Microalgae biomass holds a great potential to become the reference source of sustainable ingredients for a broad range of bio-based industries. However, it is still an underexploited feedstock in Europe, mostly used to produce low volume/high value products, due to lack of cost-competitive technological solutions for cultivation and biorefinery processes. MULTIPLY aims to demonstrate economically feasible and environmentally sustainable microalgae cultivation and biorefinery processes, for the provision of valuable algal ingredients, suited for the formulation of mid-price products for the food, feed, biomaterials, lubricants and cosmetics sectors. By enhancing and upscaling efficient, innovative and green technologies for the main steps of microalgae cultivation and downstream processing, implementing circular economy approaches and incorporating advanced monitoring and digital tools, MULTIPLY will increase productivity, reduce the use of resources and associated costs and improve the environmental performance of the processes. Based on 5 microalgae species, MULTIPLY will deliver 10 products of improved environmental impact, meeting market requirements. Led by the industry and backed up on institutes and universities of excellence, MULTIPLY brings together microalgae primary producers from southern and northern Europe, technology developers, researchers and industrial end-users of algae ingredients. A strong dissemination, communication and exploitation strategy will ensure an effective uptake of the project results, enabled by a better understanding of the social acceptance drivers and stimulating the enhanced public acceptance for algae-based products and processes. MULTIPLY will create new value chains, paving the way for the deployment of a sustainable, circular and digital microalgae industry in Europe.