We will work with young people to use digital technology to transform adolescent mental health and provide a safe, and supportive, digital environment to tackle the unmet need arising from mental health disorders in those aged 10-24 years old. We are facing a youth mental health crisis; in the UK, one in eight young people have a mental health disorder, and one in four young women aged 17-19 have significant depression or anxiety with half of those having self-harmed; non-suicidal self-harm has nearly tripled over the past 10 years, while suicide rates per 100,000 adolescents have almost doubled. However, less than a third of all young people with mental health disorders receive any treatment. Many mental health and wellbeing apps exist, but most have no evidence base and some could even be harmful. Meanwhile, few research-based digital interventions have been shown to have impact in the real world. The youth mental health crisis has coincided with huge changes in society with creation of the 'digital environment' where being online and using social media has become central to young people's lives. While social media can be a helpful place for accessing information, exchanging views and receiving support, it has also been linked with depression, suicide and self-harm. Yet not all young people are at risk of mental health problems with social media we don't yet understand why some young people are more vulnerable than others. The COVID-19 crisis has been associated with increased mental health problems and greater online activity in young people. While their need to access trusted support online is greater than ever, social media platforms are not designed to meet mental health needs of young people. Aims & objectives. We will work with young people in our Young Person Advisory Group to: 1. increase understanding of the relationship between digital risk, resilience and adolescent mental health. 2. develop and evaluate preventative and personalised digital interventions. We aim to: - identify risk and resilience factors related to troublesome online experiences and activities, to prevent or reduce the emergence of depression, anxiety, and self-harm in young people. - understand how individual differences affect digital engagement (e.g. with social media and games) and adolescent brain and psychosocial development. - build, adapt and pilot new a generation of personalised and adaptive digital interventions incorporating a mechanistic understanding of human support with a new digital platform for delivery and trials in adolescent mental health conditions. - develop and test a novel socially assistive robot to help regulate difficult emotions with a focus on adolescents who self-harm. - develop and test a new digital tool to help adolescents better manage impulsive and risky behaviour with a focus on reducing the risk of self-harm. Applications & benefits. This work will translate new knowledge into practical tools to support young people negotiate the digital world, develop resilience and protect their mental health. Our involvement of young people means that the outputs from the research will be suitable and meaningful. Young people will be actively involved shaping the research at all stages. Young people, their caregivers, teachers, clinicians and charities will benefit from a range of co-created apps and tools to manage youth mental health issues. Young people will benefit from research training offered as part of their involvement. Policy makers and academics will benefit from new understandings of risk and resilience in the digital world to support novel interventions and evidence-based policy. Our work will establish a new, ethical and responsible way of designing digital platforms and tools that supports young people's mental health. Our Mental Health & Digital Technology Policy Liaison Group and Partners Board will translate our research into a step-change in mental health outcomes.

The LEAP Digital Health Hub is a partnership of the South West's leading Universities, more than 20 supporting companies nationally, many NHS Trusts & Health Boards, 4 social care organisations, the region's Local Authorities, the West of England Academic Health Science Network (AHSN), the award-winning business incubator SETsquared and Health Data Research UK (HDRUK). The 50+ partners that shaped this bid ranged from the research director for a provider of residential care homes, to a chief clinical information officer working in an intensive care unit; from the founder of a femtech startup to the head of the healthcare analytics team for a multinational consulting firm. In workshops through June and July 2022 they told us that Digital Health is as much about design and user experience as health data analysis; it is motivated by patient benefit but must also consider viable business models for industry. All Hub partners will have access to dedicated physical office space in central Bristol alongside the EPSRC Centre for Doctoral Training (CDT) in Digital Health and Care. There, they will train, network and research together across disciplines and sectors. They will engage with partners across the UK- and beyond. Recognising that UK breakthroughs in Digital Health may be equally (or more) impactful abroad, the Hub's new "Global Digital Health Network" links the Hub to Digital Health expertise from the US, China, India, Nigeria and Australia (sections B1.2, B5). The Hub's unique Skills and Knowledge Programme is designed to address the professional training needs of industry, health and social care providers and academia within the two Themes of Transforming Health & Care Beyond the Hospital and Optimising Disease Prediction, Diagnosis & Intervention. This is proposed to be the world's largest Digital Health taught programme. The Hub's Fellowship programme will comprise 5 different schemes to develop future leaders, within not only academia, industry and the health/care sector, but also within the community - as patients or informal carers. The Hub's Research programme focusses on pre-competitive research within the Hub's two thematic areas of Transforming Health and Care Beyond the Hospital and Optimising Disease Prediction, Diagnosis and Intervention. The Hub will add value by surfacing health priorities from its partner health and social care organisations, working with the West of England AHSN and also with Hub members such as Chief Nursing Information Officers, with charities, social care providers, patient and community groups.