5G-Xcast will devise, assess and demonstrate large scale immersive media delivery by means of conceptually novel wireless technologies, contributing to the further definition of 5G and its standardisation. 5G-Xcast will focus on large scale media distribution, as this use case is one of the most demanding requirements in terms of data rate (capacity), scalability (cost-effectiveness) and ubiquity (coverage). The 5G-Xcast media delivery solution will have built-in unicast/multicast/broadcast modes and caching capabilities. The project will take a holistic approach in order to harmonize media delivery across the three communication modes being considered, and to provide a seamless user experience, as well as common Application Programming Interfaces (APIs) to content service providers. The project will cover multiple disciplines from the radio interface to the transport and application layers, including protocols and APIs, as well as network and system architecture aspects. The development of the 5G-Xcast media delivery solution will be focused on the Media and Entertainment (M&E) vertical. The automotive, Internet of Things and public safety verticals will be considered to ensure that their respective technical requirements are also identified and suitably addressed. Proof-of-concept prototypes and technology demonstrators are pivotal tasks of the project. Special emphasis will be given to emerging new immersive media services that cannot be efficiently delivered by existing technologies and networks. 5G-Xcast will enable progressive convergence in the media delivery sector while optimising the resources of the available infrastructures, enabling new business models over fixed, mobile and broadcast networks that will be also investigated in the project. The consortium is a balanced combination of telecom and media entities, covering the complete M&E value chain, with a very strong presence in 5G-PPP phase-1 and 3GPP standardization of 4G Broadcast.

As 5G approaches a very high maturity level, the testing and validation of the innovations achieved in 5G by integrators and verticals service providers has become of utmost importance. Verticals have very different needs, such as the case of the Automotive industry and Public Protection and Disaster Relief (PPDR). This will therefore require different levels of support in taking their applications and services from concepts, to prototypes and finally to products. However, it is also more and more frequent that services in different verticals need to exchange data, particularly mobility services such as those found in connected automobiles and PPDR. 5GASP aims at shortening the idea-to-market process through the creation of a European testbed for SMEs that is fully automated and self-service, in order to foster rapid development and testing of new and innovative NetApps built using the 5G NFV based reference architecture. Building on top of existing physical infrastructures, 5GASP intends to focus on innovations related to the operation of experiments and tests across several domains, providing software support tools for Continuous Integration and Continuous Deployment (CI/CD) of VNFs in a secure & trusted environment for European SMEs capitalizing in the 5G market. 5GASP targets the creation of an Open Source Software (OSS) repository and of a VNF marketplace targeting SMEs with OSS examples and building blocks, as well as the incubation of a community of NetApp developers assisted with tools and services that can enable an early validation and/or certification of products and services for 5G. We focus on inter-domain use-cases, development of operational tools and procedures (supporting day-to-day testing and validation activities) and security/trust of 3rd party IPR running in our testbeds.

<< Background >>The RLT Academy project aims to launch a multidisciplinary and transnational blended education programme for healthcare professionals on the use of radioligand therapies in cancer care. Radioligand therapy (RLT) is an innovative approach to precision cancer treatment that delivers radiation directly to tumour cells, regardless of where they are in the body, leaving healthy tissues unharmed. One of the greatest strengths of RLT is the concept of theragnostics, which effectively combines diagnosis and treatment within the same therapy. It uses the same vector to localize the disease by PET-scan (diagnosis) and then hit the tumour with radiation capable of breaking the DNA of the target tumour cell (treatment). RLT has a huge potential to transform cancer care as we know it, however, despite its great promise, this treatment option is a long way from being a mainstream cancer therapy in Europe. The lack of permeation of RLTs in cancer care is primarily a consequence of the capacity and knowledge gap that exists among healthcare professionals in the use of this innovative therapy. This gap is the result of several crucial factors. First, RLT is an innovative therapy that has only been in use at a few specialised centres in Europe in the past 20 years. Keeping up the pace with medical innovation is always a challenge. Because there hasn’t been any structured capacity building in this area, healthcare professionals haven’t had the chance yet to acquire the necessary skills to integrate RLTs in patient care. Second, while RLT falls under nuclear medicine, this subfield has been traditionally focused on diagnostics, rather than therapeutics. As a consequence, many nuclear medicine specialists in Europe still do not possess a working knowledge of RLTs and cannot act as champions for this treatment. Third, although RLT is a nuclear medicine solution, its primary application lies in oncology (cancer care). As such, the delivery of RLT requires a strong multidisciplinary approach (i.e. the cooperation between nuclear medicine specialists, oncologists, radiologists, nurses etc.) which is often a challenging task for medical professionals to facilitate. The current reality in Europe (and also globally) is that there are only a small number of healthcare professionals appropriately trained in this treatment approach, which hence remains restricted to a small number of specialized centres. The required multidisciplinary work is rarely implemented in clinical practice. Roles and responsibilities of different members of the multidisciplinary team are not properly defined, or not all necessary specialists are included in tumour boards of non-specialized hospitals. This