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In collaboration with Alain Townsend's laboratory in Oxford, we have developed an extremely simple and very inexpensive serological test based on haemagglutination, which allows the detection of antibodies directed against the RBD domain of the SARS-2 virus. This test, called HAT, can be performed anywhere without any specialized equipment. The performance of this test has so far been documented in serum banks, and has shown a sensitivity greater than 90% and a specificity of 99%. The protocol has now been adapted and optimized so that HAT can be performed anywhere, on capillary blood drawn from the fingertip, and the central aim of this project is to validate this adapted protocol. In parallel, the possibility of using flow cytometry to extend the capabilities of HAT will be explored, in particular for the quantitative evaluation of different classes of serum antibodies reacting against the virus. Our ultimate goal is to be able to make this test available to all laboratories around the world who wish to use it and possibly to health agencies who are interested.
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