Mobility is essential to our modern world to move people and goods between places and countries to serve needs relating to food, energy and all human necessities. However, mobility and its benefits do not come without harm: all transport sectors are substantial emitters of greenhouse gases and air pollutants. Furthermore, transport sectors, particularly aviation and maritime, are difficult to decarbonise by electrification, hence the combustion engines and turbines will remain in use for the foreseeable future. Energy efficiency increases and carbon-neutral fuels will reduce the climate impact of these technologies, but solutions are needed also to remove exhaust emissions completely, including those formed through secondary reactions in the atmosphere. Particulate matter (PM2.5) emissions are especially harmful, causing premature deaths and significant harm to humans and all global ecosystems. The PAREMPI project will reveal the contribution of the secondary aerosols (SecA) from transport sources to ambient PM2.5 levels via increased understanding of precursors, their atmospheric reactions and by a novel digital software (ePMI module) to be developed in the PAREMPI project. In combination with toxicity and health impact assessments, quantification of transport externalities will be improved. The consortium members are top-scientists in the research of the precursor emissions, SecA formation, and health impact of aerosols, many of them have focused in these topics all their careers and earlier collaboration assure seamless work. Consortium members have experts also on road, non-road, marine and aviation sectors, and on the emissions standards. Thus, the consortium is capable of formulating sound policy recommendations based on scientific evidence obtained. The PAREMPI results, efficiently disseminated, communicated and exploited, have the potential to significantly contribute to the goal of making transportation systems in Europe clean, secure, and efficient.

The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.