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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Mousumi Sukul; Priyanka Sahariah; Hélène L. Lauzon; João Borges; +4 Authors

    We have studied the effect of chitosan sponges, produced from chitosan batches with distinct degree of deacetylation (DDA) and molecular weight (Mw), on the adhesion, growth and differentiation of primary human osteoblasts with an aim to offer a suitable tool for guided bone regeneration. All the chitosan sponges revealed similar microstructure, irrespective of the DDA (58, 73, 82, 88, and 91 %) and Mw (749, 547, 263, 215, and 170 kDa, respectively). Cell spreading was higher on sponges having a higher DDA. Higher DDA induced a more pronounced increase in alkaline phosphatase activity, osteopontin (OPN), vascular endothelial growth factor-A (VEGF), interleukin-6 (IL-6), and reduction in monocyte chemoattractant protein-1 (MCP-1), sclerostin (SOST) and dickkopf related protein-1 as compared to lower DDA. Lower DDA induced the increased secretion of osteoprotegerin and SOST as compared to higher DDA. The combination of higher DDA and Mw induced an increased secretion of VEGF and IL-6, however reduced the secretion of OPN as compared to chitosan with similar DDA but with lower Mw. In summary, the variations in cellular responses to the different chitosan sponges indicate a potential for individual tailoring of desired responses in guided bone regeneration. published

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Norwegian Open Resea...arrow_drop_down
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    Authors: Veraldi, Noemi; Quadri, Isabelle Dentand; van de Looij, Yohan; Modernell, Laura Malaguti; +12 Authors

    Mucopolysaccharidosis IIIA is a hereditary disease caused by mutations in the sulfamidase enzyme that participates in catabolism of heparan sulfate (HS), leading to HS fragment accumulation and multisystemic failure. No cure exists and death occurs around the second decade of life. Two low molecular weight highly sulfated compounds derived from marine diabolican and infernan exopolysaccharides (A5_3 and A5_4, respectively) with heparanase inhibiting properties were tested in a MPSIIIA cell line model, resulting in limited degradation of intracellular HS. Next, we observed the effects of intraperitoneal injections of the diabolican derivative A5_3 from 4 to 12 weeks of age on MPSIIIA mice. Brain metabolism and microstructure, levels of proteins and genes involved in MPSIIIA brain pathophysiology were also investigated. 1H-Magnetic Resonance Spectroscopy (MRS) indicated deficits in energetic metabolism, tissue integrity and neurotransmission at both 4 and 12 weeks in MPSIIIA mice, with partial protective effects of A5_3. Ex-vivo Diffusion Tensor Imaging (DTI) showed white matter microstructural damage in MPSIIIA, with noticeable protective effects of A5_3. Protein and gene expression assessments displayed both pro-inflammatory and pro-apoptotic profiles in MPSIIIA mice, with benefits of A5_3 counteracting neuroinflammation. Overall, derivative A5_3 was well tolerated and was shown to be efficient in preventing brain metabolism failure and inflammation, resulting in preserved brain microstructure in the context of MPSIIIA. International audience

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    Carbohydrate Polymers
    Article . 2023 . Peer-reviewed
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    Authors: Zykwinska, Agata; Makshakova, Olga; Gélébart, Perrine; Sinquin, Corinne; +4 Authors

    International audience; With the increasing need for hydrogels with tunable properties for specific biomedical applications, a complete understanding of the structure-function relationship of polymers used for hydrogel development remains crucial for their optimal use. In the present study, by combining experimental and theoretical approaches, the structurefunction relationship of a bacterial exopolysaccharide, infernan, displaying both glycosaminoglycan-mimetic and gelling properties, was investigated at molecular and microscopic levels. Atomic force microscopy (AFM) experiments and molecular dynamics simulations were applied to determine the persistence length of individual infernan chains before studying their association induced by calcium. Infernan-based microgels were then produced using microfluidics and their mechanical properties were characterized by AFM methods. The mechanical properties of EPS/calcium microgels were finely tuned by varying the crosslinking density of their network, either by calcium or EPS concentrations. The obtained set of viscoelastic microgels with different elastic modulus values opens several possibilities for their applications in tissue engineering.

