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19 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Nicolas, Aude; Kenna, Kevin P.; Renton, Alan E.; Ticozzi, Nicola; Faghri, Faraz; Chia, Ruth; Dominov, Janice A.; Kenna, Brendan J.; Nalls, Mike A.; Keagle, Pamela; ...
    Publisher: Cell Press
    Countries: United Kingdom, Italy, Netherlands, Belgium, France, United Kingdom, United States, Finland, United Kingdom, United Kingdom ...
    Project: EC | EURO-MOTOR (259867), WT , NIH | Clinical Research in ALS ... (3U54NS092091-04S1), NHMRC | Developing insight into t... (1095215), NIH | Neuron and Glial Cellular... (3U54NS091046-03S2), NHMRC | The role of mutant cyclin... (1107644), NIH | HISPANIC SECONDARY STROKE... (1R01MD009164-01), NIH | Pathobiology of Neurodege... (3P01NS084974-02S1), NIH | CORE--EDUCATION AND INFOR... (5P30AG013846-15), EC | MODIFALS (340429),...

    © 2018 Elsevier Inc. To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Kudipudi, Pradeep K; Galuska, Sebastian P; Dietze, Raimund; Scheiner-Bobis, Georgios; Loveland, Kate L; Konrad, Lutz;
    Persistent Identifiers
    Publisher: MDPI
    Project: NHMRC | Activin Control of the Ma... (1081987), NHMRC | Developmental Switches in... (1079646)

    signaling. Treatment of Sertoli cells with GM6001, a matrix metalloproteinases (MMP) inhibitor, also counteracted BG shedding, thus suggesting MMPs to be mainly involved in shedding. Interestingly, TGF-&beta

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  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Helmstetter C; Flossdorf M; Peine M; Kupz A; Zhu J; Ahmed N. Hegazy; Ma, Duque-Correa; Zhang Q; Vainshtein Y; Radbruch A; ...
    Persistent Identifiers
    Publisher: Elsevier Inc.
    Project: EC | GUT TC PHENOTYPES (330621), NHMRC | Targeting inflammasome ac... (1052764)

    SummaryThe probabilistic expression of cytokine genes in differentiated T helper (Th) cell populations remains ill defined. By single-cell analyses and mathematical modeling, we show that one stimulation featured stable cytokine nonproducers as well as stable producers ...

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  • publication . Article . Preprint . 2018
    Open Access English
    Authors:
    Haowei Jiang; Morgan Newman; Michael Lardelli;
    Publisher: Public Library of Science
    Project: NHMRC | Identifying early molecul... (1126422), NHMRC | Defining the changes in c... (1061006)

    AbstractAlzheimer’s disease is the most common form of age-related dementia. At least 15 mutations in the human gene PRESENILIN 2 (PSEN2) have been found to cause familial Alzheimer’s disease (fAD). Zebrafish possess an orthologous gene, psen2, and present opportunities...

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  • publication . Article . 2012
    Open Access
    Authors:
    Damien S. Hunter; Ravinder Anand-Ivell; Sandra Danner; Richard Ivell;
    Persistent Identifiers
    Publisher: Informa UK Limited
    Country: Germany
    Project: NHMRC | Novel analogues of human ... (1009243)

    Understanding the mechanisms that lead to the differentiation of male germ cells from their spermatogonial stem cells through meiosis to give rise to mature haploid spermatozoa has been a major quest for many decades. Unlike most other cell types this differentiation pr...

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  • publication . Article . 2018
    Open Access English
    Authors:
    McCoy, Patrick J.; Costello, Anthony J.; Corcoran, Niall M.; Hovens, Christopher M.; Clarkson, Michael J.;
    Persistent Identifiers
    Publisher: Elsevier
    Project: NHMRC | Determining the origin of... (1047581), NHMRC | Tracking the origins and ... (1104010)

    DNA-fluorescence in situ hybridisation (DNA-FISH) allows visualisation of chromosome organisation and rearrangement. FISH probes are pools of short fluorescently labelled DNA fragments that are often produced from template plasmids that contain large genomic inserts. Fo...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Tapsell, Linda C; Batterham, Marijka J; Charlton, Karen E; Neale, Elizabeth P; Probst, Yasmine C; O’Shea, Jane E; Thorne, Rebecca L; Zhang, Qingsheng; Louie, Jimmy Chun Yu;
    Persistent Identifiers
    Publisher: BioMed Central
    Project: NHMRC | Is a higher intake of ome... (514631)

    There is some evidence in the literature that emphasising fish consumption may assist with weight loss. The aim was to assess the effects of advice to consume 2 fish meals per week in a weight loss diet. A parallel randomised placebo-controlled trial was conducted in 11...

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  • publication . Article . 2018
    Open Access
    Authors:
    Bonnin, Edith; Cabochette, Pauline; Filosa, Alessandro; Jühlen, Ramona; Komatsuzaki, Shoko; Hezwani, Mohammed; Dickmanns, Achim; Martinelli, Valérie; Vermeersch, Marjorie; Supply, Lynn; ...
    Publisher: Public Library of Science (PLoS)
    Countries: Belgium, Germany
    Project: NHMRC | Identifying disease genes... (1080587), NHMRC | Gene discovery and pathob... (1122952)

    Nucleoporins build the nuclear pore complex (NPC), which, as sole gate for nuclear-cytoplasmic exchange, is of outmost importance for normal cell function. Defects in the process of nucleocytoplasmic transport or in its machinery have been frequently described in human ...

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  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Fitzmaurice,; Undurraga,; Schutte,; Bhala,; Kopec,; Khan,; Leigh,; Latif,; Fowkes,; Huang,; ...
    Countries: Colombia, Italy, Spain, United Kingdom, Denmark, United Kingdom, United Kingdom, United Kingdom, United Kingdom, Turkey ...
    Project: EC | SHARE-PREP (211909), EC | SHARE_LEAP (227822), WT , WT | Defining the population a... (095066), SNSF | Morbidity and cost of hel... (P300P3_154634), NHMRC | Prevention of stroke and ... (GNT1042600), EC | SHARE_M4 (261982), FCT | SFRH/BPD/92934/2013 (SFRH/BPD/92934/2013), NHMRC | Prevention of stroke and ... (1042600)

    Source: doi: 10.1016/S0140-6736(16)31460-X Background: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system perf...

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  • publication . Article . 2019
    Open Access
    Authors:
    Pazhakh, Vahid; Ellett, Felix; Croker, Ben A.; O’Donnell, Joanne A.; Pase, Luke; Schulze, Keith E.; Greulich, R. Stefan; Gupta, Aakash; Reyes-Aldasoro, Constantino Carlos; Andrianopoulos, Alex; ...
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Country: United Kingdom
    Project: NHMRC | Cellular and molecular me... (1069284), NIH | project 1 (5P30NS047101-07), NIH | Bio-MicroElectroMechanica... (5P41EB002503-10), NHMRC | Finding therapeutic targe... (637394), NIH | Defining the roles of RIP... (5R01HL124209-04), NHMRC | Modelling haematopoietic ... (1044754), NHMRC | Uncoupled Research Fellow... (461208), NHMRC | Pathogen sensing in autoi... (637367)

    The initial host response to fungal pathogen invasion is critical to infection establishment and outcome. However, the diversity of leukocyte–pathogen interactions is only recently being appreciated. We describe a new form of interleukocyte conidial exchange called “shu...

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19 research outcomes, page 1 of 2