lack of preparedness is further contrasted by the expected boom of RLT solutions in the future, as this therapy will be the growth driver of nuclear medicine worldwide, becoming the next pillar of cancer care. In light of the above, there is an urgent need to address this knowledge gap through a structured transnational training programme in RLTs – something that is currently missing from the education portfolio of healthcare professionals. A consistent educational initiative at the European level, appropriate, dedicated, and tailored to the relevant professionals within multidisciplinary cancer teams needs to be urgently launched. The need for such an inter-specialty approach in nuclear medicine education for a better cancer care is also strongly advocated by the European Commission’s flagship Beating Cancer Plan initiative as well as by the Strategic Agenda for Medical Ionising Radiation Applications (SAMIRA) Action Plan. Such a training programme is a mandatory prerequisite of ensuring cancer patients can truly benefit from this innovative treatment. The potential of this new pillar in cancer care can only be fulfilled if the relevant healthcare communities are prepared for RLT’s integration into patient care.<< Objectives >>The RLT Academy project, through launching a multidisciplinary blended training in RLTs, will aim to achieve the following high-level objectives: Objective 1: Map the knowledge gap in RLTsWhile it is known that there is a considerable knowledge gap in RLTs among healthcare professionals, its exact extent and nature have never been studied before. The project will elevate the understanding of the current RLT education landscape and measure the exact knowledge gap in a qualitative and quantitative manner broken down to specialisations, geographic areas and other relevant factors. A state-of-the-art research on this topic will be published as part of the project that will serve as a benchmark for any further RLT related study and capacity building programme (including the RLT Academy). Objective 2: Bridge the knowledge gap that currently exists among healthcare professionalsThis objective will be primarily achieved through the design, creation and launch of a structured, transnational, and multidisciplinary education programme on the use of RLTs for interested healthcare professionals. This will consciously complement other mostly ad-hoc training initiatives through its unique design. The training programme will be delivered in a blended format, i.e. it will have a strong virtual as well as physical (clinical) training aspect. Through its open and free access, the training programme will fill the current knowledge gap on RLTs and strengthen the multidisciplinary cooperation between oncologists, nuclear medicine specialists and other relevant professionals. The RLT Academy project will provide adapted educational programs to relevant stakeholders on the nature of this novel therapeutic strategy, its biology, pharmacokinetic, biophysics, preclinical and clinical challenges, as well as knowledge on the most up-to-date research programmes, facilitating the transition of RLTs to routine care.Objective 3: Promote the integration of RLTs into mainstream cancer care In the long-term, by launching the RLT training programme to address the currently existing knowledge gap, the RLT Academy project will also greatly contribute to integrate RLTs in mainstream cancer care. As mentioned above, through its innovative approach, RLT has the potential to create a true paradigm shift and become a new pillar of cancer care. Adopting this treatment will transform patient outcomes and contribute to a more successful EU level effort at combatting cancer, but only if it is properly adapted into mainstream cancer care. This cannot be done without first laying the foundations through proper education and training a new generation of healthcare professionals who can integrate RLTs in their ongoing practices. These healthcare professionals, armed with the knowledge attained through completing the RLT Academy programme, will be able to initiate the positive changes in their home countries/institutions necessary for RLT integration and act as champions of this treatment for the benefit of cancer patients. This objective is fundamentally aligned with the European Commission’s initiatives to improve European cancer care, especially through its Beating Cancer Plan, as well as the SAMIRA Action Plan which specifically identifies the Erasmus+ programme as a tool to promote capacity building and training in nuclear medicine to strengthen the fight against cancer in Europe. Realising this synergy, the project will advise policymakers on addressing the complex barriers RLTs face in Europe through a set of policy recommendations. Ultimately, the project’s objectives will greatly contribute to the proper implementation of this paradigm changing solution, which will transform the approach to tackling cancer and profoundly modify the organization of therapeutic care for patients.<< Implementation >>The objectives of the RLT Academy will be achieved through five comprehensive deliverables. In particular, it will realise four main Project Results and over twenty training activities. Project Result 1: scientific study to measure knowledge gap in RLTsThis activity will deliver an in-depth research on the education of RLTs in Europe and conduct a needs analysis for the target audiences of the project. The research study will integrate systematic surveys across European universities and medical training centres with detailed comparison of the respective contents. The study will include the development of a questionnaire to evaluate the real knowledge among health care operators as well as the perceived risk of utilising ionising radiation in medical environments. The consortium will aim to publish the study in a relevant scientific journal. Project Result 2: development of training curricula and material on RLTsThe core part of the RLT Academy Project is the creation of educational pathways on RLTs, comprehensive and versatile for all categories of healthcare professionals who want to gain more knowledge about the treatment. During this phase of the project, consortium partners will design the necessary curricula and develop training courses addressing the needs resulting from the completion of Project Result 1. Different training needs addressing different audiences can be perceived with respect to different levels of