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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lyall, Andrea; Nelson, Harry; Rosenblum, Daisy; Turin, Mark;

    International audience; This paper describes the process and outcomes of a project focused on community centred reclamation of plant-based knowledge in the Kwak̓wala language from previously published materials as well as new documentation with Kwak̓wala speaking Elders. The paper describes our research process resulting in the documentation of 300 plant word names and phrases, starting with 135 plants with names and words in Kwak̓wala that had been documented between the late 19th and early 20th century by Franz Boas and George Hunt, subsequently added to and enriched by community members and academics. An audio-visual dictionary of these plant names and associated phrases is now available through the FirstVoices web portal (http://bit.ly/LDC_FirstVoices). The corresponding author initiated the work and then further developed the research in collaboration with Kwakwa̱ka̱’wakw fluent speakers, linguists, biologists, and the U’mista Cultural Society. The project has stimulated interest among community members who provided valuable feedback on the different ways in which this research can be further accessed and then delivered. The paper concludes with some structured reflections on how to proceed in community-led research projects such as this. The authors see further opportunity for continued cross-disciplinary and community-based research.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Article . 2019
    License: CC BY
    Data sources: Datacite
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Article . 2019
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Article . 2019
      License: CC BY
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Article . 2019
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Alexandre GEORGES;

    As demonstrated by Pound-Rebka experiment, the wave period of an electromagnetic radiation can be contracted or dilated due to the deformation of the geometry of Space-Time. In cosmology, this principle is the explanation of the phenomenon of gravitational redshift, highlighting an expansion of the universe caused by space dilation. One of the consequences of this fact is a kind of rupture of energy conservation, directly induced by the Planck-Einstein relation, which would then be a relative conservation of energy. In this paper, this phenomenon will be extended to mass particles, by the applying De Broglie's thesis, which will pose a mass conservation paradox. This paradox will show that mass is, like energy, relative to the deformation of the geometry of space-time in which the object is situated. No sufficient solution will be made here to this paradox.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://osf.io/hswex...arrow_drop_down
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    ZENODO
    Preprint . 2019
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    https://doi.org/10.31219/osf.i...
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://osf.io/hswex...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Preprint . 2019
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      https://doi.org/10.31219/osf.i...
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      Preprint . 2019
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      Other literature type . 2019
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Byrne, Hazel; Webster, Timothy H.; Brosnan, Sarah F.; Izar, Patrícia; +1 Authors

    The platyrrhine family Cebidae (capuchin and squirrel monkeys) exhibit among the largest primate encephalization quotients. Each cebid lineage is also characterized by notable lineage-specific traits, with capuchins showing striking similarities to Hominidae such as high sensorimotor intelligence with tool use, advanced cognitive abilities, and behavioral flexibility. Here, we take a comparative genomics approach, performing genome-wide tests for positive selection across five cebid branches, to gain insight into major periods of cebid adaptive evolution. We uncover candidate targets of selection across cebid evolutionary history that may underlie the emergence of lineage-specific traits. Our analyses highlight shifting and sustained selective pressures on genes related to brain development, longevity, reproduction, and morphology, including evidence for cumulative and diversifying neurobiological adaptations across cebid evolution. In addition to generating a high-quality reference genome assembly for robust capuchins, our results lend to a better understanding of the adaptive diversification of this distinctive primate clade.

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    ZENODO
    Article . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Article . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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      Article . 2021
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      Article . 2021
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Djermoune, El-Hadi; Thomassin, Magalie; Tomczak, Marc;

    International audience; This article presents a statistical analysis of the Matrix Pencil method for estimating the mode and the amplitude of a single damped complex exponential. This study is based on a perturbation analysis of the mode and the amplitude, assuming a high signal-to-noise ratio. Closed-form expressions of the mean and variance of these perturbations are derived. It is shown that the estimates are unbiased and that the estimator can be tuned in order to obtain a minimal variance. The theoretical results are verified using Monte Carlo simulations.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Conference object . 2009
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      Other literature type . Conference object . 2009
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Celerier, Jean-Michaël; Desainte-Catherine, Myriam; Couturier, Jean-Michel;

