UK government is committed to nuclear energy having an important role in delivering a secure, low-carbon and affordable energy future, with their aspirations for new build power stations and life extension of the existing fleet described in policy documents. Successful delivery of this policy recognises the need for research and development, skills development and international collaboration as key enablers. A central component is the need to demonstrate our ability to safely manage and dispose of civil nuclear waste. The Nuclear Decommissioning Authority is responsible for the delivery of policy aims with respect to legacy waste, with Radioactive Waste Management charged with the delivery of a geological disposal facility and waste management solutions. EPSRC strategy is to maintain investment in nuclear fission research, recognising nuclear power as having an important role in the future low-carbon energy mix, with a strategic focus being research underpinning the decommissioning, immobilisation and management of nuclear waste. Central components of all these strategies are "a joined-up approach to nuclear R&D across government, industry and academia which...benefit(s) the UK economy" and, of benefit to UK industry, that establishes it "as a global leader in waste management and decommissioning" (see Case for Support). The successful delivery of decommissioning, immobilisation and management of nuclear waste solutions also impacts on public acceptance of any new build programme. In relation to any geological disposal facility, there is a need to demonstrate an ability to safely manage and dispose of waste from legacy operations, with studies of public attitudes showing that acceptance of such a facility is directly linked to having viable routes for the safe clean-up and disposal of any waste. These strategies rely on further research and development being delivered over the next 10-20 years. The work of the consortium is part of the response to this need, providing support to an internationally leading group of researchers in this key area. The work will contribute to the health of nuclear fission research, and through developments within specific disciplines, to areas beyond nuclear. It addresses key societal challenges in relation to productive and resilient nation outcomes through the development of next generation technologies and by ensuring effective and affordable solutions for waste treatment. It will also contribute to the building of public confidence in waste management solutions, and assist the acceptance of nuclear power, as well as contributing to UK economic success by maintaining our position as a world leader in waste management research, and in assisting industry to maintain its world leading position. The consortium comprises key industry partners and leading academic researchers from 11 research intensive universities with significant expertise in nuclear research and development. The research proposed is multi-disciplinary and covers fundamental and applied topics, including 40 research projects clustered into 4 technical themes. The consortium is made up of established researchers from a diverse range of backgrounds, who are all leaders in their field, with a track-record of innovation and problem solving in the nuclear area. It also comprises many early career researchers who, as well as having relevant nuclear-related expertise, are included to provide them with invaluable experience of a large consortium project, and to further develop their profile and influence, as they mature into leaders in the field. The consortium builds upon and consolidates the work of the previous EPSRC-funded project DISTINCTIVE (Decommissioning, Immobilisation and Storage Solutions for Nuclear Waste Inventories, EP/L014041/1), bringing together researchers from a larger group of universities and increasing the multi-disciplinary nature of the group to extend and develop the academic skills base within the UK.

