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description Publicationkeyboard_double_arrow_right Article 2014 Germany, France, France, FrancePublisher:The Royal Society Funded by:EC | BIOSTRUCT-XEC| BIOSTRUCT-XTim Schulte; Jonas Lofling; Cecilia Mikaelsson; Alexey Kikhney; Karina Hentrich; Aurora Diamante; Christine Ebel; Staffan Normark; Dmitri I. Svergun; Birgitta Henriques-Normark; Adnane Achour;Streptococcus pneumoniae is a major human pathogen, and a leading cause of disease and death worldwide. Pneumococcal invasive disease is triggered by initial asymptomatic colonization of the human upper respiratory tract. The pneumococcal serine-rich repeat protein (PsrP) is a lung-specific virulence factor whose functional binding region (BR) binds to keratin-10 (KRT10) and promotes pneumococcal biofilm formation through self-oligomerization. We present the crystal structure of the KRT10-binding domain of PsrP (BR187-385) determined to 2.0 Å resolution. BR187-385 adopts a novel variant of the DEv-IgG fold, typical for microbial surface components recognizing adhesive matrix molecules adhesins, despite very low sequence identity. An extended β-sheet on one side of the compressed, two-sided barrel presents a basic groove that possibly binds to the acidic helical rod domain of KRT10. Our study also demonstrates the importance of the other side of the barrel, formed by extensive well-ordered loops and stabilized by short β-strands, for interaction with KRT10. International audience
Open Biology arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC3909270Data sources: PubMed CentralOpen BiologyOther literature type . Article . 2014 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityHyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; Hal-DiderotOther literature type . Article . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rsob.130090&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 27 citations 27 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Open Biology arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC3909270Data sources: PubMed CentralOpen BiologyOther literature type . Article . 2014 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityHyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; Hal-DiderotOther literature type . Article . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rsob.130090&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Belgium, Denmark, GermanyPublisher:American Chemical Society (ACS) Funded by:EC | iNEXT, EC | EI3PODEC| iNEXT ,EC| EI3PODYonca Ural-Blimke; Ali Flayhan; Jan Strauss; Vasileios Rantos; Kim Bartels; Rolf Nielsen; Els Pardon; Jan Steyaert; Jan Kosinski; Esben M. Quistgaard; Christian Löw;Journal of the American Chemical Society 141(6), 2404 - 2412 (2019). doi:10.1021/jacs.8b11343 Published by American Chemical Society, Washington, DC
Journal of the Ameri... arrow_drop_down Journal of the American Chemical SocietyOther literature type . Article . 2019 . Peer-reviewedVrije Universiteit Brussel Research PortalArticle . 2019Data sources: Vrije Universiteit Brussel Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/jacs.8b11343&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 45 citations 45 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of the Ameri... arrow_drop_down Journal of the American Chemical SocietyOther literature type . Article . 2019 . Peer-reviewedVrije Universiteit Brussel Research PortalArticle . 2019Data sources: Vrije Universiteit Brussel Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/jacs.8b11343&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Sweden, Germany, United Kingdom, Denmark, Estonia, Sweden, United KingdomPublisher:Public Library of Science (PLoS) Funded by:NIH | Genetic Architecture of A..., EC | ePerMed, EC | NASCENT +4 projectsNIH| Genetic Architecture of Adiposity in Multiple Large Cohorts ,EC| ePerMed ,EC| NASCENT ,EC| WIDENLIFE ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,EC| ADOPT BBMRI-ERIC ,EC| CORBELDmitry Shungin; Wei Q. Deng; Tibor V. Varga; Jian'an Luan; Evelin Mihailov; Andres Metspalu; Andrew P. Morris; Nita G. Forouhi; Cecilia M. Lindgren; Magnusson Pke.; Nancy L. Pedersen; Göran Hallmans; Audrey Y. Chu; Anne E. Justice; Mariaelisa Graff; Thomas W. Winkler; Lynda M. Rose; Claudia Langenberg; L. A. Cupples; Paul M. Ridker; Nicholas J. Wareham; Ken K. Ong; Loos Rjf.; Daniel I. Chasman; Erik Ingelsson; Tuomas O. Kilpeläinen; Robert A. Scott; Reedik Mägi; Guillaume Paré; Paul W. Franks;pmid: 28614350
pmc: PMC5489225