    International audience; The field of digital music authoring provides a wealth of creative environments in which music can be created and authored: patchers, programming languages, and multi-track sequencers. By combining the i-score interactive sequencer to the LibAudioStream audio engine, a new music software able to represent and play rich interactive audio sequences is introduced. We present new stream expressions compatible with the LibAudioStream, and use them to create an interactive audio graph: hierarchical stream and send-return streams. This allows to create branching and arbitrarily nested musical scores, in an OSC-centric environment. Three examples of interactive musical scores are presented: the recreation of a traditional multi-track sequencer, an interactive musical score, and a temporal effect graph.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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    Conference object . 2016
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    Conference object . 2016
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    Other literature type . 2016
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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      Conference object . 2016
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      Conference object . 2016
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Olena Temirova; Mykola Khaitovych; Anatoliy Burlaka; Anastasia Vovk;

    The aim. To investigate the efficacy regulation of redox-dependent mechanisms neuroprotection in case of various pharmacological schemes including N-acetylcysteine (NAC) and melatonin (Mel) in the brain of rats with experimental type 1 diabetes mellitus (DM 1). Methods. NAC (1.5g/kg), Mel (10 mg/kg) or their combination (NAC+Mel) where administrated to rats with induced DM 1 for 5 weeks. State of the mitochondria electron transport chain (ETC),velocity of generation superoxide radicals (SR), activity of nNOS, concentration of lactoferrin, “free iron”, methemoglobin, 8-oxoG in the cells of rats` brain were determined by electron paramagnetic resonance (EPR) method using a computerized spectrometer PE-1307 at the temperature of liquid nitrogen (T=77K). Results. During 7-week after induced DM 1, the rate of superoxide radicals (SR) generation by brains` mitochondria of rats with DM 1 was significantly higher and the activity of neuronal nitric oxide synthase (nNOS) was decreased compare to control group. The reduction in the activity of mitochondrial ETC Complex I and the growth of level 8-oxoG, concentration of "free iron" complexes, NO-FeS proteins, lactoferrin and MetHb concentration in the brain tissue of animals with DM1 were determined. Administration of all investigated pharmacological groups caused decreasing the rate of SR generation and recovering activity of nNOS by brains` mitochondria. After pharmacological intervention with NAC/Mel or NAC+Mel the levels of 8-oxoG and NO-FeS proteins were significantly decreased, activity of «free iron» complexes were normalizedinthe tissue of rats` brain with DM 1. Therapy of NAC also caused reduction level of MetHb and a combination therapy of NAC + Mel caused reduction level of lactoferrin of the rats` brain with DM 1. Conclusion. At induction of type 1 diabetes, mitochondrial ETC was damaged by products of incomplete catalysis of glucose, which manifested by a decrease in the synthesis of ATP, an increase in the level of SR, which are generated as a result of defection of the electron transport mechanism. The therapy of NAC and Mel or their combination was accompanied by the protection of the rats` brain cells with DM 1 from the toxic effect of SR, preventing disturbance of mitochondrial function that indicate neuroprotective action. NAC and Mel are perspective drugs for the prevention and treatment of diabetic neuropathy

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    ZENODO; ScienceRise: Pharmaceutical Science
    Article . 2018 . Peer-reviewed
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    Authors: Kaaniche, Mounir; Benazza-Benyahia, Amel; Pesquet, Jean-Christophe; Pesquet-Popescu, Béatrice;

    electronic version (5 pp.); International audience; Stereo data compression is an important issue for the new generation of vision systems. In this paper, we are interested in lossless coding methods for stereo images allowing progressive reconstruction. Most of the existing approaches account for the mutual similarities between the left and the right images. More precisely, the disparity compensation process consists in predicting the right image from the left one based on the disparity map. Then, the disparity map, the reference image, and the residual image are encoded. In this work, we propose a novel approach based on the concept of vector lifting scheme. Its main feature is that it does not generate one residual image but two compact multiresolution representations of the left and the right views, driven by the underlying disparity map. Experimental results show a significant improvement using this technique compared with conventional methods.

