As surgical techniques become more minimally invasive, there is an inevitable increase in complexity of the operating platforms. Clinically, it is of vital importance to integrate real-time microscopic visualisation into the surgical workflow in a seamless way and in combination with the existing imaging modalities such as MRI, CT and ultrasound. The aim of this proposal is to develop a new SMART-endomicroscopic probe that integrates in situ sensing and mechatronic control to allow for flexible and consistent tissue characterisation for Minimally Invasive Surgery (MIS). It addresses specific research and engineering challenges related to biophotonics, mechanical/optical miniaturisation and integration, super-resolution image reconstruction, as well as tracking, localisation and large area coverage for in vivo, in situ tissue characterisation. Through multi-scale minimally invasive imaging integration, the proposed SMART-Endomicroscope will potentially allow cancer staging and intervention to be performed as a single procedure, permitting histological and vascular examination to be performed at all stages of the operation, such that management decisions can be altered intra-operatively to ensure best treatment for the individual patient. This will help to transform surgical treatment options and patient cancer outcomes as personalised healthcare becomes a reality. The project echoes the current paradigm shift in MIS towards miniaturised smart instruments with integrated imaging and sensing, enhanced by robotic control. It is supported by a multidisciplinary team with complementary skills in physics, engineering, medical image computing and surgery.

This project proposes a radical re-evaluation of the relationship between participation and cultural value. Bringing together evidence from in-depth historical analyses, the re-use of existing quantitative data and new qualitative research on the detail, dynamics and significance of 'everyday participation', it will create new understandings of community formation, connectivity and capacity through participation. Orthodox models of the creative economy and ensuing cultural policy are based on a narrow definition of cultural participation; one that captures formal engagement with traditional cultural institutions, such as museums and galleries, but overlooks other activities, for instance community festivals and hobbies. This frame, founded historically on deficit based assumptions of the logics for state cultural support, misses opportunities to understand the variety of forms of participation and their (positive and negative) consequences. We argue that by creating new understandings of the relationships between everyday participation, community and cultural value, we will reveal evidence of hidden assets and resources that can be mobilised to promote better identification and more equitable resourcing of cultural opportunities, generate well-being and contribute to the development of creative local economies. The central research questions are: - How, historically, did we arrive at the definitions, fields of knowledge and policy frames informing notions of cultural participation and value today? - What are the forms and practices of everyday participation - where do they take place? How are they valued? And how do these practices relate to formal participation? - How is participation shaped by space, place and locality? - How are communities made, unmade, divided and connected through participation? - How can broader understandings of value in and through participation be used to inform the development of vibrant communities and creative local economies? - How do we reconnect cultural policy and institutions with everyday participation? Using a variety of methodologies, including historical analysis, qualitative work with communities of practice and use, and the reanalysis of existing data on participation and time-use, this project focuses on six contrasting 'cultural ecosystems' to investigate the connections between multiple understandings of community (geographical, elective, identity based etc), cultural value, 'cultural economy' and everyday participation. The findings from the situated case studies will inform four partnership-operated trials of new policy interventions or of professional or community practices. Throughout the project research will be integrated with key partners, stakeholder cultural and community organisations in order to evolve better, shared understandings of everyday cultural participation and the implications of this for policy makers and cultural organisations at national, local and community levels.