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description Publicationkeyboard_double_arrow_right Article 2020 Switzerland, GermanyPublisher:Proceedings of the National Academy of Sciences Patrick Ostkamp; Anke Salmen; Béatrice Pignolet; Dennis Görlich; Till F. M. Andlauer; Andreas Schulte-Mecklenbeck; Gabriel Gonzalez-Escamilla; Florence Bucciarelli; Isabelle Gennero; Johanna Breuer; Gisela Antony; Tilman Schneider-Hohendorf; Nadine Mykicki; Antonios Bayas; Florian Then Bergh; Stefan Bittner; Hans-Peter Hartung; Manuel A. Friese; Ralf A. Linker; Felix Luessi; Klaus Lehmann-Horn; Mark Mühlau; Friedemann Paul; Martin Stangel; Björn Tackenberg; Hayrettin Tumani; Clemens Warnke; Frank Weber; Brigitte Wildemann; Uwe K. Zettl; Ulf Ziemann; Bertram Müller-Myhsok; Tania Kümpfel; Luisa Klotz; Sven G. Meuth; Frauke Zipp; Bernhard Hemmer; Reinhard Hohlfeld; David Brassat; Ralf Gold; Catharina C. Gross; Carsten Lukas; Sergiu Groppa; Karin Loser; Heinz Wiendl; Nicholas Schwab; Antonios Bayas; Susanne Rothacher; Stephanie Starke; Friedemann Paul; Judith Bellmann-Strobl; Janina Behrens; Jan-Markus Dörr; Rene Gieß; Joseph Kuchling; Ludwig Rasche; Ralf Gold; Andrew Chan; Gisa Ellrichmann; Anna Lena Fisse; Anna Gahlen; Thomas Grüter; Aiden Haghikia; Robert Hoepner; Ümmügülsün Koc; Carsten Lukas; Jeremias Motte; Kalliopi Pitarokoili; Anke Salmen; Ruth Schneider; Joanna Schöllhammer; Christoph Schroeder; Björn Ambrosius; Seray Demir; Clemens Warnke; Thomas Dehmel; Kathleen Ingenhoven; Ralf Linker; De-Hyung Lee; Alexandra Lämmer; Eva Sauer; Christoph Heesen; Jan-Patrick Stellmann; Martin Stangel; Lena Boenig; Stefan Gingele; Martin Hümmert; Philipp Schwenkenbecher; Thomas Skripuletz; Wolfram Suehs; Brigitte Wildemann; Mirjam Korporal-Kuhnke; Hanna Oßwald; Alexander Schwarz; Andrea Viehöver; Volker Limmroth; Kathrin Gerbershagen; Florian Then Bergh; Barbara Ettrich; Steffi Gray; Sarah Haars; Johannes Orthgieß; Nicole Schwanitz; Muriel Stoppe; Astrid Unterlauft; Sandra Paryjas; Stefan Bittner; Vinzenz Fleischer; Sergiu Groppa; Felix Lüssi; Johannes Piepgras; Timo Uphaus; Björn Tackenberg; Michael Pütz; Christian Eienbröker; Maria Seipelt; Reinhard Hohlfeld; Tania Kümpfel; Joachim Havla; Ingrid Meinl; Hannah Pellkofer; Elisabeth Schuh; Bernhard Hemmer; Lilian Aly; Achim Berthele; Viola Pongratz; Kirsten Brinkhoff; Dorothea Buck; Christiane Gasperi; Mirjam Hermisson; Muna-Miriam Hoshi; Miriam Kaminski; Ana Klein; Benjamin Knier; Markus Kowarik; Helena Kronsbein; Klaus Lehmann Horn; Meike Mitsdörffer; Verena Pernpeintner; Veit Rothhammer; Andrea Schweikert; Rebecca Selter; Mark Mühlau; Claus Zimmer; Jan Kirschke; Frank Weber; Heike Staufer; Matthias Knop; Sandra Nischwitz; Philipp Sämann; Heinz Wiendl; Sven Meuth; Luisa Klotz; Gerd Meyer zu Hörste; Julia Krämer; Lena Schünemann; Catharina Gross; Steffen Pfeuffer; Tobias Ruck; Selma Belgriri; Alexander Buchheister; Nora Bünger; Kerstin Göbel; Lucienne Kirstein; Nico Melzer; Ole Simon; Antje Echterhoff; Uwe Zettl; Alexander Winkelmann; Ulf Ziemann; Ahmed Abdelhak; Markus Kowarik; Markus Krumbholz; Margarete Paech; Christoph Ruschil; Maria-Ioanna Stefanou; Johannes Tünnerhoff; Lena Zeltner; Hajera Sheikh; Hayrettin Tumani; Tanja Fangerau; Florian Lauda; Daniela Rau; Daniela Taranu; André Huss; David Brassat; Béatrice Pignolet; Florence Bucciarelli; Lise Scandella; Christine Lebrun-Frenay; Marc Debouverie; Sophie Pittion-Vouyovitch; Bruno Brochet; Aurelie Ruet; Gilles Defer; Nathalie Derache; Jérôme de Sèze; David Laplaud; Sandrine Wiertlewski; Oliver Casez; Eric Thouvenot;International audience; Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n NationMS = 946, n BIONAT = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-β-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests beneficial effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.
