Using adaptive optics, first applied in astronomy and then (under STFC funding) successfully adapted for use in optical microscopy, we aim to to produce micrometric resolution ultrasound imaging. Specifically, the goal is to track microbubble contrast agents in circulation thus generating detailed images of the vascular network. This is to meet the unmet clinical need for microvascular assessment in common diseases associated with abnormal microvascular networks such as cancer, ischaemia, inflammatory disease, transplant rejection and tissue regeneration. An example is the ongoing need for rapid and low-risk biomarkers of treatment outcome and its prediction in cancer. The current response evaluation criteria for solid tumours (RECIST) utilises Computerised Tomography (CT) to assess tumour volume changes which typically is done three (3) months after the treatment. Such indirect assessment significantly limits early personalisation based on treatment response and may contribute to suboptimal morbidity and mortality rates. Every year, over 250,000 people in England are diagnosed with cancer, and around 130,000 do not survived as a result of the disease. The annual NHS related costs are in the order of £4.5 billion, and the cost to society as a whole about £18.3 billion. Although these statistics are improving the UK Department of Health aims to achieve the average cancer survival rate on par with the rest of the European Union in an attempt to save an extra 5,000 lives every year. Our proposed product will be used to provide additional benefits to the care of each patient that can be used for: -Early diagnosis with the potential of becoming a screening test, -Early and fast disease monitoring that enables early patient stratification. Ultrasound provides real time images at low cost and low risk to patients, which is very attractive for repeated imaging of tissues. As recommended by the Department of Health we will assess our technique in the measurement of an established biomarker such as microvascular density (which is an established biomarker for many cancers), and consider the generation of new biomarkers such as capillary blood velocity, vessel structure and tortuosity that may provide a robust differentiation of vascular related disease. This is a significant improvement to all current imaging modalities that are macroscopic. There is a real opportunity to establish CEUS as the leading modality for perfusion assessment by translating existing technology that provides super-resolution images of point sources in optics (microscopy, astronomy), mm-wave and radar. This proposal will deploy the scatter from single microbubbles as a priori knowledge for implementing an available maximum sharpness likelihood technique similar to that used in optical microscopy. We will implement existing algorithms in an ultrasound field simulation environment to define the experiments that will be used to test these algorithms in vitro and finalize the design of the beamforming method. By utilizing existing image analysis algorithms used for particle tracking we will generate the visualization of in vitro microvascular phantoms. A prototype tool that can be implemented in existing ultrasound imaging product provided by BK Medical, our industrial partner, will be delivered. Finally, we will use existing commercial equipment to collect cancer patient data in order to identify a patient group with promising image data (in comparison with a gold standard). This will provide a focal point in a follow up project for the commercialization of the enhanced imaging capability of our prototype.

Reducing carbon emissions and securing energy supplies are crucial international goals to which energy demand reduction must make a major contribution. On a national level, demand reduction, deployment of new and renewable energy technologies, and decarbonisation of the energy supply are essential if the UK is to meet its legally binding carbon reduction targets. As a result, this area is an important theme within the EPSRC's strategic plan, but one that suffers from historical underinvestment and a serious shortage of appropriately skilled researchers. Major energy demand reductions are required within the working lifetime of Doctoral Training Centre (DTC) graduates, i.e. by 2050. Students will thus have to be capable of identifying and undertaking research that will have an impact within their 35 year post-doctoral career. The challenges will be exacerbated as our population ages, as climate change advances and as fuel prices rise: successful demand reduction requires both detailed technical knowledge and multi-disciplinary skills. The DTC will therefore span the interfaces between traditional disciplines to develop a training programme that teaches the context and process-bound problems of technology deployment, along with the communication and leadership skills needed to initiate real change within the tight time scale required. It will be jointly operated by University College London (UCL) and Loughborough University (LU); two world-class centres of energy research. Through the cross-faculty Energy Institute at UCL and Sustainability Research School at LU, over 80 academics have been identified who are able and willing to supervise DTC students. These experts span the full range of necessary disciplines from science and engineering to ergonomics and design, psychology and sociology through to economics and politics. The reputation of the universities will enable them to attract the very best students to this research area.The DTC will begin with a 1 year joint MRes programme followed by a 3 year PhD programme including a placement abroad and the opportunity for each DTC student to employ an undergraduate intern to assist them. Students will be trained in communication methods and alternative forms of public engagement. They will thus understand the energy challenges faced by the UK, appreciate the international energy landscape, develop people-management and communication skills, and so acquire the competence to make a tangible impact. An annual colloquium will be the focal point of the DTC year acting as a show-case and major mechanism for connection to the wider stakeholder community.The DTC will be led by internationally eminent academics (Prof Robert Lowe, Director, and Prof Kevin J Lomas, Deputy Director), together they have over 50 years of experience in this sector. They will be supported by a management structure headed by an Advisory Board chaired by Pascal Terrien, Director of the European Centre and Laboratories for Energy Efficiency Research and responsible for the Demand Reduction programme of the UK Energy Technology Institute. This will help secure the international, industrial and UK research linkages of the DTC.Students will receive a stipend that is competitive with other DTCs in the energy arena and, for work in certain areas, further enhancement from industrial sponsors. They will have a personal annual research allowance, an excellent research environment and access to resources. Both Universities are committed to energy research at the highest level, and each has invested over 3.2M in academic appointments, infrastructure development and other support, specifically to the energy demand reduction area. Each university will match the EPSRC funded studentships one-for-one, with funding from other sources. This DTC will therefore train at least 100 students over its 8 year life.

