The prime objective of the project is to uplift the existing Centre of Excellence AstroCeNT by transforming it into a fully independent, interdisciplinary, new legal entity: Astrocent Plus Particle Astrophysics Science and Technology Centre. Astrocent Plus will engage in cutting-edge research and development in astroparticle physics and in related aspects of innovative technology, addressing global challenges, such as healthcare, climate change and sustainable sources of energy. As a fully autonomous entity with a modern professional management and administrative structure, it will be the first scientific institution in astroparticle physics supported by Teaming for Excellence and the first one in the field in Poland. Acting in close cooperation with world-leading consortium partners, Astrocent Plus will be embedded in a network of international collaborations involved in frontier research, probing the invisible Universe through neutrino, cosmic-ray, gravitational-wave and dark matter detection. AstroCeNT and the field have a proven record of medical and commercial applications and after the uplift will bring further high-impact benefits to society and economy. The buildup of internationally-rooted research capacity, gained through strategic partnerships, will position the Centre to achieve a significant, measurable, improvement in research and innovation culture and long-term financial sustainability, in part through commercialisation. The Centre will improve mobility and gender balance, train new cadres of highly-qualified researchers in science and hi-tech industry, promote innovation and cooperation between scientists and industry and help Poland and the EU attain a competitive position in the global value chains. With modern management practices, Astrocent Plus will become the main hub for the rapidly-developing field of particle astrophysics and a role model for Poland and the region for excellence in basic sciences and fruitful cooperation with industry.