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    Carbohydrate Polymers
    Article . 2022 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ArchiMer - Instituti...arrow_drop_down
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      Carbohydrate Polymers
      Article . 2022 . Peer-reviewed
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    Authors: Leire Iturriaga; Idoia Olabarrieta; Alain Castellan; Christian Gardrat; +1 Authors

    Bioactive citrus extract-chitosan films were prepared through solvent casting-evaporation method. The impact of near UV irradiation was studied to reach a better understanding of the film behavior. The antimicrobial activity of films against Listeria innocua was maintained after UV irradiation. To study the interaction between chitosan and citrus extract components, naringin (main component) was selected as the model compound. UV treatment caused modifications of the flavanone regardless of the solvent used for its dissolution, depending on the concentration of naringin in the film: the greater the concentration the lower the modification. DSC results suggested cross-links due to UV irradiation and interactions between naringin and chitosan. This was confirmed by a decrease in the naringin release from the irradiated samples. Naringin- and citrus extract-chitosan films showed an increased absorbance in the UV region compared to pure chitosan films, showing potentiality for decreasing the lipid oxidation induced by UV light in foodstuffs. (C) 2014 Elsevier Ltd. All rights reserved. This work has been performed within an Aquitaine-Basque Country Cooperation project. This paper is contribution nr. 656 from AZTI-Tecnalia (Marine or Food Research). L. Iturriaga acknowledges the Department of Agriculture, Fisheries and Food of the Basque Government for the fellowship. A. Lafaille is also gratefully acknowledged for the antimicrobial tests.

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    Oskar Bordeaux
    Article . 2014
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    Carbohydrate Polymers
    Article . 2014 . Peer-reviewed
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    Article . 2014
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      Oskar Bordeaux
      Article . 2014
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      Carbohydrate Polymers
      Article . 2014 . Peer-reviewed
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    Authors: Zykwinska, Agata; Tripon-Le Berre, Ludivine; Sinquin, Corinne; Ropartz, David; +3 Authors

    International audience; Polysaccharides have attracted much attention due to their interesting physico-chemical and also biological properties that are explored in food, cosmetic and pharmaceutical industries. GY785 exopolysaccharide (EPS) presenting an unusual structure is secreted by the deep-sea hydrothermal bacterium, Alteromonas infernus. Low-molecular weight (LMW) derivatives obtained by chemical depolymerization of the native high molecular weight (HMW) EPS were previously shown to exhibit biological properties similar to glycosaminoglycans (GAG). In the present study, in order to generate well defined derivatives with a better control of the depolymerization, an enzymatic approach was applied for the first time. Various commercially available enzymes were firstly screened for their depolymerizing activities, however none of them was able to degrade the polysaccharide. Enzymatic assays performed with A. infernus protein extracts have shown that the bacterium produces by itself endogenous enzymes able to depolymerize its own EPS. The oligosaccharides released by the enzymes were analyzed and their structures allowed to assess that the protein extract contains several depolymerizing activities.

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    Carbohydrate Polymers
    Article . 2018 . Peer-reviewed
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      Carbohydrate Polymers
      Article . 2018 . Peer-reviewed
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    Authors: Olga, Makshakova; Agata, Zykwinska; Stephane, Cuenot; Sylvia, Colliec-Jouault; +1 Authors

    International audience; The exopolysaccharide Infernan, from the bacterial strain GY785, has a complex repeating unit of nine monosaccharides established on a double-layer of sidechains. A cluster of uronic and sulfated monosaccharides confers to Infernan functional and biological activities. We characterized the 3-dimensional structures and dynamics along Molecular Dynamics trajectories and clustered the conformations in extended two-fold and five-fold helical structures. The electrostatic potential distribution over all the structures revealed negatively charged cavities explored for Ca2+ binding through quantum chemistry computation. The transposition of the model of Ca(2+)complexation indicates that the five-fold helices are the most favourable for interactions. The ribbon-like shape of two-fold helices brings neighbouring chains in proximity without steric clashes. The cavity chelating the Ca2+ of one chain is completed throughout the interaction of a sulfate group from the neighbouring chain. The resulting is a 'junction zone' based on unique chain-chain interactions governed by a heterotypic binding mode.