Project aim This project proposes a solution for integrated supply of zero carbon heating and cooling using near ground temperature networks that enable buildings to use heat pumps and cooling machines to exchange thermal energy with the network and meet their heating and cooling demand. When a building demands cooling, it rejects its excess heat to the network that can balance the heating demand of another buildings. Therefore, in this project we refer to such networks as 'balanced heating and cooling network' (BHCN). Key contributions of this research are: (i) To investigate the optimal design and operation of BHCN using a multi-objective optimisation approach to balance costs of the system and the value it can provide to the whole power grid via providing flexibility services. In particular, we will examine inter-seasonal heat storage, and also the feasibility of using NH3 and CO2 (as alternatives to water) for heat transport mediums in BHCNs. (ii) To design a local heat market that enables peer-to-peer (P2P) heat sharing to maximise the use of zero carbon sources of thermal energy on-site, and (iii) To identify technical, regulatory and policy barriers against implementing BHCNs (i.e. managing the transition from status quo to BHCN). This research will also build significant UK research capacity in zero carbon and ambient temperature heat networks. Background The need for decarbonising heat supply: According to the 2017 Clean Growth Strategy, the UK Government believes 'decarbonising heat is our most difficult policy and technology challenge to meet our carbon targets'. Progress on energy efficiency and low carbon heat provision remains below expected levels and natural gas infrastructure continues to be expanded which poses risk to achieving the recently set net zero goal for 2050. The role of heat networks: The Clean Growth Strategy suggests 17% of domestic heat and between 17% and 24% of service sector heat could be provided through heat networks in 2050. The Committee on Climate Change suggests around 5 million homes could use district heat by 2050 based on techno-economic modelling. However, heat network growth is slow despite requiring around a tenfold increase from the current level by 2050. The growing demand for cooling: Coinciding with the crucial need for supplying low carbon heat, the demand for cooling is also increasing in the UK (and globally) due to population increase and climate change impacts which are leading to more frequent heatwaves and temperature rises. According to BRE, up to 10% of all UK electricity use is for air conditioning and cooling. Because of this established trend toward increased use of cooling, the proportion of UK electricity used for cooling is expected to rise further. A potential solution for zero carbon supply of heating and cooling: Balanced Heating and Cooling Networks (BHCN), are a form of district heating system which circulates water at near ground temperature to buildings allow them to use their own heat pumps to extract heat for heating, or to export heat to the network when cooling is required. BHCNs address many of the drawbacks of conventional heat networks through operating at reduced temperature and therefore minimising heat losses and reduce the cost of highly insulated pipes. They also open up opportunities for integrating various sources of renewable heat into the networks. The circuit can also be extended to new buildings at limited cost. Work Programme WP1 - Case study definition WP 2 - Assessing renewable heat sources and inter-seasonal storage WP 3 - Techno-economic appraisal of BHCN WP 4 - Development of a methods and tools for Peer-to-Peer (P2P) heat sharing WP 5 - Managing implementation and transition to BHCNs

The surface ocean is home to billions of microscopic plants called phytoplankton which produce organic matter in the surface ocean using sunlight and carbon dioxide. When they die they sink, taking this carbon into the deep ocean, where it is stored on timescales of hundreds to thousands of years, which helps keep our climate the way it is today. The size of the effect they have on our climate is linked to how deep they sink before they dissolve - the deeper they sink, the more carbon is stored. This sinking carbon also provides food to the animals living in the ocean's deep, dark 'twilight zone'. Computer models can help us predict how future changes in greenhouse gas emissions might change this ocean carbon store. Current models however struggle with making these predictions. This is partly because until recently we haven't even been able to answer the basic question 'Is there enough food for all the animals living in the twilight zone?'. But in a breakthrough this year we used new technology and new theory to show that there is indeed enough food. So now we can move on to asking what controls how deep the carbon sinks. There are lots of factors which might affect how deep the material sinks but at the moment we can't be sure which ones are important. In this project we will make oceanographic expeditions to two different places to test how these different factors affect carbon storage in the deep ocean. We will measure the carbon sinking into the twilight zone and the biological processes going on within it. Then we will determine if the systems are balanced - in other words, what goes in, should come out again. We will then write equations linking all the parts of the system together and analyse them to make them more simple. At the same time we will test whether the simple equations are still useful by seeing if they produce good global maps of ocean properties for which we have lots of data. Finally, when we are happy that our new equations are doing a good job we will use them in a computer model to predict the future store of carbon in the ocean.