Author summary Most contemporary studies of gene-environment interactions focus on gene variants that are known to bear strong and reliable associations with the traits of interest. The strategy is intuitive because it helps limit the number of tests performed by focusing on a relatively small number of gene variants. However, this approach is predicated on an implicit assumption that these loci are strong candidates for interactions owing to their established relationships with the index traits. The counter-argument is that, because these loci have highly consistent signals within and between populations that vary by environmental characteristics, the probability that these variants interact with other factors is low. The current analysis tests whether variants with strong marginal effects signals (i.e., those prioritized through conventional genome-wide association analyses) are strong or weak candidates for gene-environment interactions. Here we describe analyses focused on lipids and BMI that test this hypothesis by comparing marginal effect signals with variance effect signals and those derived from explicit genome-wide, gene-environment interaction analyses. We conclude that for BMI, there are features of the top-ranking marginal effect loci that render them stronger candidates for interactions than is true of variants with weaker marginal effects signals. These findings are likely to help optimize the efficiency of future gene-environment interaction analyses by providing evidence-based rankings for strong candidate loci. Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic effects (Pm). Correlations between Pv and Pm were stronger for SNPs with established marginal effects (Spearman’s ρ = 0.401 for triglycerides, and ρ = 0.236 for BMI) compared to all SNPs. When Pv and Pm were compared for all pruned SNPs, only BMI was statistically significant (Spearman’s ρ = 0.010). Overall, SNPs with established marginal effects were overrepresented in the nominally significant part of the Pv distribution (Pbinomial <0.05). SNPs from the top 1% of the Pm distribution for BMI had more significant Pv values (PMann–Whitney = 1.46×10−5), and the odds ratio of SNPs with nominally significant (<0.05) Pm and Pv was 1.33 (95% CI: 1.12, 1.57) for BMI. Moreover, BMI SNPs with nominally significant G×E interaction P-values (Pint<0.05) were enriched with nominally significant Pv values (Pbinomial = 8.63×10−9 and 8.52×10−7 for SNP × smoking and SNP × physical activity, respectively). We conclude that some loci with strong marginal effects may be good candidates for G×E, and variance-based prioritization can be used to identify them.
PLoS Genetics; DSpac... arrow_drop_down PLoS Genetics; DSpace at Tartu University LibraryOther literature type . Article . 2017 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5489225Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2017Data sources: Copenhagen University Research Information SystemPublication Server of Helmholtz Zentrum München (PuSH)Article . 2017Data sources: Publication Server of Helmholtz Zentrum München (PuSH)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pgen.1006812&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 4visibility views 4 download downloads 33 Powered bymore_vert PLoS Genetics; DSpac... arrow_drop_down PLoS Genetics; DSpace at Tartu University LibraryOther literature type . Article . 2017 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5489225Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2017Data sources: Copenhagen University Research Information SystemPublication Server of Helmholtz Zentrum München (PuSH)Article . 2017Data sources: Publication Server of Helmholtz Zentrum München (PuSH)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pgen.1006812&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 GermanyPublisher:Elsevier BV Funded by:EC | iNEXT-DiscoveryEC| iNEXT-DiscoveryPaul-Christian Burda; Thomas Crosskey; Katharina Lauk; Aimo Zurborg; Christoph Söhnchen; Benjamin Liffner; Louisa Wilcke; Emma Pietsch; Jan Strauss; Cy M. Jeffries; Dmitri I. Svergun; Danny W. Wilson; Matthias Wilmanns; Tim-Wolf Gilberger;pmid: 32579913
Proteins of the lipocalin family are known to bind small hydrophobic ligands and are involved in various physiological processes ranging from lipid transport to oxidative stress responses. The genome of the malaria parasite Plasmodium falciparum contains a single protein PF3D7_0925900 with a lipocalin signature. Using crystallography and small-angle X-ray scattering, we show that the protein has a tetrameric structure of typical lipocalin monomers; hence we name it P. falciparum lipocalin (PfLCN). We show that PfLCN is expressed in the intraerythrocytic stages of the parasite and localizes to the parasitophorous and food vacuoles. Conditional knockdown of PfLCN impairs parasite development, which can be rescued by treatment with the radical scavenger Trolox or by temporal inhibition of hemoglobin digestion. This suggests a key function of PfLCN in counteracting oxidative stress-induced cell damage during multiplication of parasites within erythrocytes. Cell reports 31(12), 107817 - (2020). doi:10.1016/j.celrep.2020.107817 Published by Elsevier, [New York, NY]
