Our society is highly dependent on catalytic science which is central to major global challenges such as efficient conversion of energy, mitigation of greenhouse gases, destroying pollutants in the atmosphere and in water, and processing biomass which all rely intrinsically on catalysis. In addition, catalysis is a key technology for the chemical industry; it is estimated that catalytic science contributes to 90% of chemical manufacturing processes. Chemistry-using industries are is a major component of the UK's manufacturing output and vital part of the overall UK economy, generating in excess of £50 billion per annum. The ONS Annual Business Survey (2012) estimated chemical and pharma manufacturing to be worth £19 billion p.a. and predicted that by 2030, the UK chemical industry will have enabled the chemistry-using industries to increase their Gross Value Added contribution to the UK economy by 50%, from £195 billion to £300 billion. Understanding how catalyst work is notoriously difficult because of the low concentrations and transient nature of catalytically active species. In this project will develop new equipment based on state-of-the-art flow NMR methods that will enable the rapid development of new catalysts for academic research and industrial processes. Crucially the equipment we propose will allow high sensitivity and real-time monitoring of catalytic reactions under a wide range of realistic reaction conditions (e.g., concentrations, temperatures and pressures). This will provide a unique facility to study the scope, productivity, selectivity and deactivation of catalysts, which in turn will provide insight into mechanisms and allow us to develop new catalytic systems. The equipment will be utilized by academic and industrial scientists and engineers at the University of Bath and throughout the UK to understand and develop catalysts for a wide range of processes of academic and industrial relevance. Areas that will benefit from the equipment will include; catalysts for renewable polymers, catalysts for utilisation and valorisation of biomass, catalysts for sustainable energy, and catalysts for sustainable synthesis of pharmaceuticals and fine chemicals. The progress that will be enabled by the equipment will be exploited, particularly within the pharma and fine chemicals sectors, through collaboration with a wide variety of UK catalyst companies and chemical producers.

The report 'Higher Degree of Concern' by the Royal Society of Chemistry highlighted the importance of effective PhD training in providing the essential skills base for UK chemistry. This is particularly true for the many industries that are reliant on catalytic skills, where entry-point recruitment is already at PhD level. However, the new-starters are usually specialists in narrow aspects of catalysis, while industry is increasingly seeking qualified postgraduates equipped with more comprehensive knowledge and understanding across the cutting edge of the whole field. The 2011 EPSRC landscape documents acknowledged the existing strengths of UK catalysis (including the concentration of academic expertise in the south-west), but recognised the critical need for growth in this strategic and high-impact field of technology. Over the following 18 months, the universities of Bath, Bristol and Cardiff worked closely together to put in place the foundations of an alliance in catalysis, based on the distinctive but complementary areas of expertise within the three institutions. This bid will build on this alliance by creating a single training centre with unified learning through teaching and research. Building on the best practice of existing and established postgraduate training, and benefitting from the close geographical proximity of the three universities, each intake of PhD students will form part of a single cohort. The first year of the PhD will involve taught material (building on and expanding Cardiff's established MSc in catalysis), a student-led catalyst design project, and research placements in research laboratories across all aspects of catalysis science and engineering (and across all three institutions). This broad foundation will ensure students have a thorough grounding in catalysis in the widest sense, fulfilling the industry need for recruits who can be nimble and move across traditional discipline boundaries to meet business needs. It will also mean the students are well-informed and fully engaged in the design of a longer PhD project for the next three years. This project will be the same as the more traditional PhD in terms of its scholarship and rigour, but still include wider training aspects. A further benefit of the broader initial training is that students will be able to complete PhD projects which transcend the traditional homogeneous, heterogeneous, engineering boundaries, and include emerging areas such as photo-, electro- and bio-catalysis. This will lead to transformative research and will be encouraged by project co-supervision that cuts across the institutions and disciplines. We have identified a core of 28 supervisors across the three universities, all with established track records of excellence which, when combined, encompasses every facet of catalysis research. Furthermore, full engagement with industry has been agreed at every stage; in management, training, project design, placements and sponsorship. This will ensure technology transfer to industry when appropriate, as well as early-stage networking for students with their potential employers.

