HyFiDress aims at developing Excellence in the Research Area of Multifunctional Hybrid Hydrogel-Fibrous Constructs for Wound Dressings. This will be achieved by twinning the Warsaw University of Technology with outstanding EU institutions with high expertise in the areas of novel antimicrobial strategies and electrospinning. HyFiDress will allow the excellence development required for a consolidated strategic research approach and designing a set of guidelines for the exploitation and commercialization of the results that will have a strong regional, national and European impact. The proposal integrates synergies in complementary fields of research that include (large-scale) electrospinning technology, dual-function peptide development and microbiology, aiming to obtain scientific breakthroughs to improve the global health and economy. The objectives of this proposal are in line with the specific challenge and scope of the topic of the Twinning bottom-up call, addressing networking gaps and deficiencies between the research institutions of the Widening countries and internationally leading counterparts at EU level. This challenge is addressed by twinning WUT with leading EU research institutions: University Hospital Regensburg, an expert in the development and invention of novel antimicrobial strategies to combat biomaterial-associated infections, such as dual-function peptides and bacteriophages. They contribute with their extensive experience on the design and testing of novel antimicrobial agents in vitro and in vivo; JUNIA, an institution internationally-recognized for its excellence in the development of functional and instrumented textiles for medical and well-being applications providing decisive expertise on. Lastly, Bioprex Medical B.V., a biotechnology company that develops antibacterial coatings for medical devices, contributes with their expertise from industry IPR protection, business development, and valorization.