Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase 3 random...

The aim of this study is to explore three techniques for unsupervised classification of airborne hyperspectral imagery of intertidal flats. The unsupervised classification techniques considered are k-means (hard clustering), the Gustafson-Kessel algorithm (Fuzzy cluster...

A method to determine the optimal transmission system topology for multiple offshore wind farms is introduced using a rule-based generic algorithm. The methodology is implemented as a software tool determining the best economical and technically feasible offshore transm...

Microsatellite flanking regions are often highly conserved in fish taxa, enabling their application in other species within or outside the source family. Moderately variable microsatellite markers may also be good candidates for species identification using multi-locus ...

Centimetre-scale saturated hydraulic conductivities (K) are derived from air permeability measurements on a selection of outcrops of the Neogene aquifer in the Campine area, Belgium. Outcrop sediments are of Miocene to Quaternary age and have a marine to continental ori...

Rhomboid proteases form one of the most widespread families of intramembrane proteases. They utilize a catalytic serine-histidine dyad located several Å below the surface of the membrane for substrate hydrolysis. Multiple studies have implicated rhomboid proteases in bi...

The origin of carbon substrates used by in situ sedimentary bacterial communities was investigated in an intertidal mangrove ecosystem and in adjacent seagrass beds in Gazi bay (Kenya) by δ13C analysis of bacteria-specific PLFA (phospholipid fatty acids) and bulk ...

An increasing variety of stresses and shocks provides challenges and opportunities for EU farming systems. This article presents findings of a participatory assessment on the sustainability and resilience of eleven EU farming systems, to inform the design of adequate an...

Cloud computing offers easy and economical access to computational capacity at a scale that had previously been available to only the largest research institutions. To take advantage, large biological datasets are increasingly analyzed on various cloud computing platfor...

ABSTRACT The pathogenic fungus Aspergillus fumigatus is able to adapt to extremely variable environmental conditions. The A. fumigatus genome contains four genes coding for mitogen-activated protein kinases (MAPKs), which are important regulatory knots involved in diver...