Copepod species of the genus Calanus (Calanus hereafter) are rice grain-sized crustaceans, distant relatives of crabs and lobsters, that occur throughout the Arctic Ocean consuming enormous quantities of microscopic algae (phytoplankton). These tiny animals represent the primary food source for many Arctic fish, seabirds and whales. During early spring they gorge on extensive seasonal blooms of diatoms, fat-rich phytoplankton that proliferate both beneath the sea ice and in the open ocean. This allows Calanus to rapidly obtain sufficient fat to survive during the many months of food scarcity during the Arctic winter. Diatoms also produce one of the main marine omega-3 polyunsaturated fatty acids that Calanus require to successfully survive and reproduce in the frozen Arctic waters. Calanus seasonally migrate into deeper waters to save energy and reduce their losses to predation in an overwintering process called diapause that is fuelled entirely by carbon-rich fat (lipids). This vertical 'lipid pump' transfers vast quantities of carbon into the ocean's interior and ultimately represents the draw-down of atmospheric carbon dioxide (CO2), an important process within the global carbon cycle. Continued global warming throughout the 21st century is expected to exert a strong influence on the timing, magnitude and spatial distribution of diatom productivity in the Arctic Ocean. Little is known about how Calanus will respond to these changes, making it difficult to understand how the wider Arctic ecosystem and its biogeochemistry will be affected by climate change. The overarching goal of this proposal is to develop a predictive understanding of how Calanus in the Arctic will be affected by future climate change. We will achieve this goal through five main areas of research: We will synthesise past datasets of Calanus in the Arctic alongside satellite-derived data on primary production. This undertaking will examine whether smaller, more temperate species have been increasingly colonising of Arctic. Furthermore, it will consider how the timing of life-cycle events may have changed over past decades and between different Arctic regions. The resulting data will be used to validate modelling efforts. We will conduct field based experiments to examine how climate-driven changes in the quantity and omega-3 content of phytoplankton will affect crucial features of the Calanus life-cycle, including reproduction and lipid storage for diapause. Cutting-edge techniques will investigate how and why Calanus use stored fats to reproduce in the absence of food. The new understanding gained will be used to produce numerical models of Calanus' life cycle for future forecasting. The research programme will develop life-cycle models of Calanus and simulate present day distribution patterns, the timing of life-cycle events, and the quantities of stored lipid (body condition), over large areas of the Arctic. These projections will be compared to historical data. We will investigate how the omega-3 fatty acid content of Calanus is affected by the food environment and in turn dictates patterns of their diapause- and reproductive success. Reproductive strategies differ between the different species of Calanus and this approach provides a powerful means by which to predict how each species will be impacted, allowing us to identify the winners and losers under various scenarios of future environmental changes. The project synthesis will draw upon previous all elements of the proposal to generate new numerical models of Calanus and how the food environment influences their reproductive strategy and hence capacity for survival in a changing Arctic Ocean. This will allow us to explore how the productivity and biogeochemistry of the Arctic Ocean will change in the future. These models will be interfaced with the UK's Earth System Model that directly feeds into international efforts to understand global feedbacks to climate change.