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    Carbohydrate Polymers
    Article . 2022 . Peer-reviewed
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    Hal-Diderot
    Article . 2022
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      Carbohydrate Polymers
      Article . 2022 . Peer-reviewed
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    Authors: T, Le Costaouëc; S, Cérantola; D, Ropartz; J, Ratiskol; +3 Authors

    Some marine bacteria collected around deep-sea hydrothermal vents are able to produce, in laboratory conditions, complex and innovative exopolysaccharides. In a previous study, the mesophilic strain Alteromonas macleodii subsp. fijiensis biovar deepsane was collected on the East Pacific Rise at 2600m depth. It was isolated from a polychaete annelid Alvinella pompejana and is able to synthesise and excrete the exopolysaccharide deepsane. Biological activities have been screened and some protective properties have been established. Deepsane is commercially available in cosmetics under the name of Abyssine (R) for soothing and reducing irritation of sensitive skin against chemical, mechanical and UVB aggression. This study presents structural data for this original and complex bacterial exopolysaccharide and highlights some structural similarities with other known EPS produced by marine Alteromonas strains. Highlights ► Structural data of a complex bacterial exopolysaccharide of deep-sea origin are presented. ► This exopolysaccharide, named deepsane, is commercialised in cosmetics. ► Structural similarities with other exopolysaccharide-producing marine Alteromonas strains are reported.

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    Carbohydrate Polymers
    Article . 2012 . Peer-reviewed
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      Carbohydrate Polymers
      Article . 2012 . Peer-reviewed
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    Authors: Florian Lelchat; Stéphane Cérantola; Christophe Brandily; Sylvia Colliec-Jouault; +3 Authors

    We have studied the exopolysaccharide produced by Cobetia marina DSMZ 4741, a marine bacterium isolated from coastal seawater. This strain is able to produce a polysaccharide in presence of carbon sources as glucose, mannitol and alginate. The maximum production occurs in aerobic condition, during the end of the exponential phase. The polymer is a non-viscous, acidic heteropolysaccharide of 270 kDa constituted of a repeating unit of: -> 2)-beta-D-Ribf-(1 -> 4)-[7,8-O-(Pyr)]-alpha-D-KDOp-(2 -> This kind of chemical structure is generally related to K-antigen polysaccharide of pathogenic Escherichla coli strains. This is the first time this type of EPS is described from a marine bacterium. Moreover the polysaccharide exhibits a pyruvate substitution on its 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) residue never encountered before. The discovery of such an unexpected EPS with high biotechnological potential is a new incentive for a better exploration of bioactive marine resources. (c) 2015 Elsevier Ltd. All rights reserved. International audience

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    Carbohydrate Polymers
    Article . 2015 . Peer-reviewed
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    Article . 2015
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      Carbohydrate Polymers
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    Authors: C. Rigouin; C. Delbarre Ladrat; Corinne Sinquin; Sylvia Colliec-Jouault; +1 Authors

    To find biocatalyst allowing depolymerization of new polysaccharides, one needs to get a sensitive and well adapted method to a screening program. This led us to compare biochemical methods of detection of the depolymerization. Currently used methods such as reducing sugars assays, double bond monitoring or molecular weight determination were tested to follow the kinetic of depolymerization with different enzyme / polysaccharide couples. The range of concentrations of assorted enzymes allowed us to identify the most sensitive and appropriate method to detect polysaccharide degradation. Reducing sugars assays are quantitative, sensitive and almost usable with all kind of polysaccharide but some compounds may interfere with them. When polysaccharide is bearing charges, agarose gel electrophoresis, although being a qualitative assay is as sensitive as high performance size exclusion chromatography analysis, easy to handle, quite high-throughput and thus preferred.

