This proposal describes the third core project of the Graphene Flagship. It forms the fourth phase of the FET flagship and is characterized by a continued transition towards higher technology readiness levels, without jeopardizing our strong commitment to fundamental research. Compared to the second core project, this phase includes a substantial increase in the market-motivated technological spearhead projects, which account for about 30% of the overall budget. The broader fundamental and applied research themes are pursued by 15 work packages and supported by four work packages on innovation, industrialization, dissemination and management. The consortium that is involved in this project includes over 150 academic and industrial partners in over 20 European countries.

The 2D Experimental Pilot Line (2D-EPL) project will establish a European ecosystem for prototype production of Graphene and Related Materials (GRM) based electronics, photonics and sensors. The project will cover the whole value chain including tool manufacturers, chemical and material providers and pilot lines to offer prototyping services to companies, research centers and academics. The 2D-EPL targets to the adoption of GRM integration by commercial semiconductor foundries and integrated device manufacturers through technology transfer and licensing. The project is built on two pillars. In Pillar 1, the 2D-EPL will offer prototyping services for 150 and 200 mm wafers, based on the current state of the art graphene device manufacturing and integration techniques. This will ensure external users and customers are served by the 2D-EPL early in the project and guarantees the inclusion of their input in the development of the final processes by providing the specifications on required device layouts, materials and device performances. In Pillar 2, the consortium will develop a fully automated process flow on 200 and 300 mm wafers, including the growth and vacuum transfer of single crystalline graphene and TMDCs. The knowledge gained in Pillar 2 will be transferred to Pillar 1 to continuously improve the baseline process provided by the 2D-EPL. To ensure sustainability of the 2D-EPL service after the project duration, integration with EUROPRACTICE consortium will be prepared. It provides for the European actors a platform to develop smart integrated systems, from advanced prototype design to small volume production. In addition, for the efficiency of the industrial exploitation, an Industrial Advisory Board consisting mainly of leading European semiconductor manufacturers and foundries will closely track and advise the progress of the 2D-EPL. This approach will enable European players to take the lead in this emerging field of technology.

This proposal describes the third stage of the EC-funded part of the Graphene Flagship. It builds upon the results achieved in the ramp-up phase (2013 - 2016) and the first core project (2016 - 2018), and covers the period April 2018 - March 2020. The progress of the flagship follows the general plans set out in the Framework Partnership Agreement, and the second core project represents an additional step towards higher technology and manufacturing readiness levels. The Flagship is built upon the concept of value chains, one of which is along the axis of materials-components-systems; the ramp-up phase placed substantial resources on the development of materials production technologies, the first core project moved to emphasise components, and the second core project will move further towards integrating components in larger systems. This evolution is manifested, e.g., in the introduction of six market-motivated spearhead projects during the Core 2 project.

Oral hygiene is the cornerstone of good oral health and World Health Organization recognizes oral health as an integral part of systemic health. Among the non-invasive organic fluids, saliva is one of the most preferable and practical specimens for oral and systemic health monitoring as it is readily available and easily collected and stored. Saliva is frequently called a “mirror of the body” since it can reflect both the physiological and pathological conditions in the entire human organism. The SALSETH project proposal facilitates exchange of knowledge, skills, competencies and capabilities (through secondments) of 8 internationally top-ranking participating organizations (4 from academic sector and 4 SMEs) from Germany, Italy, Spain, Poland, Serbia, Ukraine, Malaysia and Australia. This project proposal promotes international and intersectoral collaboration between participating institutions, bringing experts from different fields of science in a unique R&I set up. The SALSETH brings together expertise of the respectable institutions to reach beyond the-state-of-the-art advances in: (1) natural and bio-inspired biocompatible materials; (2) edible food-based sensors which can promptly detect important biomarkers from saliva; (3) external smart electronic device for wireless reading data from sensors; and (4) microfluidic devices for optimal administration of drugs or essential oils as a main part of the intraoral appliances for better oral and systemic health. Through carefully designed secondments, the seconded staff will work on significant technological breakthrough in salivary theranostics for personalized dental bio-medicine. This interdisciplinary project offers an excellent research oriented environment for the personal and professional growth of the involved staff members. The SALSETH will open possibilities of salivary diagnostics for personalized individual medicine applications including clinical treatment options and outcome evaluation predictions.

FLEXPOL aims to develop a pilot line for the production of a cost effective antimicrobial (AM) adhesive film for its use in hospitals. The obtained adhesive film will inhibit growth of a wide range of microbes and will be suitable for high-touch surfaces, providing a durable protection with good resistance. It will assure the highest level of hygiene and patient safety, reducing the use of disinfectants. These objectives will be achieved, using a multi-functional approach combining prevention of adhesion with killing of microorganisms, by means of essential oil (EO) emulsions embedded in a micro and nanopatterned polypropylene matrix. FLEXPOL covers the following key aspects: -It addresses the development, upscaling and demonstration in a relevant industrial environment of the production of films with AM, biocompatible and anti-adhesive properties. Existing extrusion and nanoimprinting pilot lines will act as the starting point in which new additives based on blends of EO will be incorporated. -Previously validated technologies constitute the basis of the approach. These technologies will be extended to large scale production and demonstrated in a real operational environment. The pilot line will include real time characterization for inspection of the film at the nanoscale. -Robustness and repeatability of film fabrication and its behavior in a real environment will be studied. The effectiveness of the solution will be compared with standard protocols. -Materials are chosen according to their cost for large-scale application. Productivity and cost of the fabrication process will be analyzed attending to energetic optimization of the product fabrication and the raw material cost. -Access to the pilot line for AM films in this or a different application will be ensured to European Industries at a cost that promotes technology transfer. -Non-technological aspects key for the marketing of the product (such as regulatory issues, HSE aspects, LCA...) are considered.