The SMAR3TS project arises as a response to climate change and environmental degradation. It orchestrates an ambitious international, interdisciplinary, and intersectoral staff exchange program for research and innovation, aimed at accelerating sociotechnical transitions for inclusive and sustainable growth. It actively tackles grand societal challenges that endanger global stability and prosperity, and adversely impact fundamental human needs such as food, mobility, energy, and housing. Rising temperatures, extreme weather events, sea-level rise, loss of biodiversity, and disruptions to ecosystems all have far-reaching consequences that transcend borders and require collaboration to develop timely and innovative solutions. SMAR3TS builds a Powerhouse Consortium with amplified network effect by uniting cross-disciplinary expertise of researchers and practitioners from 23 beneficiary partners, and 13 Associate/Third Country Partners working on research excellence through secondments, conferences, workshops, summer schools, knowledge-sharing platforms and activities to transform research outputs into tangible outcomes. United in diversity, SMAR3TS network spearheads innovations across various sectors to support resilient, restorative, and regenerative futures. By leveraging Open innovation strategies, SMAR3TS facilitates knowledge exchange, capacity building, and the co-creation of actionable solutions. By enabling a Quadruple-Helix approach (i.e. university-industry-government-civil society collaboration) and offering advanced training opportunities on research translation, futures thinking, foresight and other necessary tools and techniques, it equips researchers with key skills to design pathways for societal impact. Overall, SMAR3TS pursues a proactive strategy to build a fair, inclusive and regenerating world by collectively advancing science, technology, and innovation, triggering behavioural, organization and policy changes.