OceanRep arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.celrep.2020.107817&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 21 citations 21 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert OceanRep arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.celrep.2020.107817&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2020 France, United StatesPublisher:The Company of Biologists Funded by:EC | CORBEL, EC | ASSEMBLE Plus, ANR | i-MMEJEC| CORBEL ,EC| ASSEMBLE Plus ,ANR| i-MMEJLechable, Marion; Jan, Alexandre; Duchene, Axel; Uveira, Julie; Weissbourd, Brandon; Gissat, Loann; Collet, Sophie; Gilletta, Laurent; Chevalier, Sandra; Leclère, Lucas; Peron, Sophie; Barreau, Carine; Lasbleiz, Régis; Houliston, Evelyn; Momose, Tsuyoshi;ABSTRACT The jellyfish species Clytia hemisphaerica (Cnidaria, Hydrozoa) has emerged as a new experimental model animal in the last decade. Favorable characteristics include a fully transparent body suitable for microscopy, daily gamete production and a relatively short life cycle. Furthermore, whole genome sequence assembly and efficient gene editing techniques using CRISPR/Cas9 have opened new possibilities for genetic studies. The quasi-immortal vegetatively-growing polyp colony stage provides a practical means to maintain mutant strains. In the context of developing Clytia as a genetic model, we report here an improved whole life cycle culture method including an aquarium tank system designed for culture of the tiny jellyfish form. We have compared different feeding regimes using Artemia larvae as food and demonstrate that the stage-dependent feeding control is the key for rapid and reliable medusa and polyp rearing. Metamorphosis of the planula larvae into a polyp colony can be induced efficiently using a new synthetic peptide. The optimized procedures detailed here make it practical to generate genetically modified Clytia strains and to maintain their whole life cycle in the laboratory. This article has an associated First Person interview with the two first authors of the paper. Summary: We developed a reliable whole life cycle culture method for the hydrozoan jellyfish Clytia hemisphaerica, a model animal for genetics and developmental biology.
Biology Open arrow_drop_down Biology OpenArticle . 2020 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7657476Data sources: PubMed CentralArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of IfremerArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of IfremerMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02990858/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1242/bio.051268&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Biology Open arrow_drop_down Biology OpenArticle . 2020 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7657476Data sources: PubMed CentralArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of IfremerArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of IfremerMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02990858/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1242/bio.051268&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2014 Germany, France, France, FrancePublisher:The Royal Society Funded by:EC | BIOSTRUCT-XEC| BIOSTRUCT-XTim Schulte; Jonas Lofling; Cecilia Mikaelsson; Alexey Kikhney; Karina Hentrich; Aurora Diamante; Christine Ebel; Staffan Normark; Dmitri I. Svergun; Birgitta Henriques-Normark; Adnane Achour;Streptococcus pneumoniae is a major human pathogen, and a leading cause of disease and death worldwide. Pneumococcal invasive disease is triggered by initial asymptomatic colonization of the human upper respiratory tract. The pneumococcal serine-rich repeat protein (PsrP) is a lung-specific virulence factor whose functional binding region (BR) binds to keratin-10 (KRT10) and promotes pneumococcal biofilm formation through self-oligomerization. We present the crystal structure of the KRT10-binding domain of PsrP (BR187-385) determined to 2.0 Å resolution. BR187-385 adopts a novel variant of the DEv-IgG fold, typical for microbial surface components recognizing adhesive matrix molecules adhesins, despite very low sequence identity. An extended β-sheet on one side of the compressed, two-sided barrel presents a basic groove that possibly binds to the acidic helical rod domain of KRT10. Our study also demonstrates the importance of the other side of the barrel, formed by extensive well-ordered loops and stabilized by short β-strands, for interaction with KRT10. International audience
Open Biology arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC3909270Data sources: PubMed CentralOpen BiologyOther literature type . Article . 2014 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityHyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; Hal-DiderotOther literature type . Article . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rsob.130090&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 27 citations 27 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Open Biology arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC3909270Data sources: PubMed CentralOpen BiologyOther literature type . Article . 2014 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityHyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; Hal-DiderotOther literature type . Article . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rsob.130090&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Belgium, Denmark, GermanyPublisher:American Chemical Society (ACS) Funded by:EC | iNEXT, EC | EI3PODEC| iNEXT ,EC| EI3PODYonca Ural-Blimke; Ali Flayhan; Jan Strauss; Vasileios Rantos; Kim Bartels; Rolf Nielsen; Els Pardon; Jan Steyaert; Jan Kosinski; Esben M. Quistgaard; Christian Löw;Journal of the American Chemical Society 141(6), 2404 - 2412 (2019). doi:10.1021/jacs.8b11343 Published by American Chemical Society, Washington, DC
