HZG

Regenerative medicine aims to develop biomaterial and cell-based therapies that restore function to damaged tissues and organs. It is a cornerstone of contemporary and future medicine that needs a multidisciplinary approach. There is a world-wide shortage in scientists with such skillsets, which was highlighted in 2012 by the Research Councils UK in their 'A Strategy for UK Regenerative Medicine" which promotes 'training programmes to build capacity and provide the skills-base needed for the field to flourish'. The major clinical need for regenerative medicine was highlighted by the Science and Technology Committee (House of Lords; July 2013), who identified that 'The UK has the chance to be a leader in [regenerative medicine] and this opportunity must not be missed', and that 'there is likely to be a £44-54bn NHS funding gap by 2022 and that management of chronic disease accounts for around 75% of all UK health costs'. Vascular diseases are the leading cause of death and disability worldwide, musculoskeletal diseases have a huge burden in pain and disability, diabetes may be the 7th leading cause of death by 2030, and peripheral nerve injuries impair mobility after traumatic injuries. There is a pressing need for commercial input into regenerative medicine. Whilst the next generation of therapies, such as stem cells and biomaterials, will be underpinned by cutting-edge biology and bioengineering, strong industrial-academic partnerships are essential for developing and commercialising these advances for clinical benefit. We have established strong industrial partnerships which will both enhance the CDT training experience and provide major added value to our industrial partners. Regenerative medicine is a top priority for the University of Manchester (UoM) which has excellence in interdisciplinary graduate training and a critical mass of internationally renowned researchers, including newly appointed world-leaders. Our regenerative medicine encompasses physical, chemical, biological and medical sciences; we focus on tissue regeneration and inflammation, engineering and fabrication of biomaterials, and in vivo imaging and clinical translation, all on our integrated biomedical campus. We propose a timely Centre for Doctoral Training in Regenerative Medicine in Manchester that draws on our exceptional multidisciplinary depth and breadth, and directly addresses the skills shortage in non-clinical and clinical RM scientists. Our expertise integrates tissue regeneration & repair, the design & engineering of biomaterials, and the clinical translation of both biological and synthetic constructs. Our centres of excellence and internationally-leading supervisors across this multidisciplinary spectrum (details in Case for Support and UoM Letter of Support) highlight the strength of our scientific training environment. Defining CDT features will be: integrated cohort-based multidisciplinary training; skills training in engineering, biomedical sciences and pre-clinical translation; imaging in national Large Facilities; medical problem-solving nature of clinically co-supervised PhD projects, including in vivo training; comprehensive instruction in transferable skills and commercialisation; outward-facing ethos with placements with UK Regenerative Medicine Platform hub partners (UoM is partner on all three funded hubs), industrial partners, and international exchanges with world-class similarly-orientated doctoral schools; presentations in seminars and conferences. In this way, we will deliver a cadre of multidisciplinary scientists to meet the needs of academia and industry, and ensure the UK's continuing international leadership in RM. Ultimately, through training this cadre of doctoral scientists in regenerative medicine, we will be able to improve wound healing, repair injured nerves, blood vessels, tendon and ligaments, treat joint disease and restore function to organs damaged by disease.

Metallic materials are used in an enormous range of applications, from everyday objects, such as aluminium drinks cans and copper wiring to highly-specialised, advanced applications such as nickel superalloy turbine blades in jet engines and stainless steel nuclear reactor pressure vessels. Despite advances in the understanding of metallic materials and their manufacture, significant challenges remain. Research in advanced metallic systems helps us to understand how the structure of a material and the way it is processed affects its properties and performance. This knowledge is essential for us to develop the materials needed to tackle current challenges in energy, transport and sustainability. We must learn how to use the earth's resources in a sustainable way, finding alternatives for rare but strategically important elements and increasing how much material we recycle and reuse. This will partly be achieved through developing manufacturing and production processes which use less energy and are less wasteful and through improving product designs or developing and improving the materials we use. In order to deliver these new materials and processes, industry requires a lot more specialists who have a thorough understanding of metallic materials science and engineering coupled with the professional and technical leadership skills to apply this expertise. The EPSRC Centre for Doctoral Training in Advanced Metallic Systems will increase the number of metallurgical specialists, currently in short supply, by training high level physical science and engineering graduates in fundamental materials science and engineering in preparation for doctoral level research on challenging metallic material and manufacturing problems. By working collaboratively with industry, while undertaking a comprehensive programme of professional skills training, our graduates will be equipped to be tomorrow's research leaders, knowledge workers and captains of industry.