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    Carbohydrate Polymers
    Article . 2009 . Peer-reviewed
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    Article . 2009
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      Carbohydrate Polymers
      Article . 2009 . Peer-reviewed
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    Authors: Gélébart, Perrine; Cuenot, Stéphane; Sinquin, Corinne; Halgand, Boris; +5 Authors

    International audience; Bone Morphogenetic Protein (BMP-2) is an osteoinductive growth factor clinically used for bone regeneration. Tuneable sustained strategies for BMP-2 delivery are intensely developed to avoid severe complications related to supraphysiological doses applied. To address this issue, we investigated the ability of the bacterial exopolysaccharide (EPS) called Infernan produced by the deep-sea hydrothermal vent bacterium Alteromonas infernus, exhibiting both glycosaminoglycan-mimetic and physical gelling properties, to efficiently bind and release the bioactive BMP-2. Two delivery systems were designed based on BMP-2 retention in either single or complex EPSbased microgels, both manufactured using a microfluidic approach. BMP-2 release kinetics were highly influenced by the ionic strength, affecting both microgel stability and growth factor/EPS binding, appearing essential for BMP-2 bioactivity. The osteogenic activity of human bone-marrow derived mesenchymal stem cells studied in vitro emphasized that Infernan microgels constitute a promising platform for BMP-2 delivery for further in vivo bone repair.

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    Carbohydrate Polymers
    Article . 2022 . Peer-reviewed
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    Authors: Mousumi Sukul; Priyanka Sahariah; Hélène L. Lauzon; João Borges; +4 Authors

    We have studied the effect of chitosan sponges, produced from chitosan batches with distinct degree of deacetylation (DDA) and molecular weight (Mw), on the adhesion, growth and differentiation of primary human osteoblasts with an aim to offer a suitable tool for guided bone regeneration. All the chitosan sponges revealed similar microstructure, irrespective of the DDA (58, 73, 82, 88, and 91 %) and Mw (749, 547, 263, 215, and 170 kDa, respectively). Cell spreading was higher on sponges having a higher DDA. Higher DDA induced a more pronounced increase in alkaline phosphatase activity, osteopontin (OPN), vascular endothelial growth factor-A (VEGF), interleukin-6 (IL-6), and reduction in monocyte chemoattractant protein-1 (MCP-1), sclerostin (SOST) and dickkopf related protein-1 as compared to lower DDA. Lower DDA induced the increased secretion of osteoprotegerin and SOST as compared to higher DDA. The combination of higher DDA and Mw induced an increased secretion of VEGF and IL-6, however reduced the secretion of OPN as compared to chitosan with similar DDA but with lower Mw. In summary, the variations in cellular responses to the different chitosan sponges indicate a potential for individual tailoring of desired responses in guided bone regeneration. published

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    Authors: Veraldi, Noemi; Quadri, Isabelle Dentand; van de Looij, Yohan; Modernell, Laura Malaguti; +12 Authors

