INNAXE aims at strengthening the interconnection and fostering the dialog among European Life Sciences and Healthtech innovation ecosystems, to increase their efficiency and innovation capacities, with the focus on the twin transformation that ecosystems’ stakeholders are already experiencing. INNAXE intends to define and prepare a joint actionable plan towards more interconnected, inclusive, sustainable, dynamic and competitive Life Sciences and Healthcare innovation ecosystems across the EU and Associated countries, to overcome the current fragmentation when it comes to innovation capabilities. The consortium is composed of 6 leading cluster organisations that bring together, connect, coordinate, dynamise, and accelerate the Life Sciences and Healthtech innovation ecosystems’ community at regional level in Catalonia (Biocat, ES), Île de France (Medicen, FR), Rhine-Neckar (BioRN, DE); at national level in Bulgaria (HLSC, BG) and Denmark (DLSC, DK) and at EU level and Associated Countries (CEBR, BE). The regional/national ecosystems in this consortium cover all the innovation levels of the European Innovation Scoreboard (EIS) and Regional Innovation Scoreboard (RIS) , from emerging innovators to innovation leaders. The Joint Action Plan will specifically address performance gaps of emerging and moderate innovator regions, with the help of strong innovator and innovation leader regions. The project will broaden its scope to include ecosystems from other EU and Associated countries through the Council of European BioRegions (CEBR), a partner in this project. INNAXE intends to align the project outcomes to the diverse policies in the EU agenda for innovation, EC Work Programs, and regional, local and national agendas, as well as other EU-funded projects, exploring complementarities and synergies to draft an optimal Joint Action Plan (JAP).