The AutoTRUST project aims to develop and demonstrate a novel AI-leveraged self-adaptive framework of advanced vehicle technologies and solutions which optimize usability, perception, and experience on-board, and when boarding/off-boarding, in terms of security, privacy, well-being, health and assistance. AutoTRUST provides enhanced inclusiveness and trust in the interaction between users and new automated modes of road transport and mobility services in the transition from human-driven to automated vehicles. Safety and security of vehicle occupants in all circumstances even when the vehicle is driverless by helping to prevent dangerous and inconvenient situations will be of paramount importance. Intense cooperation between users, vehicle manufacturers, suppliers, researchers, and other stakeholders to co-design vehicles with solutions that optimize the on-board experience will be adopted. Moreover, an in-depth knowledge of the benefits of new vehicle technologies and solutions in terms of on-board experience, accessibility, inclusiveness, and trust will be acquired to enable wider user acceptability and contribute to the creation of future standards.