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    Authors: Tim Bayne; Anil K. Seth; Marcello Massimini;

    Ordinary human experience is embedded in a web of causal relations that link the brain to the body and the wider environment. However, there might be conditions in which brain activity supports consciousness even when that activity is fully causally isolated from the body and its environment. Such cases would involve what we call islands of awareness: conscious states that are neither shaped by sensory input nor able to be expressed by motor output. This Opinion paper considers conditions in which such islands might occur, including ex cranio brains, hemispherotomy, and in cerebral organoids. We examine possible methods for detecting islands of awareness, and consider their implications for ethics and for the nature of consciousness.

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    ZENODO; Trends in Neurosciences
    Other literature type . Article . 2020 . Peer-reviewed
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      ZENODO; Trends in Neurosciences
      Other literature type . Article . 2020 . Peer-reviewed
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      Trends in Neurosciences
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    Authors: Lodewijk J.A. Toonen; Maurice Overzier; Melvin M. Evers; Leticia G. Leon; +10 Authors

    Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein. Expression of mutant ataxin-3 is known to result in transcriptional dysregulation, which can contribute to the cellular toxicity and neurodegeneration. Since the exact causative mechanisms underlying this process have not been fully elucidated, gene expression analyses in brains of transgenic SCA3 mouse models may provide useful insights. Methods Here we characterised the MJD84.2 SCA3 mouse model expressing the mutant human ataxin-3 gene using a multi-omics approach on brain and blood. Gene expression changes in brainstem, cerebellum, striatum and cortex were used to study pathological changes in brain, while blood gene expression and metabolites/lipids levels were examined as potential biomarkers for disease. Results Despite normal motor performance at 17.5 months of age, transcriptional changes in brain tissue of the SCA3 mice were observed. Most transcriptional changes occurred in brainstem and striatum, whilst cerebellum and cortex were only modestly affected. The most significantly altered genes in SCA3 mouse brain were Tmc3, Zfp488, Car2, and Chdh. Based on the transcriptional changes, α-adrenergic and CREB pathways were most consistently altered for combined analysis of the four brain regions. When examining individual brain regions, axon guidance and synaptic transmission pathways were most strongly altered in striatum, whilst brainstem presented with strongest alterations in the pi-3 k cascade and cholesterol biosynthesis pathways. Similar to other neurodegenerative diseases, reduced levels of tryptophan and increased levels of ceramides, di- and triglycerides were observed in SCA3 mouse blood. Conclusions The observed transcriptional changes in SCA3 mouse brain reveal parallels with previous reported neuropathology in patients, but also shows brain region specific effects as well as involvement of adrenergic signalling and CREB pathway changes in SCA3. Importantly, the transcriptional changes occur prior to onset of motor- and coordination deficits. Electronic supplementary material The online version of this article (10.1186/s13024-018-0261-9) contains supplementary material, which is available to authorized users.

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    Article . 2018
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    Article . 2018
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    ZENODO; Molecular Neurodegeneration; NARCIS
    Other literature type . Article . 2018 . Peer-reviewed
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    Molecular Neurodegeneration
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      Radboud Repository
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      ZENODO; Molecular Neurodegeneration; NARCIS
      Other literature type . Article . 2018 . Peer-reviewed
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      LUMC Scholarly Publications
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      Molecular Neurodegeneration
      Article
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    Authors: Mihai, Florin-Constantin; Minea, Ionut; Grozavu, Adrian;

    International audience; The paper examines the exposure of mountain creeks towards illegal waste disposal practices related to the lack of waste collection services in rural areas of Romania prior to EU accession and the low waste collection efficiency following the closure of rural wild dumps in 2009-2010. The paper estimates the amounts of household waste uncollected and disposed in selected small Carpathian rivers in the NorthEast development region. The expansion of built-up areas along the water courses leads to waste dumping practices across mountain villages in the context of poor waste management facilities. Particular morphology of villages and hydrological characteristics of the creeks may influence the magnitude of such bad practices. The paper points out the role of flash floods in cleaning upstream catchments from debris, thus, polluting the downstream rivers and human settlements. An efficient waste collection system in mountain areas has a crucial role to play in mitigating and ultimately preventing the waste dumping practices in water bodies.

