Personalised Medicine (PM) approaches, thanks to the latest technological advances notably in the fields of biomedical and digital technologies, prove their potential to improve healthcare and underpin more efficient and sustainable health systems. PM is at the top of the European Commission research agenda, with funding devoted to projects along the entire value chain. In China, PM is attracting massive interest, with the government capitalising on its expertise in biotechnology, computing hardware and the ability to put in place the infrastructures for supporting large bioinformatics projects. Turning PM into an opportunity for all citizens and patients requires the engagement of all stakeholders, in order to define common research and development approaches, standards, and priorities, and to scale up the collaboration at the International level. In order to respond to these challenges, the EU supports actions developed within the International Consortium for Personalised Medicine (ICPerMed). IC2PerMed project will provide key solutions for enabling the convergence under ICPerMed consortium of European and Chinese stakeholders towards a common approach of PM research, innovation, development and implementation involving policy makers and healthcare beneficiaries, by: - mapping policies, programmes, standards and initiatives related to PM in Europe in China for identifying the opportunities for research collaborations; - structuring its developments upon an ecosystem of European and Chinese experts, collaborating in Working Groups centred on ICPerMed Action plan priorities; - setting bridges with key organisms involved in the definition and implementation of PM and healthcare systems in both economic areas, both on benefits for coordinated approaches for research and on concrete developments taking place within and along the project; - inserting its developments in international contexts, through ICPerMed and its involvement in relevant initiatives and networks.

Adaptation to climate change has become a central focus for researchers across various fields, including climate science, environmental science, urban planning, information science and social science, to support policymakers in making informed decisions to build a climate-prepared and resilient society. The major challenges in achieving this goal are (i) lack of seamless interaction between platforms, data spaces, and users, (ii) poor data interoperability as well as service interoperability, (iii) lack of infrastructural support for generating FAIR data, and (iv) legal barriers hindering access to data. CLIMATE-ADAPT4EOSC aims to overcome these challenges by providing an EOSC-centred collaborative research environment equipped with existing EOSC data and services and extended with new data and services, such as Interoperability, FAIRification, Research Results Publishing as Open Data, Data Adaptation, Data Format Compliancy, Mapping and Entity Matching, enabling interoperability and seamless interaction of data that allow the creation of extended services, e.g., Big Data Analytics for climate risk assessments. The project develops a climate change adaption ontology and an EOSC Climate-Adapt Knowledge Graph based on the ontology, supporting findability, accessibility, tracking and life cycle management of research outputs of various kinds, including data, scientific papers, methods, code, software packages and tools. CLIMATE-ADAPT4EOSC also develops three innovative services that provides support to EU Mission climate change adaptation and the European Green Deal. These services have been planned to be demonstrated in Five EU countries.

The overarching goal of CARIOQA-PMP is to prepare the deployment of quantum gravimeters/accelerometers in space, within the decade, through a Quantum Pathfinder Mission. Indeed, the emergence of quantum sensors offers an opportunity to provide new applications for climate sciences through the improvement of space gravimetry performance. Hence, the mastery of this technology in space is one of the major environmental, technological and strategic challenges of the decade. Three main objectives have been set for the scope and duration of CARIOQA-PMP: 1. To develop an Engineering Model (EM) of the mission’s instrument and to increase the TRL of the critical subsystems up to 5. Complementary EU industrial partners develop the subsystems of the instrument (i.e. Physics Package, Laser System, Microwave Source and Ground Support Equipment) and increase its TRL by assessing the critical technologies in relevant environments. Excellent institutes bring their quantum expertise for the definition of the EM and the mastering of its performance 2. To guarantee the adequacy of the hardware development with the future scientific needs. Through their knowledge of scientific applications, leading institutes in geodesy analyse and simulate potential mission scenarios for the Quantum Pathfinder Mission and future Post-Pathfinder scientific missions 3. To establish a technical and programmatic roadmap for Quantum Space Gravimetry Missions. This roadmap will be shared and validated by European stakeholders. It ensures the impact maximisation of the project’s results through its harmonisation with the European programmatic framework CARIOQA-PMP brings together the main players of quantum sensors in Europe. It gathers unique skills among 16 partners from 5 EU Member States including 2 space agencies, 8 research organisations and 6 industries. As a result, CARIOQA-PMP will secure the capacities for implementing quantum gravimeters/accelerometers in space within the EU, contributing to the EU's strategic goal of non-dependence and autonomy.

Water, energy, food, and ecosystems (WEFE) are interconnected, comprising a coherent system (nexus) dominated by complexity and modulated by climatic and socio-economic drivers. Resource constraints, and their interconnectedness could hamper economic development, including optimal trade, market and policy solutions. Moreover, policy objectives tend to be developed with little consideration to multiple sectors, and policy implementation may change nexus characteristics, in turn affecting actor behaviour and policy formulation. NEXOGENESIS will develop and validate: (a) a coherent cross-sectoral policy-making framework at different scales addressing climate and socio-economic change, as well as stakeholder behaviour and transboundary (diplomacy) issues, developed for and validated by stakeholders, policy makers, and academics; (b) a Self-Learning Nexus Assessment Engine (SLNAE) exploiting reinforcement learning, and supporting streamlining water-related policies into the WEFE nexus; (c) a WEFE Nexus Footprint, accompanying the SLNAE. NEXOGENESIS will apply its approach to four European and one case study in southern Africa. Through the case studies, strong stakeholder engagement and validation of output, NEXOGENESIS will improve policies and policy making processes to enhance cooperation and help the EU achieve targets related to the Water Framework Directive, the greener CAP, Green Deal ambitions, as well as ambitions on water diplomacy. NEXOGENESIS outcomes, both during and after the project, will have a major impact on advancing nexus understanding and governance, resulting in a more innovative and more competitive European Union regarding nexus policy-making, backed up by state-of-the-art evidence. NEXOGENESIS will continue to drive impact after the end of the funding period through dedicated outscaling and exploitation objectives to maximise future impacts and will bring project results to extended group of users via an innovative stakeholder engagement process.

The EU aims to transforming 150 European regions into sustainable and climate resilient regions by 2030. VALORADA contributes to address this challenge by co-developing tested FAIR customizable data-manipulation tools to access available climate datasets and to enable the sharing, community validation and use of locally socioeconomic, demographic and Earth-Observation data. In a rigorous transdisciplinary approach, the respective risks of climate change are analysed in five demonstrators in Europe with the local actors. Data required for the analysis are compiled from the various already existing repositories (e.g., Climate Data Store) and locally-sourced non-climate data catalogues processed by local communities and regions, prototype analysis tools developed in an iterative process, tested by the actors and subsequently improved. We will co-develop and make available prototype climate data and non-climate data manipulation tools to support and improve existing data portals and platforms and to enable user-oriented multi-data integration. VALORADA aims to reach TRL 7 and above. VALORADA’s tools will enable to acquire different useful climate and non-climate data and make them “interoperable” in terms of metadata, as well as tools able to harmonise the geographical and time references chosen for the data. “Analyst toolbox” will be composed of tools able to combine different kinds of data all relevant for assessing climate risks and to calculate resulting indicators. VALORADA will contribute to scaling up to 150 regions through the implementation of dedicated scalability and replicability activities with at least 10 European regions, and through strong collaboration with other Horizon projects. Additional activities include capacity-building schemes for end users as well as providers of climate services. VALORADA will explore and assess the options to facilitate the connection of the VALORADA data tools to the Copernicus Atmosphere Data Store.