 20-01214S National Institutes of Health (NIH) - USA UK Research & Innovation (UKRI) University of Brasilia 04/2019
BOA - Bicocca Open A... arrow_drop_down BOA - Bicocca Open Archive; IRIS - Università degli Studi di Verona; Social Psychological and Personality Science; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2022 . 2023 . Peer-reviewedLicense: SAGE TDMRepositorio Institucional Universidad de GranadaArticle . 2022Data sources: Repositorio Institucional Universidad de GranadaIRIS - Università degli Studi di VeronaArticle . 2022Data sources: IRIS - Università degli Studi di VeronaRepositório Institucional da Universidade Católica PortuguesaOther literature type . 2023License: CC BY NC NDMunin - Open Research Archive; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BYMémoires en Sciences de l'Information et de la CommunicationArticle . 2022Full-Text: https://hal.science/hal-03846884/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 74visibility views 74 download downloads 289 Powered bymore_vert BOA - Bicocca Open A... arrow_drop_down BOA - Bicocca Open Archive; IRIS - Università degli Studi di Verona; Social Psychological and Personality Science; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2022 . 2023 . Peer-reviewedLicense: SAGE TDMRepositorio Institucional Universidad de GranadaArticle . 2022Data sources: Repositorio Institucional Universidad de GranadaIRIS - Università degli Studi di VeronaArticle . 2022Data sources: IRIS - Università degli Studi di VeronaRepositório Institucional da Universidade Católica PortuguesaOther literature type . 2023License: CC BY NC NDMunin - Open Research Archive; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BYMémoires en Sciences de l'Information et de la CommunicationArticle . 2022Full-Text: https://hal.science/hal-03846884/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2015 Netherlands, Spain, Netherlands, Turkey, Netherlands, United Kingdom, Italy, France, Italy, United Kingdom, Netherlands, Denmark, Italy, Netherlands, Italy, Italy, Turkey, United Kingdom, Germany, Netherlands, Netherlands, DenmarkPublisher:Elsevier BV Publicly fundedAuthors: Forouzanfar, Mohammad H; Alexander, Lily; Anderson, H. Ross; Bachman, Victoria F.; +393 AuthorsForouzanfar, Mohammad H; Alexander, Lily; Anderson, H. Ross; Bachman, Victoria F.; Biryukov, Stan; Brauer, Michael; Burnett, Richard; Casey, Daniel; Coates, Matthew M.; Cohen, Aaron; Delwiche, Kristen; Estep, Kara; Frostad, Joseph J.; Astha, K. C.; Kyu, Hmwe H.; Moradi Lakeh, Maziar; Ng, Marie; Slepak, Erica Leigh; Thomas, Bernadette A.; Wagner, Joseph; Aasvang, Gunn Marit; Abbafati, Cristiana; Abbasoglu Ozgoren, Ayse; Abd Allah, Foad; Abera, Semaw F.; Aboyans, Victor; Abraham, Biju; Puthenpurakal Abraham, Jerry; Abubakar, Ibrahim; Abu Rmeileh, Niveen M. E.; Aburto, Tania C.; Achoki, Tom; Adelekan, Ademola; Adofo, Koranteng; Adou, Arsène K.; Adsuar, José C.; Afshin, Ashkan; Agardh, Emilie E.; Al Khabouri, Mazin J.; Al Lami, Faris H.; Alam, Sayed Saidul; Alasfoor, Deena; Albittar, Mohammed I.; Alegretti, Miguel A.; Aleman, Alicia V.; Alemu, Zewdie A.; Alfonso Cristancho, Rafael; Alhabib, Samia; Ali, Raghib; Ali, Mohammed K.; Alla, François; Allebeck, Peter; Allen, Peter J.; Alsharif, Ubai; Alvarez, Elena; Alvis Guzman, Nelson; Amankwaa, Adansi