Hydrogen and alternative liquid fuels (HALF) have an essential role in the net-zero transition by providing connectivity and flexibility across the energy system. Despite advancements in the field of hydrogen research both in the physical sciences and engineering, significant barriers remain to the scalable adoption of hydrogen and alternative liquid fuel technologies, and energy services, into the UK's local and national whole system infrastructure. These are technical barriers, organisational barriers, regulatory and societal barriers, and financial barriers. There are, therefore, significant gaps between current levels of hydrogen production, transportation, storage, conversion, and usage, and the estimated requirement for achieving net-zero by 2050. To address this, our proposed research programme has four interlinked work packages. WP1 will develop forward-thinking HALF technology roadmaps. We will assess supply chain availability and security. Selected representative HALF use cases will be used to identify and quantify any opportunities, risks and dependencies within a whole systems analysis. We will also develop an overarching roadmap for HALF system integration in order to inform technology advancement, industry and business development, as well as policy making and social interventions. WP2 will improve HALF characterisation and explore urgent new perspectives on the energy transition, including those related to ensuring resilience and security while also achieving net-zero. We will contrast the energy transition delivered by real incentives/behaviour versus those projected by widely-used optimisation models. The WP provides the whole systems modelling engine of the HI-ACT Hub, with a diverse array of state-of-the-art tools to explore HALF integration. WP 3 will explore the vital coupling of data and information relating to whole system planning and operational decision support, through the creation of a cyber physical architecture (CPA). This will generate new learning on current and future opportunities and risks, from a data and information perspective, which will lead to a whole system ontology for accelerated integration of hydrogen technologies. WP 4 considers options for a future energy system with HALF from a number of perspectives. The first is to consider expert views on HALF energy futures, and the public perceptions of those views. The second perspective considers place-based options for social benefit in HALF energy futures. The third perspective is to consider regulatory and policy options which would better enable HALF futures. Embedded across the research programme is the intent to create robust tools which are investment-oriented in their analysis. A Whole Systems and Energy Systems Integration approach is needed here, in order to better understand the interconnected and interdependent nature of complex energy systems from a technical, social, environmental and economic perspective. The Hub is led by Prof Sara Walker, Director of the EPSRC National Centre for Energy Systems Integration, supported by a team of 16 academics at a range of career stages. The team have extensive experience of large energy research projects and strong networks of stakeholders across England, Wales, Scotland and Northern Ireland. They bring to the Hub major hydrogen demonstrators through support from partners involved in InTEGReL in Gateshead, ReFLEX in Orkney, and FLEXIS Demonstration in South Wales for example. We shall engage to create a vibrant, diverse, and open community that has a deeper understanding of whole systems approaches and the role of hydrogen and alternative liquid fuels within that. We shall do so in a way which embeds Equality, Diversity and Inclusion in the approach. We shall do so in a way which is a hybrid of virtual and in-person field work consultation and develop appropriate digital tools for engagement.

Hydrogen and alternative liquid fuels (HALF) have an essential role in the net-zero transition by providing connectivity and flexibility across the energy system. Despite advancements in the field of hydrogen research both in the physical sciences and engineering, significant barriers remain to the scalable adoption of hydrogen and alternative liquid fuel technologies, and energy services, into the UK's local and national whole system infrastructure. These are technical barriers, organisational barriers, regulatory and societal barriers, and financial barriers. There are, therefore, significant gaps between current levels of hydrogen production, transportation, storage, conversion, and usage, and the estimated requirement for achieving net-zero by 2050. To address this, our proposed research programme has four interlinked work packages. WP1 will develop forward-thinking HALF technology roadmaps. We will assess supply chain availability and security. Selected representative HALF use cases will be used to identify and quantify any opportunities, risks and dependencies within a whole systems analysis. We will also develop an overarching roadmap for HALF system integration in order to inform technology advancement, industry and business development, as well as policy making and social interventions. WP2 will improve HALF characterisation and explore urgent new perspectives on the energy transition, including those related to ensuring resilience and security while also achieving net-zero. We will contrast the energy transition delivered by real incentives/behaviour versus those projected by widely-used optimisation models. The WP provides the whole systems modelling engine of the HI-ACT Hub, with a diverse array of state-of-the-art tools to explore HALF integration. WP 3 will explore the vital coupling of data and information relating to whole system planning and operational decision support, through the creation of a cyber physical architecture (CPA). This will generate new learning on current and future opportunities and risks, from a data and information perspective, which will lead to a whole system ontology for accelerated integration of hydrogen technologies. WP 4 considers options for a future energy system with HALF from a number of perspectives. The first is to consider expert views on HALF energy futures, and the public perceptions of those views. The second perspective considers place-based options for social benefit in HALF energy futures. The third perspective is to consider regulatory and policy options which would better enable HALF futures. Embedded across the research programme is the intent to create robust tools which are investment-oriented in their analysis. A Whole Systems and Energy Systems Integration approach is needed here, in order to better understand the interconnected and interdependent nature of complex energy systems from a technical, social, environmental and economic perspective. The Hub is led by Prof Sara Walker, Director of the EPSRC National Centre for Energy Systems Integration, supported by a team of 16 academics at a range of career stages. The team have extensive experience of large energy research projects and strong networks of stakeholders across England, Wales, Scotland and Northern Ireland. They bring to the Hub major hydrogen demonstrators through support from partners involved in InTEGReL in Gateshead, ReFLEX in Orkney, and FLEXIS Demonstration in South Wales for example. We shall engage to create a vibrant, diverse, and open community that has a deeper understanding of whole systems approaches and the role of hydrogen and alternative liquid fuels within that. We shall do so in a way which embeds Equality, Diversity and Inclusion in the approach. We shall do so in a way which is a hybrid of virtual and in-person field work consultation and develop appropriate digital tools for engagement.

Powered by data, Industrial Digital Technologies (IDTs) such as artificial intelligence and autonomous robots, can be used to improve all aspects of manufacturing and supply of products along supply chains to the customer. Many companies are embracing these technologies but uptake within the pharmaceutical sector has not been as rapid. The Medicines Made Smarter Data Centre (MMSDC) looks to address the key challenges which are slowing digitalisation, and adoption of IDTs that can transform processes to deliver medicines tailored to patient needs. Work will be carried out across five integrated platforms designed by academic and industrial researcher teams. These are: 1) The Data Platform, 2) Autonomous MicroScale Manufacturing Platform, 3) Digital Quality Control Platform, 4) Adaptive Digital Supply Platform, and 5) The MMSDC Network & Skills Platform. Platform 1 addresses one of the sector's core digitalisation challenges - a lack of large data sets and ways to access such data. The MMSDC data platform will store and analyse data from across the MMSDC project, making it accessible, searchable and reusable for the medicines manufacturing community. New approaches for ensuring consistently high-quality data, such as good practice guides and standards, will be developed alongside data science activities which will identify what the most important data are and how best to use them with IDTs in practice. Platform 2 will accelerate development of medicine products and manufacturing processes by creating agile, small-scale production facilities that rapidly generate large data sets and drive research. Robotic technologies will be assembled to create a unique small-scale medicine manufacturing and testing system to select drug formulations and processes to produce stable products with the desired in-vitro performance. Integrating several IDTs will accelerate drug product manufacture, significantly reducing experiments and dramatically reducing development time, raw materials and associated costs. Platform 3 focusses on the digitalisation of Quality Control (QC) aspects of medicines development which is important for ensuring a medicine's compliance with regulatory standards and patient safety requirements. Currently, QC checks are carried out after a process has been completed possibly spotting problems after they have occurred. This approach is inefficient, fragmented, costly (>20% of total production costs) and time consuming. The digital QC platform will research how to transform QC by utilising rich data from IDTs to confirm in real time product and process compliance. Platform 4 will generate new understanding on future supply chain needs of medicines to support adoption of adaptive digital supply chains for patient-centric supply. IDTs make smaller scale, autonomous factory concepts viable that support more flexible and distributed manufacture and supply. Supply flexibility and agility extends to scale, product variety, and shorter lead-times (from months to days) offering a responsive patient-centric or rapid replenishment operating model. Finally, technology developments closer to the patient, such as diagnostics provide visibility on patient specific needs. Platform 5 will establish the MMSDC Network & Skills Platform. This Network will lead engagement and collaboration across key stakeholder groups involved in medicines manufacturing and investments. The Network brings together the IDT-using community and other relevant academic and industrial groups to share developments across pharmaceuticals and broader digital manufacturing sectors ensuring cross-sector diffusion of MMSDC research. Existing strategic networks will support MMSDC and act as gateways for IDT dissemination and uptake. The lack of appropriate skills in the workforce has been highlighted as a key barrier to IDT adoption. An MMSDC priority is to identify skills needs and with partners develop and deliver training to over 100 users