training (medical doctors, nurses, technicians, medical physicists), clinical experience (board certified attendings, residents, medical students), and previous exposure to nuclear medicine and RLT (minimal vs. high-level knowledge on RLT). The design will pursue a tiered approach of training including an introductory online course (basic – part 1), an advanced hybrid online and in presence course (advanced – part 2) and a mainly in presence professional course (professional – part 3).Project Result 3: A unique online platform for RLT education: “Virtual RLT Academy” The Consortium will develop a fully-fledged online education platform, where most of the trainings offered within the project will take place. The system will be designed in an interactive way to offer tailored training opportunity to participants, integrating the materials developed during Project Result 2. The Virtual Academy will bring together all the different medical and technical skills, simplify the transfer of knowledge, and thus facilitate the implementation of RLT to countries and regions where this treatment is not yet available. The platform will provide information about: 1) project background and details, 2) RLT education landscape (e.g. heatmap), 3) Virtual RLT Academy (training site), 4) RLT library (scientific knowledge repository).RLT clinical training activitiesThe project will also offer 20 short-term (two-week long) intensive clinical training opportunities and 4 long-term (six-months long) fellowships for interested healthcare professionals who complete the prerequisite online trainings (Virtual RLT Academy). These clinical trainings are essential to properly education stakeholders on the various complex aspects around the use and delivery of RLTs to patients. Project Result 4: Policy recommendations to ensure wider uptake of RLTs in EuropeBuilding on the lessons learned from the project, the consortium will go beyond the educational scope and will provide policy recommendations to EU and national level policymakers on RLTs. Education of healthcare professionals is only one of the key elements of ensuring that countries can provide access to these therapies. The effective uptake of RLTs require also infrastructural developments, regulatory adjustments and the enaction of other relevant policies before wider patient access can be achieved. This can be done by educating policymakers on the value and importance that RLTs will increasingly have in the near future, as a key element of the precision cancer medicine.<< Results >>The key outcomes of the RLT Academy project are closely tied together with its proposed Project Results and high-level objectives. Key outcome 1: mapping the RLT education landscape and the exact knowledge gap of target audiences. The consortium will carry out a research and needs analysis mapping existing RLT trainings and measuring the needs of target audiences. The findings will be crucial to inform the development of training curricula. This research will be published on the project’s online platform, in a scientific journal and disseminated across the relevant medical communities. The research results will also be presented at an online event.Key outcome 2: developing RLT training curricula and creating virtual interactive training courses. Informed by the findings of the research exercise and the existing expertise of the consortium partners, the project will see the development of an exhaustive and customizable training curricula. This outcome will include both the intellectual output of writing the right contents and designing exams and tests in advance, as well as a more practical side of creating and recording of video lectures. The curriculum will be designed in a way that it will recommend three main approaches depending on pre-existing knowledge and background. As such, participants with minimal experience in nuclear medicine and RLTs will be offered a more comprehensive training programme, while people with a more established professional profile in this field will be offered a specialised immersive approach. Key outcome 3: launching the Virtual RLT Academy online education platform. The consortium will design and launch an education platform which will integrate a complete Learning Management System, an online education platform where target groups will be able to create a profile and access a tailored online programme in form of MOOCs (Massive Online Open Courses) and SPOCs (Small Online Personalised Courses) based on their background. The contents will include scientific reading materials, interactive video lectures, tests and exams, and peer-learning interactions. The platform will also include an RLT Library, a repository of the most state-of-the art and relevant information. The Virtual RLT Academy will be unveiled at an online event in September 2023.Key outcome 4: publishing a set of policy recommendations to advise policymakers on how to address barriers around the uptake of RLTs. As the project will bring together some of the most established experts in the medical fields relevant for RLTs, the consortium will be perfectly placed to provide guidance to policymakers with the necessary weight to be heard. The adoption of RLTs in Europe and ultimately proper patient access does not only depend on proper education, it must also address other barriers such as setting up proper healthcare infrastructures, finetuning relevant regulatory contexts and harmonising cooperation between all relevant stakeholders from regional to European levels. The policy recommendations will build on the best practice attained through the project and set out concrete actions for the policymakers to take. The results will be presented at an event in Brussels to maximise impact. Key outcome 5: encouraging adequate skills attainment for healthcare professionals through clinical trainings. A proper training programme in RLTs cannot happen on a strictly virtual basis. As such, the participants will be offered physical training opportunities at select clinical sites where there is an accumulated clinical expertise in the delivery of RLTs to patients. By the conclusion of the programme, the consortium will aim to train at least 44 healthcare professionals and offer additional placements through seeking external financing support. As an ultimate long-term outcome, the RLT Academy seeks to positively influence the adoption of RLTs in Europe and increase the number of patients who can receive this therapy.