An emerging area of research in the field of Natural Language Processing (NLP) is text-to-text generation. Text-to-text generation takes naturally occurring texts as input and transforms them into new texts satisfying constraints such as length or style. Examples of applications that require text-totext generation are single- and multidocument summarization, text simplification, sentence compression, and question answering. At the heart of methods developed for text-to-text generation lies the ability to identify and generate paraphrases, i.e., alternative ways to convey the same information either at the sentence or at the document level.The aim of this grant is to create algorithms and software for the collection of corpora appropriate for studying meaning equivalences and to develop and evaluate a summarisation system that incorporates models for identifying and generating paraphrases at the sentence and document level. The application is particularly suited for studying text-rewriting as it involves the extraction, potentially regeneration and ordering of information across multiple information sources.

Reducing carbon emissions and securing energy supplies are crucial international goals to which energy demand reduction must make a major contribution. On a national level, demand reduction, deployment of new and renewable energy technologies, and decarbonisation of the energy supply are essential if the UK is to meet its legally binding carbon reduction targets. As a result, this area is an important theme within the EPSRC's strategic plan, but one that suffers from historical underinvestment and a serious shortage of appropriately skilled researchers. Major energy demand reductions are required within the working lifetime of Doctoral Training Centre (DTC) graduates, i.e. by 2050. Students will thus have to be capable of identifying and undertaking research that will have an impact within their 35 year post-doctoral career. The challenges will be exacerbated as our population ages, as climate change advances and as fuel prices rise: successful demand reduction requires both detailed technical knowledge and multi-disciplinary skills. The DTC will therefore span the interfaces between traditional disciplines to develop a training programme that teaches the context and process-bound problems of technology deployment, along with the communication and leadership skills needed to initiate real change within the tight time scale required. It will be jointly operated by University College London (UCL) and Loughborough University (LU); two world-class centres of energy research. Through the cross-faculty Energy Institute at UCL and Sustainability Research School at LU, over 80 academics have been identified who are able and willing to supervise DTC students. These experts span the full range of necessary disciplines from science and engineering to ergonomics and design, psychology and sociology through to economics and politics. The reputation of the universities will enable them to attract the very best students to this research area.The DTC will begin with a 1 year joint MRes programme followed by a 3 year PhD programme including a placement abroad and the opportunity for each DTC student to employ an undergraduate intern to assist them. Students will be trained in communication methods and alternative forms of public engagement. They will thus understand the energy challenges faced by the UK, appreciate the international energy landscape, develop people-management and communication skills, and so acquire the competence to make a tangible impact. An annual colloquium will be the focal point of the DTC year acting as a show-case and major mechanism for connection to the wider stakeholder community.The DTC will be led by internationally eminent academics (Prof Robert Lowe, Director, and Prof Kevin J Lomas, Deputy Director), together they have over 50 years of experience in this sector. They will be supported by a management structure headed by an Advisory Board chaired by Pascal Terrien, Director of the European Centre and Laboratories for Energy Efficiency Research and responsible for the Demand Reduction programme of the UK Energy Technology Institute. This will help secure the international, industrial and UK research linkages of the DTC.Students will receive a stipend that is competitive with other DTCs in the energy arena and, for work in certain areas, further enhancement from industrial sponsors. They will have a personal annual research allowance, an excellent research environment and access to resources. Both Universities are committed to energy research at the highest level, and each has invested over 3.2M in academic appointments, infrastructure development and other support, specifically to the energy demand reduction area. Each university will match the EPSRC funded studentships one-for-one, with funding from other sources. This DTC will therefore train at least 100 students over its 8 year life.

SoRo for Health is a unique interdisciplinary Platform uniting three new and rapidly advancing areas of science (soft robotics, advanced biomaterials and bioprinting, regenerative medicine) in a collaboration that will deliver transformative technological solutions to major unmet health problems. We are a collaborative scientific group including representatives from three of the most exciting and rapidly advancing technology areas in the world. Soft robotics is a new branch of robotics that uses compliant materials to create robots that move in ways mirroring those in nature; a new paradigm that is already transforming fields as diverse as aerospace and manufacturing. Advanced biomaterials is a rapidly progressing field exploring the application of novel and conventional materials to restoring structure and function. It has recently been augmented by advances in 3D- and Bio-printing with seminal clinical breakthroughs. Regenerative medicine uses a range of biological tools, such as cells, genes and biomaterials, to replace and restore function in patients with a range of disorders. It explores the interface between materials and cells and tissues and has been applied to regenerate critical organs and tissues. Our three groups have combined over the last few years to develop a range of prototype solutions to unmet health needs, in areas as diverse as breathing and swallowing, motor disorders and cardiovascular disease. Here we seek to further coalesce our activity in a unique EPSRC Platform with five primary goals. Firstly and most importantly, we will support, retain and develop the careers of three dynamic rising stars (postdoctoral research assistants, PDRAs) who might otherwise be lost from the field. Primarily supporting their career development, we will thereby also ensure the provision of a cadre of stellar individuals with cross-cutting scientific skills and leadership training who can provide leadership and direction to this nascent, but incredibly exciting, field of Soft Robotics (SoRo) for Health. This will benefit these scientists, the field, and the UK through scientific advance and commercial partnerships. Secondly, we will support our PDRAs to explore novel and high-risk hypotheses related to our combined fields through a flexible inbuilt funding stream. This will help their development, but also generate new ideas and technologies to take forward towards further scientific exploration and, where appropriate, clinic; ideas that might otherwise have fallen by the funding wayside. Thirdly, we will expand and develop a vibrant international network that will further support the development of our stars as well as energising the whole field internationally, with its hub here in the UK. Fourthly, we will engage with end-users, from both healthcare professional and patient/carer communities. We will use professional facilitators and established qualitative techniques to identify the key challenges and opportunities for SoRo as it seeks to address the outstanding and imminent issues in population health and healthcare. Finally, we will work with UK industry and biotech business leaders to develop an effective, streamlined route to IP protection, application and commercialisation that gives SoRo for Health technologies the best possible chance for widespread health gains and speedy application to those in need. Thus, the SoRo for Health Platform combines the talents, and specifically emergent talents, of internationally-leading groups in three new areas with the common Vision of transforming the lives of millions through the development of responsive, customised soft robotic-based implants and devices to address some of the major unmet health challenges of the 21st Century.

