research product . 2013

BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer

Mitrović Olivera; Mićić Mileva; Čokić V.; Koko Vesna; Đikić Dragoslava; Budeč Mirela; Vignjević Sanja; Breković Tijana;
Open Access English
  • Published: 01 Jan 2013
  • Publisher: Archives of Biological Sciences
  • Country: Serbia
Abstract
We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression. The highest percentage of TOP2A amplification (47.8%) and deletion (13%) was detected in Luminal B subtypes. Of 11 Luminal B tumors with TOP2A amplification, 9 (81.8%) overexpressed TOP2A. BRCA1 protein overexpression showed significant positive correlation with TOP2A protein expression. BRCA1 and TOP2A proteins exhibited similar patterns of expression in Luminal B and triple-negative breast cancer, suggesting the same prognosis in those patients. [Projekat Ministarstva nauke Republike Srbije, br. 175053]
Subjects
Medical Subject Headings: skin and connective tissue diseases
free text keywords: BRCA1, TOP2A, FISH, immunohistochemistry, molecular subtypes of breast cancer
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