Non-communicable diseases (NCDs) account for 80% of the disease burden as well as for the majority of premature deaths in the EU; diminishing the citizens’ quality of life, life expectancy and increasing the financial burden (from those affected to the health system). During the last 3 decade environmental stressors have been addressed through numerous studies, which have raised concerns about the detrimental effects of the environment on human health. Most evaluated environmental stressors are air temperature, particulate and gaseous air pollutants, urban noise, food pollutants and radiation. By end of 2022, air pollution was reported to be responsible of an excess mortality of 311.000 people per year in the UE-27 , driving not only premature deaths but also an increased risk of vascular diseases such as ischemic heart disease, stroke, and other non-communicable non-vascular diseases like chronic respiratory diseases or depression. Some newly considered stressors such as electromagnetic field, and light exposure are also susceptible to affect human health (e.g ocular and dermatological NCD diseases). ENACT aims at building a pathway to generate clinical, technological and economic short & long-term impact targeting local and regional stakeholders and create impact by: Developing a state-of-the-art environmental risk score and analyser driven framework and platform to predict, monitor and prevent the exposomic risk of acute and chronic health conditions of chronic vascular and non-vascular NCDs. This new exposomic risk score and analyser will support (a) patients, (b) health professionals/hospitals, and (c) policy makers; aiming at reducing the human and financial burden of NCD, considering potential individual vulnerability factors, and reinforcing both a clinical and a policy implementation that enables prevention and disease management for higher quality of life.

Over 30% of EU citizens at vulnerable stages and situations in life are at increased risk to transgress from healthy weight to overweight and further to obesity. Though many interventions to tackle obesity have been proposed, they have rarely been effective. The aim of HealthyW8 is to advance the efficacy of current and future efforts and investments in obesity prevention initiatives across Europe. Most interventions suffer from not adapting to personal context (e.g. socioeconomic aspects, host-biological factors, environment, dietary preferences, fitness level etc.), focus only on diet or physical activity alone, do especially overlook emotional aspects, and fail to engage and motivate the user. Thus, initiatives on obesity prevention in policy and practice are often of marginal impact. HealthyW8 will address these shortcomings by iteratively developing, together with stakeholders, a digital-based healthy lifestyle recommender for evidence-based, tailored interventions and tools including a human digital twin to bridge the gap between science, societal actors and stakeholders (e.g. healthcare professionals, food industries, policymakers) and EU citizens. The targeted populations are those undergoing transitions, i.e. schoolchildren (5-10 y, and their parents), young adults (18-25 y) and the elderly (>65 y). In the mid-term, we estimate that with 200,000 HealthyW8 users, we will prevent 10,000 obesity cases/y. In the long run, the impact will be maximized through adopting the project’s proposed methodology, platform and tools by as many EU institutions and entities as possible. HealthyW8 is a highly experienced, synergistic and complementary consortium that will built on a previously developed digital dietary app (LIFANA) and draw on transdisciplinary research in pan-EU multicentre pilots and long-term randomized control trials to achieve its overarching objective of increasing impact of current and future obesity prevention interventions and policies in the EU.

Combining expertise across all facets of transport and analytical tools, WE-TRANSFORM aims to apply a participatory approach, using Collective Intelligence (CI), to generate an evidence-based and action-oriented agenda to research, formulate and prioritize the challenges connected to the effects of automation on the transport labour force, on future working conditions and on skills requirements. The WE-TRANSFORM consortium, leveraging existing data and people’s expertise, and empowered by the range and depth of its composition, will create a system of thematic and modal cross-national living hub as a knowledge & prioritization agenda-creation platform, offering a path forward for smarter decisions, more innovative and evidence-based policymaking, through informed governance. The approach of WE-TRANSFORM is highly collaborative, promoting discovery, debate and prioritization of themes by the active participation of representative types of stakeholders, using state-of-the-art data collection and analysis tools while drawing information and themes for the collectively constructed agenda from wide-ranging environments. The composition of the consortium and the Artificial Intelligence (AI) tools to be used guarantee access and involvement across a wide range of relevant parties ranging from transport-chains’ stakeholders and extending to citizens’ associations and beyond including information mining from electronic social media. Robust analytical tools are combined with information findings drawn at AI speed and coverage potential, while the simulation of a social debate within a living hub environment allows the dialogue and ultimately the formulation of a collectively defined agenda enriched with co-created knowledge. The proposal includes also a final provision for maintaining the electronic environment created in a sustainable way as to serve for future research in the area.