PHENOmenon will develop and validate an integral manufacturing approach (material, process and technology) for large area direct laser writing of 2&3D optical structures, targeting high speed production of optical surfaces with subwavelength resolution, using NonLinear Absorption. Developments in photochemistry and laser beam forming will allow to produce structures at different scales (100 nm to 10 microns). An unedited productivity in freeform fabrication of 3D structures will trigger the manufacturing of new and powerful optostructures with applications in lighting, displays, sensing, etc. The novelty focuses on the combination of ultrasensitive nonlinear photocurable materials, and the laser projection of up to 1 million simultaneous laser spots. The photochemistry relies on new types of ultrasensitive photoinitiators and groundbreaking nonlinear sensitized resins for CW [Continuous Wave] laser writing. The developments in beam forming are based in modulation with SLMs [Spatial Light Modulators] and hybrid diffractive optics for massive 3D parallelization by imaging and holographic projection. The enabled optical structures (hybrid microlenses, waveguides, polarizers, metasurfaces and holograms) will be modelled at the micro and macroscale, to develop application oriented simulation and design methodologies. Selected demonstrators will show the capability to produce 3D optical micro-nanostructured components with unique optical characteristics, offering differential advantages in many products: advanced security holograms, efficient lighting, high performance optics, backlighting units for displays, holographic HMIs [Human Machine Interface] and planar concentrator microlenses. These components will contribute to address societal challenges like energy efficiency or security while reinforcing EU industry competitiveness. A consortium comprising 4 top Research Institutions and 8 Industrial partners (4 SMEs) covering the complete value chain, will develop this project clearly driven by user needs.

The PHOCNOSIS project aims at the development and the preclinical validation of a nanotechnology-based handheld point-of-care testing (POCT) analysis device for its application in the early diagnosis of cardiovascular diseases (CVD). The diagnosis will be carried out by means of the fast (<10 minutes), ultra-sensitive (<1 ng/L) and label-free detection of multiple cardiac biomarkers, using a small volume of whole blood (<100 μL). This POCT analysis device will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates. The PHOCNOSIS analysis device will be based on two state-of-the-art technological elements in order to obtain a compact and highly sensitive final device. First, an integrated micro-/nanofluidic system will be used for biomarkers separation, purification and concentration, targeting an effective concentration increase by a factor greater than 1000x for the targeted biomarkers. Then, the concentrated biomarkers will be detected using a novel nanophotonic-based sensing technique, envisaging a final combined detection limit below 1 ng/L. This novel sensing technique allows us to obtain systems which are low-cost, compact and with a lower complexity, thus making them suitable for the development of portable devices for POCT. The PHOCNOSIS project will target the deployment of disposable biochips with an envisaged cost below €3 to be used in a handheld analysis device with an envisaged cost below €3000. Special attention will be paid within the PHOCNOSIS project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.