MediaTUM arrow_drop_down Institutional Repository for Molecular Medicine (MDC)Article . 2021 . Peer-reviewedData sources: Institutional Repository for Molecular Medicine (MDC)Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefBern Open Repository and Information System (BORIS)Article . 2021 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NC NDFull-Text: https://hal.science/hal-03659860/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2018457118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu30 citations 30 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert MediaTUM arrow_drop_down Institutional Repository for Molecular Medicine (MDC)Article . 2021 . Peer-reviewedData sources: Institutional Repository for Molecular Medicine (MDC)Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefBern Open Repository and Information System (BORIS)Article . 2021 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NC NDFull-Text: https://hal.science/hal-03659860/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2018457118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2010 Switzerland, SpainPublisher:Proceedings of the National Academy of Sciences Funded by:EC | PRATIQUEEC| PRATIQUEPyšek, Petr; Jarošík, Vojtěch; Hulme, Philip E.; Kühn, Ingolf; Wild, Jan; Arianoutsou, Margarita; Bacher, Sven; Chiron, Francois; Didžiulis, Viktoras; Essl, Franz; Genovesi, Piero; Gherardi, Francesca; Hejda, Martin; Kark, Salit; Lambdon, Philip W.; Desprez-Loustau, Marie-Laure; Nentwig, Wolfgang; Pergl, Jan; Poboljšaj, Katja; Rabitsch, Wolfgang; Roques, Alain; Roy, David B.; Shirley, Susan; Solarz, Wojciech; Vilà, Montserrat; Winter, Marten;handle: 10261/52375
The accelerating rates of international trade, travel, and transport in the latter half of the twentieth century have led to the progressive mixing of biota from across the world and the number of species introduced to new regions continues to increase. The importance of biogeographic, climatic, economic, and demographic factors as drivers of this trend is increasingly being realized but as yet there is no consensus regarding their relative importance. Whereas little may be done to mitigate the effects of geography and climate on invasions, a wider range of options may exist to moderate the impacts of economic and demographic drivers. Here we use the most recent data available from Europe to partition between macroecological, economic, and demographic variables the varia- tion in alien species richness of bryophytes, fungi, vascular plants, terrestrial insects, aquatic invertebrates, fish, amphibians, reptiles, birds, and mammals. Only national wealth and human population density were statistically significant predictors in the majority of models when analyzed jointly with climate, geography, and land cover. The economic and demographic variables reflect the intensity of human activities and integrate the effect of factors that directly determine the outcome of invasion such as propagule pressure, pathways of introduction, eutrophication, and the intensity of anthropogenic disturbance. The strong influence of economic and demographic variables on the levels of invasion by alien species demonstrates that future solutions to the problem of biological invasions at a national scale lie in mitigating the negative environ- mental consequences of human activities that generate wealth and by promoting more sustainable population growth Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2010 . Peer-reviewedProceedings of the National Academy of SciencesArticle . 2010 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1002314107&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 449 citations 449 popularity Top 0.1% influence Top 1% impulse Top 1% Powered by BIP!visibility 18visibility views 18 download downloads 17 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2010 . Peer-reviewedProceedings of the National Academy of SciencesArticle . 2010 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1002314107&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2006Publisher:Proceedings of the National Academy of Sciences Siri-Christine, Seehuus; Kari, Norberg; Ulrike, Gimsa; Trygve, Krekling; Gro V, Amdam;Research on aging shows that regulatory pathways of fertility and senescence are closely interlinked. However, evolutionary theories on social species propose that lifelong care for offspring can shape the course of senescence beyond the restricted context of reproductive capability. These observations suggest that control circuits of aging are remodeled in social organisms with continuing care for offspring. Here, we studied a circuit of aging in the honey bee ( Apis mellifera ). The bee is characterized by the presence of a long-lived reproductive queen caste and a shorter-lived caste of female workers that are life-long alloparental care givers. We focus on the role of the conserved yolk precursor gene vitellogenin that, in Caenorhabditis elegans , shortens lifespan as a downstream element of the insulin/insulin-like growth factor signaling cascade. Vitellogenin protein is synthesized at high levels in honey bee queens and is abundant in long-lived workers. We establish that vitellogenin gene activity protects worker bees from oxidative stress. Our finding suggests that one mechanistic explanation for patterns of longevity in bees is that a reproductive regulatory pathway has been remodeled to extend life. This perspective is of considerable relevance to research on longevity regulation that builds largely on inference from solitary model species.
Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2006 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.0502681103&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 479 citations 479 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2006 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.0502681103&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016Publisher:Proceedings of the National Academy of Sciences Nadin, Pade; Dirk, Michalik; Wolfgang, Ruth; Natalia, Belkin; Wolfgang R, Hess; Ilana, Berman-Frank; Martin, Hagemann;Significance Trichodesmium spp. are globally significant contributors of new nitrogen to the surface ocean. Marine organisms must accumulate compatible solutes in their cells, counteracting the high exterior osmotic pressure. However, Trichodesmium does not possess any known genes for the synthesis of compatible solutes, making its proliferation in the high-salinity environment enigmatic. We demonstrate that Trichodesmium cultures in the laboratory as well as natural populations in the ocean synthesize homoserine betaine, previously unknown as a compatible solute, and elucidated the biosynthetic pathway. The high intracellular concentrations will lead to a major injection of this organic compound into the oligotrophic ocean, when natural Trichodesmium blooms lyse. Such sudden releases of homoserine betaine could impact the biogeochemical cycling of carbon and nitrogen.
Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2016 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1611666113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 34 citations 34 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2016 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1611666113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Portugal, Norway, Netherlands, United States, United Kingdom, Spain, NorwayPublisher:Proceedings of the National Academy of Sciences Publicly fundedFunded by:NSF | Collaborative Research: G..., NSF | Biodiversity and Complex ..., NSF | Collaborative Research: G... +1 projectsNSF| Collaborative Research: Global biodiversity and functioning of eelgrass ecosystems ,NSF| Biodiversity and Complex Forcing of Ecosystem Functioning in the Marine Foundation Species, Eelgrass: A Global Experimental Network ,NSF| Collaborative Research: Global biodiversity and functioning of eelgrass ecosystems ,NSF| Collaborative Research: Global biodiversity and functioning of eelgrass ecosystemsJ. Emmett Duffy; John J. Stachowicz; Pamela L. Reynolds; Kevin A. Hovel; Marlene Jahnke; Erik E. Sotka; Christoffer Boström; Katharyn E. Boyer; Mathieu Cusson; Johan Eklöf; Aschwin H. Engelen; Britas Klemens Eriksson; F. Joel Fodrie; John N. Griffin; Clara M. Hereu; Masakazu Hori; A. Randall Hughes; Mikhail V. Ivanov; Pablo Jorgensen; Claudia Kruschel; Kun-Seop Lee; Jonathan S. Lefcheck; Per-Olav Moksnes; Masahiro Nakaoka; Mary I. O’Connor; Nessa E. O’Connor; Robert J. Orth; Bradley J. Peterson; Henning Reiss; Katrin Reiss; J. Paul Richardson; Francesca Rossi; Jennifer L. Ruesink; Stewart T. Schultz; Jonas Thormar; Fiona Tomas; Richard Unsworth; Erin Voigt; Matthew A. Whalen; Shelby L. Ziegler; Jeanine L. Olsen;pmid: 35939678
pmc: PMC9371661
Distribution of Earth's biomes is structured by the match between climate and plant traits, which in turn shape associated communities and ecosystem processes and services. However, that climate-trait match can be disrupted by historical events, with lasting ecosystem impacts. As Earth's environment changes faster than at any time in human history, critical questions are whether and how organismal traits and ecosystems can adjust to altered conditions. We quantified the relative importance of current environmental forcing versus evolutionary history in shaping the growth form (stature and biomass) and associated community of eelgrass (Zostera marina), a widespread foundation plant of marine ecosystems along Northern Hemisphere coastlines, which experienced major shifts in distribution and genetic composition during the Pleistocene. We found that eelgrass stature and biomass retain a legacy of the Pleistocene colonization of the Atlantic from the ancestral Pacific range and of more recent within-basin bottlenecks and genetic differentiation. This evolutionary legacy in turn influences the biomass of associated algae and invertebrates that fuel coastal food webs, with effects comparable to or stronger than effects of current environmental forcing. Such historical lags in phenotypic acclimatization may constrain ecosystem adjustments to rapid anthropogenic climate change, thus altering predictions about the future functioning of ecosystems. This work was supported by the US NSF (OCE-1031061, OCE-1336206, OCE0-1336741, OCE-1336905) and the Smithsonian Institution. F.T. was supported by José Castillejo Award CAS14/00177. A.H.E. was supported by the FCT (Foundation for Science and Technology) through Project UIDB/04326/2020 and Contract CEECINST/00114/2018. This is Contribution 106 from the Smithsonian’s MarineGEO and Tennenbaum Marine Observatories Network and Contribution 4105 of the Virginia Institute of Marine Science, College of William & Mary.
NARCIS arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Sapientia Repositório da Universidade do AlgarveArticle . 2022License: CC BY NC NDData sources: Sapientia Repositório da Universidade do Algarveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2121425119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 32visibility views 32 download downloads 39 Powered bymore_vert NARCIS arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Sapientia Repositório da Universidade do AlgarveArticle . 2022License: CC BY NC NDData sources: Sapientia Repositório da Universidade do Algarveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2121425119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2012Publisher:Proceedings of the National Academy of Sciences Huang, Ruiqi; Hippauf, Frank; Rohrbeck, Diana; Haustein, Maria; Wenke, Katrin; Feike, Janie; Sorrelle, Noah; Piechulla, Birgit; Barkman, Todd J.;In this study, we investigated the role for ancestral functional variation that may be selected upon to generate protein functional shifts using ancestral protein resurrection, statistical tests for positive selection, forward and reverse evolutionary genetics, and enzyme functional assays. Data are presented for three instances of protein functional change in the salicylic acid/benzoic acid/theobromine (SABATH) lineage of plant secondary metabolite-producing enzymes. In each case, we demonstrate that ancestral nonpreferred activities were improved upon in a daughter enzyme after gene duplication, and that these functional shifts were likely coincident with positive selection. Both forward and reverse mutagenesis studies validate the impact of one or a few sites toward increasing activity with ancestrally nonpreferred substrates. In one case, we document the occurrence of an evolutionary reversal of an active site residue that reversed enzyme properties. Furthermore, these studies show that functionally important amino acid replacements result in substrate discrimination as reflected in evolutionary changes in the specificity constant ( k cat / K M ) for competing substrates, even though adaptive substitutions may affect K M and k cat separately. In total, these results indicate that nonpreferred, or even latent, ancestral protein activities may be coopted at later times to become the primary or preferred protein activities.
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2012 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1019605109&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 80 citations 80 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2012 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1019605109&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2009 SwitzerlandPublisher:Proceedings of the National Academy of Sciences Marten, Winter; Oliver, Schweiger; Stefan, Klotz; Wolfgang, Nentwig; Pavlos, Andriopoulos; Margarita, Arianoutsou; Corina, Basnou; Pinelopi, Delipetrou; Viktoras, Didziulis; Martin, Hejda; Philip E, Hulme; Philip W, Lambdon; Jan, Pergl; Petr, Pysek; David B, Roy; Ingolf, Kühn;Human activities have altered the composition of biotas through two fundamental processes: native extinctions and alien introductions. Both processes affect the taxonomic (i.e., species identity) and phylogenetic (i.e., species evolutionary history) structure of species assemblages. However, it is not known what the relative magnitude of these effects is at large spatial scales. Here we analyze the large-scale effects of plant extinctions and introductions on taxonomic and phylogenetic diversity of floras across Europe, using data from 23 regions. Considering both native losses and alien additions in concert reveals that plant invasions since AD 1500 exceeded extinctions, resulting in ( i ) increased taxonomic diversity (i.e., species richness) but decreased phylogenetic diversity within European regions, and ( ii ) increased taxonomic and phylogenetic similarity among European regions. Those extinct species were phylogenetically and taxonomically unique and typical of individual regions, and extinctions usually were not continent-wide and therefore led to differentiation. By contrast, because introduced alien species tended to be closely related to native species, the floristic differentiation due to species extinction was lessened by taxonomic and phylogenetic homogenization effects. This was especially due to species that are alien to a region but native to other parts of Europe. As a result, floras of many European regions have partly lost and will continue to lose their uniqueness. The results suggest that biodiversity needs to be assessed in terms of both species taxonomic and phylogenetic identity, but the latter is rarely used as a metric of the biodiversity dynamics.