Chemistry is a key underpinning science for solving many global problems. The ability to make any molecule or material, in any quantity needed in a prescribed timescale, and in a sustainable way, is important for the discovery and supply of new medicines to cure diseases, agrochemicals for better crop yields/protection, as well as new electronic and smart materials to improve our daily lives. Traditionally, synthetic chemistry is performed manually in conventional glassware. This approach is becoming increasingly inadequate to keep pace with the demand for greater accuracy and reproducibility of reactions, needed to support further discovery and development, including scaling up processes for manufacturing. The future of synthetic chemistry will require the wider adoption of automated (or autonomous) reaction platforms to perform reactions, with full capture of reaction conditions and outcomes. The data generated will be valuable for the development of better reactions and better predictive tools that will facilitate faster translation to industrial applications. The chemical and pharmaceutical industry is a significant provider of jobs and creator of wealth for the UK. Data from the Chemical Industries Association (CIA) shows that the chemical industry has a total turnover of £40B, adding £14.4B of value to the UK economy every year, employs 140,000 people directly, and supports a further 0.5M jobs. The sector is highly innovation-intensive: much of its annual spend of £4B on investment in capital and R&D is based on synthetic chemistry with many SME's and CRO's establishing novel markets in Science Parks across the UK regions, particularly in the South East and North West. The demand for graduate recruits by the Chemicals and Pharmaceutical industries for the period 2015-2025 is projected to be between 50,000-77,000, driven by an aging workforce creating significant volumes of replacement jobs, augmented by the need to address skills shortages in key enabling technologies, particularly automation and data skills. This CDT will provide a new generation of molecular scientists that are conversant with the practical skills, associated data science and digital technology to acquire, analyse and utilise large data sets in their daily work. This will be achieved by incorporating cross-disciplinary skills from engineering, as well as computing, statistics, and informatics into chemistry graduate programs, which are largely lacking from existing doctoral training in synthetic chemistry. Capitalising upon significant strategic infrastructural and capital investment on cutting edge technology at Imperial College London made in recent years, this CDT also attracts very significant inputs from industrial partners, as well as Centres of Excellence in the US and Europe, to deliver a unique multi-faceted training programme to improve the skills, employability and productivity of the graduates for future academic and industrial roles.

30 years' research on metal biorecovery from wastes has paid scant attention to strong CONTEMPORARY demands for (i) conservation of dwindling vital resources (e.g platinum group metals (PGM), recently rare earth elements, (REE), base metals (BMs) and uranium) and (ii) the unequivocal need to extract/refine them in a non-polluting, low-energy way. 21stC technologies increasingly rely on nanomaterials which have novel properties not seen in bulk materials. Bacteria can fabricate nanoparticles (NPs), bottom up, atom by atom, with exquisite fine control offered by enzymatic synthesis and bio-scaffolding that chemistry cannot emulate. Bio-nanoparticles have proven applications in green chemistry, low carbon energy, environmental protection and potentially in photonic applications. Bacteria can be grown cheaply at scale for facile production. We have shown that bacteria can make nanomaterials from secondary wastes, yielding, in some cases, a metallic mixture which can show better activity than 'pure' nanoparticles. Such fabrication of structured bimetallics can be hard to achieve chemically. For some metals like rare earths and uranium (which often co-occur in wastes) their biorecovery from scraps e.g. magnets (rare earths) and wastes (mixed U/rare earths), when separated, can make 'enriched' solids for delivery into further commercial refining to make new magnets (rare earths) or nuclear fuel (U). Biofabricating these solids is often beyond the ability of living cells but they can form scaffolds, with enzymatic processes harnessed to make biomineral precursors, often selectively. B3 will invoke tiered levels of complexity, maturity and risk. (i) Base metal mining wastes (e.g. Cu, Ni) will be biorefined into concentrated sludges for chemical reprocessing or alternatively to make base metal-bionanoproducts. (ii) Precious metal wastes will be converted into bionanomaterials for catalysis, environmental and energy applications. (iii) Rare earth metal wastes will be biomineralised for enriched feed into further refining or into new catalysts. (iv) Uranium-waste will be biorefined into mineral precursors for commercial nuclear fuels. In all, the environment will be spared dual impacts of both primary source pollution AND the high energy demand of processing from primary 'crude'. Metallic scraps are tougher, requiring acids for dissolution. Approaches will include the use of acidophilic bacteria, use of alkalinizing enzymes or using bacteria to first make a chemical catalyst (benignly) which can then convert the target metal of interest from the leachate into new nanomaterials (a hybrid living/nonliving system, already shown). Environmentally-friendly leaching & acids recycle will be evaluated and leaching processes optimised via extant predictive models. The interface between biology, chemistry, mineralogy and physics, exemplified by nanoparticles held in their unique 'biochemical nest', will receive special focus, being where major discoveries will be made; cutting edge technologies will relate structure to function, and validate the contribution of upstream waste doping or 'blending'; these, as well as novel materials processing, will increase bio-nanoparticle efficacy. Secondary wastes to be biorefined will include magnet scraps (rare earths), print cartridges (precious metals), road dusts (PMs, Fe,Ce) & metallurgical wastes (mixed rare earths/base metals/uranium). Their complex, often refractory nature gives a higher 'risk' than mine wastes but in compensation, the volumes are lower, & the scope for 'doping' or 'steering' to fabricate/steer engineered nanomaterials is correspondingly higher. B3 will have an embedded significant (~15%) Life Cycle Analysis iterative assessment of highlighted systems, with end-user trialling (supply chains; validations in conjunction with an industrial platform). B3 welcomes new 'joiners' from a raft of problem holders brought via Partner network backup.

Sustainability is defined as "the ability to meet the needs of the present without compromising the ability of future generations to meet their own needs". Achieving sustainable development is the key global challenge of the 21st Century. It can only be met with the adoption of a range of new sustainable technologies. Sustainable chemical technologies are those involving chemistry as the central science. They span a wide range of areas, many of which make major impacts on society. Key sustainable chemical technologies include: use of renewable resources and biotechnology (e.g., making fuels, chemicals and products from biomass rather than petrochemicals); clean energy conversion and storage (e.g., solar energy, the hydrogen economy and advanced battery technologies); sustainable use of water (e.g., membrane technologies for water purification and upcycling of nutrients in waste water); developing sustainable processes and manufacturing (e.g., making production of chemicals, pharmaceuticals and plastics more energy-efficient and less wasteful through developing sustainable supply chains as well as through technological advances); and developing advanced healthcare technologies (e.g., developing new drugs, medical treatments and devices). To address these needs, we propose a Centre for Doctoral Training (CDT) in Sustainable Chemical Technologies. The £5.08m requested from the EPSRC will be supplemented by £2.0m from the University and a £4.13m industrial contribution. The CDT will place fundamental concepts of sustainability at the core of a broad spectrum of research and training at the interfaces of chemistry, chemical engineering, biotechnology and manufacturing. This will respond to a national and global need for highly skilled and talented scientists and engineers in the area as well as training tomorrow's leaders as advocates for sustainable innovation. All students will receive foundation training to supplement their undergraduate knowledge, in addition to training in Sustainable Chemical Technologies. Broader training and practice in public engagement and creativity will encourage responsible innovation and attention to ethical, societal, and business aspects of research. They will all conduct high quality and challenging research directed by supervisory teams comprising joint supervisors from at least two of the disciplines of chemistry, chemical engineering, biotechnology and management as well as an industrial and/or international advisor. The broad research themes encompass the areas of: Renewable Resources and Biotechnology, Energy and Water, Processes and Manufacturing and Healthcare Technologies. Participation from key industry partners will address stakeholder needs, and partner institutions in the USA, Germany, Australia, and South Korea will provide world-leading international input, along with exciting opportunities for student placements and internships. The CDT will utilize dedicated physical and virtual space for the students as well as a supervisory base of more than fifty academics. Building on the success of the current Doctoral Training Centre and evolving to keep pace with the growing importance of biotechnology and manufacturing to UK industry, the centre will provide a dynamic and truly multidisciplinary environment for innovative PhD research and training.