In response to evolving risk landscapes, governments and international organizations have adopted comprehensive programs to enhance preparedness and response capabilities. Building on eNOTICE and eNOTICE-2, eNOVATION addresses the increasing threat of Chemical and Biological threats including Toxin (CB/T) incidents, whether natural, intentional, or accidental, as well as the risk posed by "Do-It-Yourself" technologies. eNOVATION aims to expand and strengthen the network of CBRN training centres, including the CBRN Centre of Excellence in regions like the Africa Atlantic Façade (Rabat, Morocco), Central Asia (Tashkent, Uzbekistan), and South East and East Europe (Tbilisi, Georgia, and CBRN CoE partner in Armenia). The project's main goal is to upgrade the training (Trg) framework for first responders in managing CB/T incidents and evaluating on-site emerging tools and technologies for detection, identification, monitoring, and decontamination. eNOVATION introduces new Trg methods that integrate upgraded courses, AI-supported technologies, enhancing automation and user-friendliness, as well as augmented and extended reality (AR/XR). The Network will guide pre-normative research for technologies and Trg methodologies. Altogether, technologies evaluated on-site are sourced from eNOVATION partners, ENCIRCLE, and eNOVATION supplier platforms. The project outcomes aim to integrate human factors and societal considerations into emergency response, including international Assistance to vulnerable and disabled people, assessment of stockpile mobilisation for hospitals in CBRN CoE partner countries during CB/T crises. The web application “eNOVATION Cube” is central to the project: integrating an ontology-driven matchmaking process to serve as a reference and benchmark for training FR and for technologies labelled after success evaluation on-site. This will have a direct impact on research, operational, and policy processes while supporting the sustainability of the netw