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    Authors: Lyall, Andrea; Nelson, Harry; Rosenblum, Daisy; Turin, Mark;

    International audience; This paper describes the process and outcomes of a project focused on community centred reclamation of plant-based knowledge in the Kwak̓wala language from previously published materials as well as new documentation with Kwak̓wala speaking Elders. The paper describes our research process resulting in the documentation of 300 plant word names and phrases, starting with 135 plants with names and words in Kwak̓wala that had been documented between the late 19th and early 20th century by Franz Boas and George Hunt, subsequently added to and enriched by community members and academics. An audio-visual dictionary of these plant names and associated phrases is now available through the FirstVoices web portal (http://bit.ly/LDC_FirstVoices). The corresponding author initiated the work and then further developed the research in collaboration with Kwakwa̱ka̱’wakw fluent speakers, linguists, biologists, and the U’mista Cultural Society. The project has stimulated interest among community members who provided valuable feedback on the different ways in which this research can be further accessed and then delivered. The paper concludes with some structured reflections on how to proceed in community-led research projects such as this. The authors see further opportunity for continued cross-disciplinary and community-based research.

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    Authors: Alexandre GEORGES;

    As demonstrated by Pound-Rebka experiment, the wave period of an electromagnetic radiation can be contracted or dilated due to the deformation of the geometry of Space-Time. In cosmology, this principle is the explanation of the phenomenon of gravitational redshift, highlighting an expansion of the universe caused by space dilation. One of the consequences of this fact is a kind of rupture of energy conservation, directly induced by the Planck-Einstein relation, which would then be a relative conservation of energy. In this paper, this phenomenon will be extended to mass particles, by the applying De Broglie's thesis, which will pose a mass conservation paradox. This paradox will show that mass is, like energy, relative to the deformation of the geometry of space-time in which the object is situated. No sufficient solution will be made here to this paradox.

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    https://doi.org/10.31219/osf.i...
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    Authors: Byrne, Hazel; Webster, Timothy H.; Brosnan, Sarah F.; Izar, Patrícia; +1 Authors

    The platyrrhine family Cebidae (capuchin and squirrel monkeys) exhibit among the largest primate encephalization quotients. Each cebid lineage is also characterized by notable lineage-specific traits, with capuchins showing striking similarities to Hominidae such as high sensorimotor intelligence with tool use, advanced cognitive abilities, and behavioral flexibility. Here, we take a comparative genomics approach, performing genome-wide tests for positive selection across five cebid branches, to gain insight into major periods of cebid adaptive evolution. We uncover candidate targets of selection across cebid evolutionary history that may underlie the emergence of lineage-specific traits. Our analyses highlight shifting and sustained selective pressures on genes related to brain development, longevity, reproduction, and morphology, including evidence for cumulative and diversifying neurobiological adaptations across cebid evolution. In addition to generating a high-quality reference genome assembly for robust capuchins, our results lend to a better understanding of the adaptive diversification of this distinctive primate clade.

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    Authors: Djermoune, El-Hadi; Thomassin, Magalie; Tomczak, Marc;

    International audience; This article presents a statistical analysis of the Matrix Pencil method for estimating the mode and the amplitude of a single damped complex exponential. This study is based on a perturbation analysis of the mode and the amplitude, assuming a high signal-to-noise ratio. Closed-form expressions of the mean and variance of these perturbations are derived. It is shown that the estimates are unbiased and that the estimator can be tuned in order to obtain a minimal variance. The theoretical results are verified using Monte Carlo simulations.

