Imagine if tumor growth would be reduced and then kept in a minimal and safe volume in an automated manner and in a personalized way, i.e. cancer drug would be injected using a continuous therapy improving the patient’s quality of life. By control engineering approaches it is possible to create model-based strategies for health problems. Artificial pancreas is an adequate example for this, where by continuous glucose measurement device and insulin pump it is possible to improve diabetes treatment. Gaining expertise from this problem, the current proposal focuses on taming the cancer by developing an engineering-based medical therapy. The interdisciplinary approach focuses on modern robust control algorithm development in order to stop the angiogenesis process (i.e. vascular system development) of the tumor; hence, to stop tumor growth, maintaining it in a minimal, “tamed” form. This breakthrough concept could revitalize cancer treatment. It is the right time to do it as some investigations regarding tumor growth modeling have been already done; now, it should be refined by model identification tools and validated on animal trials. The benefit of robust control was already demonstrated in artificial pancreas; hence, it could be adapted to cancer research. The result could end with a personalized healthcare approach for drug-delivery in cancer, improving quality of life, optimizing drug infusion and minimizing treatment costs. This interdisciplinary approach combines control engineering with mathematics, computer science and medical sciences. As a result, the model-based robust control approach envisage refining the currently existing tumor growth modeling aspects, design an optimal control algorithm and extend it by robust control theory to guarantee its general applicability. Based on our research background, validation will be done first in a manually controlled way, but then in an automatic mode to propose it for further human investigations.

Patient safety, which is the reduction of risk of unnecessary harm associated with healthcare to an acceptable minimum, has become the most emphasised issue in healthcare policymaking as every 10th patient admitted to a hospital is harmed while receiving hospital care. In 85-90% of the cases, the weakness of the process is responsible for the error instead of individuals. Around 15% of hospital expenditures are produced by the additional tests and interventions needed to treat the effects of an adverse event.Education with respect to patient safety is the first step in changing the mindsets of professionals and contributing to the improvement of patient safety culture in an organisation. Patient safety education is recommended by the European Union (EU) (Recommendation on Patient Safety, 2009/C 151/01), the World Health Organization (WHO) also emphasises the importance of patient safety education, as it has developed curricula for graduate and postgraduate education as well. According to the reports on the patient safety education, there are only a few courses on the topic in the EU Member States, and they differ from each other in content and method. In addition to deepening and/or broadening the knowledge of providers, what is also important is to influence the organisational culture as much as possible through these courses. In order to achieve this goal, it is necessary to define the best method in line with the content of the training course.Therefore, the main goal of our project was to improve safety during care by developing and disseminating more effective educational courses for healthcare professionals which lead to real changes in daily, clinical practice by making it safer. Also, it was expected to create recommendations for best practices based on our project results and experiences.Considering that the problem in focus is relevant regarding all across Europe and even more, we built our project in an international level. Three different institutions from three different countries took part in the initiative as follows. Semmelweis University Health Services Management Training Centre (SU) - the project leader - is a department of the Faculty of Health and Public Services. Beside its education experience and numerous international and national research and development projects, the safety of patient care is a special focus of professional activity in the SU. Towarzystwo Promocji Jakości Opieki Zdrowotnej w Polsce (TPJ) is the first not-for-profit non-governmental organisation in Poland, that is focused on the issues of quality and patient safety in healthcare and participates in many quality initiatives, both at the national and international level. The Spanish Ministry of Health, Consumer Affairs and Social Welfare is responsible of the proposal and implementation of government policy in health, planning and health care and consumer goods, as well as the exercise of the powers of the General State Administration to ensure the right of the citizens to health protection. To achieve the project goal our activities were:- developing three different training methods for health professionals with the same, 30-hour long time-frame - developing educational material according to the three training methods mentioned above- developing the methods of measurements that can show us the results of the effectiveness of the different training courses - involving three middle-sized hospitals in Poland and three in Hungary where the training courses and measurements could be realized and analysed- analysing the results of the above-mentioned measurements- finalizing the educational materials and training methods and compiling packages with the content of method description, educational material, suggestions for use and the expectable effects of the training - making conclusions from the results and sorting them according to different stakeholders and levels- disseminating the results and conclusions in many ways like conference, posts/articles and webpages.As a result we managed to compile:- patient safety educational material for healthcare professionals, - survey questionnaires for measuring patient safety knowledge and organisational culture- patient safety educational methodology guideline and - recommendation on patient safety education for the EU. The results of our project exceeded what we had expected. Beside the three, public training packages, we managed to make recommendations not just to the hospitals, but also to training centres, policy-makers and patients with their loved ones. Additionally, our results can be useful for other sectors, too, e.g. social or education sectors. All the important information and outputs of our project are available on our webpage.