    Mucopolysaccharidosis IIIA is a hereditary disease caused by mutations in the sulfamidase enzyme that participates in catabolism of heparan sulfate (HS), leading to HS fragment accumulation and multisystemic failure. No cure exists and death occurs around the second decade of life. Two low molecular weight highly sulfated compounds derived from marine diabolican and infernan exopolysaccharides (A5_3 and A5_4, respectively) with heparanase inhibiting properties were tested in a MPSIIIA cell line model, resulting in limited degradation of intracellular HS. Next, we observed the effects of intraperitoneal injections of the diabolican derivative A5_3 from 4 to 12 weeks of age on MPSIIIA mice. Brain metabolism and microstructure, levels of proteins and genes involved in MPSIIIA brain pathophysiology were also investigated. 1H-Magnetic Resonance Spectroscopy (MRS) indicated deficits in energetic metabolism, tissue integrity and neurotransmission at both 4 and 12 weeks in MPSIIIA mice, with partial protective effects of A5_3. Ex-vivo Diffusion Tensor Imaging (DTI) showed white matter microstructural damage in MPSIIIA, with noticeable protective effects of A5_3. Protein and gene expression assessments displayed both pro-inflammatory and pro-apoptotic profiles in MPSIIIA mice, with benefits of A5_3 counteracting neuroinflammation. Overall, derivative A5_3 was well tolerated and was shown to be efficient in preventing brain metabolism failure and inflammation, resulting in preserved brain microstructure in the context of MPSIIIA. International audience

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    Carbohydrate Polymers
    Article . 2023 . Peer-reviewed
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    Authors: Zykwinska, Agata; Makshakova, Olga; Gélébart, Perrine; Sinquin, Corinne; +4 Authors

    International audience; With the increasing need for hydrogels with tunable properties for specific biomedical applications, a complete understanding of the structure-function relationship of polymers used for hydrogel development remains crucial for their optimal use. In the present study, by combining experimental and theoretical approaches, the structurefunction relationship of a bacterial exopolysaccharide, infernan, displaying both glycosaminoglycan-mimetic and gelling properties, was investigated at molecular and microscopic levels. Atomic force microscopy (AFM) experiments and molecular dynamics simulations were applied to determine the persistence length of individual infernan chains before studying their association induced by calcium. Infernan-based microgels were then produced using microfluidics and their mechanical properties were characterized by AFM methods. The mechanical properties of EPS/calcium microgels were finely tuned by varying the crosslinking density of their network, either by calcium or EPS concentrations. The obtained set of viscoelastic microgels with different elastic modulus values opens several possibilities for their applications in tissue engineering.

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    Carbohydrate Polymers
    Article . 2022 . Peer-reviewed
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      Carbohydrate Polymers
      Article . 2022 . Peer-reviewed
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    Authors: Leire Iturriaga; Idoia Olabarrieta; Alain Castellan; Christian Gardrat; +1 Authors

    Bioactive citrus extract-chitosan films were prepared through solvent casting-evaporation method. The impact of near UV irradiation was studied to reach a better understanding of the film behavior. The antimicrobial activity of films against Listeria innocua was maintained after UV irradiation. To study the interaction between chitosan and citrus extract components, naringin (main component) was selected as the model compound. UV treatment caused modifications of the flavanone regardless of the solvent used for its dissolution, depending on the concentration of naringin in the film: the greater the concentration the lower the modification. DSC results suggested cross-links due to UV irradiation and interactions between naringin and chitosan. This was confirmed by a decrease in the naringin release from the irradiated samples. Naringin- and citrus extract-chitosan films showed an increased absorbance in the UV region compared to pure chitosan films, showing potentiality for decreasing the lipid oxidation induced by UV light in foodstuffs. (C) 2014 Elsevier Ltd. All rights reserved. This work has been performed within an Aquitaine-Basque Country Cooperation project. This paper is contribution nr. 656 from AZTI-Tecnalia (Marine or Food Research). L. Iturriaga acknowledges the Department of Agriculture, Fisheries and Food of the Basque Government for the fellowship. A. Lafaille is also gratefully acknowledged for the antimicrobial tests.