Journal of the Ameri... arrow_drop_down Journal of the American Chemical SocietyOther literature type . Article . 2019 . Peer-reviewedVrije Universiteit Brussel Research PortalArticle . 2019Data sources: Vrije Universiteit Brussel Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/jacs.8b11343&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 45 citations 45 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of the Ameri... arrow_drop_down Journal of the American Chemical SocietyOther literature type . Article . 2019 . Peer-reviewedVrije Universiteit Brussel Research PortalArticle . 2019Data sources: Vrije Universiteit Brussel Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/jacs.8b11343&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Sweden, Germany, United Kingdom, Denmark, Estonia, Sweden, United KingdomPublisher:Public Library of Science (PLoS) Funded by:NIH | Genetic Architecture of A..., EC | ePerMed, EC | NASCENT +4 projectsNIH| Genetic Architecture of Adiposity in Multiple Large Cohorts ,EC| ePerMed ,EC| NASCENT ,EC| WIDENLIFE ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,EC| ADOPT BBMRI-ERIC ,EC| CORBELDmitry Shungin; Wei Q. Deng; Tibor V. Varga; Jian'an Luan; Evelin Mihailov; Andres Metspalu; Andrew P. Morris; Nita G. Forouhi; Cecilia M. Lindgren; Magnusson Pke.; Nancy L. Pedersen; Göran Hallmans; Audrey Y. Chu; Anne E. Justice; Mariaelisa Graff; Thomas W. Winkler; Lynda M. Rose; Claudia Langenberg; L. A. Cupples; Paul M. Ridker; Nicholas J. Wareham; Ken K. Ong; Loos Rjf.; Daniel I. Chasman; Erik Ingelsson; Tuomas O. Kilpeläinen; Robert A. Scott; Reedik Mägi; Guillaume Paré; Paul W. Franks;pmid: 28614350
pmc: PMC5489225
Author summary Most contemporary studies of gene-environment interactions focus on gene variants that are known to bear strong and reliable associations with the traits of interest. The strategy is intuitive because it helps limit the number of tests performed by focusing on a relatively small number of gene variants. However, this approach is predicated on an implicit assumption that these loci are strong candidates for interactions owing to their established relationships with the index traits. The counter-argument is that, because these loci have highly consistent signals within and between populations that vary by environmental characteristics, the probability that these variants interact with other factors is low. The current analysis tests whether variants with strong marginal effects signals (i.e., those prioritized through conventional genome-wide association analyses) are strong or weak candidates for gene-environment interactions. Here we describe analyses focused on lipids and BMI that test this hypothesis by comparing marginal effect signals with variance effect signals and those derived from explicit genome-wide, gene-environment interaction analyses. We conclude that for BMI, there are features of the top-ranking marginal effect loci that render them stronger candidates for interactions than is true of variants with weaker marginal effects signals. These findings are likely to help optimize the efficiency of future gene-environment interaction analyses by providing evidence-based rankings for strong candidate loci. Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic effects (Pm). Correlations between Pv and Pm were stronger for SNPs with established marginal effects (Spearman’s ρ = 0.401 for triglycerides, and ρ = 0.236 for BMI) compared to all SNPs. When Pv and Pm were compared for all pruned SNPs, only BMI was statistically significant (Spearman’s ρ = 0.010). Overall, SNPs with established marginal effects were overrepresented in the nominally significant part of the Pv distribution (Pbinomial <0.05). SNPs from the top 1% of the Pm distribution for BMI had more significant Pv values (PMann–Whitney = 1.46×10−5), and the odds ratio of SNPs with nominally significant (<0.05) Pm and Pv was 1.33 (95% CI: 1.12, 1.57) for BMI. Moreover, BMI SNPs with nominally significant G×E interaction P-values (Pint<0.05) were enriched with nominally significant Pv values (Pbinomial = 8.63×10−9 and 8.52×10−7 for SNP × smoking and SNP × physical activity, respectively). We conclude that some loci with strong marginal effects may be good candidates for G×E, and variance-based prioritization can be used to identify them.
