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TRAJECTORY is a highly interdisciplinary and intersectoral training network focused on training 14 doctoral candidates (DN) in the field of tumor heterogeneity for improving treatment of cancer relapses. In TRAJECTORY, we support the idea, that in order to advance in the implementation of adapted therapeutic approaches to treat relapsing patients, we need to train the next generation of early-stage researchers (ESRs) to i) be aware of the limitations and shortcomings of the current methodology used to explore ITH, ii) have a multidisciplinary approach to their future research project ii) engage in the validation, standardization, and implementation of clinically-relevant models. Therefore, the main scientific objectives of TRAJECTORY are to combine the most advanced technologies to explore ITH in cancer relapses while focusing on training. TRAJECTORY brings together world leaders in the field of tumor heterogeneity with experts in tumor ecosystems (Itay Tirosh and Sarah-Maria Fendt ), tumor evolution (Trevor Graham ), or drug design (Raphael Rodriguez ). Moreover, we aggregate experts with a significant interdisciplinarity ranging from tumor biology (Itay Tirosh, Sarah-Maria Fendt, Christophe Ginestier ), to preclinical modeling (Julie Pannequin , Emmanuelle Charafe-Jauffret , HUB organoids), system biology (Francesca Ciccarelli ), mathematical modelling (Trevor Graham) robotics (Roderick Beijersbergen ), bioengineering (EpiQMAx, Miltenyi), chemistry (Raphael Rodriguez) or philosophy (Lucie Laplane , Javier Suarez). All beneficiaries, including three industrials companies focused on technology development (EpiQMAx, HUB Organoids, Miltenyi) will deliver research objectives through the supervision of one doctoral candidate and will lead several of the research and transferable skills training modules. Ultimately this industry-academic interaction will increase the innovation capacity of all participating organizations by facilitating intersectoral exchanges that contribute to European competitiveness. It will strengthen the European research and Innovation potential by fostering entrepreneurial skills of academic young researchers
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