RERO DOC Digital Lib... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2009 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.0907088106&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 304 citations 304 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert RERO DOC Digital Lib... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2009 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.0907088106&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:EC | OCEAN SENTINELEC| OCEAN SENTINELHenri Weimerskirch; Julien Collet; Alexandre Corbeau; Adrien Pajot; Floran Hoarau; Cédric Marteau; D. Filippi; Samantha C. Patrick;International audience; With threats to nature becoming increasingly prominent, in order for biodiversity levels to persist, there is a critical need to improve implementation of conservation measures. In the oceans, the surveillance of fisheries is complex and inadequate, such that quantifying and locating nondeclared and illegal fisheries is persistently problematic. Given that these activities dramatically impact oceanic ecosystems, through overexploitation of fish stocks and bycatch of threatened species, innovative ways to monitor the oceans are urgently required. Here, we describe a concept of “Ocean Sentinel” using animals equipped with state-of-the-art loggers which monitor fisheries in remote areas. Albatrosses fitted with loggers detecting and locating the presence of vessels and transmitting the information immediately to authorities allowed an estimation of the proportion of nondeclared fishing vessels operating in national and international waters of the Southern Ocean. We found that in international waters, more than one-third of vessels had no Automatic Identification System operating; in national Exclusive Economic Zones (EEZs), this proportion was lower on average, but variable according to EEZ. Ocean Sentinel was also able to provide unpreceded information on the attraction of seabirds to vessels, giving access to crucial information for risk-assessment plans of threatened species. Attraction differed between species, age, and vessel activity. Fishing vessels attracted more birds than other vessels, and juveniles both encountered fewer vessels and showed a lower attraction to vessels than adults. This study shows that the development of technologies offers the potential of implementing conservation policies by using wide-ranging seabirds to patrol oceans.
Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedData sources: CrossrefMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02462482/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1915499117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 59 citations 59 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!download 12download downloads 12 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedData sources: CrossrefMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02462482/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1915499117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 GermanyPublisher:Proceedings of the National Academy of Sciences Alexey Ryabov; Bernd Blasius; Helmut Hillebrand; Irina Olenina; Thilo Gross;The twin crises of climate change and biodiversity loss define a strong need for functional diversity monitoring. While the availability of high-quality ecological monitoring data is increasing, the quantification of functional diversity so far requires the identification of species traits, for which data is harder to obtain. However, the traits that are relevant for the ecological function of a species also shape its performance in the environment and hence should be reflected indirectly in its spatio-temporal distribution. Thus it may be possible to reconstruct these traits from a sufficiently extensive monitoring dataset. Here we use diffusion maps, a deterministic and de-facto parameter-free analysis method, to reconstruct a proxy representation of the species' traits directly from monitoring data and use it to estimate functional diversity. We demonstrate this approach both with simulated data and real-world phytoplankton monitoring data from the Baltic sea. We anticipate that wider application of this approach to existing data could greatly advance the analysis of changes in functional biodiversity. Comment: 37 pages, main text ends on page 13, color figures
Electronic Publicati... arrow_drop_down Electronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information CenterProceedings of the National Academy of SciencesArticle . 2022 . Peer-reviewedLicense: CC BYData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2021License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2118156119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Electronic Publicati... arrow_drop_down Electronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information CenterProceedings of the National Academy of SciencesArticle . 2022 . Peer-reviewedLicense: CC BYData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2021License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2118156119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United Kingdom, NetherlandsPublisher:Proceedings of the National Academy of Sciences Vassilis Douris; Denise Steinbach; Rafaela Panteleri; Ioannis Livadaras; John A. Pickett; Thomas Van Leeuwen; Ralf Nauen; John Vontas;pmid: 27930336
pmc: PMC5187681
Despite the major role of chitin biosynthesis inhibitors such as benzoylureas (BPUs) in the control of pests in agricultural and public health for almost four decades, their molecular mode of action (MoA) has in most cases remained elusive. BPUs interfere with chitin biosynthesis and were thought to interact with sulfonylurea receptors that mediate chitin vesicle transport. Here, we uncover a mutation (I1042M) in the chitin synthase 1 (CHS1) gene of BPU-resistant Plutella xylostella at the same position as the I1017F mutation reported in spider mites that confers etoxazole resistance. Using a genome-editing CRISPR/Cas9 approach coupled with homology-directed repair (HDR) in Drosophila melanogaster, we introduced both substitutions (I1056M/F) in the corresponding fly CHS1 gene (kkv). Homozygous lines bearing either of these mutations were highly resistant to etoxazole and all tested BPUs, as well as buprofezin—an important hemipteran chitin biosynthesis inhibitor. This provides compelling evidence that BPUs, etoxazole, and buprofezin share in fact the same molecular MoA and directly interact with CHS. This finding has immediate effects on resistance management strategies of major agricultural pests but also on mosquito vectors of serious human diseases such as Dengue and Zika, as diflubenzuron, the standard BPU, is one of the few effective larvicides in use. The study elaborates on how genome editing can directly, rapidly, and convincingly elucidate the MoA of bioactive molecules, especially when target sites are complex and hard to reconstitute in vitro.