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    Oskar Bordeaux
    Article . 2014
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    Carbohydrate Polymers
    Article . 2014 . Peer-reviewed
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    Article . 2014
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      Oskar Bordeaux
      Article . 2014
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      Carbohydrate Polymers
      Article . 2014 . Peer-reviewed
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      Article . 2014
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    Authors: Zykwinska, Agata; Tripon-Le Berre, Ludivine; Sinquin, Corinne; Ropartz, David; +3 Authors

    International audience; Polysaccharides have attracted much attention due to their interesting physico-chemical and also biological properties that are explored in food, cosmetic and pharmaceutical industries. GY785 exopolysaccharide (EPS) presenting an unusual structure is secreted by the deep-sea hydrothermal bacterium, Alteromonas infernus. Low-molecular weight (LMW) derivatives obtained by chemical depolymerization of the native high molecular weight (HMW) EPS were previously shown to exhibit biological properties similar to glycosaminoglycans (GAG). In the present study, in order to generate well defined derivatives with a better control of the depolymerization, an enzymatic approach was applied for the first time. Various commercially available enzymes were firstly screened for their depolymerizing activities, however none of them was able to degrade the polysaccharide. Enzymatic assays performed with A. infernus protein extracts have shown that the bacterium produces by itself endogenous enzymes able to depolymerize its own EPS. The oligosaccharides released by the enzymes were analyzed and their structures allowed to assess that the protein extract contains several depolymerizing activities.

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    Carbohydrate Polymers
    Article . 2018 . Peer-reviewed
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      Carbohydrate Polymers
      Article . 2018 . Peer-reviewed
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    Authors: Olga, Makshakova; Agata, Zykwinska; Stephane, Cuenot; Sylvia, Colliec-Jouault; +1 Authors

    International audience; The exopolysaccharide Infernan, from the bacterial strain GY785, has a complex repeating unit of nine monosaccharides established on a double-layer of sidechains. A cluster of uronic and sulfated monosaccharides confers to Infernan functional and biological activities. We characterized the 3-dimensional structures and dynamics along Molecular Dynamics trajectories and clustered the conformations in extended two-fold and five-fold helical structures. The electrostatic potential distribution over all the structures revealed negatively charged cavities explored for Ca2+ binding through quantum chemistry computation. The transposition of the model of Ca(2+)complexation indicates that the five-fold helices are the most favourable for interactions. The ribbon-like shape of two-fold helices brings neighbouring chains in proximity without steric clashes. The cavity chelating the Ca2+ of one chain is completed throughout the interaction of a sulfate group from the neighbouring chain. The resulting is a 'junction zone' based on unique chain-chain interactions governed by a heterotypic binding mode.

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    Carbohydrate Polymers
    Article . 2022 . Peer-reviewed
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    Article . 2022
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      Carbohydrate Polymers
      Article . 2022 . Peer-reviewed
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    Authors: T, Le Costaouëc; S, Cérantola; D, Ropartz; J, Ratiskol; +3 Authors

    Some marine bacteria collected around deep-sea hydrothermal vents are able to produce, in laboratory conditions, complex and innovative exopolysaccharides. In a previous study, the mesophilic strain Alteromonas macleodii subsp. fijiensis biovar deepsane was collected on the East Pacific Rise at 2600m depth. It was isolated from a polychaete annelid Alvinella pompejana and is able to synthesise and excrete the exopolysaccharide deepsane. Biological activities have been screened and some protective properties have been established. Deepsane is commercially available in cosmetics under the name of Abyssine (R) for soothing and reducing irritation of sensitive skin against chemical, mechanical and UVB aggression. This study presents structural data for this original and complex bacterial exopolysaccharide and highlights some structural similarities with other known EPS produced by marine Alteromonas strains. Highlights ► Structural data of a complex bacterial exopolysaccharide of deep-sea origin are presented. ► This exopolysaccharide, named deepsane, is commercialised in cosmetics. ► Structural similarities with other exopolysaccharide-producing marine Alteromonas strains are reported.

