Imagine being able to manufacture food anywhere in the world, or even in space, so everyone, everywhere, has enough nutritious food to eat! This dream can be achieved through Cellular Agriculture (Cell Ag). Cell Ag enables the production of food products that would normally come from an animal, such as meat and milk from cows, or from monocultures of crops such as oil palm trees, without having to keep increasing animal or plant numbers to feed our growing global population. Cell Ag, uses biological cell-level processes to create food via the 'building blocks of life' - the proteins, fats and carbohydrates. By delivering these building blocks, Cell Ag will transform food production by complementing traditional food production, so not only can we feed the world, but we can manufacture the food so that sustainability and social responsibility is embedded from the outset. Why would we wish to use Cell Ag rather than animals? Let's take the example of the building block, protein, from traditional meat. Life Cycle Assessments have shown that when comparing traditional meat manufacturing against the expected benefits of using Cell Ag, there is a predicted reduction in greenhouse gas emissions, and land use, of up to 95%. The analysis also estimates that we could achieve up to 50% reduction in the use of water, compared to cattle farming. And we could reduce need for intensive farming so improving animal welfare too. So, with these benefits and the urgent need to achieve Net Zero Manufacturing and protect the planets resources. Why do we not have Cell Ag manufacturing in our homes or across all our food manufacturing sectors? There are several reasons - and our research will remove these blockers to Cell Ag manufacturing. Current status of Cell Ag Manufacturing research and outputs in the UK: In the UK (and across the World), there are pockets of excellent research being done, but little that focuses on delivering useable and scalable manufacturing machinery, processes, and systems in a coherent manner. The research tends to be in silos and focussed on aspects of the Manufacturing Value Chain. There are fundamental areas of research that need to be delivered to enable us to realise the Cell Ag potential, as well as transforming current research outputs to be useable. Through this Hub we will bring together the pockets of excellence in the UK, and deliver a coherent and targeted research programme that will ensure the UK Cell Ag research ecosystem is world-leading and has manufacturing impact. Rather than target a particular sector/type of food/product - the Hub will deliver manufacturing research which will enable production of food building blocks at local, regional and international levels. Our vision is to be the world leader in delivering materials, manufacturing processes and skills to escalate the world's adoption of sustainable Cell Ag food production. We will achieve this through becoming the net exporter of the building blocks of life.

Chemical separations are critical to almost every aspect of our daily lives, from the energy we use to the medications we take, but consume 10-15% of the total energy used in the world. It has been estimated that highly selective membranes could make these separations 10-times more energy efficient and save 100 million tonnes/year of carbon dioxide emissions and £3.5 billion in energy costs annually (US DoE). More selective separation processes are essential to "maximise the advantages for UK industry from the global shift to clean growth", and will assist the move towards "low carbon technologies and the efficient use of resources" (HM Govt Clean Growth Strategy, 2017). In the healthcare sector there is growing concern over the cost of the latest pharmaceuticals, which are often biologicals, with an unmet need for highly selective separation of product-related impurities such as active from inactive viruses (HM Govt Industrial Strategy 2017). In the water sector, the challenges lie in the removal of ions and small molecules at very low concentrations, so-called micropollutants (Cave Review, 2008). Those developing sustainable approaches to chemicals manufacture require novel separation approaches to remove small amounts of potent inhibitors during feedstock preparation. Manufacturers of high-value products would benefit from higher recovery offered by more selective membranes. In all these instances, higher selectivity separation processes will provide a step-change in productivity, a critical need for the UK economy, as highlighted in the UK Government's Industrial Strategy and by our industrial partners. SynHiSel's vision is to create the high selectivity membranes needed to enable the adoption of a novel generation of emerging high-value/high-efficiency processes. Our ambition is to change the way the global community perceives performance, with a primary focus on improved selectivity and its process benefits - while maintaining gains already made in permeance and longevity.

