dRural overall goal it to co-develop and implement a digital solution that delivers multiple services to rural citizens while creating opportunities economic growth and quality of life improvements. Then, to ensure the successful exploitation and sustainability after the project’s lifetime and its replication in other European territories. As such, our aspiration is to become the service marketplace of reference for European rural areas. dRural will build a service network for rural areas and communities based on four rural regions of Europe, namely: Extremadura (ES), Dubrovnik-Neretva County (HR) and Region Gelderland Midden (NL). Each of these settings are called regional demonstrators. The solution building will follow agile methodologies and ensure end-users co-creation and validation in each regional demonstrator. Besides, dRural will be developed with a 'by-design' approach to ethics, privacy, and data protection. An internet coverage optimization in the demonstrators will be done to guarantee a smooth deployment. Then, the solution will be set up in each region, guaranteeing its personalization and customization to the regional needs, and integrating with the local service providers. In parallel, an ecosystem of relevant players surrounding the dRural solution will be created in each region by identifying the key stakeholders, current problems and designing a value proposition for each of them. The ecosystem building exercise will be supported by an open call in each demonstrator leveraging financial support to third parties to incentivize the solution take up and expand the ecosystem of players involved. This will offer opportunities for entrepreneurs by promoting new market openings allowing also smaller and newer players to capture value. An evaluation of usage and impacts will be performed to ensure on-going support in the region after the project completionend.

In the face of a rapidly advancing digital healthcare terrain, the DTRIP4H project emerges as a momentous effort to revolutionize predictive, preventive, personalized, and participatory health paradigms within the EU. Amid significant incidence of chronic conditions and cancer, there is a pressing need for a proactive shift in health strategies. Yet, the full potential of European research infrastructures (RIs) is curtailed by investment deficits, fragmentation, and the intricacies of data management. Digital Twin (DT) technology introduces a new age of precision by enabling sophisticated simulations and analyses of intricate biological processes. In DTRIP4H, we start a new initiative in Europe “decentralized health digital twin ecosystem consisting of RIs”. Using DTs, we aim to resolve critical challenges around data harmonization, equitable access, and stringent privacy safeguards. Incorporating technologies such as federated learning, Generative AI, and Virtual Reality (VR), the project aspires to create a decentralized digital twin environment (DDTE). This will empower both internal and external RI users, such as researchers, innovators, and SMEs, to craft DT applications that address specific scientific challenges, utilizing a blend of real-world and synthetic data in compliance with regulatory frameworks, i.e. GDPR. We will develop 7 innovative proof of concept thematic health-related Use cases fulfilling the needs of scientists, SMEs, and industrial end users, particularly in health topics related to cancer treatment, drug development, human environmental exposome, precision treatment for schizophrenia and personalized medicine through Artificial Intelligence (AI), AR/VR empowered DTs utilizing DDTE, while adhering to FAIR data principles. DTRIP4H adopts a human-centric methodology to elevate research efficacy, narrow the skills gap, and align with the objectives of the European Research Area (ERA) and the Sustainable Development Goals (SDGs) by 2030.

Companies developing healthcare IT solutions (e.g. Electronic or Personal Health Record Systems, mHealth, eHealth, Connected Devices, IoT) deal with health sensitive data and need to ensure compliance with strict data protection regulations and cyber security standards. Implementing security and compliance requirements represents a costly, time consuming and risky activity for health application developers. Chino.io Platform offers secure API for storing and managing sensitive health data, ensuring compliance with EU, member states and US regulations, and offering medical grade quality and security guarantees (we are ISO 9001 & ISO 27001 certified, as mandated by Medical Device Regulation for service providers). Chino.io Platform introduces a new service (PaaS) into the developers’ market that provides to developers a classical development tool (e.g. a database and REST API) for solving security and legal issues. This helps developers drastically to speed up application development and shorten the time to market. The cloud based and “as a Service” delivery model makes the Chino.io Platform affordable for startups, SMEs and large companies, since it offers a volume-based subscription plans which are extremely scalable. At the same time this approach gives to Chino.io the possibility to assist companies from an early stage and to grow together over time. The eHealth is a big and fast-growing market, and its transition to cloud is speeding up in the recent years. Chino.io team combines unique knowledge on technologies for the healthcare market, cloud technologies for developers, and data protection regulations for healthcare sector. ThThe main outcome of the SME Phase II project will be to bring Chino.io to industrial readiness and maturity (TRL6 to TRL9) for its wide market disruption and penetration in multiple verticals.

Europe still sees a quarter of the world's cancer cases each year, making cancer the second leading cause of death and illness in the region after cardiovascular diseases. Unless we take decisive action, lives lost to cancer in the EU are set to increase by more than 24% by 2035, making it the leading cause of death in the EU. Cross-border collaboration can address this challenge by combining data from various modalities and sources, extracting meaningful insights to deepen our understanding of cancer. However, ethical, legal, and national regulations, along with data access processes, including differing interpretations of the EU GDPR create significant hurdles. Technical interoperability issues across European cancer RIs, and patients' and citizens' rights to control who uses their personal information and for what purposes further complicate data sharing. The project will provide European researchers, SMEs, and innovators with a decentralized collaborative network, “UNCAN-CONNECT,” for cancer research. It consists of both technical components, a governance, compliance, and operational framework based on the UNCAN blueprint, with the goal of operationalizing it. The objective is to facilitate access to cancer data, promote open science, and revolutionize cancer research and treatment by co-creating an open-source federation of federations platform. It will be developed using specific use cases focused on six major cancer types: Paediatric, Lymphoid malignancies, Pancreatic cancer, Ovarian, Lung, and Prostate cancers and active collaboration with a diverse range of stakeholders, including researchers, SMEs, industrial end users, and citizens. It will build on existing European RIs such as BBMRI as well as initiatives like EOSC4CANCER, CanSERV, EUCAIM, to enable seamless storage, access, sharing, and processing of data across Member States and associated countries. This approach will foster interoperability and collaboration, accelerating progress in cancer research. This action is part of the Cancer Mission clusters of projects 'Understanding' established in 2022.

Digital health applications are disrupting the healthcare sector by bringing huge innovation and improving the quality of care. However, this innovation brings also some risks since those apps collect and store extremely privacy sensitive data in cloud and mobile environments. According to analysis performed by 39 Data Protection Authorities worldwide in 2014, 85% of the 1.211 analyzed mobile health apps do not comply with data protection laws and security requirements. This behavior puts at serious risk users’ privacy and trust in digital health. Chino helps application developers and enterprises to solve security and privacy law compliance issues by offering a secure platform to manage application users and how they access, store and share health sensitive data. Developers can easily integrate the Chino platform (its API) into their apps to ensure compliance, increase security, speed up application development, shorten time to market, at affordable pay-per-use cost. To ensure security of data transfers and storage Chino applies security-by-design principles and state-of-the-art security mechanisms. From compliance point of view, Chino terms of service define its liabilities and it ensures that the data management is performed according to EU and Member States laws. In addition, Chino is working on ISO 9001 & 27001 certifications, giving more guarantees to its customers. Thanks to its innovative services, the market opportunity, and the EC support (which will speed up the adequate team growth, marketing plan, technological roadmap implementation and international commercialization), the company expect to create over 46 high qualified jobs and generate a turnover over 10M€ by 2020. Furthermore, the overall results of this project will catapult Chino company as a global leader on the digital health & cyber security market.