The ultimate goal of REGALE is to pave the way of next generation HPC applications to exascale systems. To accomplish this, we define an open architecture, build a prototype system and incorporate in this system appropriate sophistication in order to equip supercomputing systems with the mechanisms and policies for effective resource utilization and execution of complex applications. The REGALE architecture and prototype will be co-designed considering both state-of-the-art and next generation HPC applications, maximizing in this way its applicability.