The proof of concept of correlative microscopy has been demonstrated for the observation and the characterization of biological cells involving Electron Microscopes (EMs). Nevertheless, up to date, correlative techniques involving the EM suffer from the fact that they are not yet able to provide a precise 3D rendering and topography informations. The ambition of the project is to provide a complete robotic instrument integrated in an EM to give to an operator without engineering skills a precise 3D rendering of intercellular structures with a typical size between 10 nm and 500 nm. We argue that embedding an AFM probe on a high-speed multi-dof nano-robotic system able to ensure a precise positioning of the probe in the three-dimensional space inside EMs will deeply modify the way of how topography images and force characterization are obtained at the nano-scale.