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Particle and radiation beams are commonly used in our daily life. For example, electrons are accelerated and deflected in the cathode tube of television or computer screens. Higher-energy electrons slowing down in targets with high atomic number produce X rays by the so-called Bremsstrahlung process. Such X rays are routinely used for radiography and non destructive material or body inspection, for example to check human bodies (to visualize tumour cells, dental caries and osseous fractures) or to increase the safety of travellers by inspecting their luggage. Ionizing radiations are efficiently used in radiation therapy to cure cancers by damaging the DNA of cells, for which most of the radiation effect is through free radicals, notably hydroxyl radicals, which result from the ionization of water. To cure cancer, it is also very important to have detailed localisation of tumour cells and detailed knowledge of surrounding regions crossed by the ionizing radiation which will irradiate the patients. These data are crucial for optimizing treatment planning since the dose deposition depends sensitively on the constitution of the body. Such images are also performed with X ray beams or using radio-isotopes produced with particle beams. From the fundamental point of view, the development of ultra short bunches of energetic particles and X ray photons is of crucial importance in biology, chemistry, and solid state physics, where these beams could be used to diagnose the electronic, atomic or molecular dynamics with unprecedented, simultaneous time and space resolution. On the other hand, achievement of high X ray intensities will extend nonlinear optics to the X ray spectral range and permit the creation of new states of matter such as dense plasmas of astrophysical or geophysical interests. Intense and energetic photon and neutron beams are also important developments that can benefit to the nuclear physicists community. It has been demonstrated in the last ten years that short pulse delivered by compact lasers can generate these various particle sources[1]. These bright sources of electrons, protons, gamma radiation and neutrons are now more and more reproducible and particularly their parameters (energy, brightness, emittance, …) have been found to be adjustable. The LOA has played with other important laboratories in Europe, in Asia and in America a major rule in the development of these innovative sources of particle and radiation. The excellent knowledge of the Romanian groups in nuclear physics and in particle and radiation detectors added to the knowledge of the LOA groups on these sources development will give a new impulse in these research areas, it will contribute through this jointed and collaborative ANR to build up a strong exchange of knowledge, to train nuclear physicists from Romania to use and to master the experimental and complex apparatus around nice and performance laser plasma interaction platform recently upgraded. The work that will be covered and achieved during this three years contract will be of course of major relevance to prepare the ELI-NP (Extreme Light Infrasctructure – Nuclear Physics) Romanian project.
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