CORE (RIOXX-UK Aggre... arrow_drop_down Rothamsted Repository; Proceedings of the National Academy of SciencesOther literature type . Article . 2016 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1618258113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 141 citations 141 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!download 10download downloads 10 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Rothamsted Repository; Proceedings of the National Academy of SciencesOther literature type . Article . 2016 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1618258113&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2020 Switzerland, GermanyPublisher:Proceedings of the National Academy of Sciences Patrick Ostkamp; Anke Salmen; Béatrice Pignolet; Dennis Görlich; Till F. M. Andlauer; Andreas Schulte-Mecklenbeck; Gabriel Gonzalez-Escamilla; Florence Bucciarelli; Isabelle Gennero; Johanna Breuer; Gisela Antony; Tilman Schneider-Hohendorf; Nadine Mykicki; Antonios Bayas; Florian Then Bergh; Stefan Bittner; Hans-Peter Hartung; Manuel A. Friese; Ralf A. Linker; Felix Luessi; Klaus Lehmann-Horn; Mark Mühlau; Friedemann Paul; Martin Stangel; Björn Tackenberg; Hayrettin Tumani; Clemens Warnke; Frank Weber; Brigitte Wildemann; Uwe K. Zettl; Ulf Ziemann; Bertram Müller-Myhsok; Tania Kümpfel; Luisa Klotz; Sven G. Meuth; Frauke Zipp; Bernhard Hemmer; Reinhard Hohlfeld; David Brassat; Ralf Gold; Catharina C. Gross; Carsten Lukas; Sergiu Groppa; Karin Loser; Heinz Wiendl; Nicholas Schwab; Antonios Bayas; Susanne Rothacher; Stephanie Starke; Friedemann Paul; Judith Bellmann-Strobl; Janina Behrens; Jan-Markus Dörr; Rene Gieß; Joseph Kuchling; Ludwig Rasche; Ralf Gold; Andrew Chan; Gisa Ellrichmann; Anna Lena Fisse; Anna Gahlen; Thomas Grüter; Aiden Haghikia; Robert Hoepner; Ümmügülsün Koc; Carsten Lukas; Jeremias Motte; Kalliopi Pitarokoili; Anke Salmen; Ruth Schneider; Joanna Schöllhammer; Christoph Schroeder; Björn Ambrosius; Seray Demir; Clemens Warnke; Thomas Dehmel; Kathleen Ingenhoven; Ralf Linker; De-Hyung Lee; Alexandra Lämmer; Eva Sauer; Christoph Heesen; Jan-Patrick Stellmann; Martin Stangel; Lena Boenig; Stefan Gingele; Martin Hümmert; Philipp Schwenkenbecher; Thomas Skripuletz; Wolfram Suehs; Brigitte Wildemann; Mirjam Korporal-Kuhnke; Hanna Oßwald; Alexander Schwarz; Andrea Viehöver; Volker Limmroth; Kathrin Gerbershagen; Florian Then Bergh; Barbara Ettrich; Steffi Gray; Sarah Haars; Johannes Orthgieß; Nicole Schwanitz; Muriel Stoppe; Astrid Unterlauft; Sandra Paryjas; Stefan Bittner; Vinzenz Fleischer; Sergiu Groppa; Felix Lüssi; Johannes Piepgras; Timo Uphaus; Björn Tackenberg; Michael Pütz; Christian Eienbröker; Maria Seipelt; Reinhard Hohlfeld; Tania Kümpfel; Joachim Havla; Ingrid Meinl; Hannah Pellkofer; Elisabeth Schuh; Bernhard Hemmer; Lilian Aly; Achim Berthele; Viola Pongratz; Kirsten Brinkhoff; Dorothea Buck; Christiane Gasperi; Mirjam Hermisson; Muna-Miriam Hoshi; Miriam Kaminski; Ana Klein; Benjamin Knier; Markus Kowarik; Helena Kronsbein; Klaus Lehmann Horn; Meike Mitsdörffer; Verena Pernpeintner; Veit Rothhammer; Andrea Schweikert; Rebecca Selter; Mark Mühlau; Claus Zimmer; Jan Kirschke; Frank Weber; Heike Staufer; Matthias Knop; Sandra Nischwitz; Philipp Sämann; Heinz Wiendl; Sven Meuth; Luisa Klotz; Gerd Meyer zu Hörste; Julia Krämer; Lena Schünemann; Catharina Gross; Steffen Pfeuffer; Tobias Ruck; Selma Belgriri; Alexander Buchheister; Nora Bünger; Kerstin Göbel; Lucienne Kirstein; Nico Melzer; Ole Simon; Antje Echterhoff; Uwe Zettl; Alexander Winkelmann; Ulf Ziemann; Ahmed Abdelhak; Markus Kowarik; Markus Krumbholz; Margarete Paech; Christoph Ruschil; Maria-Ioanna Stefanou; Johannes Tünnerhoff; Lena Zeltner; Hajera Sheikh; Hayrettin Tumani; Tanja Fangerau; Florian Lauda; Daniela Rau; Daniela Taranu; André Huss; David Brassat; Béatrice Pignolet; Florence Bucciarelli; Lise Scandella; Christine Lebrun-Frenay; Marc Debouverie; Sophie Pittion-Vouyovitch; Bruno Brochet; Aurelie Ruet; Gilles Defer; Nathalie Derache; Jérôme de Sèze; David Laplaud; Sandrine Wiertlewski; Oliver Casez; Eric Thouvenot;International audience; Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n NationMS = 946, n BIONAT = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-β-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests beneficial effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.
