As the world is becoming more urbanized and cities of the future need to be people-centred, robust evidence-based knowledge on the underlying biological and psychological processes, by which Urban Planning & Design influence brain circuits and human behaviour, will be critical for policy making on urban health. Emotions are key drivers of our decisions; similarly, our choices are the conduit for our well-being and health. Thus, research focusing on the signals triggered in our neurobiological architecture, responsible for emotions and decisions, while humans interact with the urban environment will shed light on how to improve population health, physical and/or mental. The eMOTIONAL Cities project was designed to fully characterise the intensity and complexity of urban health challenges and inequalities. By exploring the mechanisms and their dynamic, it complements conventional descriptive perspectives focused on exposure-outcome associations. It adopts a systems approach, based on natural experiments and actual problems of case-study cities (Copenhagen, Lisbon, London; and Lansing/Detroit in the USA). Building on theoretical foundations, novel eMOTIONAL city mapping will be generated by combining spatial analysis on social/health data with neuroscience experiments. Our research relies on mixed (qualitative/quantitative) methods and uses multidisciplinary instruments from Urban Planning & Design (GIS for land use, transport, climate and health), Neuroscience (fMRI, EEG) and Data Science & Technology (AI, Big Data and VR/AR reality). The analysis also addresses gender aspects and contemplates a clinical study to show that urban design can impact a vulnerable elderly population at risk of developing dementia. Finally, a novel machine-learning scenario discovery framework will allow testing and impact assessment (for cost-effectiveness, barriers and facilitators) of urban policy strategies to turn EU cities into smart, sustainable and inclusive environments. The eMOTIONAL Cities is a part of the European Cluster on Urban Health.

Due to lack of targeted interventions, compliance issues, insufficient effect sizes and a high non-responder rate to currently available interventions, there is an urgent need to develop innovative and new interventions for chronic paediatric neuropsychiatric disorders, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). Transcranial direct current stimulation (tDCS) has been shown to be an innovative, effective and safe alternative treatment approach for neuropsychiatric disorders in adults. Here, for the first time, the effect of tDCS on core neurocognitive and behavioral outcomes will be proven in children and adolescents. First, effect sizes and safety of standard tDCS in the clinical setting targeting core brain regions and disorder specific cognitive tasks will be established by three phase-IIa randomized, double blind, sham-controlled studies in ADHD and ASD. Second, the impact of brain development and age-dependent anatomical / functional features on effects of tDCS will be studied systematically using methods of modern neurophysiology, neuroimaging and electric current modeling. This involves an additional phase-I clinical trial. Third, mechanisms of tDCS on brain function will be studied, and biomarkers will be developed in order to predict individual response to standard and individualized stimulation protocols. Finally, the applicability of tDCS in children and adolescents will be improved by developing an innovative personalized home-based treatment option in combination with a telemental health service, which will be tested by a fifth, phase-IIa clinical trial. Throughout the entire project, ethical concerns of the target population will be addressed. This project opens a new avenue for the application of tDCS as an alternative treatment for a great number of chronic neuropsychiatric disorders in children and adolescents and will allow flexible integration of tDCS in the daily routine of families.