Chemical technologies underpin almost every aspect of our lives, from the energy we use to the materials we rely on and the medications we take. The UK chemical industry generates £73.3 billion revenue and employs 161,000 highly skilled workers. It is highly diverse (therefore resilient) with SMEs and microbusinesses making up a remarkable 96% of the sector. Today's global chemicals industry is responsible for 10% of greenhouse gas (GHG) emissions and consumes 20% of oil and gas as carbon feedstock to make products. Decarbonisation (defossilisation) of the chemicals sector is, therefore, urgently required, but to do so presents major technical and societal challenges. New sustainable chemical technologies, enabled by new synthesis, catalysis, reaction engineering, digitalisation and sustainability assessment, are needed. In order to ensure that the UK develops a resource efficient, resilient and sustainable economy underpinned by chemical manufacturing, developments in chemical technologies must be closely informed by whole systems approaches to measure and minimise environmental footprints, understand supply chains and assess economic and technological viability, using techniques such as life cycle assessment and material flow analysis. Lack of access to experts in science and engineering with a holistic understanding of sustainable systems is widely and publicly recognised as a significant risk. It is therefore extremely timely to establish a new EPSRC CDT in Sustainable Chemical Technologies that fully integrates a whole systems approach to training and world leading research in an innovation-driven context. This CDT will train the next generation of leaders in sustainable chemical technologies with new skills to address the growing demand for highly skilled PhD graduates with the ability to develop and transfer sustainable practices into industry and society. The new CDT will be a unique and vibrant focus of innovative doctoral training in the UK by taking full advantage of two exciting new developments at Bath. First, the CDT will be embedded in our new Institute for Sustainability (IfS) which has evolved from the internationally leading Centre for Sustainable and Circular Technologies (CSCT) and which fully integrates whole systems research and sustainable chemical technologies - two world-leading research groupings at Bath - under one banner. Second, the CDT will operate in close partnership with our recently established Swindon-based Innovation Centre for Applied Sustainable Technologies (iCAST, www.iCAST.org.uk) a £17M partnership for the rapid translation of university research to provide a dynamic innovation-focused context for PhD training in the region. Our fresh and dynamic approach has been co-created with key industrial, research, training and civic partners who have indicated co-investment of over £17M of support. This unique partnership will ensure that a new generation of highly skilled, entrepreneurial, innovative PhD graduates is nurtured to be the leaders of tomorrow's green industrial revolution in the UK.

The Sustainable Chemicals and Materials Manufacturing Hub (SCHEMA) will transform current centralised, fossil-based petrochemicals manufacturing into a sustainable, flexible and digital industry; replacing oil and gas with raw materials from wastes, air and water, driving processes with renewable electricity rather than heat and integrating advances in and computation and information technology to design future materials for functionality and sustainability throughout their life cycles. SCHEMA will deliver UK supply chain resilience and manufacturing sector interconnectivity from chemicals to polymers. By exploiting synergies between diverse industry users, SCHEMA empowers high-growth 'downstream' businesses in transport, energy generation/storage, construction, electronics and fast-moving consumer goods to reach net-zero emissions. This vision requires both a critical mass of diverse research expertise and focussed academic-industry collaboration. SCHEMA convenes experts in sustainable chemistry, process engineering, polymer science and digital technologies from the Universities of Oxford, Bath, Cambridge, Cardiff, Liverpool, Centre for Process Innovation, National Composites Centre, 2 Local Enterprise Partnerships, 25 companies and international partners to co-deliver innovative research, commercialisation and manufacturing advances for a net-zero chemical manufacturing future. Led by Prof Charlotte Williams, SCHEMA augments existing Future Manufacturing Hubs by focussing on interconnected, fundamental research to address four inter-connected sustainable chemical manufacturing Grand Challenges: Transform renewable resources & wastes, with renewable power, to chemicals & polymers. Develop innovative manufacturing processes adaptable for future operations. Integrate digital and information technologies to maximise sustainability and resilience. Design products for life-cycle sustainability, i.e. re-manufacturing, recycling and, in some cases, biodegradation to keep sustainable carbon recirculating. SCHEMA will deliver these through five inter-linked research work packages (WPs) across the manufacturing supply chain: Catalysis and Renewable Power: Selective, scalable and efficient methods to transform air (CO2, water, O2) and wastes into chemical intermediates and monomers. Processes must integrate with renewables, exploiting novel electrochemistry and engineering. Digital and Information Technologies: High efficiency manufacturing delivered through innovative chemistry, in situ/operando analyses, computational feedback loops and automation. Polymerizations and Application Development: Transforming 'green' chemical intermediates into sustainable polymers, elastomers, resins and adhesives. Process Chemistry and Engineering: Developing reactor and process engineering, scalable processes and purification designs for sustainable multi-phase manufacturing process chemistry and engineering. Sustainability Assessments: Assessment, benchmarking and standardisation of new manufacturing processes and products using leading sustainability and techno-economic models. Research integrated and prioritised for technical and theoretical breakthroughs. SCHEMA will integrate industry into these five themes via: