Safe-and-Sustainable-by-Design (SSbD) is a promising approach to develop new chemicals. However, well-elaborated tools to guide selection of SSbD alternatives that fullfill the desired and essential function in a given application are missing. In this proposal, we will focus on Persistent, Mobile and Toxic chemicals, as they pose a risk to the watercycle and human and ecological health. This TOSS project will develop integrated tools to select and produce SSbD alternatives for PMTs, will gain experience with putting SSbD in practice including active contributions of different stakeholders, and will formulate lessons for industry, academic research and policy.

The granted three projects of this NWA-call span the continuum from chemicals, materials and products and their safety, sustainability and circularity during their entire life cycle from design to waste. Here, we will synthesize the knowledge and tools developed, and in this way facilitate interaction between the domains of chemicals, materials or products. This Phase II BenignSynthesis project will as far as possible further generalize, integrate and simplify methods developed in the three Phase I projects, aiming for an overarching Safe,Sustainable&Circular-by-Design approach for the Chemicals-Materials-Product continuum in which the life cycle of design, production, consumption and waste is accounted for.