Before a proposed new medicine reaches the stage of a clinical trial - so before it is allowed to be used on people - it must have already undergone a great deal of testing. The tests will principally examine the safety of the drug and its efficacy. Perhaps the most crucial stage in the drug development pathway prior to human trials involves testing drugs on mice. There are many reasons why mice are used, a key one being that their genetic and biological characteristics are sufficiently similar to humans that many human diseases or medical conditions can be replicated or modelled in mice. In recent years, with the advent of genetically-altered mice and the increase control it offers, mouse models have become even more useful. One of the key questions that is asked during these tests is: where has the drug ended up in the body? If the drug is designed to treat the gut, for example, does it end up in the gut or does it accumulate elsewhere in the body with potentially damaging consequences? Tests of this sort are called biodistribution studies. The ideal tool for biodistribution studies would be a device that can provide an image of the whole mouse in 3D, in high resolution, and can pick out where in that image the drug is located, eg. by being able to detect its unique spectral signature. It would also be helpful if the imaging technique could be used on a live mouse and, furthermore, did no damage to the mouse. This latter point is especially important as it means that the same animal can be imaged at several points in time to see how the distribution of the drug changes, or see what changes are occurring in the mouse itself over time. There are several small animal imaging modalities that are in routine use today, but none of them come close to meeting this ideal. There is rapidly growing interest in photoacoustic tomography for small animal imaging because it has the potential to become this ideal tool. Photoacoustic tomography is an emerging technique that uses short pulses of light to generate ultrasound waves within the mouse wherever the light is absorbed. The photoacoustic waves, which carry spatially-resolved information about the structure and even the molecular content of the tissue, propagate out to an array of detectors. A numerical algorithm is then used to reconstruct a 3D volumetric image of the interior of the mouse. The technique is non-invasive, harmless (as it uses non-ionising radiation), and, because it is based on optical absorption, it has the potential to identify components within the tissue based on their optical spectra (which are unique to every type of molecule). There is one factor holding photoacoustic tomography back from becoming the default approach for small animal imaging the world over: the image quality is not yet as good as it could be. There are three reasons for this. First, the most readily-available sensors cannot detect the full frequency bandwidth of the photoacoustic signals and so fail to capture key information; second, most imaging systems do not detect from all around the animal due to the fabrication complexity and cost of the arrays that would be needed, resulting in image artefacts; third, distortions of the photoacoustic waves due to sound speed variations between and within the different tissue types leads to aberration and blurring in the image, especially at depth. The scanner proposed here will overcome all three of these limitations of the currently available technologies, through the use of optical detection and generation of ultrasound, and by using ultrasound computed tomography as a adjunct modality to facilitate aberration correction during the image reconstruction.

Photonics has moved from a niche industry to being embedded in the majority of deployed systems, spanning sensing, biomedical devices and advanced manufacturing, through communications, ranging from chip-to-chip and wireless access to transcontinental scale, to display technologies, bringing higher resolution, lower energy operation and new ways of human-machine interaction. Its combination with electronics enables the Digital Future. The Government's UK Semiconductor Strategy and UK Wireless Infrastructure Strategy both recognise the need for highly trained people to lead developments in these technology areas, the Semiconductor Strategy referring explicitly to the role of CDTs in filling the current shortage of highly trained researchers. Our proposed CDT has been designed to meet this need. Currently manufactured systems are realised by combining separately developed photonics, electronic and wireless components. This approach is labour intensive and requires many electrical interconnects as well as optical alignment on the micron scale. Devices are optimised separately and then brought together to meet systems specifications. Such an approach, although it has delivered remarkable results, not least the communications systems upon which the internet and our Digital Future depends, limits the benefits that could come from systems-led co-design and the development of technologies for seamless integration of photonics, electronics and wireless. Our proposed CDT aims to provide multi-disciplinary training enabling researchers to create the optimally integrated, energy efficient, systems of the future. To realise such integrated systems requires researchers who have not only deep understanding of their specialist area, but also an excellent understanding across this interdisciplinary area ranging across the fields of photonics, electronics and wireless, hardware and software. We aim to meet this important need by building upon the uniqueness and extent of the Cambridge and UCL research programmes, where activities range across materials for future systems; higher levels of electronic, photonic and wireless integration; the convergence of wireless and optical communication systems; combined quantum and classical communication systems; the application of THz and optical low-latency connections in data centres; techniques for high capacity access networks; the substitution of many conventional illumination products with photonic light sources and extensive application of photonics in medical diagnostics and personalised medicine. Future systems will increasingly rely on more advanced systems integration, and so the CDT supervisor team includes experts in electronic circuits, wireless systems and enabling software. By drawing these complementary activities together it is proposed to develop an advanced training programme to equip the next generation of very high calibre doctoral students with the required technical expertise, RRI, ES, commercial and business skills to enable the > £24 billion annual turnover UK electronics and photonics manufacturing industry to create the optimised, closely integrated systems of the future. The PES CDT will provide a wide range of learning methods for research students, well beyond that conventionally available, so that they can gain the required skills. In addition to conventional lectures and seminars, for example, there will be bespoke experimental coursework activities, educational retreats, reading clubs, road-mapping activities, RRI and ES studies, secondments to companies and other research laboratories and business and entrepreneurship courses. Students trained by the CDT will be equipped to expand the range of applications into which these technologies are deployed in key sectors of the Digital Futures and wider economy, such as communications, industrial manufacturing, consumer electronics, data processing, defence, energy, engineering, security and medicine.