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      Other literature type . Conference object . 2009
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    Authors: Celerier, Jean-Michaël; Desainte-Catherine, Myriam; Couturier, Jean-Michel;

    International audience; The field of digital music authoring provides a wealth of creative environments in which music can be created and authored: patchers, programming languages, and multi-track sequencers. By combining the i-score interactive sequencer to the LibAudioStream audio engine, a new music software able to represent and play rich interactive audio sequences is introduced. We present new stream expressions compatible with the LibAudioStream, and use them to create an interactive audio graph: hierarchical stream and send-return streams. This allows to create branching and arbitrarily nested musical scores, in an OSC-centric environment. Three examples of interactive musical scores are presented: the recreation of a traditional multi-track sequencer, an interactive musical score, and a temporal effect graph.

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    Authors: Olena Temirova; Mykola Khaitovych; Anatoliy Burlaka; Anastasia Vovk;

    The aim. To investigate the efficacy regulation of redox-dependent mechanisms neuroprotection in case of various pharmacological schemes including N-acetylcysteine (NAC) and melatonin (Mel) in the brain of rats with experimental type 1 diabetes mellitus (DM 1). Methods. NAC (1.5g/kg), Mel (10 mg/kg) or their combination (NAC+Mel) where administrated to rats with induced DM 1 for 5 weeks. State of the mitochondria electron transport chain (ETC),velocity of generation superoxide radicals (SR), activity of nNOS, concentration of lactoferrin, “free iron”, methemoglobin, 8-oxoG in the cells of rats` brain were determined by electron paramagnetic resonance (EPR) method using a computerized spectrometer PE-1307 at the temperature of liquid nitrogen (T=77K). Results. During 7-week after induced DM 1, the rate of superoxide radicals (SR) generation by brains` mitochondria of rats with DM 1 was significantly higher and the activity of neuronal nitric oxide synthase (nNOS) was decreased compare to control group. The reduction in the activity of mitochondrial ETC Complex I and the growth of level 8-oxoG, concentration of "free iron" complexes, NO-FeS proteins, lactoferrin and MetHb concentration in the brain tissue of animals with DM1 were determined. Administration of all investigated pharmacological groups caused decreasing the rate of SR generation and recovering activity of nNOS by brains` mitochondria. After pharmacological intervention with NAC/Mel or NAC+Mel the levels of 8-oxoG and NO-FeS proteins were significantly decreased, activity of «free iron» complexes were normalizedinthe tissue of rats` brain with DM 1. Therapy of NAC also caused reduction level of MetHb and a combination therapy of NAC + Mel caused reduction level of lactoferrin of the rats` brain with DM 1. Conclusion. At induction of type 1 diabetes, mitochondrial ETC was damaged by products of incomplete catalysis of glucose, which manifested by a decrease in the synthesis of ATP, an increase in the level of SR, which are generated as a result of defection of the electron transport mechanism. The therapy of NAC and Mel or their combination was accompanied by the protection of the rats` brain cells with DM 1 from the toxic effect of SR, preventing disturbance of mitochondrial function that indicate neuroprotective action. NAC and Mel are perspective drugs for the prevention and treatment of diabetic neuropathy

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    ZENODO; ScienceRise: Pharmaceutical Science
    Article . 2018 . Peer-reviewed
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    ScienceRise: Pharmaceutical Science
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      Article . 2018 . Peer-reviewed
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    Authors: Kaaniche, Mounir; Benazza-Benyahia, Amel; Pesquet, Jean-Christophe; Pesquet-Popescu, Béatrice;

    electronic version (5 pp.); International audience; Stereo data compression is an important issue for the new generation of vision systems. In this paper, we are interested in lossless coding methods for stereo images allowing progressive reconstruction. Most of the existing approaches account for the mutual similarities between the left and the right images. More precisely, the disparity compensation process consists in predicting the right image from the left one based on the disparity map. Then, the disparity map, the reference image, and the residual image are encoded. In this work, we propose a novel approach based on the concept of vector lifting scheme. Its main feature is that it does not generate one residual image but two compact multiresolution representations of the left and the right views, driven by the underlying disparity map. Experimental results show a significant improvement using this technique compared with conventional methods.