A.; Amare, Azmeraw T.; Ameh, Emmanuel A.; Ameli, Omid; Amini, Heresh; Ammar, Walid; Anderson, Benjamin O.; Antonio, Carl Abelardo T.; Anwari, Palwasha; Argeseanu Cunningham, Solveig; Arnlöv, Johan; Arsic Arsenijevic, Valentina S.; Artaman, Al; Asghar, Rana J.; Assadi, Reza; Atkins, Lydia S.; Atkinson, Charles; Avila, Marco A.; Awuah, Baffour; Badawi, Alaa; Bahit, Maria C.; Bakfalouni, Talal; Balakrishnan, Kalpana; Balalla, Shivanthi; Balu, Ravi Kumar; Banerjee, Amitava; Barber, Ryan M.; Barker Collo, Suzanne L.; Barquera, Simon; Barregard, Lars; Barrero, Lope H.; Barrientos Gutierrez, Tonatiuh; Basto Abreu, Ana C.; Basu, Arindam; Basu, Sanjay; Basulaiman, Mohammed O.; Batis Ruvalcaba, Carolina; Beardsley, Justin; Bedi, Neeraj; Bekele, Tolesa; Bell, Michelle L.; Benjet, Corina; Bennett, Derrick A.; Benzian, Habib; Bernabé, Eduardo; Beyene, Tariku J.; Bhala, Neeraj; Bhalla, Ashish; Bhutta, Zulfiqar A.; Bikbov, Boris; Bin Abdulhak, Aref A.; Blore, Jed D.; Blyth, Fiona M.; Bohensky, Megan A.; Bora Başara, Berrak; Borges, Guilherme; Bornstein, Natan M.; Bose, Dipan; Boufous, Soufiane; Bourne, Rupert R.; Brainin, Michael; Brazinova, Alexandra; Breitborde, Nicholas J.; Brenner, Hermann; Briggs, Adam D. M.; Broday, David M.; Brooks, Peter M.; Bruce, Nigel G.; Brugha, Traolach S.; Brunekreef, Bert; Buchbinder, Rachelle; Bui, Linh N.; Bukhman, Gene; Bulloch, Andrew G.; Burch, Michael; Burney, Peter G. J.; Campos Nonato, Ismael R.; Campuzano, Julio C.; Cantoral, Alejandra J.; Caravanos, Jack; Cárdenas, Rosario; Cardis, Elisabeth; Carpenter, David O.; Caso, Valeria; Castañeda Orjuela, Carlos A.; Castro, Ruben E.; Catalá López, Ferrán; Cavalleri, Fiorella; Çavlin, Alanur; Chadha, Vineet K.; Chang, Jung Chen; Charlson, Fiona J.; Chen, Honglei; Chen, Wanqing; Chen, Zhengming; Chiang, Peggy P.; Chimed Ochir, Odgerel; Chowdhury, Rajiv; Christophi, Costas A.; Chuang, Ting Wu; Chugh, Sumeet S.; Cirillo, Massimo; Claßen, Thomas K. D.; Colistro, Valentina; Colomar, Mercedes; Colquhoun, Samantha M.; Contreras, Alejandra G.; Cooper, Cyrus; Cooperrider, Kimberly; Cooper, Leslie T.; Coresh, Josef; Courville, Karen J.; Criqui, Michael H.; Cuevas Nasu, Lucia; Damsere Derry, James; Danawi, Hadi; Dandona, Lalit; Dandona, Rakhi; Dargan, Paul I.; Davis, Adrian; Davitoiu, Dragos V.; Dayama, Anand; De Castro, E. Filipa; De La Cruz Góngora, Vanessa; De Leo, Diego; De Lima, Graça; Degenhardt, Louisa; Del Pozo Cruz, Borja; Dellavalle, Robert P.; Deribe, Kebede; Derrett, Sarah; Des Jarlais, Don C.; Dessalegn, Muluken; Deveber, Gabrielle A.; Devries, Karen M.; Dharmaratne, Samath D.; Dherani, Mukesh K.; Dicker, Daniel; Ding, Eric L.; Dokova, Klara; Dorsey, E. Ray; Driscoll, Tim R.; Duan, Leilei; Durrani, Adnan M.; Endres, Matthias; Erskine, Holly E.; Esteghamati, Alireza; Faraon, Emerito Jose A.; Farzadfar, Farshad; Feigin, Valery L.; Ferrari, Alize J.; Foigt, Nataliya; Fra Paleo, Urbano; Franklin, Richard C.; Gabbe, Belinda; Geleijnse, Johanna M.; Ginawi, Ibrahim A. M.; Giussani, Giorgia; Goenka, Shifalika; Goto, Atsushi; Gouda, Hebe N.; Hankey, Graeme J.; Haro, Josep Maria; Hay, Simon I.; Hedayati, Mohammad T.; Heydarpour, Pouria; Hoek, Hans W.; Hu, Howard; Hubbell, Bryan J.; Husseini, Abdullatif; Idrisov, Bulat T.; Innos, Kaire; Islami, Farhad; Jacobsen, Kathryn H.; Jansen, Henrica