MediaTUM arrow_drop_down Institutional Repository for Molecular Medicine (MDC)Article . 2021 . Peer-reviewedData sources: Institutional Repository for Molecular Medicine (MDC)Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefBern Open Repository and Information System (BORIS)Article . 2021 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NC NDFull-Text: https://hal.science/hal-03659860/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2018457118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu30 citations 30 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert MediaTUM arrow_drop_down Institutional Repository for Molecular Medicine (MDC)Article . 2021 . Peer-reviewedData sources: Institutional Repository for Molecular Medicine (MDC)Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefBern Open Repository and Information System (BORIS)Article . 2021 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NC NDFull-Text: https://hal.science/hal-03659860/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2018457118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2010 Switzerland, SpainPublisher:Proceedings of the National Academy of Sciences Funded by:EC | PRATIQUEEC| PRATIQUEPyšek, Petr; Jarošík, Vojtěch; Hulme, Philip E.; Kühn, Ingolf; Wild, Jan; Arianoutsou, Margarita; Bacher, Sven; Chiron, Francois; Didžiulis, Viktoras; Essl, Franz; Genovesi, Piero; Gherardi, Francesca; Hejda, Martin; Kark, Salit; Lambdon, Philip W.; Desprez-Loustau, Marie-Laure; Nentwig, Wolfgang; Pergl, Jan; Poboljšaj, Katja; Rabitsch, Wolfgang; Roques, Alain; Roy, David B.; Shirley, Susan; Solarz, Wojciech; Vilà, Montserrat; Winter, Marten;handle: 10261/52375
The accelerating rates of international trade, travel, and transport in the latter half of the twentieth century have led to the progressive mixing of biota from across the world and the number of species introduced to new regions continues to increase. The importance of biogeographic, climatic, economic, and demographic factors as drivers of this trend is increasingly being realized but as yet there is no consensus regarding their relative importance. Whereas little may be done to mitigate the effects of geography and climate on invasions, a wider range of options may exist to moderate the impacts of economic and demographic drivers. Here we use the most recent data available from Europe to partition between macroecological, economic, and demographic variables the varia- tion in alien species richness of bryophytes, fungi, vascular plants, terrestrial insects, aquatic invertebrates, fish, amphibians, reptiles, birds, and mammals. Only national wealth and human population density were statistically significant predictors in the majority of models when analyzed jointly with climate, geography, and land cover. The economic and demographic variables reflect the intensity of human activities and integrate the effect of factors that directly determine the outcome of invasion such as propagule pressure, pathways of introduction, eutrophication, and the intensity of anthropogenic disturbance. The strong influence of economic and demographic variables on the levels of invasion by alien species demonstrates that future solutions to the problem of biological invasions at a national scale lie in mitigating the negative environ- mental consequences of human activities that generate wealth and by promoting more sustainable population growth Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2010 . Peer-reviewedProceedings of the National Academy of SciencesArticle . 2010 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1002314107&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 449 citations 449 popularity Top 0.1% influence Top 1% impulse Top 1% Powered by BIP!visibility 18visibility views 18 download downloads 17 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2010 . Peer-reviewedProceedings of the National Academy of SciencesArticle . 2010 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1002314107&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2006Publisher:Proceedings of the National Academy of Sciences Siri-Christine, Seehuus; Kari, Norberg; Ulrike, Gimsa; Trygve, Krekling; Gro V, Amdam;Research on aging shows that regulatory pathways of fertility and senescence are closely interlinked. However, evolutionary theories on social species propose that lifelong care for offspring can shape the course of senescence beyond the restricted context of reproductive capability. These observations suggest that control circuits of aging are remodeled in social organisms with continuing care for offspring. Here, we studied a circuit of aging in the honey bee ( Apis mellifera ). The bee is characterized by the presence of a long-lived reproductive queen caste and a shorter-lived caste of female workers that are life-long alloparental care givers. We focus on the role of the conserved yolk precursor gene vitellogenin that, in Caenorhabditis elegans , shortens lifespan as a downstream element of the insulin/insulin-like growth factor signaling cascade. Vitellogenin protein is synthesized at high levels in honey bee queens and is abundant in long-lived workers. We establish that vitellogenin gene activity protects worker bees from oxidative stress. Our finding suggests that one mechanistic explanation for patterns of longevity in bees is that a reproductive regulatory pathway has been remodeled to extend life. This perspective is of considerable relevance to research on longevity regulation that builds largely on inference from solitary model species.
Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2006 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.0502681103&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 479 citations 479 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2006 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.0502681103&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016Publisher:Proceedings of the National Academy of Sciences Nadin, Pade; Dirk, Michalik; Wolfgang, Ruth; Natalia, Belkin; Wolfgang R, Hess; Ilana, Berman-Frank; Martin, Hagemann;Significance Trichodesmium spp. are globally significant contributors of new nitrogen to the surface ocean. Marine organisms must accumulate compatible solutes in their cells, counteracting the high exterior osmotic pressure. However, Trichodesmium does not possess any known genes for the synthesis of compatible solutes, making its proliferation in the high-salinity environment enigmatic. We demonstrate that Trichodesmium cultures in the laboratory as well as natural populations in the ocean synthesize homoserine betaine, previously unknown as a compatible solute, and elucidated the biosynthetic pathway. The high intracellular concentrations will lead to a major injection of this organic compound into the oligotrophic ocean, when natural Trichodesmium blooms lyse. Such sudden releases of homoserine betaine could impact the biogeochemical cycling of carbon and nitrogen.
Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2016 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1611666113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 34 citations 34 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2016 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1611666113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Portugal, Norway, Netherlands, United States, United Kingdom, Spain, NorwayPublisher:Proceedings of the National Academy of Sciences Publicly fundedFunded by:NSF | Collaborative Research: G..., NSF | Biodiversity and Complex ..., NSF | Collaborative Research: G... +1 projectsNSF| Collaborative Research: Global biodiversity and functioning of eelgrass ecosystems ,NSF| Biodiversity and Complex Forcing of Ecosystem Functioning in the Marine Foundation Species, Eelgrass: A Global Experimental Network ,NSF| Collaborative Research: Global biodiversity and functioning of eelgrass ecosystems ,NSF| Collaborative Research: Global biodiversity and functioning of eelgrass ecosystemsJ. Emmett Duffy; John J. Stachowicz; Pamela L. Reynolds; Kevin A. Hovel; Marlene Jahnke; Erik E. Sotka; Christoffer Boström; Katharyn E. Boyer; Mathieu Cusson; Johan Eklöf; Aschwin H. Engelen; Britas Klemens Eriksson; F. Joel Fodrie; John N. Griffin; Clara M. Hereu; Masakazu Hori; A. Randall Hughes; Mikhail V. Ivanov; Pablo Jorgensen; Claudia Kruschel; Kun-Seop Lee; Jonathan S. Lefcheck; Per-Olav Moksnes; Masahiro Nakaoka; Mary I. O’Connor; Nessa E. O’Connor; Robert J. Orth; Bradley J. Peterson; Henning Reiss; Katrin Reiss; J. Paul Richardson; Francesca Rossi; Jennifer L. Ruesink; Stewart T. Schultz; Jonas Thormar; Fiona Tomas; Richard Unsworth; Erin Voigt; Matthew A. Whalen; Shelby L. Ziegler; Jeanine L. Olsen;pmid: 35939678
pmc: PMC9371661
Distribution of Earth's biomes is structured by the match between climate and plant traits, which in turn shape associated communities and ecosystem processes and services. However, that climate-trait match can be disrupted by historical events, with lasting ecosystem impacts. As Earth's environment changes faster than at any time in human history, critical questions are whether and how organismal traits and ecosystems can adjust to altered conditions. We quantified the relative importance of current environmental forcing versus evolutionary history in shaping the growth form (stature and biomass) and associated community of eelgrass (Zostera marina), a widespread foundation plant of marine ecosystems along Northern Hemisphere coastlines, which experienced major shifts in distribution and genetic composition during the Pleistocene. We found that eelgrass stature and biomass retain a legacy of the Pleistocene colonization of the Atlantic from the ancestral Pacific range and of more recent within-basin bottlenecks and genetic differentiation. This evolutionary legacy in turn influences the biomass of associated algae and invertebrates that fuel coastal food webs, with effects comparable to or stronger than effects of current environmental forcing. Such historical lags in phenotypic acclimatization may constrain ecosystem adjustments to rapid anthropogenic climate change, thus altering predictions about the future functioning of ecosystems. This work was supported by the US NSF (OCE-1031061, OCE-1336206, OCE0-1336741, OCE-1336905) and the Smithsonian Institution. F.T. was supported by José Castillejo Award CAS14/00177. A.H.E. was supported by the FCT (Foundation for Science and Technology) through Project UIDB/04326/2020 and Contract CEECINST/00114/2018. This is Contribution 106 from the Smithsonian’s MarineGEO and Tennenbaum Marine Observatories Network and Contribution 4105 of the Virginia Institute of Marine Science, College of William & Mary.
NARCIS arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Sapientia Repositório da Universidade do AlgarveArticle . 2022License: CC BY NC NDData sources: Sapientia Repositório da Universidade do Algarveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2121425119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 32visibility views 32 download downloads 39 Powered bymore_vert NARCIS arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Sapientia Repositório da Universidade do AlgarveArticle . 2022License: CC BY NC NDData sources: Sapientia Repositório da Universidade do Algarveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2121425119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2012Publisher:Proceedings of the National Academy of Sciences Huang, Ruiqi; Hippauf, Frank; Rohrbeck, Diana; Haustein, Maria; Wenke, Katrin; Feike, Janie; Sorrelle, Noah; Piechulla, Birgit; Barkman, Todd J.;In this study, we investigated the role for ancestral functional variation that may be selected upon to generate protein functional shifts using ancestral protein resurrection, statistical tests for positive selection, forward and reverse evolutionary genetics, and enzyme functional assays. Data are presented for three instances of protein functional change in the salicylic acid/benzoic acid/theobromine (SABATH) lineage of plant secondary metabolite-producing enzymes. In each case, we demonstrate that ancestral nonpreferred activities were improved upon in a daughter enzyme after gene duplication, and that these functional shifts were likely coincident with positive selection. Both forward and reverse mutagenesis studies validate the impact of one or a few sites toward increasing activity with ancestrally nonpreferred substrates. In one case, we document the occurrence of an evolutionary reversal of an active site residue that reversed enzyme properties. Furthermore, these studies show that functionally important amino acid replacements result in substrate discrimination as reflected in evolutionary changes in the specificity constant ( k cat / K M ) for competing substrates, even though adaptive substitutions may affect K M and k cat separately. In total, these results indicate that nonpreferred, or even latent, ancestral protein activities may be coopted at later times to become the primary or preferred protein activities.
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2012 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1019605109&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 80 citations 80 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2012 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1019605109&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2009 SwitzerlandPublisher:Proceedings of the National Academy of Sciences Marten, Winter; Oliver, Schweiger; Stefan, Klotz; Wolfgang, Nentwig; Pavlos, Andriopoulos; Margarita, Arianoutsou; Corina, Basnou; Pinelopi, Delipetrou; Viktoras, Didziulis; Martin, Hejda; Philip E, Hulme; Philip W, Lambdon; Jan, Pergl; Petr, Pysek; David B, Roy; Ingolf, Kühn;Human activities have altered the composition of biotas through two fundamental processes: native extinctions and alien introductions. Both processes affect the taxonomic (i.e., species identity) and phylogenetic (i.e., species evolutionary history) structure of species assemblages. However, it is not known what the relative magnitude of these effects is at large spatial scales. Here we analyze the large-scale effects of plant extinctions and introductions on taxonomic and phylogenetic diversity of floras across Europe, using data from 23 regions. Considering both native losses and alien additions in concert reveals that plant invasions since AD 1500 exceeded extinctions, resulting in ( i ) increased taxonomic diversity (i.e., species richness) but decreased phylogenetic diversity within European regions, and ( ii ) increased taxonomic and phylogenetic similarity among European regions. Those extinct species were phylogenetically and taxonomically unique and typical of individual regions, and extinctions usually were not continent-wide and therefore led to differentiation. By contrast, because introduced alien species tended to be closely related to native species, the floristic differentiation due to species extinction was lessened by taxonomic and phylogenetic homogenization effects. This was especially due to species that are alien to a region but native to other parts of Europe. As a result, floras of many European regions have partly lost and will continue to lose their uniqueness. The results suggest that biodiversity needs to be assessed in terms of both species taxonomic and phylogenetic identity, but the latter is rarely used as a metric of the biodiversity dynamics.
