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CSIC

Spanish National Research Council
Country: Spain
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1,779 Projects, page 1 of 356
  • Open Access mandate for Publications
    Funder: EC Project Code: 700196
    Overall Budget: 158,122 EURFunder Contribution: 158,122 EUR
    Partners: CSIC

    Taphonomy is the interdisciplinary science, between the fields of biology and geology, that evaluates the transition of live organisms into death assemblages and, eventually, into fossil remains. Modern death assemblages provide a basis for understanding what components of living communities may be preserved in the fossil record and what biases are to be expected. Also, methods and discoveries of taphonomic research in modern ecosystems are of value to ecologists because skeletal remains hold a wealth of information about the vertebrate species inhabiting an ecosystem. Despite the interdisciplinary information that these studies contain, naturally occurring bone accumulations are largely unexplored and have not been studied neither in the European realm nor in a Mediterranean ecosystem. We propose here a training-through-research project based on the taphonomic monitoring and fidelity evaluation of the vertebrate death assemblage (mainly >5 kg terrestrial vertebrates) of a UNESCO World Heritage Site, Doñana National Park (DNP) (Spain). The candidate has experience in the taphonomic reconstruction of fossil sites but has limited exposure to taphonomic field techniques and analyses of modern death assemblages and live:dead fidelity studies. The LiveDeadFossil project will broaden her professional experience and contribute to her growth as independent researcher. The research will shed light on the ecological and post-mortem processes undergone by vertebrate remains in a Mediterranean ecosystem and will complement the study and management of the vertebrate communities of the park. The selected host organization, Doñana Biological Station-CSIC (Seville, Spain), is a world-class research center for ecology and conservation biology, manages all the activities at DNP and has all the facilities and services in place (including population census data, osteological collections, laboratories, etc.) for the successful fulfilment of this training and research programme.

  • Open Access mandate for Publications and Research data
    Funder: EC Project Code: 896293
    Overall Budget: 245,732 EURFunder Contribution: 245,732 EUR
    Partners: CSIC

    Epithelial paracellular, i.e., tight junction, permeability is largely defined by the integrated functions of claudin proteins that can either seal the paracellular space or form highly-selective conductance channels. The importance of claudins is exemplified by the many human diseases caused by barrier dysregulation and claudin mutations. The host laboratory recently reported the first measurements of single channel tight junction currents, thereby demonstrating that claudin channels transition between open and closed states. The central hypothesis of this application is that claudin channel activity is regulated by specific molecular interactions. Unfortunately, the trans-tight junction patch-clamp method developed by the host laboratory is extremely labor intensive and unable to capture more than a small section of a single tight junction, making it unsuitable for comprehensive analyses. To overcome this obstacle, we first aim to develop a nanopillar array chip that will supersede the patch-clamp method. Cells grown over and around the nanopillars will form tight junctions above the nanoelectrode at the tip of each nanopillar. This will make it possible to measure large numbers of single-channel events over many junctions. The second aim will exploit the nanopillar chip to define the conductances and gating activities of claudin proteins and the mechanisms by which they are regulated. This novel technology will also allow others to analyze claudin function in health and disease. The nanopillar chip and data generated using this tool will accelerate our understanding of tight junction biology and enable development of channel modulators that, in a manner analogous to the advances enabled by transmembrane ion channel modulators, will lead to novel therapeutic approaches.

  • Open Access mandate for Publications
    Funder: EC Project Code: 654906
    Overall Budget: 158,122 EURFunder Contribution: 158,122 EUR
    Partners: CSIC

    This training-through-research project at the Institute of Heritage Sciences of the Spanish National Research Council (Incipit-CSIC), aims both to generate new scientific knowledge on the archaeology of the landscapes and the socio-political processes of the Final Iron Age and the Early Roman period, and to enhance their value for cultural heritage management and development in Murcia, in the Spanish Southeast. In this sense, this proposal aims to create a fruitful link between the applicant’s historical and archaeological research background and skills and the opportunities to learn and to develop a heritage outreach project. The interest of the project is due to both, the lack of landscapes studies which focus on the Iron Age in this region from a diachronical and landscape perspective, and the remarkable socio-political transformations undergone by the local communities in the period between the 5th and the 1st centuries BC. The landscape will be here understood like expression of the social and political interactions, but also like a space with an active role in their development, at different levels. All the evidences will be compiled, for the first time, through an interdisciplinary methodology (archaeological record, ancient texts, paleoenvironmental data, integration in a GIS, etc.) and will be analysed from a contextualized and comparative European perspective, which the regional research in this period lacks. Results will be disseminated by means of several impact publications but also beyond the strictly scientific environment, with the support of the host centre, the regional museums and other institutions. Regarding the heritage perspective this project aims to allow the applicant to learn how to re-direct all this knowledge towards a proper and effective management and communication of the important and rather unknown heritage value of those sites.

  • Open Access mandate for Publications and Research data
    Funder: EC Project Code: 845014
    Overall Budget: 245,732 EURFunder Contribution: 245,732 EUR
    Partners: CSIC

    The degradation of our rich stone cultural heritage (CH) represents an irreversible loss; an issue that has become urgent due to the increase of natural decay caused by climate change and the impact of atmospheric pollution and/or the current use of inappropriate treatments against stone weathering. The main challenge of BIONA4ART project will be to address this issue within an innovative framework in the conservation science: i) the development of a new generation of bioinspired nacre-like composites with self- healing and antimicrobial properties; and ii) its validation as stone conservation treatments with the aid of advanced characterization techniques. Thereby this research is marked by an interdisciplinary approach involving material science, biomaterials, physics, chemistry, petrophysics and CH conservation. In order to develop the proposed research the applicant will acquire new research skills by partnering her with the three specialized institutions involved: the Spanish National Research Council (CSIC) (supervisor Prof. R. Fort, world-renowned expert in the stone CH conservation), the Johns Hopkins University (JHU) (supervisor: Prof. H. Fairbrother, expert in nanocomposites, environmental implications and applications of nanomaterials), and the Max Planck Institute for Polymer Research (MPI-P), (supervisor Dr. S. Weber, internationally recognized expert in the use and development of SFM methods to study the underlying physics of nanoscale systems). The new knowledge and transferable skills gained during the project coupled with the opening of an innovative and exciting research line in the stone-CH field, will be an ideal springboard for the applicant´s subsequent career, which is to become a fully independent academic researcher in a top european university.