A.; Jarvis, Deborah L.; Jayaraman, Sudha; Jeemon, Panniyammakal; Jha, Vivekanand; Juel, Knud; Karch, André; Karthikeyan, Ganesan; Kemp, Andrew H.; Kengne, Andre P.; Khader, Yousef S.; Khan, Ejaz A.; Kieling, Christian; Kim, Daniel; Kimokoti, Ruth W.; Kinfu, Yohannes; Kissela, Brett M.; Knibbs, Luke D.; Knudsen, Ann Kristin; Kosen, Soewarta; Kravchenko, Michael; Kromhout, Hans; Kuate Defo, Barthelemy; Kucuk Bicer, Burcu; Kuipers, Ernst J.; Kumar, G. Anil; Kwan, Gene F.; Lalloo, Ratilal; Lallukka, Tea; Lansingh, Van C.; Larson, Heidi J.; Laryea, Dennis O.; Leasher, Janet L.; Leung, Ricky; Li, Yichong; Liu, Yang; Logroscino, Giancarlo; London, Stephanie J.; Lotufo, Paulo A.; Lozano, Rafael; Lunevicius, Raimundas; Mahdi, Abbas A.; Majdan, Marek; Marks, Guy B.; Martin, Randall V.; Marzan, Melvin B.; Matzopoulos, Richard; Mckee, Martin; Meaney, Peter A.; Melaku, Yohannes A.; Meretoja, Atte; Apolinary Mhimbira, Francis; Miller, Ted R.; Mohammad, Karzan A.; Mokdad, Ali H.; Monasta, Lorenzo; Montico, Marcella; Morawska, Lidia; Mori, Rintaro; Moturi, Wilkister N.; Mukaigawara, Mitsuru; Nahas, Ziad; Naheed, Aliya; Naldi, Luigi; Nash, Denis; Neal, Bruce; Nejjari, Chakib; Neupane, Sudan P.; Newton, Charles R.; Nguyen, Nhung T.; Nisar, Muhammad I.; Nogueira, José R.; Nolte, Sandra; Norheim, Ole F.; Nyakarahuka, Luke; Ohkubo, Takayoshi; Olusanya, Bolajoko O.; Pandian, Jeyaraj D.; Parry, Charles D.; Patten, Scott B.; Pearce, Neil; Pedraza, Lilia S.; Pereira, David M.; Perico, Norberto; Pesudovs, Konrad; Phillips, Michael R.; Polanczyk, Guilherme V.; Pope, Daniel; Prabhakaran, Dorairaj; Qato, Dima M.; Rahimi, Kazem; Rakovac, Ivo; Rana, Saleem M.; Razavi, Homie; Reddy, K. Srinath; Refaat, Amany H.; Remuzzi, Giuseppe; Riccio, Patricia M.; Rodriguez, Alina; Roy, Nobhojit; Ruhago, George M.; Sahathevan, Ramesh; Sahraian, Mohammad Ali; Salomon, Joshua A.; Salvo, Deborah; Sánchez Pimienta, Tania G.; Sanchez Riera, Lidia; Santos, Itamar S.; Sapkota, Amir; Satpathy, Maheswar; Saylan, Mete I.; Schneider, Ione J. C.; Schöttker, Ben; Scott, James G.; Seedat, Soraya; Shibuya, Kenji; Shin, Hwashin H.; Shiri, Rahman; Shishani, Kawkab; Shiue, Ivy; Sindi, Shireen; Singh, Jasvinder A.; Soljak, Michael; Søreide, Kjetil; Soshnikov, Sergey; Sreeramareddy, Chandrashekhar T.; Stein, Dan J.; Stöckl, Heidi; Stroumpoulis, Konstantinos; Sunguya, Bruno F.; Swaroop, Mamta; Tabb, Karen M.; Takahashi, Ken; Te Ao, Braden J.; Téllez Rojo, Martha M.; Terkawi, Abdullah S.; Texcalac Sangrador, José Luis; Thomson, Blake; Thrift, Amanda G.; Tillmann, Taavi; Tonelli, Marcello; Topouzis, Fotis; Traebert, Jefferson; Tran, Bach X.; Trasande, Leonardo; Trillini, Matias; Tsilimbaris, Miltiadis; Ukwaja, Kingsley N.; Van Dingenen, Rita; Van Gool, Coen H.; Van Os, Jim; Vasconcelos, Ana Maria N.; Veerman, Lennert J.; Villalpando, Salvador; Victorovich Vlassov, Vasiliy; Warouw, Tati S.; Weiderpass, Elisabete; Whiteford, Harvey A.; Wilkinson, James D.; Williams, Hywel C.; Woldeyohannes, Solomon M.; Woolf, Anthony D.; Xu, Gelin; Ye, Pengpeng; Younis, Mustafa Z.; Zaki, Maysaa E.; Zhao, Yong;pmc: PMC4685753