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    Conference object . 2007
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    Authors: Tim Bayne; Anil K. Seth; Marcello Massimini;

    Ordinary human experience is embedded in a web of causal relations that link the brain to the body and the wider environment. However, there might be conditions in which brain activity supports consciousness even when that activity is fully causally isolated from the body and its environment. Such cases would involve what we call islands of awareness: conscious states that are neither shaped by sensory input nor able to be expressed by motor output. This Opinion paper considers conditions in which such islands might occur, including ex cranio brains, hemispherotomy, and in cerebral organoids. We examine possible methods for detecting islands of awareness, and consider their implications for ethics and for the nature of consciousness.

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    ZENODO; Trends in Neurosciences
    Other literature type . Article . 2020 . Peer-reviewed
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    Trends in Neurosciences
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      ZENODO; Trends in Neurosciences
      Other literature type . Article . 2020 . Peer-reviewed
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      Trends in Neurosciences
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    Authors: Lodewijk J.A. Toonen; Maurice Overzier; Melvin M. Evers; Leticia G. Leon; +10 Authors

    Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein. Expression of mutant ataxin-3 is known to result in transcriptional dysregulation, which can contribute to the cellular toxicity and neurodegeneration. Since the exact causative mechanisms underlying this process have not been fully elucidated, gene expression analyses in brains of transgenic SCA3 mouse models may provide useful insights. Methods Here we characterised the MJD84.2 SCA3 mouse model expressing the mutant human ataxin-3 gene using a multi-omics approach on brain and blood. Gene expression changes in brainstem, cerebellum, striatum and cortex were used to study pathological changes in brain, while blood gene expression and metabolites/lipids levels were examined as potential biomarkers for disease. Results Despite normal motor performance at 17.5 months of age, transcriptional changes in brain tissue of the SCA3 mice were observed. Most transcriptional changes occurred in brainstem and striatum, whilst cerebellum and cortex were only modestly affected. The most significantly altered genes in SCA3 mouse brain were Tmc3, Zfp488, Car2, and Chdh. Based on the transcriptional changes, α-adrenergic and CREB pathways were most consistently altered for combined analysis of the four brain regions. When examining individual brain regions, axon guidance and synaptic transmission pathways were most strongly altered in striatum, whilst brainstem presented with strongest alterations in the pi-3 k cascade and cholesterol biosynthesis pathways. Similar to other neurodegenerative diseases, reduced levels of tryptophan and increased levels of ceramides, di- and triglycerides were observed in SCA3 mouse blood. Conclusions The observed transcriptional changes in SCA3 mouse brain reveal parallels with previous reported neuropathology in patients, but also shows brain region specific effects as well as involvement of adrenergic signalling and CREB pathway changes in SCA3. Importantly, the transcriptional changes occur prior to onset of motor- and coordination deficits. Electronic supplementary material The online version of this article (10.1186/s13024-018-0261-9) contains supplementary material, which is available to authorized users.

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    Radboud Repository
    Article . 2018
    Data sources: Radboud Repository
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    Article . 2018
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    ZENODO; Molecular Neurodegeneration; NARCIS
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    Molecular Neurodegeneration
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      Molecular Neurodegeneration
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    Authors: Mihai, Florin-Constantin; Minea, Ionut; Grozavu, Adrian;

    International audience; The paper examines the exposure of mountain creeks towards illegal waste disposal practices related to the lack of waste collection services in rural areas of Romania prior to EU accession and the low waste collection efficiency following the closure of rural wild dumps in 2009-2010. The paper estimates the amounts of household waste uncollected and disposed in selected small Carpathian rivers in the NorthEast development region. The expansion of built-up areas along the water courses leads to waste dumping practices across mountain villages in the context of poor waste management facilities. Particular morphology of villages and hydrological characteristics of the creeks may influence the magnitude of such bad practices. The paper points out the role of flash floods in cleaning upstream catchments from debris, thus, polluting the downstream rivers and human settlements. An efficient waste collection system in mountain areas has a crucial role to play in mitigating and ultimately preventing the waste dumping practices in water bodies.

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