Europe faces the joint challenge of decarbonising ever newer sectors and applications, whilst also seeking clean waste treatment and valorisation pathways. With over 300Mt of waste generated each year, Europe could produce up to 30Mt of clean hydrogen from waste to accelerate the decarbonisation of challenging sectors like aviation and heavy industry. However, exploiting this energy potential remains a challenge and so far, no robust and cost-effective solutions has been successfully commercialised. HYIELD aims to open a new low-cost pathway for clean hydrogen production and waste disposal. The project proposes a novel multi-stage steam gasification and syngas purification plant concept, which will efficiently convert different organic waste streams into hydrogen and is expected to achieve H2 99.97% purity and 62-74% energy conversion efficiency. The concept includes several beyond state-of-the-art innovations, including a novel process design, waste heat exploitation, Water-Gas-Shift membrane reactor, low-pressure metal hydride storage buffer and IA driven digital twin. The solution will be implemented at 3MW scale in a cement plant in Spain, where the hydrogen will be exploited for cement kiln firing. The demonstrator is expected to operate for 4,000h over a 15-month testing period with at least 10 different organic waste streams, treating over 3.9kt of dry material and producing 650t of hydrogen. It will also carry out the groundwork for up-scaling post-project locally and across the EU, working closely with industrial partners from the cement, steel, copper and gas sectors. It is forecasted that the solution will be able to deliver a Levelized Cost of Hydrogen of 2.19€/kg at industrial scale (20,000t/year waste treated), far below current electrolyser pathways (>5.5€/kg). The project is led by a consortium of Europe’s leading research groups, technology developers and industrial players in the hydrogen sector, from Spain, France, Germany, Norway and Luxembourg.

Innovation in paediatric health is critical to ensure that children, regardless of their age, health condition, socio-economic situation or place of birth, have access to the life-changing healthcare solutions they need to grow-up stronger and contribute to a better society. Children are not just small adults and they need targeted innovative solutions. However, paediatric innovation is still elusive. There are two main causes for this: i) Stakeholders perceive paediatric innovation as risky and they just try to adapt adult solutions to children. ii) Paediatric experts, innovators and other relevant stakeholders are scattered in a fragmented ecosystem across Europe failing to identify opportunities or deliver effective and harmonized action. Thus, the unexploited innovation potential is large, particularly in emerging and moderate innovator countries. To reduce barriers and exploit these opportunities, while ensuring equality across different countries, the establishment of a European Paediatric Innovation Ecosystem is of paramount importance. The i4KIDS-EUROPE project builds on an existing successful initiative (i4KIDS), and it will expand its activities towards Europe in order to enlarge the participation of diverse European paediatric stakeholders and territories. The project will allow synergies, avoid duplications, reduce differences between strong and emerging/moderate innovator territories and strengthen competitiveness to optimise the innovation potential of the European paediatric sector. To achieve this, we will analyse the landscape of paediatric innovation in Europe as well as the barriers that emerging/moderate innovator countries face. i4KIDS-EUROPE will offer an interconnected paediatric innovation ecosystem that will capacitate its underrepresented actors and make them participate in the design of the future European Paediatric Innovation Ecosystem.

CCRI Knowledge Hub aims at increasing the impact of the existing Circular Cities and Regions Initiative (CCRI) by enlarging the network of involved stakeholders, bringing together the knowledge and critical mass already developed around Circular Economy implementation and building upon the CE stakeholder platform. The goal is to promote and make the circular economy concept a reality in EU cities and regions, in particular in those in the early stage of circular economy transition. To reach its objective, CCRI Knowledge Hub will leverage existing initiatives and projects to foster the adoption of circular economy in EU cities and regions. CCRI Knowledge Hub´s formula is based on three principles: (a) easy access to systematized workable knowledge; (b) tailored mentoring according to users’ needs and (c) effective awareness-raising to make the circular economy more desirable, that build upon four main dimensions: (i) Public engagement; (ii) Innovation and technology; (iii) Business models and financial support; and (iv) Impact evaluation. CCRI Knowledge Hub gathers a multidisciplinary expert consortium of 11 partners from 6 EU countries (research and technological centres, universities, research organizations, international networks and associations, regional authorities as well as specialized companies and SMEs) that bring in complementary skills and competences to achieve the project´s objectives.

Lung cancer is the leading cause of cancer-related deaths, with 1.8 million deaths expected globally in 2021. Lung adenocarcinomas (LUAD) represent 1/3 of all lung cancer cases. Despite notable advances, current treatments remain ineffective, resulting in <25% survival beyond 5 years. Due to the high heterogeneity of molecular abnormalities driving lung cancers, targeted therapies are applicable to only a small subset of patients. There is therefore an urgent unmet need for developing novel therapeutic approaches generally applicable to LUAD patients. Alternative pre-mRNA splicing (AS) allows the synthesis of different protein variants from a single gene by differential selection of exonic sequences. Increased inclusion of exon 9 of the gene NUMB encodes a protein isoform that promotes cancer cell proliferation. This occurs in the vast majority of LUAD tumours, correlating with worse disease prognosis. Supported by the ERC PoC VALSL, we developed an innovative therapeutic approach based on the use of Antisense Oligonucleotides (AONs) that regulate NUMB AS. Our proprietary AONs correct NUMB pathological splicing, inhibit cancer cell proliferation and reduce tumour growth in four different mouse models of LUAD, including 2 Patient-Derived Xenograft models. With support from the EIC Transition, we will bring this technology to a stage where it is ready to be validated in clinical trials. We will optimise our lead AONs by improving their chemistry, formulation and administration and will carry out regulatory pre-clinical studies. These will pave the way to the first application of AON-based splicing modulation in clinical oncology. To commercialise this technology, we also aim to develop the business plan for a spin-off company, AON Therapeutics. In the long term, our project has the potential to generate compounds, presentations and delivery methods that can be applicable to other target AS events and/or cancer types, as well as to other AS-related diseases.

EU is currently responsible for 11.6% of the world's final energy consumption (9425 Mtoe in 2014) and for 10.8% of the world's final CO2 emissions (33.3 GtCO2 in 2014) with Industry accounting for 25.9% of the energy consumption and for 47.7% of the final CO2 emissions. Energy in industry is mostly used for process heating and cooling, which represents about 63% of the total industry final energy demand. A rather significant theoretical waste heat potential, accounting to 370.41 TWh (Waste heat) per year, has been estimated in the European industry. Energy Intensive Industries (EEIs) are unsurprisingly the top heat emitters. On the other hand, it is estimated that at least 50-70% of EU households could be served more cheaply by thermal infrastructure through district heating networks. District heating currently provides only 8% of the heating demand in Europe. There is therefore an opportunity for increasing energy efficiency growth rates and contributing significantly to the decarbonization targets of European Industry by using the large underutilized energy resources found throughout European EEIs to substitute conventional heat sources in the European industrial and urban sector. The overall objective of INCUBIS is: To help decarbonise European industry by 2050 by unlocking the market potential of ENERGY SYMBIOSIS through developing and deploying five (5) Energy Symbiosis Incubators across Europe, complemented by a digital Cloud Incubator, thus enabling the utilization of waste energy from EEIs. In doing so INCUBIS will achieve total energy savings of 200GWh/year, trigger €6 Million of investments in sustainable energy, generate benefits of €4 Million, achieve GHG reduction of 55k tCO2-eq/year, and convince 1450 business over 40 industrial parks to commit to energy cooperation. To achieve this INCUBIS has put together a prestigious consortium of 8 partners including 5 SMEs that span 6 European countries and will work for the duration of 36 months.