Summary Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian metaregression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5−89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks. Funding Bill & Melinda Gates Foundation. Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the fi rst of a series of annual updates of the GBD. Risk factor quantifi cation, particularly of modifi able risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the fi rst level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular fi ltration rate. For most risks, data for exposure were synthesised with a Bayesian metaregression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5−89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks. Funding Bill & Melinda Gates Foundation.
Flore (Florence Rese... arrow_drop_down Hacettepe Üniversitesi Açık Erişim SistemiArticle . 2015Data sources: Hacettepe Üniversitesi Açık Erişim SistemiDigitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2015 . Peer-reviewedFlore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Recolector de Ciencia Abierta, RECOLECTAArticle . 2015Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2015License: CC BYOxford University Research ArchiveOther literature type . 2018Data sources: Oxford University Research ArchiveArchivio della Ricerca - Università di Salerno; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; The Lancet; PURE Aarhus University; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2015Data sources: Erasmus University Rotterdam - Research Information Portal; OD-Maastricht University | MUMC+ Research Information; Archivio della Ricerca - Università di Salerno; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; PURE Aarhus University; Archivio della ricerca - Università degli studi di Napoli Federico IIResearch@WUR; Publications at Bielefeld University; The LancetOther literature type . Article . 2015 . Peer-reviewedLicense: Elsevier TDMArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoArchivio della ricerca- Università di Roma La SapienzaArticle . 2015Data sources: Archivio della ricerca- Università di Roma La SapienzaVBN; Aalborg University Research PortalArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 2K citations 2,177 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!visibility 224visibility views 224 download downloads 286 Powered bymore_vert Flore (Florence Rese... arrow_drop_down Hacettepe Üniversitesi Açık Erişim SistemiArticle . 2015Data sources: Hacettepe Üniversitesi Açık Erişim SistemiDigitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2015 . Peer-reviewedFlore (Florence Research Repository)Article . 2015Data sources: Flore (Florence Research Repository)Recolector de Ciencia Abierta, RECOLECTAArticle . 2015Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2015License: CC BYOxford University Research ArchiveOther literature type . 2018Data sources: Oxford University Research ArchiveArchivio della Ricerca - Università di Salerno; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; The Lancet; PURE Aarhus University; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2015Data sources: Erasmus University Rotterdam - Research Information Portal; OD-Maastricht University | MUMC+ Research Information; Archivio della Ricerca - Università di Salerno; Archivio della ricerca- Università di Roma La Sapienza; Aalborg University Research Portal; PURE Aarhus University; Archivio della ricerca - Università degli studi di Napoli Federico IIResearch@WUR; Publications at Bielefeld University; The LancetOther literature type . Article . 