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    Carbohydrate Polymers
    Article . 2012 . Peer-reviewed
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      Carbohydrate Polymers
      Article . 2012 . Peer-reviewed
      License: Elsevier TDM
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    Authors: Florian Lelchat; Stéphane Cérantola; Christophe Brandily; Sylvia Colliec-Jouault; +3 Authors

    We have studied the exopolysaccharide produced by Cobetia marina DSMZ 4741, a marine bacterium isolated from coastal seawater. This strain is able to produce a polysaccharide in presence of carbon sources as glucose, mannitol and alginate. The maximum production occurs in aerobic condition, during the end of the exponential phase. The polymer is a non-viscous, acidic heteropolysaccharide of 270 kDa constituted of a repeating unit of: -> 2)-beta-D-Ribf-(1 -> 4)-[7,8-O-(Pyr)]-alpha-D-KDOp-(2 -> This kind of chemical structure is generally related to K-antigen polysaccharide of pathogenic Escherichla coli strains. This is the first time this type of EPS is described from a marine bacterium. Moreover the polysaccharide exhibits a pyruvate substitution on its 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) residue never encountered before. The discovery of such an unexpected EPS with high biotechnological potential is a new incentive for a better exploration of bioactive marine resources. (c) 2015 Elsevier Ltd. All rights reserved. International audience

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    Carbohydrate Polymers
    Article . 2015 . Peer-reviewed
    License: Elsevier TDM
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    Hal-Diderot
    Article . 2015
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      Carbohydrate Polymers
      Article . 2015 . Peer-reviewed
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      Article . 2015
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    Authors: C. Rigouin; C. Delbarre Ladrat; Corinne Sinquin; Sylvia Colliec-Jouault; +1 Authors

    To find biocatalyst allowing depolymerization of new polysaccharides, one needs to get a sensitive and well adapted method to a screening program. This led us to compare biochemical methods of detection of the depolymerization. Currently used methods such as reducing sugars assays, double bond monitoring or molecular weight determination were tested to follow the kinetic of depolymerization with different enzyme / polysaccharide couples. The range of concentrations of assorted enzymes allowed us to identify the most sensitive and appropriate method to detect polysaccharide degradation. Reducing sugars assays are quantitative, sensitive and almost usable with all kind of polysaccharide but some compounds may interfere with them. When polysaccharide is bearing charges, agarose gel electrophoresis, although being a qualitative assay is as sensitive as high performance size exclusion chromatography analysis, easy to handle, quite high-throughput and thus preferred.

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    Carbohydrate Polymers
    Article . 2009 . Peer-reviewed
    License: Elsevier TDM
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    Hal-Diderot
    Article . 2009
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Carbohydrate Polymers
      Article . 2009 . Peer-reviewed
      License: Elsevier TDM
      Data sources: Crossref
      Hal-Diderot
      Article . 2009
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    Authors: Gélébart, Perrine; Cuenot, Stéphane; Sinquin, Corinne; Halgand, Boris; +5 Authors

    International audience; Bone Morphogenetic Protein (BMP-2) is an osteoinductive growth factor clinically used for bone regeneration. Tuneable sustained strategies for BMP-2 delivery are intensely developed to avoid severe complications related to supraphysiological doses applied. To address this issue, we investigated the ability of the bacterial exopolysaccharide (EPS) called Infernan produced by the deep-sea hydrothermal vent bacterium Alteromonas infernus, exhibiting both glycosaminoglycan-mimetic and physical gelling properties, to efficiently bind and release the bioactive BMP-2. Two delivery systems were designed based on BMP-2 retention in either single or complex EPSbased microgels, both manufactured using a microfluidic approach. BMP-2 release kinetics were highly influenced by the ionic strength, affecting both microgel stability and growth factor/EPS binding, appearing essential for BMP-2 bioactivity. The osteogenic activity of human bone-marrow derived mesenchymal stem cells studied in vitro emphasized that Infernan microgels constitute a promising platform for BMP-2 delivery for further in vivo bone repair.

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    Carbohydrate Polymers
    Article . 2022 . Peer-reviewed
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Carbohydrate Polymers
      Article . 2022 . Peer-reviewed
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