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392 research outcomes, page 1 of 40
  • publication . Article . 2013
    Open Access
    Authors:
    Ansari, Morad; Mckeigue, Paul M.; Skerka, Christine; Hayward, Caroline; Rudan, Igor; Vitart, Veronique; Polasek, Ozren; Armbrecht, Ana-Maria; Yates, John R. W.; Vatavuk, Zoran; ...
    Countries: United Kingdom, Netherlands
    Project: MZOS | The population structure ... (196-1962766-2751), WT

    It is a longstanding puzzle why non-coding variants in the complement factor H (CFH) gene are more strongly associated with age-related macular degeneration (AMD) than functional coding variants that directly influence the alternative complement pathway. The situation i...

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  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Monika Mendelova; Andrew S. Hein; Robert McCulloch; Bethan J. Davies;
    Countries: United Kingdom, France

    This paper reviews published geochronological data on glacier fluctuations and environmental changes in central Patagonia (44° S - 49° S) from the Last Glacial Maximum (LGM) through to the Holocene. Well-dated glacial chronologies from the southern mid-latitudes can inf...

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  • publication . Article . 2021
    Open Access
    Authors:
    Hemant Bengani; Detelina Grozeva; Lambert Moyon; Shipra Bhatia; Susana R. Louros; Jilly Hope; Adam Jackson; James Prendergast; Liusaidh J Owen; Magali Naville; ...
    Publisher: Public Library of Science (PLoS)
    Countries: France, United Kingdom

    Identifying causative variants in cis-regulatory elements (CRE) in neurodevelopmental disorders has proven challenging. We have used in vivo functional analyses to categorize rigorously filtered CRE variants in a clinical cohort that is plausibly enriched for causative ...

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  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Edelman, Nathaniel,; Frandsen, Paul,; Miyagi, Michael; Clavijo, Bernardo; Davey, John; Dikow, Rebecca,; García-Accinelli, Gonzalo; Van Belleghem, Steven,; Patterson, Nick; Neafsey, Daniel,; ...
    Publisher: bioRxiv
    Countries: France, United Kingdom, Colombia, United Kingdom
    Project: NIH | Large Scale Sequencing an... (3U54HG003067-07S1), NSF | RII Track-2 FEC: Genomic ... (1736026), NIH | Whole-genome shotgun sequ... (2R01HG003474-06A1), UKRI | BBR GenomeHubs - agile ge... (BB/R015325/1), NIH | Project 1: Modeling tumor... (1U54CA193313-01), EC | FITINV (655857), NSERC , UKRI | Building a genome analyti... (BB/K020161/1), NIH | Characterizing the Molecu... (5R01GM108626-03), ANR | HybEvol (ANR-12-JSV7-0005),...

    We here pioneer a low-cost assembly strategy for 20 Heliconiini genomes to characterize the evolutionary history of the rapidly radiating genus Heliconius. A bifurcating tree provides a poor fit to the data, and we therefore explore a reticulate phylogeny for Heliconius...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Matthew Dumont; Laetitia Pichevin; Walter Geibert; Xavier Crosta; Elisabeth Michel; Steven Grahame Moreton; Keira Dobby; Raja S. Ganeshram;
    Publisher: HAL CCSD
    Countries: France, France, Germany, France, France, United Kingdom

    Changes in ocean circulation and the biological carbon pump have been implicated as the drivers behind the rise in atmospheric CO2 across the last deglaciation; however, the processes involved remain uncertain. Previous records have hinted at a partitioning of deep ocea...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Grelet, C.; Vanlierde, A.; Hostens, M.; Foldager, L.; Salavati, M.; Ingvartsen, K. L.; Crowe, M.; Sorensen, M. T.; Froidmont, E.; Ferris, C. P.; ...
    Countries: Belgium, United Kingdom, Ireland
    Project: EC | GPLUSE (613689)

    Unbalanced metabolic status in the weeks after calving predisposes dairy cows to metabolic and infectious diseases. Blood glucose, IGF-I, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB) are used as indicators of the metabolic status of cows. This work aims...

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  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Macqueen, Daniel J.; Primmer, Craig R.; Houston, Ross D.; Nowak, Barbara F.; Bernatchez, Louis; Bergseth, Steinar; Davidson, William S.; Gallardo-Escárate, Cristian; Goldammer, Tom; Guiguen, Yann; ...
    Countries: Norway, Ireland, France, Chile, United Kingdom, Norway, Norway
    Project: UKRI | Canada: Functional annota... (BB/P02582X/1)

    We describe an emerging initiative - the ‘Functional Annotation of All Salmonid Genomes’ (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ancestor, to develop an integrative understanding ...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Spampinato, Concetto; Palazzo, Simone; Boom, Bastian; van Ossenbruggen, Jacco; Kavasidis, Isaak; Di Salvo, Roberto; Lin, Fang-Pang; Giordano, Daniela; Hardman, Lynda; Fisher, Robert B;
    Countries: Netherlands, United Kingdom
    Project: EC | FISH4KNOWLEDGE (257024)

    The study of fish populations in their own natural environment is a task that has usually been tackled in invasive ways which inevitably influenced the behavior of the fish under observation. Recent projects involving the installation of permanent underwater cameras (e....

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  • publication . Article . 2020
    Open Access English
    Authors:
    Louise van der Weyden; Thomas Brenn; E. Elizabeth Patton; Geoffrey A. Wood; David J. Adams;
    Country: United Kingdom
    Project: EC | ZF-MEL-CHEMBIO (648489)

    Abstract In contrast to other cancer types, melanoma incidence has been increasing over the last 50 years, and while it still represents less than 5% of all cutaneous malignancies, melanoma accounts for the majority of skin cancer deaths, due to its propensity to metast...

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  • publication . Article . 2017
    Open Access English
    Authors:
    De Clippele, Laurence H; Gafeira, J; Robert, K; Hennige, S; Lavaleye, MS; Duineveld, GCA; Huvenne, VAI; Roberts, JM;
    Countries: Netherlands, United Kingdom, Netherlands
    Project: EC | ATLAS (678760), UKRI | Impacts of ocean acidific... (NE/H017305/1), UKRI | Coral pH regulation and c... (NE/K009028/1), EC | CODEMAP (258482)

    Cold-water corals form substantial biogenic habitats on continental shelves and in deep-sea areas with topographic highs, such as banks and seamounts. In the Atlantic, many reef and mound complexes are engineered by Lophelia pertusa, the dominant framework-forming coral...

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392 research outcomes, page 1 of 40