The RESCUE project aims to strengthen the resilience, security, and adaptability of critical infrastructure systems through advanced edge computing, AI-driven anomaly detection, and robust communication networks. In an era of increasing cyber threats, environmental challenges, and resource uncertainties, maintaining stable and secure critical infrastructure is vital for societal well-being and economic continuity. RESCUE focuses on real-time data processing at the edge, resilient communication channels, and advanced cybersecurity to enable continuous operation and rapid response to risks. The project will deliver cutting-edge solutions to enhance the reliability of power distribution, urban infrastructure, and communication networks by implementing flexible, autonomous systems that maintain functionality even in the face of unexpected disruptions. By integrating diverse sensor data, strengthening multi-channel connectivity, and employing AI for predictive insights, RESCUE ensures that infrastructure systems can detect, classify, and respond to threats autonomously. The project combines technical innovations with a strong emphasis on data privacy and security, aligning with EU regulations like the Cyber Resilience Act and the AI Act. Through rigorous testing and demonstrative use cases across Europe, RESCUE’s solutions will set new standards for critical infrastructure resilience, paving the way for safer and more dependable smart city and energy systems.