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European Marine Science Marine Drugs

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European Marine Science Marine Drugs

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478 research outcomes, page 1 of 48
  • publication . Article . 2014
    Open Access English
    Authors:
    Miguel C. Leal; Christopher Sheridan; Ronald Osinga; Gisela Dionísio; Rui J. M. Rocha; Bruna Silva; Rui Rosa; Ricardo Calado;
    Persistent Identifiers
    Countries: Netherlands, Portugal
    Project: FCT | SFRH/BD/63783/2009 (SFRH/BD/63783/2009), EC | SPECIAL (266033), FCT | PEst-C/MAR/LA0017/2013 (PEst-C/MAR/LA0017/2013)

    The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the. blue gold. in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past ...

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  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Chunyan Yang; Qianrong Li; Yong Li;
    Persistent Identifiers
    Publisher: MDPI AG
    Country: France

    Nuclear receptors (NRs) are important pharmaceutical targets because they are key regulators of many metabolic and inflammatory diseases, including diabetes, dyslipidemia, cirrhosis, and fibrosis. As ligands play a pivotal role in modulating nuclear receptor activity, t...

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  • publication . Article . 2013
    Open Access
    Authors:
    Phelan, Robert; Barret, Matthieu; Cotter, Paul; O'Connor, Paula; Chen, Rui; Morrissey, John; Dobson, Alan; O'Gara, Fergal; Barbosa, Teresa;
    Persistent Identifiers
    Publisher: MDPI AG
    Country: France
    Project: SFI | Functional Genomics of a ... (08/RFP/GEN1295), EC | PHARMASEA (312184), EC | MACUMBA (311975), SFI | Systems analysis of modul... (08/RFP/GEN1319), EC | MICRO B3 (287589)

    This research was supported in parts by grants awarded to FOG by the Science Foundation of Ireland (08/RFP/GEN1295, 08/RFP/GEN1319, SFI09/RFP/BMT2350); the Department of Agriculture, Fisheries and Food (RSF grants 06-321 and 06-377; FIRM grants 06RDC459 06RDC506 and 08R...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Sandra Lage; Heléne Annadotter; Ulla Rasmussen; Sara Rydberg;
    Persistent Identifiers
    Publisher: Multidisciplinary Digital Publishing Institute

    β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and repres...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Laura Núñez-Pons; Andrew J Shilling; Cinzia Verde; Bill J. Baker; Daniela Giordano;
    Persistent Identifiers
    Publisher: MDPI

    Polar marine biota have adapted to thrive under one of the ocean’s most inhospitable scenarios, where extremes of temperature, light photoperiod and ice disturbance, along with ecological interactions, have selected species with a unique suite of secondary metabolites. ...

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  • publication . Article . 2010
    Open Access
    Authors:
    Heidrun Moll; Ute Hentschel; Chris M. Ireland; Tim S. Bugni; Svitlana Kozytska; Sheila Marie Pimentel-Elardo;
    Persistent Identifiers
    Publisher: MDPI AG
    Country: Germany

    Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean spong...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Marisa Silva; Aldo Barreiro; Paula Rodríguez; Paz Otero; Joana Azevedo; Amparo Alfonso; Luis M. Botana; Vitor Vasconcelos;
    Publisher: MDPI
    Countries: Spain, Portugal
    Project: EC | BLUEandGREEN (692419), FCT | SFRH/BD/73269/2010 (SFRH/BD/73269/2010)

    The prevalence of poisoning events due to harmful algal blooms (HABs) has declined during the last two decades through monitoring programs and legislation, implemented mainly for bivalves. However, new toxin vectors and emergent toxins pose a challenge to public health....

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  • publication . Article . 2021
    Open Access English
    Authors:
    Alejandro Moreiras-Figueruelo; Genoveffa Nuzzo; Christian Galasso; Clementina Sansone; Fabio Crocetta; Valerio Mazzella; Carmela Gallo; Giusi Barra; Angela Sardo; Antonella Iuliano; ...
    Persistent Identifiers
    Publisher: Multidisciplinary Digital Publishing Institute
    Country: Norway

    The marine environment is potentially a prolific source of small molecules with significant biological activities. In recent years, the development of new chromatographic phases and the progress in cell and molecular techniques have facilitated the search for marine nat...

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  • publication . Article . 2011
    Open Access English
    Authors:
    Toshiaki J. Hara;
    Persistent Identifiers
    Publisher: Molecular Diversity Preservation International

    Fish detect extremely low levels of marine toxins tetrodotoxin (TTX) and saxitoxin (STX) via the specialized gustatory receptor(s). Physiological and pharmacological studies show that receptor(s) for TTX and STX are distinct from those which detect feeding stimulant ami...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Bin Wu; Vanessa Oesker; Jutta Wiese; Rolf Schmaljohann; Johannes F. Imhoff;
    Persistent Identifiers
    Publisher: Multidisciplinary Digital Publishing Institute
    Country: Germany

    Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new co...

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478 research outcomes, page 1 of 48