The overall aim of this project will be to establish molecular and epigenetic differences in stress induced senescence programmes with ageing. Key regulatory elements and genes common/unique to melanocytes from different skin phototypes will be identified. This will be fundamental for developing better intervention strategies for healthy skin ageing tailored to different skin ethnicity.

This interdisciplinary and collaborative studentship will assess the role of co-design in the development of new mental health services. It is a collaboration between the Bradford District Care NHS Foundation Trust and the Faculty of Health Studies at the University of Bradford. It embodies our joint commitment to improving the wellness and health of marginalised communities who face the highest rates of mental health inequality. The studentship will focus on the experience of Black and Asian mental health service users and carers in the co-design process, and the impact this has on their trust in, and satisfaction with the service model and the care they receive. This constitutes an essential part of de-colonising mental health services. We anticipate real world impact at a local, regional and national level in how service users engage in co-design in the future. The successful applicant will be fully embedded within Bradford District Care NHS Foundation Trust (BDCT) working as an integral part of the mental health leadership team, evaluating the impact of the services' approach and effectiveness in co-design as part of the NHS Long Term Plan. They will work with stakeholders across the Bradford district to gain feedback via interviews, focus groups and surveys to assess the impact of co-design on community attitudes and service satisfaction. Health inequality is a priority area in both Bradford and West Yorkshire Integrated Care System. The study will not only inform the BDCT future pathways of codesign, but all five NHS trusts across the network, with national applicability and importance, particularly for other Health Care Authorities with similarly high levels of ethnic and racial diversity, and poverty.

With major progress being made in tissue engineering and organ regeneration, it is important to understand how the expression of genes in stem cells leads to their development into specialised cell types. Skin epithelium is a self-renewing biological structure that consists of the stem cells residing in the basal layer and differentiating into keratinocytes of suprabasal layers. This process results in a formation of an epidermal barrier protecting organisms from harmful environmental factors and is accompanied by activation of a number of epidermis-specific genes, located in the genome as clusters on four distinct chromosomes. However, it is unclear how these clusters are distributed in the nuclei of epidermal cells and what regulates their intra-nuclear arrangements and activity. We will test whether this process is regulated by a specific Satb1 protein that intergrates remodeling of large chromatin domains with regulation of gene expression. This project will shed light on the mechanisms that control gene reorganisation in the nuclei of epidermal cells and will be useful for better understanding the principles of stem cell-driven organ regeneration. Success of this project will be important for the progress in establishing new approaches in stem cell-based therapy and regenerative medicine.

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

With the fast development of electronic devices and computing technologies, various emerging applications (e.g., big data analysis, artificial intelligence and 3-dimensional (3D) media, Internet of things, etc.) have been entering our society with significant amounts of data traffic. While mobile networks are already indispensable to our society for "anywhere anytime connection," one main characteristic of future mobile networks (i.e., B5G: Beyond 5G) is the very huge amount of data, which requires very high throughput per devices (multiple Gbps, up to Tera bps: Tbps) and multiple Tbps per area efficiency (Tbps/km2). Though some disrupting 5G technologies may provide a few Gbps service, it is still not able to achieve hundreds of Gbps or Tbps rates. In the near future, the peak rate of mobile communication networks is expected to reach hundreds of Gbps or even Tbps rates, which requires either very high spectrum efficiency (e.g., much higher than 10 bits/s/Hz) in millimetre wave bands or very large bandwidth (e.g., more than 20GHz). While the former is very challenging, the latter can be achieved in THz bands (roughly, 100GHz to 10THz). The design of ubiquitous access with very high rates in mobile and heterogeneous network (HetNet) environments is the key to the development of future mobile networks, and so the objective of this collaborative 6G-TERAFIT is to create a knowledge transfer between the researchers and the engineers who will contribute to the design and implementation of future B5G ultra-fast networks and create the pedestal for them to become potential leaders in the resulting scientific, technological, and industrial fields. This project is committed to creating an "excellent" educational training platform that is multi-disciplinary and inter-sectoral in nature.