Synthetic Biology is the engineering of biology. In this spirit, this Fellowship aims at combining control engineering methodology and expertise with synthetic biology current know-how to solve important real-world problems of high industrial and societal importance. Anticipated high-impact applications of synthetic biology range from cell-based diagnostics and therapies for treating human diseases, to efficiently transforming feedstocks into fuels or biochemicals, to biosensing, bioremediation or production of advanced biomaterials. Central to tackling these problems is the development of in-cell automatic feedback control mechanisms ensuring robust functionality and performance of engineered cells that need to operate under uncertain and changing environments. The availability of methods for designing and implementing feedback control mechanisms that yield improved robustness, efficiency and performance is one of the key factors behind the tremendous advances in engineering fields such as transportation, industrial production and energy. As in these and other engineering disciplines, systems and control engineering will accelerate the development of high-impact synthetic biology applications of societal, commercial and industrial importance. In particular, through this Fellowship, I propose a comprehensive engineering approach to push forward the robustness frontier in synthetic biology towards reliable cell-based biotechnology and biomedicine. This ambitious goal requires: (1) the development of feedback mechanisms to reduce the footprint of engineered metabolic pathways on their cell "chassis", (2) the development of system-level feedback mechanisms to robustly and efficiently manage one or more synthetic devices in the context of whole-cell fitness, and (3) the development of synthetic cell-based systems designed to restore and maintain the extra-cellular concentration of some biomolecules within tight homeostatic bounds. These three aspects define three work packages in my Fellowship. Each work package on its own tackles important synthetic biology challenges for real-world applications, while their combination in WP4 aims towards robust cell-based biotechnology and biomedicine. The corresponding work packages are: *WP1*: Automatic management of fluxes for robust and efficient metabolic pathways (through genetic-metabolic feedback control) *WP2*: Automatic management of cellular burden for robust and efficient whole-cell behaviour (through host-circuit feedback control) *WP3*: Automatic management of extra-cellular concentrations for robust homeostatic regulation of environmental conditions (through cell-environment feedback control) *WP4*: System integration and combination of the feedback control mechanisms developed in WP 1-3 The first two work packages address device robustness to cellular context, while the third addresses robust adaptation to and control of changing environmental conditions. WP4 will use and further develop the systems and control engineering framework developed in WP 1-3 to explore the synergistic combination of the proposed feedback control mechanisms. By providing systematic engineering solutions that endow engineered biosystems with robust functionalities, we will enable the enhancement of existing biotechnological processes and the reliable development of industrial applications to improve health and quality of life. Through the above, this Fellowship will foster strong and long-lasting economic and societal impact in the UK and globally and promote knowledge-based UK leadership.

As Earth heats up in the coming decades, global rainfall patterns will shift with uncertain regional outcomes. Nowhere is this problem more acute than in North Africa. The world's largest hot desert and biggest source of atmospheric dust, the Sahara, grew by >10% in the 20th century. In the semi-arid Sahel and Mediterranean borderlands, where annual rainfall amounts are low and inter-annual rainfall variability is high, tens of millions of people live in extreme water stress with sometimes devastating consequences as during the late 20th century Sahel drought. These are major incentives to understand the mechanisms driving past variability in the climate of North Africa. However, the instrumental record is short (~150 yrs) and geological and archaeological data reveal a capacity for far more extreme shifts in North African climate. Paced by Earth's gradually changing orbit around the Sun and millennial-scale variability in the climate system, North Africa's past climate has shifted repeatedly between drier and dustier conditions than today and humid green Sahara periods (GSPs) when the desert was transformed into a well vegetated landscape crosscut by rivers and lakes, populated by hippopotamuses and our early ancestors (most recently during the African Humid Period, AHP, ~14.5 to 5 thousand years ago, ka). What caused these past shifts? What do they imply for the future? We lack convincing answers to these questions because the extreme shifts indicated by the palaeo-data are not reproduced by the computer models used to predict future change. A main weakness of the existing palaeo-data is their limited diagnosis of mechanistic control. North Africa has two latitudinal and seasonally distinct rainfall regimes, the summer monsoon and winter westerly storm track, but we know too little of their temporal and spatial contributions to the profound changes in humidity-aridity and vegetation recorded in the data. A main weakness in the models is that we do not know whether their lack of skill reflects missing processes and feedbacks that dampen the response to climate forcing or whether they adequately represent the key processes but are inadvertently hard-wired for stability because uncertain parameter values are determined solely by evaluation against contemporary observational targets. We propose to transform our understanding of climate shifts in the North African dust belt and to upskill models to successfully simulate them by capitalizing on recent breakthroughs that we have made (see Track Record). We will develop proxy climate records for a bellwether Saharan region to tease apart past variability in summer monsoon and winter storm-track rainfall (see Objectives). And we will configure an IPCC-class Earth System model (ESM) that shows novel power to green the Sahara and is sufficiently computationally inexpensive to permit adequate sampling of parameter space to confront our new proxy records (see Objectives). This will allow us to develop a mechanistic understanding of extreme change and to translate our findings to those scientists who are developing the next generation of ESMs that will be used to predict future change over the coming decades (see Academic Beneficiaries).