PLoS Genetics; DSpac... arrow_drop_down PLoS Genetics; DSpace at Tartu University LibraryOther literature type . Article . 2017 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5489225Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2017Data sources: Copenhagen University Research Information SystemPublication Server of Helmholtz Zentrum München (PuSH)Article . 2017Data sources: Publication Server of Helmholtz Zentrum München (PuSH)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 4visibility views 4 download downloads 33 Powered bymore_vert PLoS Genetics; DSpac... arrow_drop_down PLoS Genetics; DSpace at Tartu University LibraryOther literature type . Article . 2017 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5489225Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2017Data sources: Copenhagen University Research Information SystemPublication Server of Helmholtz Zentrum München (PuSH)Article . 2017Data sources: Publication Server of Helmholtz Zentrum München (PuSH)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 GermanyPublisher:Elsevier BV Funded by:EC | iNEXT-DiscoveryEC| iNEXT-DiscoveryPaul-Christian Burda; Thomas Crosskey; Katharina Lauk; Aimo Zurborg; Christoph Söhnchen; Benjamin Liffner; Louisa Wilcke; Emma Pietsch; Jan Strauss; Cy M. Jeffries; Dmitri I. Svergun; Danny W. Wilson; Matthias Wilmanns; Tim-Wolf Gilberger;pmid: 32579913
Proteins of the lipocalin family are known to bind small hydrophobic ligands and are involved in various physiological processes ranging from lipid transport to oxidative stress responses. The genome of the malaria parasite Plasmodium falciparum contains a single protein PF3D7_0925900 with a lipocalin signature. Using crystallography and small-angle X-ray scattering, we show that the protein has a tetrameric structure of typical lipocalin monomers; hence we name it P. falciparum lipocalin (PfLCN). We show that PfLCN is expressed in the intraerythrocytic stages of the parasite and localizes to the parasitophorous and food vacuoles. Conditional knockdown of PfLCN impairs parasite development, which can be rescued by treatment with the radical scavenger Trolox or by temporal inhibition of hemoglobin digestion. This suggests a key function of PfLCN in counteracting oxidative stress-induced cell damage during multiplication of parasites within erythrocytes. Cell reports 31(12), 107817 - (2020). doi:10.1016/j.celrep.2020.107817 Published by Elsevier, [New York, NY]
OceanRep arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.celrep.2020.107817&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 21 citations 21 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert OceanRep arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.celrep.2020.107817&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2020 France, United StatesPublisher:The Company of Biologists Funded by:EC | CORBEL, EC | ASSEMBLE Plus, ANR | i-MMEJEC| CORBEL ,EC| ASSEMBLE Plus ,ANR| i-MMEJLechable, Marion; Jan, Alexandre; Duchene, Axel; Uveira, Julie; Weissbourd, Brandon; Gissat, Loann; Collet, Sophie; Gilletta, Laurent; Chevalier, Sandra; Leclère, Lucas; Peron, Sophie; Barreau, Carine; Lasbleiz, Régis; Houliston, Evelyn; Momose, Tsuyoshi;ABSTRACT The jellyfish species Clytia hemisphaerica (Cnidaria, Hydrozoa) has emerged as a new experimental model animal in the last decade. Favorable characteristics include a fully transparent body suitable for microscopy, daily gamete production and a relatively short life cycle. Furthermore, whole genome sequence assembly and efficient gene editing techniques using CRISPR/Cas9 have opened new possibilities for genetic studies. The quasi-immortal vegetatively-growing polyp colony stage provides a practical means to maintain mutant strains. In the context of developing Clytia as a genetic model, we report here an improved whole life cycle culture method including an aquarium tank system designed for culture of the tiny jellyfish form. We have compared different feeding regimes using Artemia larvae as food and demonstrate that the stage-dependent feeding control is the key for rapid and reliable medusa and polyp rearing. Metamorphosis of the planula larvae into a polyp colony can be induced efficiently using a new synthetic peptide. The optimized procedures detailed here make it practical to generate genetically modified Clytia strains and to maintain their whole life cycle in the laboratory. This article has an associated First Person interview with the two first authors of the paper. Summary: We developed a reliable whole life cycle culture method for the hydrozoan jellyfish Clytia hemisphaerica, a model animal for genetics and developmental biology.
Biology Open arrow_drop_down Biology OpenArticle . 2020 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7657476Data sources: PubMed CentralArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of IfremerArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of IfremerMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02990858/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1242/bio.051268&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Biology Open arrow_drop_down Biology OpenArticle . 2020 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7657476Data sources: PubMed CentralArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of IfremerArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of IfremerMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02990858/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1242/bio.051268&type=result"></script>'); --> </script>
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