RERO DOC Digital Lib... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2009 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.0907088106&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 304 citations 304 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert RERO DOC Digital Lib... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2009 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.0907088106&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:EC | OCEAN SENTINELEC| OCEAN SENTINELHenri Weimerskirch; Julien Collet; Alexandre Corbeau; Adrien Pajot; Floran Hoarau; Cédric Marteau; D. Filippi; Samantha C. Patrick;International audience; With threats to nature becoming increasingly prominent, in order for biodiversity levels to persist, there is a critical need to improve implementation of conservation measures. In the oceans, the surveillance of fisheries is complex and inadequate, such that quantifying and locating nondeclared and illegal fisheries is persistently problematic. Given that these activities dramatically impact oceanic ecosystems, through overexploitation of fish stocks and bycatch of threatened species, innovative ways to monitor the oceans are urgently required. Here, we describe a concept of “Ocean Sentinel” using animals equipped with state-of-the-art loggers which monitor fisheries in remote areas. Albatrosses fitted with loggers detecting and locating the presence of vessels and transmitting the information immediately to authorities allowed an estimation of the proportion of nondeclared fishing vessels operating in national and international waters of the Southern Ocean. We found that in international waters, more than one-third of vessels had no Automatic Identification System operating; in national Exclusive Economic Zones (EEZs), this proportion was lower on average, but variable according to EEZ. Ocean Sentinel was also able to provide unpreceded information on the attraction of seabirds to vessels, giving access to crucial information for risk-assessment plans of threatened species. Attraction differed between species, age, and vessel activity. Fishing vessels attracted more birds than other vessels, and juveniles both encountered fewer vessels and showed a lower attraction to vessels than adults. This study shows that the development of technologies offers the potential of implementing conservation policies by using wide-ranging seabirds to patrol oceans.
Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedData sources: CrossrefMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02462482/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1915499117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 59 citations 59 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!download 12download downloads 12 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedData sources: CrossrefMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02462482/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1915499117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 GermanyPublisher:Proceedings of the National Academy of Sciences Alexey Ryabov; Bernd Blasius; Helmut Hillebrand; Irina Olenina; Thilo Gross;The twin crises of climate change and biodiversity loss define a strong need for functional diversity monitoring. While the availability of high-quality ecological monitoring data is increasing, the quantification of functional diversity so far requires the identification of species traits, for which data is harder to obtain. However, the traits that are relevant for the ecological function of a species also shape its performance in the environment and hence should be reflected indirectly in its spatio-temporal distribution. Thus it may be possible to reconstruct these traits from a sufficiently extensive monitoring dataset. Here we use diffusion maps, a deterministic and de-facto parameter-free analysis method, to reconstruct a proxy representation of the species' traits directly from monitoring data and use it to estimate functional diversity. We demonstrate this approach both with simulated data and real-world phytoplankton monitoring data from the Baltic sea. We anticipate that wider application of this approach to existing data could greatly advance the analysis of changes in functional biodiversity. Comment: 37 pages, main text ends on page 13, color figures
Electronic Publicati... arrow_drop_down Electronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information CenterProceedings of the National Academy of SciencesArticle . 2022 . Peer-reviewedLicense: CC BYData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2021License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2118156119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Electronic Publicati... arrow_drop_down Electronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information CenterProceedings of the National Academy of SciencesArticle . 2022 . Peer-reviewedLicense: CC BYData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2021License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2118156119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United Kingdom, NetherlandsPublisher:Proceedings of the National Academy of Sciences Vassilis Douris; Denise Steinbach; Rafaela Panteleri; Ioannis Livadaras; John A. Pickett; Thomas Van Leeuwen; Ralf Nauen; John Vontas;pmid: 27930336
pmc: PMC5187681
Despite the major role of chitin biosynthesis inhibitors such as benzoylureas (BPUs) in the control of pests in agricultural and public health for almost four decades, their molecular mode of action (MoA) has in most cases remained elusive. BPUs interfere with chitin biosynthesis and were thought to interact with sulfonylurea receptors that mediate chitin vesicle transport. Here, we uncover a mutation (I1042M) in the chitin synthase 1 (CHS1) gene of BPU-resistant Plutella xylostella at the same position as the I1017F mutation reported in spider mites that confers etoxazole resistance. Using a genome-editing CRISPR/Cas9 approach coupled with homology-directed repair (HDR) in Drosophila melanogaster, we introduced both substitutions (I1056M/F) in the corresponding fly CHS1 gene (kkv). Homozygous lines bearing either of these mutations were highly resistant to etoxazole and all tested BPUs, as well as buprofezin—an important hemipteran chitin biosynthesis inhibitor. This provides compelling evidence that BPUs, etoxazole, and buprofezin share in fact the same molecular MoA and directly interact with CHS. This finding has immediate effects on resistance management strategies of major agricultural pests but also on mosquito vectors of serious human diseases such as Dengue and Zika, as diflubenzuron, the standard BPU, is one of the few effective larvicides in use. The study elaborates on how genome editing can directly, rapidly, and convincingly elucidate the MoA of bioactive molecules, especially when target sites are complex and hard to reconstitute in vitro.
CORE (RIOXX-UK Aggre... arrow_drop_down Rothamsted Repository; Proceedings of the National Academy of SciencesOther literature type . Article . 2016 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1618258113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 141 citations 141 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!download 10download downloads 10 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Rothamsted Repository; Proceedings of the National Academy of SciencesOther literature type . Article . 2016 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1618258113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu