Carbenes are highly reactive species that find many applications in organic chemistry and beyond. Diazirines are carbene precursors that are more stable, less dangerous and tolerate a much broader substitution pattern than the traditional diazoalkanes. Those have been extensively studied but their large-scale application is limited by their poor stability and structural requirements. In sharp contrast, the carbene-related reactivity of diazirines remains mostly untapped toward applications in organic synthesis. This project thus aims at harnessing the potential of diazirine-born carbenes by overcoming the decoupling between their generation and their control. To achieve this, DIAZICOOL proposes to take advantage of modern synthetic techniques, recently uncovered activation conditions and various catalysts to generate, trap and use these reactive carbene species in relevant reactions.