2015 . Peer-reviewedLicense: Elsevier TDMArchivio della Ricerca - Università di SalernoArticle . 2015Data sources: Archivio della Ricerca - Università di SalernoArchivio della ricerca- Università di Roma La SapienzaArticle . 2015Data sources: Archivio della ricerca- Università di Roma La SapienzaVBN; Aalborg University Research PortalArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2013 France, Switzerland, Italy, CyprusPublisher:Cold Spring Harbor Laboratory Fariello, María Inés; Servin, Bertrand; Tosser-Klopp, Gwenola; Rupp, Rachel; Moreno, Carole Rénée; Cristobal, Magali San; Boitard, Simon B.; Arranz, Juan Jose; Banos, Georgios; Barendse, William J.; El Beltagy, Ahmedn; Benenwitz, Jorn; Bishop, Steve C.; Bunger, Lutz; Calvo, Jorge H.; Carta, Antonello; Cemal, İbrahim; Ciani, Elena; Cockett, Noelle E.; Coltman, David W.; Dalrymple, Brian P.; D'Andrea, Mariasilvia Silvia; Distl, Ottmar; Drogemuller, Cord; Erhardt, Georg J.; Eythorsdottir, Emma; Gietzen, Kimberly J.; Gill, Clare; Gootwine, Clare; Gupta, Vidya Shrikant; Hanotte, Olivier H.; Hayes, Ben J.; Heaton, Michael P.; Hiendleder, Stefan G.; Jialin, Han; Kantanen, Juha; Kent, Matthew; Kijas, James W.; Larkin, Denis M.; Lenstra, Johannes A.; Li, Kui; Longhurst, Terry; Ma, Runlin; McCulloch, Russell J.; MacHugh, David E.; McWilliam, Sean M.; McEwan, John C.; Maddox, Jillian F.; Malek, Massoud; Mdomar, Faruque; Miltiadou, Despoina; Monteagudo Ibez, Luis V.; Nicholas, Frank W.; Nowak, Kristen J.; Oddy, Victor Hutton; Paiva, Samuel Rezende; Pardeshi, Varsha Chhotusing; Pemberton, Josephine M. M.; Pilla, Fabio; Porto Neto, Laércio R.; Raadsma, Herman W.; Roberts, Cyril; San Cristobal, Magali; Sechi, Tiziana; Scheet, Paul A.; Shariflou, Mohammad Reza; Silva, Pradeepa; Simianer, Henner; Slate, Jon; Tapio, Miika; Vattathil, Selina; Whan V., Vicki A.;International audience; The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset to identify selection signatures in worldwide sheep populations. Compared to previous analyses, we made use of statistical methods that (i) take account of the hierarchical structure of sheep populations, (ii) make use of linkage disequilibrium information and (iii) focus specifically on either recent or older selection signatures. We show that this allows pinpointing several new selection signatures in the sheep genome and distinguishing those related to modern breeding objectives and to earlier post-domestication constraints. The newly identified regions, together with the ones previously identified, reveal the extensive genome response to selection on morphology, color and adaptation to new environments.
bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4134316Data sources: PubMed CentralBern Open Repository and Information System (BORIS)Article . 2014 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 129 citations 129 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 4visibility views 4 download downloads 15 Powered bymore_vert bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4134316Data sources: PubMed CentralBern Open Repository and Information System (BORIS)Article . 2014 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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